antipyrine has been researched along with Pregnancy in 238 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our objective was to determine the effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of the anti-HIV drug zalcitabine (2',3'-dideoxycytidine; ddC) in the pigtailed macaque (Macaca nemestrina)." | 7.69 | Effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of zalcitabine (2', 3'-dideoxycytidine) in the pigtailed macaque (Macaca nemestrina). ( Nosbisch, C; Tuntland, T; Unadkat, JD, 1997) |
| "Antipyrine pharmacokinetics as well as estradiol and progesterone concentrations were measured in plasma of 11 healthy pregnant women during the first two trimesters and again in the same patients 6 to 20 weeks after interruption of pregnancy." | 7.67 | Pregnancy-specific changes of antipyrine pharmacokinetics correlate inversely with changes of estradiol/progesterone plasma concentration ratios. ( Dvorchik, BH; Loock, W; Nau, H; Schmidt-Gollwitzer, M, 1988) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 7.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Pretreatment with edaravone significantly inhibited hypoxia-induced oxidative stress formation and sFlt-1 expression in trophoblasts." | 5.40 | Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia. ( Han, L; Liu, XX; Luo, QQ; Yan, T; Zhao, Y; Zheng, YF; Zou, L, 2014) |
| " The identity of pharmacokinetic regularities of antipyrin in samples of blood plasma and saliva permit the use of saliva as biological material for assessment of the metabolic profile of pregnant women." | 5.29 | [A prospective study of antipyrine pharmacokinetics in pregnancy]. ( Asymbekova, GU, 1995) |
| " Treatment of mothers from the 38th week of pregnancy reduced neonatal plasma-bilirubin concentrations on the 4th day after birth by an average of 44%." | 5.04 | Prophylaxis of neonatal jaundice with maternal antipyrine treatment. ( Friedman, LA; Lewis, PJ, 1979) |
| " This has allowed us to study whether the way of delivery, placental weight, and/or the length of pregnancy affect the two major criteria of a successful perfusion: volume loss (leak) from fetal to maternal circulation, and transplacental transfer of the reference compound antipyrine." | 3.81 | Criteria and challenges of the human placental perfusion – Data from a large series of perfusions. ( Karttunen, V; Myllynen, P; Myöhänen, K; Repo, JK; Sahlman, H; Vähäkangas, KH; Woo, CS, 2015) |
| "Methadone is the therapeutic agent of choice for the treatment of opiate addiction in pregnancy." | 3.75 | The impact of cocaine and heroin on the placental transfer of methadone. ( Malek, A; Obrist, C; von Mandach, U; Wenzinger, S, 2009) |
| "The adverse effects of smoking during pregnancy on fetal development are, in part, due to nicotine." | 3.73 | Effects of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across the human placenta. ( Ahmed, MS; Hankins, GD; Keyler, DE; Nanovskaya, TN; Nekhayeva, IA; Pentel, PR, 2005) |
