antipyrine has been researched along with Sepsis in 9 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis was induced by cecal ligation and puncture (CLP) and the mice were divided into three groups-CLP vehicle (CLPV), CLP and edaravone (MCI-186, 3-methyl-1-phenyl-2-pyrazolin-5-one) (CLPE), and sham-operated (Sham)." | 5.42 | Metabolomic Analyses of Brain Tissue in Sepsis Induced by Cecal Ligation Reveal Specific Redox Alterations--Protective Effects of the Oxygen Radical Scavenger Edaravone. ( Chijiiwa, M; Elmér, E; Hara, N; Inazu, M; Ishida, Y; Karlsson, M; Kuroda, M; Ogiwara, Y; Sjovall, F; Uchino, H; Yara, M, 2015) |
| "Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication." | 5.38 | Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone. ( Chiba, S; Hattori, Y; Sagara, H; Takano, Y; Takashina, M; Tomita, K; Yagisita, S; Yokoo, H, 2012) |
| "Neonatal sepsis is complicated by pulmonary hypertension." | 5.37 | Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis. ( Daoud, GA; Fukuda, S; Goto, T; Hashimoto, T; Hussein, MH; Ito, T; Kakita, H; Kato, I; Kato, S; Mizuno, H; Suzuki, S; Togari, H; Yamaguchi, S, 2011) |
| "A retrospective review was carried out of 207 Japanese patients with acute stroke who developed renal disorders on edaravone treatment." | 3.74 | Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance. ( Hishida, A, 2007) |
| "Fifty-one consecutive children with sepsis and six critically ill children without sepsis were enrolled and given 18 mg/kg antipyrine per NG." | 3.72 | Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. ( Burckart, GJ; Carcillo, JA; Doughty, L; Frye, RF; Kaplan, SS; Kofos, D; Sasser, H, 2003) |
| "Sepsis was induced by cecal ligation and puncture (CLP) and the mice were divided into three groups-CLP vehicle (CLPV), CLP and edaravone (MCI-186, 3-methyl-1-phenyl-2-pyrazolin-5-one) (CLPE), and sham-operated (Sham)." | 1.42 | Metabolomic Analyses of Brain Tissue in Sepsis Induced by Cecal Ligation Reveal Specific Redox Alterations--Protective Effects of the Oxygen Radical Scavenger Edaravone. ( Chijiiwa, M; Elmér, E; Hara, N; Inazu, M; Ishida, Y; Karlsson, M; Kuroda, M; Ogiwara, Y; Sjovall, F; Uchino, H; Yara, M, 2015) |
| "Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication." | 1.38 | Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone. ( Chiba, S; Hattori, Y; Sagara, H; Takano, Y; Takashina, M; Tomita, K; Yagisita, S; Yokoo, H, 2012) |
| "Neonatal sepsis is complicated by pulmonary hypertension." | 1.37 | Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis. ( Daoud, GA; Fukuda, S; Goto, T; Hashimoto, T; Hussein, MH; Ito, T; Kakita, H; Kato, I; Kato, S; Mizuno, H; Suzuki, S; Togari, H; Yamaguchi, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 1 |
| Song, Y | 1 |
| Zhao, M | 1 |
| Yi, Z | 1 |
| Zeng, Q | 1 |
| Hara, N | 1 |
| Chijiiwa, M | 1 |
| Yara, M | 1 |
| Ishida, Y | 1 |
| Ogiwara, Y | 1 |
| Inazu, M | 1 |
| Kuroda, M | 1 |
| Karlsson, M | 1 |
| Sjovall, F | 1 |
| Elmér, E | 1 |
| Uchino, H | 1 |
| Kato, S | 2 |
| Hussein, MH | 2 |
| Kakita, H | 2 |
| Goto, T | 2 |
| Daoud, GA | 2 |
| Kato, T | 1 |
| Sugiura, T | 1 |
| Nobata, M | 1 |
| Nakajima, Y | 1 |
| Endo, T | 1 |
| Mizuno, K | 1 |
| Ito, T | 2 |
| Kato, I | 2 |
| Suzuki, S | 2 |
| Togari, H | 2 |
| Shi, M | 1 |
| Cao, TW | 1 |
| Shen, L | 1 |
| Sun, ZD | 1 |
| Zhu, HC | 1 |
| Yamaguchi, S | 1 |
| Mizuno, H | 1 |
| Fukuda, S | 1 |
| Hashimoto, T | 1 |
| Yokoo, H | 1 |
| Chiba, S | 1 |
| Tomita, K | 1 |
| Takashina, M | 1 |
| Sagara, H | 1 |
| Yagisita, S | 1 |
| Takano, Y | 1 |
| Hattori, Y | 1 |
| Carcillo, JA | 1 |
| Doughty, L | 1 |
| Kofos, D | 1 |
| Frye, RF | 1 |
| Kaplan, SS | 1 |
| Sasser, H | 1 |
| Burckart, GJ | 1 |
| FERENCZ, P | 1 |
| BODA, D | 1 |
| Hishida, A | 1 |
9 other studies available for antipyrine and Sepsis
| Article | Year |
|---|---|
Protective effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced acute kidney injury in a rat model of sepsis.
Topics: Acute Kidney Injury; Animals; Antipyrine; Apoptosis; Blood Urea Nitrogen; Catalase; Cells, Cultured; | 2015 |
Metabolomic Analyses of Brain Tissue in Sepsis Induced by Cecal Ligation Reveal Specific Redox Alterations--Protective Effects of the Oxygen Radical Scavenger Edaravone.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Brain; Cecum; Cell Death; Edaravone; Fre | 2015 |
Edaravone, a novel free radical scavenger, reduces high-mobility group box 1 and prolongs survival in a neonatal sepsis model.
Topics: Animals; Animals, Newborn; Antioxidants; Antipyrine; Blood Pressure; Body Weight; Cyclic N-Oxides; E | 2009 |
[The protective effect of edaravone on the treatment of sepsis in rats].
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Lung; Random Alloca | 2009 |
Edaravone, a hydroxyl radical scavenger, ameliorates the severity of pulmonary hypertension in a porcine model of neonatal sepsis.
Topics: Animals; Antipyrine; Blood Pressure; Edaravone; Free Radical Scavengers; Humans; Hydroxyl Radical; H | 2011 |
Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone.
Topics: Animals; Antipyrine; Blood-Brain Barrier; Cecum; Cytokines; Edaravone; Evans Blue; Fluorescein; Free | 2012 |
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.
Topics: Adolescent; Age Factors; Analysis of Variance; Antipyrine; Case-Control Studies; Child; Child, Presc | 2003 |
[Influence of pyramidone and ACTH on experimental bacteremia].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Antipyrine; Bacteremia; Humans; Pseudomonas Infections; Se | 1958 |
Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance.
Topics: Aged; Aged, 80 and over; Antipyrine; Blood Urea Nitrogen; Creatinine; Edaravone; Female; Free Radica | 2007 |