antipyrine has been researched along with Sensitivity and Specificity in 25 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction." | 7.74 | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction. ( Akuzawa, S; Bashar, AH; Fujie, M; Kazui, T; Ohishi, K; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Washiyama, N; Yamamoto, S; Yamashita, K, 2007) |
| "Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction." | 3.74 | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction. ( Akuzawa, S; Bashar, AH; Fujie, M; Kazui, T; Ohishi, K; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Washiyama, N; Yamamoto, S; Yamashita, K, 2007) |
| "Edaravone was unstable in plasma, but it presented a good stability performance in the plasma with sodium metabisulfite (SMB), an effective antioxidant." | 1.46 | A Novel LC-MS-MS Method With an Effective Antioxidant for the Determination of Edaravone, a Free-Radical Scavenger in Dog Plasma and its Application to a Pharmacokinetic Study. ( Hu, XL; Liu, X; Shan, MT; Shao, F, 2017) |
| "Edaravone was separated on an Agilent Eclipse Plus C18 column (100×2." | 1.40 | Two complementary liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods to study the excretion and metabolic interaction of edaravone and taurine in rats. ( Bian, TT; Du, Q; Jiang, SS; Li, YJ; Tang, DQ; Yang, DZ; Yu, YY; Zheng, XX, 2014) |
| " Topotecan, an anti-cancer drug widely used in metastatic carcinoma, is a P-glycoprotein substrate having oral bioavailability of 30% with large inter-patient variability." | 1.34 | Concurrent determination of topotecan and model permeability markers (atenolol, antipyrine, propranolol and furosemide) by reversed phase liquid chromatography: utility in Caco-2 intestinal absorption studies. ( Bansal, T; Jaggi, M; Khar, RK; Mishra, G; Mukherjee, R; Singh, M; Talegaonkar, S, 2007) |
| "Vancomycin was added to the maternal medium and perfused through the maternal circulation of the cotyledon." | 1.32 | Transplacental passage of vancomycin in the ex vivo human perfusion model. ( Bawdon, RE; Gainer, J; Hnat, MD; Wendel, GD, 2004) |
| "Antipyrine is a useful probe to evaluate variation of in vivo activities of oxidative hepatic drug-metabolizing enzymes." | 1.30 | Direct detection of antipyrine metabolites in rat urine by (13)C labeling and NMR spectroscopy. ( Akira, K; Hashimoto, T; Negishi, E; Sakuma, C, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 13 (52.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ibrahim, H | 1 |
| Hamdy, AM | 1 |
| Merey, HA | 1 |
| Saad, AS | 1 |
| Shao, F | 1 |
| Hu, XL | 1 |
| Liu, X | 1 |
| Shan, MT | 1 |
| Hong, SJ | 1 |
| Im, GJ | 1 |
| Chang, J | 1 |
| Chae, SW | 1 |
| Lee, SH | 1 |
| Kwon, SY | 1 |
| Jung, HH | 1 |
| Chung, AY | 1 |
| Park, HC | 1 |
| Choi, J | 1 |
| Tang, DQ | 1 |
| Zheng, XX | 1 |
| Li, YJ | 1 |
| Bian, TT | 1 |
| Yu, YY | 1 |
| Du, Q | 1 |
| Yang, DZ | 1 |
