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antipyrine and Seizures

antipyrine has been researched along with Seizures in 20 studies

Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"To explore the effect of edaravone (ED) on apoptosis of hippocampus neurons in seizures rats induced by pentylenetetrazole (PTZ)."7.80Effect of edaravone on apoptosis of hippocampus neuron in seizures rats kindled by pentylenetetrazole. ( Cheng, XL; Zhang, JJ, 2014)
"To explore the effect of edaravone (ED) on apoptosis of hippocampus neurons in seizures rats induced by pentylenetetrazole (PTZ)."3.80Effect of edaravone on apoptosis of hippocampus neuron in seizures rats kindled by pentylenetetrazole. ( Cheng, XL; Zhang, JJ, 2014)
" Edaravone increased expression of GRP78 and decreased expression of caspase-12 in hippocampus rat with pilocarpine-induced seizures, reduced the number of neuronal apoptosis."3.77[Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive]. ( Jiang, CM; Li, GQ; Wang, HP, 2011)
"Edaravone inhibited expression of IL-1beta and NF-kappaB in pilocarpine-induced seizures in rat hippocampus, reduced the number of neuronal apoptosis."3.75[Effects of edaravone on the expression of interleukin-1beta, nuclear factor-kappaB and neuron apoptosis in juvenile rat hippocampus after status convulsion]. ( Deng, XL; Li, GQ; Wang, HP, 2009)
" In the rat model of amygdala-kindled seizures, we measured CBF changes with the quantitative [(14)C]-iodoantipyrine autoradiographic method during secondary generalized (SGS, n=26 fully-kindled rats) and focal seizures (FS, n=19 partially kindled rats), according to sequential timing of injection with respect to seizure onset."3.74[Epileptogenic and non-epileptogenic zones: blood flow studies of temporo-limbic seizures]. ( Armspach, JP; Chassagnon, S; Hirsch, E; Kehrli, P; Namer, IJ; Nehlig, A, 2007)
" Local coupling of blood flow and metabolism was studied under different types of anesthesia (barbiturate, halothane), following experimental tumor implantation, and during penicillin seizures or spreading depression."3.66A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats. ( Hossmann, KA; Mies, G; Niebuhr, I, 1981)
"The kainic acid (KA) model of induced seizures has been widely used to study temporal lobe epilepsy."1.403-Methyl-1-phenyl-2-pyrazolin-5-one or N-acetylcysteine prevents hippocampal mossy fiber sprouting and rectifies subsequent convulsive susceptibility in a rat model of kainic acid-induced seizure ceased by pentobarbital. ( Fukui, M; Miyamoto, R; Nomura, S; Shimakawa, S; Tamai, H, 2014)
"The tracer was injected at 30 s before seizure induction (early ictal), simultaneous with the application of stimulation (ictal), at 60 s after stimulation (late ictal), at the end of the electrical afterdischarge (early postictal), and at 6 min after the stimulation (late postictal)."1.33Time course and mapping of cerebral perfusion during amygdala secondarily generalized seizures. ( Chassagnon, S; de Vasconcelos, AP; Ferrandon, A; Koning, E; Marescaux, C; Nehlig, A, 2005)
"During stage 0 seizures, LCBF rates increased significantly ipsilaterally in medial and central amygdala and substantia nigra."1.33Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats. ( André, V; Chassagnon, S; Ferrandon, A; Koning, E; Nehlig, A, 2006)
"Seizures were induced by topical bicuculline methiodide applied through two cranial windows drilled over homotopic sites of the frontal cortex, and LCBF was measured by quantitative autoradiography by using 4-iodo[N-methyl-14C]antipyrine."1.29Nitric oxide mediates the increase in local cerebral blood flow during focal seizures. ( Baldwin, RA; Pereira de Vasconcelos, A; Wasterlain, CG, 1995)
"Limbic seizure status was induced by microinjection of kainic acid into a unilateral amygdala in rats."1.28Uncoupling of local blood flow and metabolism in the hippocampal CA3 in kainic acid-induced limbic seizure status. ( Nishihara, I; Sako, K; Tanaka, S; Tanaka, T; Yonemasu, Y, 1990)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19907 (35.00)18.7374
1990's3 (15.00)18.2507
2000's5 (25.00)29.6817
2010's5 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cheng, XL1
Zhang, JJ1
Nomura, S1
Shimakawa, S1
Miyamoto, R1
Fukui, M1
Tamai, H1
Baba, A1
Kawakami, Y1
Saito, K1
Murashima, YL1
Itoh, Y1
Wang, HP3
Deng, XL2
Li, GQ3
Jiang, CM1
André, V2
Henry, D1
Nehlig, A4
ZAKHARIIA, EA1
ZAPADNIUK, VI1
TOPCHIBASHEV, IM1
ISAKHANOV, AG1
Chassagnon, S3
de Vasconcelos, AP1
Ferrandon, A2
Koning, E2
Marescaux, C1
Armspach, JP1
Namer, IJ1
Kehrli, P1
Hirsch, E1
Büch, HP1
Baldauf, J1
Wolff, I1
Mies, G1
Niebuhr, I1
Hossmann, KA1
Pereira de Vasconcelos, A1
Baldwin, RA1
Wasterlain, CG1
Ueno, H1
Yamashita, Y1
Caveness, WF1
Shih, TM1
Scremin, OU1
Tanaka, S1
Sako, K1
Tanaka, T1
Nishihara, I1
Yonemasu, Y1
Rimmer, EM1
Richens, A1
Dupont, V1
Vachon, F1
Emile, J1
Carbon, C1

