antipyrine has been researched along with Pyrexia in 22 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Antipyrine and metronidazole were administered as a cocktail to young (4 weeks old) male Wistar rats (N = 12 for each treatment) to investigate the effect of malaria infection due to the rodent parasite Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of the two compounds in vivo." | 7.68 | Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat. ( Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO; Ward, SA, 1993) |
| "To determine whether natural human interferon administered under the usual therapeutic dosing scheme would inhibit the hepatic drug metabolism, we performed an antipyrine test in eight patients with chronic B or non-A, non-B hepatitis before and after a subchronic interferon therapy (6 megaunits/day for 17 +/- 4 days, mean +/- SD)." | 7.68 | Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis. ( Echizen, H; Ishizaki, T; Oda, T; Ohta, Y; Shirataki, H; Tsukamoto, K; Umeda, N, 1990) |
| "Antipyrine clearance was estimated by a one-sample technique in 14 patients with acute fever and clinical pneumonia." | 7.67 | Antipyrine clearance in pneumonia. ( Andreasen, PB; Døssing, M; Loft, S; Sonne, J, 1985) |
| "1 The elimination of antipyrine from saliva was measured in six children aged 5 months to 5 years during fever and during a control period 2-4 weeks after the cessation of fever." | 7.66 | The effect of fever on antipyrine metabolism in children. ( Forsyth, JS; Moreland, TA; Rylance, GW, 1982) |
| "The pharmacokinetics of 14C-antipyrine were studied in rats with fever induced by intracerebroventricular injections of prostaglandin E1." | 7.66 | Lack of effect of fever on antipyrine oxidation in the rat. ( Aarbakke, J; Gadeholt, G; Olsen, H, 1978) |
| "The plasma half-life and metabolic clearance rate of antipyrine, a drug metabolized by hepatic microsomal enzymes, were determined in 33 normal volunteers during a basal state and during fever induced with a single intramuscular injection of etiocholanolone." | 7.65 | Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance. ( Elin, RJ; Vesell, ES; Wolff, SM, 1975) |
| "Antipyrine and metronidazole were administered as a cocktail to young (4 weeks old) male Wistar rats (N = 12 for each treatment) to investigate the effect of malaria infection due to the rodent parasite Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of the two compounds in vivo." | 3.68 | Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat. ( Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO; Ward, SA, 1993) |
| "To determine whether natural human interferon administered under the usual therapeutic dosing scheme would inhibit the hepatic drug metabolism, we performed an antipyrine test in eight patients with chronic B or non-A, non-B hepatitis before and after a subchronic interferon therapy (6 megaunits/day for 17 +/- 4 days, mean +/- SD)." | 3.68 | Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis. ( Echizen, H; Ishizaki, T; Oda, T; Ohta, Y; Shirataki, H; Tsukamoto, K; Umeda, N, 1990) |
| "Antipyrine clearance was estimated by a one-sample technique in 14 patients with acute fever and clinical pneumonia." | 3.67 | Antipyrine clearance in pneumonia. ( Andreasen, PB; Døssing, M; Loft, S; Sonne, J, 1985) |
| "1 The elimination of antipyrine from saliva was measured in six children aged 5 months to 5 years during fever and during a control period 2-4 weeks after the cessation of fever." | 3.66 | The effect of fever on antipyrine metabolism in children. ( Forsyth, JS; Moreland, TA; Rylance, GW, 1982) |
| "The pharmacokinetics of 14C-antipyrine were studied in rats with fever induced by intracerebroventricular injections of prostaglandin E1." | 3.66 | Lack of effect of fever on antipyrine oxidation in the rat. ( Aarbakke, J; Gadeholt, G; Olsen, H, 1978) |
| "The plasma half-life and metabolic clearance rate of antipyrine, a drug metabolized by hepatic microsomal enzymes, were determined in 33 normal volunteers during a basal state and during fever induced with a single intramuscular injection of etiocholanolone." | 3.65 | Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance. ( Elin, RJ; Vesell, ES; Wolff, SM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (77.27) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uramaru, N | 1 |
| Shigematsu, H | 1 |
| Toda, A | 1 |
| Eyanagi, R | 1 |
| Kitamura, S | 1 |
| Ohta, S | 1 |
| FLORIS, E | 1 |
| Telegdy, G | 1 |
| Adamik, A | 1 |
| Tóth, G | 1 |
| Lucaská, B | 1 |
| Sokolík, J | 1 |
| Tumová, I | 1 |
| Svec, P | 1 |
| Krätsmár-Smogrović, J | 1 |
| Forsyth, JS | 1 |
| Moreland, TA | 1 |
| Rylance, GW | 1 |
| Soriani, S | 1 |
| Voghenzi, A | 1 |
| Scorrano, M | 1 |
| Kokwaro, GO | 1 |
| Ismail, S | 1 |
| Glazier, AP | 1 |
| Ward, SA | 1 |
| Edwards, G | 1 |
| Shedlofsky, SI | 1 |
| Israel, BC | 1 |
| Tosheva, R | 1 |
| Blouin, RA | 1 |
| Keip, R | 1 |
| Böhme, P | 1 |
| Aarbakke, J | 1 |
| Gadeholt, G | 1 |
| Olsen, H | 1 |
| Matuszek, M | 1 |
| Elin, RJ | 1 |
| Vesell, ES | 1 |
| Wolff, SM | 1 |
| Echizen, H | 1 |
| Ohta, Y | 1 |
| Shirataki, H | 1 |
| Tsukamoto, K | 1 |
| Umeda, N | 1 |
| Oda, T | 1 |
| Ishizaki, T | 1 |
| Andrianakis, P | 1 |
| Walker, DW | 1 |
| Ralph, MM | 1 |
| Thorburn, GD | 1 |
| Sonne, J | 1 |
| Døssing, M | 1 |
| Loft, S | 1 |
| Andreasen, PB | 1 |
| van Miert, AS | 1 |
| van Essen, JA | 1 |
| Tromp, GA | 1 |
| Nishio, A | 2 |
| Kano, S | 2 |
| Karle, H | 1 |
| Nemoto, EM | 1 |
| Frankel, HM | 1 |
| Cashin, CH | 1 |
| Heading, CE | 1 |
| Yoshida, M | 1 |
| Benzi, G | 1 |
| Crema, A | 1 |
| Pavese-Pesce, A | 1 |
1 trial available for antipyrine and Pyrexia
| Article | Year |
|---|---|
Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; C-Reactive Protein; Cy | 1997 |
21 other studies available for antipyrine and Pyrexia
| Article | Year |
|---|---|
Design, synthesis, and pharmacological activity of nonallergenic pyrazolone-type antipyretic analgesics.