| " A cocktail of essential trace elements along with antipyrine as internal reference marker were then injected intra-peritoneally to diabetic and matched control pregnant rats on the 20th day of pregnancy." | 3.73 | Maternal-fetal transport and disposition of copper, iron, molybdenum, selenium and zinc in experimentally induced diabetic rats. ( Al-Saleh, E; Al-Shammari, M; Fatinikun, T; Nandakumaran, M; Sadan, T, 2006) |
| "Maternal smoking during pregnancy causes reduction of fetal breathing movements, an effect attributed to nicotine in fetal blood." | 3.70 | Formation and retention of cotinine during placental transfer of nicotine in human placental cotyledon. ( Chance, MB; Goddijn-Wessel, TA; Hemontolor, ME; Sastry, BV, 1998) |
| "Our objective was to determine the effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of the anti-HIV drug zalcitabine (2',3'-dideoxycytidine; ddC) in the pigtailed macaque (Macaca nemestrina)." | 3.69 | Effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of zalcitabine (2', 3'-dideoxycytidine) in the pigtailed macaque (Macaca nemestrina). ( Nosbisch, C; Tuntland, T; Unadkat, JD, 1997) |
| " Therefore, placental transfer of antipyrine, 3-O-methyl-D-glucose and urea was measured in control pregnant sheep and in sheep with restricted placental growth (pre-pregnancy excision of endometrial caruncles)." | 3.67 | Restriction of placental size in sheep enhances efficiency of placental transfer of antipyrine, 3-O-methyl-D-glucose but not of urea. ( Falconer, J; Owens, JA; Robinson, JS, 1987) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 3.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Pretreatment with edaravone significantly inhibited hypoxia-induced oxidative stress formation and sFlt-1 expression in trophoblasts." | 1.40 | Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia. ( Han, L; Liu, XX; Luo, QQ; Yan, T; Zhao, Y; Zheng, YF; Zou, L, 2014) |
| " We characterized the transplacental transfer of paroxetine in perfused human placenta, fitting a pharmacokinetic model to the results and applying the model and parameters to evaluate a tapered dosage regimen." | 1.39 | Characterization of transplacental transfer of paroxetine in perfused human placenta: development of a pharmacokinetic model to evaluate tapered dosing. ( Fujii, T; Hori, S; Matsuoka, S; Nagai, M; Ohtani, H; Satoh, H; Sawada, Y; Taketani, Y, 2013) |
| "We tested in human breast cancer adenocarcinoma cell line MCF-7 whether ethanol affects ABCG2/BCRP, which is also the major transporter in human placenta." | 1.37 | Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion. ( Auriola, S; Halonen, T; Karttunen, V; Myllynen, P; Myöhänen, K; Vähäkangas, K; Veid, J, 2011) |
| "Cimetidine was used as an inhibitor for OCT-dependent active transfer." | 1.36 | The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta. ( Ekblad, U; Heikkinen, T; Laine, K; Rahi, M; Rönnemaa, T; Tertti, K, 2010) |