| Jiang, SS | 1 |
| Wang, YH | 1 |
| Avula, B | 1 |
| Tang, W | 1 |
| Wang, M | 1 |
| Elsohly, MA | 1 |
| Khan, IA | 1 |
| Annola, K | 1 |
| Keski-Rahkonen, P | 1 |
| Vähäkangas, K | 1 |
| Lehtonen, M | 1 |
| Dowling, G | 1 |
| Malone, E | 1 |
| Bräutigam, L | 1 |
| Nefflen, JU | 1 |
| Geisslinger, G | 1 |
| Huang, XR | 1 |
| Zhang, YS | 1 |
| Fu, CM | 1 |
| Liu, WN | 1 |
| Zhang, ZH | 1 |
| Song, WS | 1 |
| Huang, J | 1 |
| Wang, SX | 1 |
| Takahashi, G | 1 |
| Sakurai, M | 1 |
| Abe, K | 1 |
| Itoyama, Y | 1 |
| Tabayashi, K | 1 |
| Hnat, MD | 1 |
| Gainer, J | 1 |
| Bawdon, RE | 2 |
| Wendel, GD | 1 |
| Aghazadeh-Habashi, A | 1 |
| Carran, J | 1 |
| Anastassiades, T | 1 |
| Jamali, F | 1 |
| Chawla, S | 1 |
| Ghosh, S | 1 |
| Sihorkar, V | 1 |
| Nellore, R | 1 |
| Kumar, TR | 1 |
| Srinivas, NR | 1 |
| Puchowicz, MA | 1 |
| Radhakrishnan, K | 1 |
| Xu, K | 1 |
| Magness, DL | 1 |
| LaManna, JC | 1 |
| Gilbert-López, B | 1 |
| Llorent-Martínez, EJ | 1 |
| Ortega-Barrales, P | 1 |
| Molina-Díaz, A | 1 |
| Suzuki, T | 1 |
| Kazui, T | 1 |
| Yamamoto, S | 1 |
| Washiyama, N | 1 |
| Ohkura, K | 1 |
| Ohishi, K | 1 |
| Bashar, AH | 1 |
| Yamashita, K | 1 |
| Terada, H | 1 |
| Suzuki, K | 1 |
| Akuzawa, S | 1 |
| Fujie, M | 1 |
| Bansal, T | 1 |
| Singh, M | 1 |
| Mishra, G | 1 |
| Talegaonkar, S | 1 |
| Khar, RK | 1 |
| Jaggi, M | 1 |
| Mukherjee, R | 1 |
| Fu, D | 1 |
| O'Neill, RA | 1 |
| Itoh, Y | 1 |
| Sugimoto, T | 1 |
| Ukai, Y | 1 |
| Morino, A | 1 |
| Kimura, K | 1 |
| Nemchenko, NS | 1 |
| Vagner, VK | 1 |
| Erashev, ON | 1 |
| Vogel, J | 1 |
| Möbius, C | 1 |
| Kuschinsky, W | 1 |
| Shen, X | 1 |
| Perreault, H | 1 |
| Akira, K | 1 |
| Negishi, E | 1 |
| Sakuma, C | 1 |
| Hashimoto, T | 1 |
| Casey, B | 1 |
| Rozaklis, T | 1 |
| Ramsay, SL | 1 |
| Whitfield, PD | 1 |
| Ranieri, E | 1 |
| Hopwood, JJ | 1 |
| Meikle, PJ | 1 |
25 other studies available for antipyrine and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous Determination of Paracetamol, Propyphenazone and Caffeine in Presence of Paracetamol Impurities Using Dual-Mode Gradient HPLC and TLC Densitometry Methods.
Topics: Acetaminophen; Aminophenols; Antipyrine; Caffeine; Chromatography, High Pressure Liquid; Chromatogra | 2021 |
A Novel LC-MS-MS Method With an Effective Antioxidant for the Determination of Edaravone, a Free-Radical Scavenger in Dog Plasma and its Application to a Pharmacokinetic Study.
Topics: Animals; Antioxidants; Antipyrine; Chromatography, Liquid; Dogs; Edaravone; Female; Linear Models; M | 2017 |
Protective effects of edaravone against cisplatin-induced hair cell damage in zebrafish.
Topics: Animals; Antipyrine; Cell Survival; Cells, Cultured; Cisplatin; Cytoprotection; Dose-Response Relati | 2013 |
Two complementary liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods to study the excretion and metabolic interaction of edaravone and taurine in rats.