Other Studies

20 other studies available for antipyrine and Seizures

ArticleYear
Effect of edaravone on apoptosis of hippocampus neuron in seizures rats kindled by pentylenetetrazole.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:6

    Topics: Animals; Antipyrine; Apoptosis; Caspase 3; Edaravone; fas Receptor; Hippocampus; Kindling, Neurologi

2014
3-Methyl-1-phenyl-2-pyrazolin-5-one or N-acetylcysteine prevents hippocampal mossy fiber sprouting and rectifies subsequent convulsive susceptibility in a rat model of kainic acid-induced seizure ceased by pentobarbital.
    Brain research, 2014, Nov-24, Volume: 1590

    Topics: Acetylcysteine; Aldehydes; Animals; Anticonvulsants; Antipyrine; Cell Survival; Edaravone; Excitator

2014
Effects of Edaravone on Hippocampal Antioxidants in EL Mice.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2016, Volume: 83, Issue:3

    Topics: Action Potentials; Animals; Antioxidants; Antipyrine; Edaravone; Electroencephalography; Glutathione

2016
[Effects of edaravone on the expression of interleukin-1beta, nuclear factor-kappaB and neuron apoptosis in juvenile rat hippocampus after status convulsion].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2009, Volume: 47, Issue:8

    Topics: Animals; Antipyrine; Apoptosis; Edaravone; Hippocampus; Interleukin-1beta; Male; Neurons; NF-kappa B

2009
[Effects of edaravone on glial fibrillary acidic protein and interleukin-lβ expression and neuronal apoptosis in juvenile rat hippocampus after status convulsion].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2011, Volume: 13, Issue:3

    Topics: Animals; Antipyrine; Apoptosis; Edaravone; Free Radical Scavengers; Glial Fibrillary Acidic Protein;

2011
[Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2011, Volume: 49, Issue:1

    Topics: Animals; Antipyrine; Apoptosis; Caspase 12; Edaravone; Heat-Shock Proteins; Hippocampus; Male; Rats;

2011
Dynamic variations of local cerebral blood flow in maximal electroshock seizures in the rat.
    Epilepsia, 2002, Volume: 43, Issue:10