| "Metformin is a polar positively charged compound." | 1.35 | Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model. ( Golan, A; Hoffman, A; Kogman, N; Kovo, M; Nakash, I; Ovadia, O, 2008) |
| "Oseltamivir phosphate was extensively metabolized in the ex vivo model." | 1.35 | The metabolism and transplacental transfer of oseltamivir in the ex vivo human model. ( Bawdon, RE; Roberts, SW; Worley, KC, 2008) |
| " The transplacental pharmacokinetic model was fitted to the time profiles of the drug concentrations in the effluent and placenta to obtain transplacental pharmacokinetic parameters." | 1.35 | Transplacental pharmacokinetics of diclofenac in perfused human placenta. ( Fujii, T; Hori, S; Nagata, H; Nakano, H; Ohtani, H; Satoh, S; Sawada, Y; Shintaku, K; Taketani, Y; Tsujimoto, M; Tsukimori, K, 2009) |
| "Vancomycin was added to the maternal medium and perfused through the maternal circulation of the cotyledon." | 1.32 | Transplacental passage of vancomycin in the ex vivo human perfusion model. ( Bawdon, RE; Gainer, J; Hnat, MD; Wendel, GD, 2004) |
| " Seven-day-old rat pups were subjected to a modified Levine procedure, then given either vehicle or MCI-186 (at one of three dosage levels: 3, 6, or 9 mg/kg), and the extent of brain damage was evaluated either 24 h or 7 days later." | 1.31 | Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats. ( Ikeda, T; Ikenoue, T; Kaneko, M; Sameshima, H; Xia, YX, 2002) |
| "Zidovudine was administered as a constant-rate infusion or a bolus dose to the dam, fetus and amniotic cavity (bolus dose only) of the near-term pigtailed macaque model." | 1.30 | In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens. ( Nosbisch, C; Odinecs, A; Tuntland, T; Unadkat, JD, 1998) |
| "Taurine is a nonessential amino acid that plays a critical role in development." | 1.30 | Influence of chronic alcohol intake on intestinal taurine and antipyrine transport in pregnant rats. ( Fernández-Villalba, E; Guerri, C; Martín-Algarra, RV; Plá Delfina, JM; Polache, A, 1998) |
| "Antipyrine has been used extensively in fetal metabolic studies and is now known to inhibit prostaglandin synthesis; therefore we wished to determine the effects of antipyrine on fetal umbilical and regional metabolism." | 1.29 | Effects of antipyrine on umbilical and regional metabolism in late gestation in the fetal lamb. ( Charlton, V; Gull, I, 1993) |
| "Zalcitabine was also administred at a 10-fold higher infusion rate to the dam (n = 3)." | 1.29 | Mechanism and rate of placental transfer of zalcitabine (2',3'-dideoxycytidine) in Macaca nemestrina. ( Baughman, WL; Massarella, J; Nosbisch, C; Tuntland, T; Unadkat, JD, 1996) |
| "Metildigoxin (Lanitop) was added to the maternal medium at a concentration of 5." | 1.29 | Digoxin transfer across the isolated placenta is influenced by maternal and fetal albumin concentrations. ( Jung, S; Reinsberg, J; Schlebusch, H; Schmolling, J, 1996) |