Topics: Animals; Antipyrine; Bile; Chromatography, Liquid; Drug Stability; Edaravone; Feces; Linear Models; | 2014 |
Ultra-HPLC method for quality and adulterant assessment of steviol glycosides sweeteners - Stevia rebaudiana and stevia products.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Diterpenes, Kaurane; Edaravone; Food Analysis; Foo | 2015 |
Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fluid and placental tissue by liquid chromatography-electrospray tandem mass spectrometry.
Topics: Acrylamide; Antipyrine; Chromatography, Liquid; Epoxy Compounds; Female; Humans; Perfusion; Placenta | 2008 |
Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry.
Topics: 4-Butyrolactone; Acetonitriles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Calibr | 2011 |
Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation.
Topics: Antipyrine; Chromatography, Liquid; Cyclooxygenase Inhibitors; Etoricoxib; Humans; Pyridines; Refere | 2003 |
[Determination of naoning pian by multi-wavelength linear regression method].
Topics: Analgesics, Non-Narcotic; Antipyrine; Caffeine; Drug Combinations; Linear Models; Pharmaceutical Pre | 2001 |
MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits.
Topics: Animals; Antipyrine; Biopsy, Needle; Disease Models, Animal; Edaravone; Immunohistochemistry; Inject | 2003 |
Transplacental passage of vancomycin in the ex vivo human perfusion model.
Topics: Anti-Bacterial Agents; Antipyrine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Femal | 2004 |
High performance liquid chromatographic determination of N-butyryl glucosamine in rat plasma.
Topics: Administration, Oral; Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Glucosam | 2005 |
High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal per
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Drug Stability; Furosemide; Intestinal Ab | 2006 |
Computational study on use of single-point analysis method for quantitating local cerebral blood flow in mice.
Topics: Algorithms; Animals; Antipyrine; Autoradiography; Carbon Radioisotopes; Cerebrovascular Circulation; | 2005 |
Development of a multicommuted flow-through optosensor for the determination of a ternary pharmaceutical mixture.
Topics: Antipyrine; Buffers; Caffeine; Flow Injection Analysis; Methanol; Pharmaceutical Preparations; Repro | 2007 |
Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction.
Topics: Analysis of Variance; Animals; Antipyrine; Blood Chemical Analysis; Cardiopulmonary Bypass; Cerebral | 2007 |
Concurrent determination of topotecan and model permeability markers (atenolol, antipyrine, propranolol and furosemide) by reversed phase liquid chromatography: utility in Caco-2 intestinal absorption studies.
Topics: Antipyrine; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chromat | 2007 |
Monosaccharide composition analysis of oligosaccharides and glycoproteins by high-performance liquid chromatography.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Edaravone; Glyco | 1995 |
Permeability of NS-3, a thyrotropin-releasing hormone analogue, into the brain after its systemic administration in rats: a microdialysis study.
Topics: Animals; Antipyrine; Blood-Brain Barrier; Cerebral Cortex; Dialysis; Extracellular Space; Male; Micr | 1995 |
[Antipyrine test in evaluation of patient's hepatic failure in early postoperative period].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Bilirubin; Biomarkers; Humans; Liver Fai | 1998 |
Early delineation of ischemic tissue in rat brain cryosections by high-contrast staining.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Arterial Occlusive Diseases; Autoradio | 1999 |
Electrospray ionization mass spectrometry of 1-phenyl-3-methyl-5-pyrazolone derivatives of neutral and N-acetylated oligosaccharides.
Topics: Acetylation; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Oligosaccharides; Sensitiv | 1999 |
Direct detection of antipyrine metabolites in rat urine by (13)C labeling and NMR spectroscopy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Carbon Isotopes; Isotope Labeling; Mag | 1999 |
Ex vivo human placental transfer of trovafloxacin.
Topics: Anti-Infective Agents; Antipyrine; Carbon Isotopes; Chromatography, High Pressure Liquid; Diffusion; | 2000 |
Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry.
Topics: Adolescent; Adult; Antipyrine; Child; Child, Preschool; Edaravone; Glycogen Storage Disease Type II; | 2002 |