    Topics: Animals; Antipyrine; Autoradiography; Brain; Carbon Radioisotopes; Cerebral Cortex; Electroshock; Hy

2002
[THE REPRODUCTION OF AUDIOGENIC CONVULSIONS AFTER THE PRELIMINARY ADMINISTRATION OF PYRAMIDONE TO ANIMALS].
    Biulleten' eksperimental'noi biologii i meditsiny, 1964, Volume: 57

    Topics: Acetazolamide; Aminopyrine; Anticonvulsants; Antipyrine; Epilepsy, Reflex; Mice; Pharmacology; Pheno

1964
[Control of convulsions in tetanus with analgesin].
    Khirurgiia, 1951, Volume: 4

    Topics: Antipyrine; Drug Combinations; Ether; Humans; Plant Oils; Procaine; Seizures; Tetanus; Tetanus Toxoi

1951
Time course and mapping of cerebral perfusion during amygdala secondarily generalized seizures.
    Epilepsia, 2005, Volume: 46, Issue:8

    Topics: Amygdala; Animals; Antipyrine; Autoradiography; Brain; Brain Mapping; Carbon Radioisotopes; Cerebral

2005
Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats.
    Epilepsy research, 2006, Volume: 69, Issue:2

    Topics: Amygdala; Animals; Antipyrine; Carbon Radioisotopes; Cerebrovascular Circulation; Electric Stimulati

2006
[Epileptogenic and non-epileptogenic zones: blood flow studies of temporo-limbic seizures].
    Revue neurologique, 2007, Volume: 163, Issue:12

    Topics: Animals; Antipyrine; Cerebrovascular Circulation; Electroencephalography; Epilepsy, Temporal Lobe; F

2007
[Drug distribution during convulsive seizure in comparison with narcosis].
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:12

    Topics: Adipose Tissue; Animals; Antipyrine; Brain; Female; Liver; Pentylenetetrazole; Phenobarbital; Rats;

1980
A double tracer autoradiographic technique for simultaneous measurement of cerebral blood flow and cerebral metabolism in rats.
    European neurology, 1981, Volume: 20, Issue:3

    Topics: Animals; Antipyrine; Autoradiography; Brain; Brain Neoplasms; Cerebrovascular Circulation; Cortical

1981
Nitric oxide mediates the increase in local cerebral blood flow during focal seizures.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Apr-11, Volume: 92, Issue:8

    Topics: Amino Acid Oxidoreductases; Animals; Antipyrine; Arginine; Autoradiography; Bicuculline; Cerebrovasc

1995
Regional cerebral blood flow pattern in focal epileptiform seizures in the monkey.
    Experimental neurology, 1975, Volume: 47, Issue:1

    Topics: Animals; Antipyrine; Carbon Radioisotopes; Caudate Nucleus; Cerebellum; Cerebral Cortex; Cerebrovasc

1975
Cerebral blood flow and metabolism in soman-induced convulsions.
    Brain research bulletin, 1992, Volume: 28, Issue:5

    Topics: Animals; Antipyrine; Autoradiography; Behavior, Animal; Blood Pressure; Brain Chemistry; Cerebrovasc

1992
Uncoupling of local blood flow and metabolism in the hippocampal CA3 in kainic acid-induced limbic seizure status.
    Neuroscience, 1990, Volume: 36, Issue:2

    Topics: Animals; Antipyrine; Autoradiography; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; D

1990
Interaction between vigabatrin and phenytoin.
    British journal of clinical pharmacology, 1989, Volume: 27 Suppl 1

    Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Antipyrine; Blood Proteins; Drug Interactions; F

1989
[Cerebral malaria with deep coma and acute renal insufficiency. Cure after 6 days of respiratory resuscitation associated with specific treatment of the malaria].
    Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1967, Nov-17, Volume: 118, Issue:13

    Topics: Acute Kidney Injury; Antipyrine; Brain Diseases; Coma; Humans; Malaria; Male; Middle Aged; Neurologi

1967