| "Bupivacaine transfer was studied using the recirculating (closed) model and the single pass (open) model." | 1.29 | Bupivacaine transfer across the human term placenta. A study using the dual perfused human placental model. ( Arney, TL; Downing, JW; Gonzalez, H; Herman, N; Johnson, HV; Johnson, RF, 1995) |
| " In a third infusion, the dams alone received a higher dosage of dideoxyinosine (425 micrograms/min/kg) and the same dosage of antipyrine (41." | 1.29 | Transplacental pharmacokinetics of dideoxyinosine in pigtailed macaques. ( Baughman, WL; Nosbisch, C; Pereira, CM; Unadkat, JD; Winter, HR, 1994) |
| "Parathion was analysed by means of gas chromatography with a N-P detector." | 1.28 | Parathion transfer and acetylcholinesterase activity in an in-vitro perfused term human placenta. ( Benjaminov, O; Brandes, JM; Hoffer, E; Taitelman, U; Urbach, J, 1992) |
| "During cerebral hypoxia-ischemia (unilateral common carotid artery ligation and hypoxia with 8% oxygen), blood flows to all regions of the ipsilateral cerebral hemisphere were not different from control at 10 and 20 min." | 1.28 | Regional cerebral blood flow during hypoxia-ischemia in the immature rat: comparison of iodoantipyrine and iodoamphetamine as radioactive tracers. ( Bryan, RM; Ringel, M; Vannucci, RC, 1991) |
| "Antipyrine was used as a reference marker for comparison." | 1.28 | Transfer of cyclosporine in the perfused human placenta. ( Eldeen, AS; Nandakumaran, M, 1990) |
| "Antipyrine was included in each perfusion, and the data are expressed as clearance index, the ratio of hydroxyvitamin D3 to antipyrine clearance." | 1.27 | Transfer of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 across the perfused human placenta. ( Chuba, J; Dancis, J; Levitz, M; Ron, M, 1984) |
| " Two hours after maternal dosage there was equilibration of antipyrine across the placenta, but equilibration of cimetidine was incomplete (fetal/maternal ratio = 0." | 1.27 | Low clearance of cimetidine across the human placenta. ( Ching, MS; Date, NM; Hardy, KJ; Mihaly, GW; Morgan, DJ; Smallwood, RA, 1987) |
| "Antipyrine was infused throughout as an index of materno-fetal exchange." | 1.27 | Transfer of fentanyl across the rabbit placenta. Effect of umbilical flow and concurrent drug administration. ( Knott, C; Reynolds, F; Vella, LM, 1986) |
| "Antipyrine has been used previously to estimate total body water in infants." | 1.25 | Serial measurements of plasma half-lives and urinary excretion of antipyrine in low-birth-weight infants. ( Davies, DS; Murdock, AI; Rossiger, H; Thorgeirsson, SS, 1975) |
| "Antipyrine was administered to identical or monozygotic twins and to fraternal or dizygotic twins." | 1.25 | Genetic control of drug levels in man: antipyrine. ( Page, JG; Vesell, ES, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 132 (55.46) | 18.7374 |
| 1990's | 48 (20.17) | 18.2507 |
| 2000's | 34 (14.29) | 29.6817 |
| 2010's | 22 (9.24) | 24.3611 |
| 2020's | 2 (0.84) | 2.80 |
| Authors | Studies |
|---|---|
| Kuoni, S | 1 |
| Müller, D | 1 |
| Simões-Wüst, AP | 1 |
| Steiner, R | 1 |