Topics: Allergens; Analgesics; Animals; Antipyretics; Body Temperature; Drug Design; Fever; Guinea Pigs; Hyp | 2010 |
[CLINICO-EXPERIMENTAL RESEARCH ON THE ANTIRHEUMATIC ACTIVITY OF AN ASSOCIATION OF 2-(BETA-CHLOROETHYL)-2,3-DIHYDRO-4-OXO-6-AMINO-1,3-BENZOXAZINE (ICI-350) AND PYRAMIDONE (DEREUMA I.C.I.)].
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Antipyrin | 1964 |
The action of urocortins on body temperature in rats.
Topics: Animals; Antipyrine; Body Temperature; Cerebral Ventricles; Colon; Corticotropin-Releasing Hormone; | 2006 |
[Antiphlogistic, antipyretic and toxicological properties of carboxylate-copper compounds].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Carboxylic A | 1982 |
The effect of fever on antipyrine metabolism in children.
Topics: Antipyrine; Child, Preschool; Fever; Half-Life; Humans; Infant; Kinetics; Saliva | 1982 |
[Fontanelle bombée : the possible consequence of sulphenazone therapy].
Topics: Antipyrine; Female; Fever; Humans; Infant; Pseudotumor Cerebri; Sulfamethoxypyridazine | 1981 |
Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat.
Topics: Animals; Antipyrine; Body Temperature; Disease Models, Animal; Endotoxins; Fever; Lipopolysaccharide | 1993 |
[Phenomenology of antipyresis. A study on Fortalidon].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Aspirin; Barbiturates; Caffeine; Codeine; Drug | 1977 |
Lack of effect of fever on antipyrine oxidation in the rat.
Topics: Animals; Antipyrine; Body Temperature; Fever; In Vitro Techniques; Injections, Intraventricular; Kin | 1978 |
Studies on antilipolytic activity of antipyretics. Part I. Influence of sodium salicylate, acetylsalicylic acid, phenazone, aminophenazone, and acetophenidin on lipolysis in fever induced by E. coli pyrogen.
Topics: Aminopyrine; Analgesics; Animals; Antipyrine; Aspirin; Body Temperature; Escherichia coli; Fatty Aci | 1976 |
Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance.
Topics: Adolescent; Adult; Antipyrine; Etiocholanolone; Female; Fever; Half-Life; Humans; Male; Metabolic Cl | 1975 |
Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis.
Topics: Adult; Antipyrine; Chromatography, High Pressure Liquid; Female; Fever; Half-Life; Hepatitis B; Hepa | 1990 |
Effect of inhibiting prostaglandin synthesis in pregnant sheep with 4-aminoantipyrine under normothermic and hyperthermic conditions.
Topics: Ampyrone; Animals; Antipyrine; Blood Gas Analysis; Blood Glucose; Body Temperature; Dinoprost; Dinop | 1989 |
Antipyrine clearance in pneumonia.
Topics: Adult; Aged; Antipyrine; Female; Fever; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; | 1985 |
The antipyretic effect of pyrazolone derivatives and salicylates on fever induced with leukocytic or bacterial pyrogen.
Topics: Analgesics; Animals; Antipyrine; Aspirin; Central Nervous System; Drug Antagonism; Escherichia coli; | 1972 |
[Studies on the effect of some antipyretics against endogenous pyrogen in rabbit].
Topics: Aminopyrine; Analgesics; Animals; Antipyrine; Aspirin; Fever; Leukocytes; Lipopolysaccharides; Phena | 1971 |
The mechanism of erythrocyte destruction induced by injection of bacterial pyrogen.
Topics: Animals; Antipyrine; Bacillus; Body Temperature; Chromium Isotopes; Cortisone; Erythrocytes; Fever; | 1969 |
Cerebrovascular response during progressive hyperthermia in dogs.
Topics: Alkalosis; Animals; Antipyrine; Blood Pressure; Body Temperature; Carbon Dioxide; Cerebrovascular Ci | 1970 |
The assay of anti-pyretic drugs in mice, using intracerebral injection of pyretogenins.
Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Biological Assay; Body Temperature; Cerebra | 1968 |
[Studies on the pyrogens. V. Comparative studies of some antipyretics and analgesics].
Topics: Aminopyrine; Analgesics; Animals; Antipyrine; Body Temperature; Fever; Mice; Pyrogens; Rabbits | 1968 |
[Comparative evaluation of the activity of antipyretics by means of different pharmacological tests].
Topics: Analgesics; Animals; Antipyrine; Biological Assay; Fever; Indoles; Rabbits; Rats; Salicylates | 1966 |