| Mandelbrot, L | 1 |
| Ceccaldi, PF | 1 |
| Duro, D | 1 |
| Lê, M | 1 |
| Pencolé, L | 1 |
| Peytavin, G | 1 |
| Mohammed, AM | 1 |
| Huuskonen, P | 1 |
| Juvonen, R | 1 |
| Sahlman, H | 2 |
| Repo, J | 1 |
| Myöhänen, K | 4 |
| Myllynen, P | 5 |
| Woo, CJ | 1 |
| Karttunen, V | 5 |
| Vähäkangas, K | 8 |
| Conings, S | 1 |
| Amant, F | 1 |
| Annaert, P | 1 |
| Van Calsteren, K | 1 |
| Tanaka, S | 1 |
| Kanagawa, T | 1 |
| Momma, K | 1 |
| Hori, S | 5 |
| Satoh, H | 3 |
| Nagamatsu, T | 1 |
| Fujii, T | 4 |
| Kimura, T | 1 |
| Sawada, Y | 5 |
| Aengenheister, L | 1 |
| Keevend, K | 1 |
| Muoth, C | 1 |
| Schönenberger, R | 1 |
| Diener, L | 1 |
| Wick, P | 1 |
| Buerki-Thurnherr, T | 1 |
| Al-Sannan, B | 1 |
| Nandakumaran, M | 8 |
| Al-Harmi, J | 3 |
| Al-Shammari, M | 4 |
| Fouda, M | 1 |
| Poulsen, MS | 2 |
| Mose, T | 5 |
| Maroun, LL | 2 |
| Mathiesen, L | 4 |
| Knudsen, LE | 5 |
| Rytting, E | 2 |
| Nagai, M | 1 |
| Ohtani, H | 4 |
| Matsuoka, S | 1 |
| Taketani, Y | 3 |
| Stanley, JA | 1 |
| Sivakumar, KK | 1 |
| Arosh, JA | 1 |
| Burghardt, RC | 1 |
| Banu, SK | 1 |
| Zhao, Y | 1 |
| Zheng, YF | 1 |
| Luo, QQ | 1 |
| Yan, T | 1 |
| Liu, XX | 1 |
| Han, L | 1 |
| Zou, L | 1 |
| Repo, JK | 1 |
| Woo, CS | 1 |
| Vähäkangas, KH | 2 |
| Kovo, M | 3 |
| Kogman, N | 1 |
| Ovadia, O | 1 |
| Nakash, I | 1 |
| Golan, A | 2 |
| Hoffman, A | 3 |
| Worley, KC | 1 |
| Roberts, SW | 1 |
| Bawdon, RE | 3 |
| Annola, K | 1 |
| Keski-Rahkonen, P | 1 |
| Segerbäck, D | 1 |
| Heinonen, S | 1 |
| SCHONBAUER, L | 1 |
| Al-Saleh, E | 3 |
| Shintaku, K | 3 |
| Tsujimoto, M | 2 |
| Nagata, H | 2 |
| Satoh, S | 2 |
| Tsukimori, K | 3 |
| Nakano, H | 3 |
| Rahi, MM | 1 |
| Heikkinen, TM | 1 |
| Hakala, KE | 1 |
| Laine, KP | 1 |
| Malek, A | 1 |
| Obrist, C | 1 |
| Wenzinger, S | 1 |
| von Mandach, U | 1 |
| Watanabe, M | 3 |
| Masaoka, N | 3 |
| Nakajima, Y | 3 |
| Nagaishi, M | 3 |
| Yamamoto, T | 3 |
| Tertti, K | 1 |
| Ekblad, U | 1 |
| Heikkinen, T | 2 |
| Rahi, M | 2 |
| Rönnemaa, T | 1 |
| Laine, K | 2 |
| Mørck, TJ | 1 |
| Nielsen, JK | 2 |
| Nielsen, LK | 1 |
| Dziegiel, MH | 1 |
| Larsen, LG | 1 |
| Kojima, T | 1 |
| Ueda, Y | 1 |
| Adati, N | 1 |
| Kitamoto, A | 1 |
| Sato, A | 1 |
| Huang, MC | 1 |
| Noor, J | 1 |
| Sameshima, H | 2 |
| Ikenoue, T | 2 |
| Balakrishnan, B | 1 |
| Henare, K | 1 |
| Thorstensen, EB | 1 |
| Ponnampalam, AP | 1 |
| Mitchell, MD | 3 |
| Frederiksen, M | 1 |
| Vorkamp, K | 1 |
| Menjoge, AR | 1 |
| Rinderknecht, AL | 1 |
| Navath, RS | 1 |
| Faridnia, M | 1 |
| Kim, CJ | 1 |
| Romero, R | 1 |
| Miller, RK | 1 |
| Kannan, RM | 1 |
| Wainstein, J | 1 |
| Matas, Z | 1 |
| Haroutiunian, S | 2 |
| Veid, J | 1 |
| Auriola, S | 1 |
| Halonen, T | 1 |
| Hutson, JR | 1 |
| Lubetsky, A | 1 |
| Walfisch, A | 1 |
| Ballios, BG | 1 |
| Garcia-Bournissen, F | 1 |
| Koren, G | 1 |
| Sieppi, E | 1 |
| Kummu, M | 1 |
| Mørck, TA | 1 |
| Partanen, H | 1 |
| Fan, J | 1 |
| Zhang, N | 1 |
| Yin, G | 1 |
| Zhang, Z | 1 |
| Cheng, G | 1 |
| Qian, W | 1 |
| Long, H | 1 |
| Cai, W | 1 |
| Ikeda, T | 1 |
| Xia, YX | 1 |
| Kaneko, M | 1 |
| Serrano, MA | 2 |
| Macias, RI | 2 |
| Vallejo, M | 1 |
| Briz, O | 2 |
| Bravo, A | 1 |
| Pascual, MJ | 1 |
| St-Pierre, MV | 1 |
| Stieger, B | 1 |
| Meier, PJ | 1 |
| Marin, JJ | 2 |
| Myllynen, PK | 1 |
| Pienimäki, PK | 1 |
| González-Gallego, J | 1 |
| Bayón, JE | 1 |
| LAMBIOTTE-ESCOFFIER, C | 1 |
| MOORE, DB | 1 |
| TAYLOR, HC | 1 |
| DANCIS, J | 9 |
| MONEY, WL | 1 |
| MCCOLL, JD | 1 |
| GLOBUS, M | 1 |
| ROBINSON, S | 1 |
| Burdan, F | 5 |
| Hnat, MD | 1 |
| Gainer, J | 1 |
| Wendel, GD | 1 |
| Yokota, A | 1 |
| Nakai, A | 1 |
| Taniuchi, Y | 1 |
| Okuda, N | 1 |
| Nakai, M | 1 |
| Takeshita, T | 1 |
| Nekhayeva, IA | 1 |
| Nanovskaya, TN | 1 |
| Pentel, PR | 1 |
| Keyler, DE | 1 |
| Hankins, GD | 1 |
| Ahmed, MS | 2 |
| Hayakawa, Y | 2 |
| Sakata, H | 1 |
| Sadan, T | 1 |
| Fatinikun, T | 1 |
| Honma, T | 1 |
| Oinuma, T | 1 |
| Nemoto, N | 1 |
| Härtter, S | 1 |
| Hakkola, J | 1 |
| Hakala, K | 1 |
| Wallerman, O | 1 |
| Wadelius, M | 1 |
| Wadelius, C | 1 |
| Arima, Y | 1 |
| Dan, Y | 1 |
| Takeda, T | 1 |
| Kogushi, K | 1 |
| Feldman, N | 1 |
| Glezerman, M | 1 |
| Al-Rashdan, I | 1 |
| Meschia, G | 12 |
| Battaglia, FC | 12 |
| Bruns, PD | 2 |
| Behrman, RE | 6 |
| Miller, GE | 1 |
| Banerjee, NC | 1 |
| Stowe, CM | 1 |
| Sodha, RJ | 3 |
| Schneider, H | 7 |
| Challier, JC | 4 |
| D'Athis, P | 2 |
| Guerre-Millo, M | 2 |
| McKercher, HG | 1 |
| Derewlany, LO | 1 |
| Radde, IC | 1 |
| Vesell, ES | 14 |
| Quentin, CF | 1 |
| Besnard, RM | 1 |
| Bonnard, O | 1 |
| Akbaraly, R | 1 |
| Brachet-Liermain, A | 1 |
| Leng, JJ | 4 |
| Bebear, C | 1 |
| McRae, AC | 1 |
| Lemons, JA | 1 |
| Schreiner, RL | 1 |
| El Badry, A | 1 |
| Figueroa, JP | 2 |
| Poore, ER | 1 |
| Sunderji, S | 1 |
| Levine, S | 1 |
| Nathanielsz, PW | 2 |
| Pelkonen, O | 5 |
| Kärki, NT | 1 |
| Sotaniemi, EA | 2 |
| Nash, RM | 1 |
| Stein, L | 1 |
| Penno, MB | 2 |
| Passananti, GT | 3 |
| Ron, M | 1 |
| Levitz, M | 7 |
| Chuba, J | 1 |
| Proegler, M | 1 |
| Wilkening, RB | 2 |
| Anderson, S | 3 |
| Kammerman, S | 1 |
| Jansen, V | 4 |
| Miodovnik, M | 2 |
| Lavin, JP | 2 |
| Harrington, DJ | 2 |
| Leung, LS | 1 |
| Seeds, AE | 6 |
| Clark, KE | 3 |
| Chiba, K | 1 |
| Ishizaki, T | 1 |
| Tabuchi, T | 1 |
| Wagatsuma, T | 1 |
| Nakazawa, Y | 1 |
| Brandes, JM | 5 |
| Tavoloni, N | 1 |
| Potter, BJ | 1 |
| Sarkozi, L | 1 |
| Shepard, MD | 1 |
| Berk, PD | 1 |
| Dvorchik, BH | 2 |
| Paxton, JW | 1 |
| Crandell, SS | 1 |
| Palma, PA | 1 |
| Morriss, FH | 1 |
| Martensson, L | 1 |
| Leung, L | 1 |
| Bonds, DR | 1 |
| Gardey, CL | 1 |
| Richard, MO | 1 |
| Panigel, M | 2 |
| Olive, G | 2 |
| Booth, C | 1 |
| Elphick, MC | 1 |
| Hendrickse, W | 1 |
| Hull, D | 2 |
| Welsch, F | 1 |
| Pienimäki, P | 3 |
| Hartikainen, AL | 1 |
| Arvela, P | 1 |
| Partanen, T | 1 |
| Herva, R | 2 |
| Asymbekova, GU | 1 |
| Closse, C | 1 |
| Saux, MC | 3 |
| Breilh, D | 1 |
| Bouvier d'Yvoire, M | 1 |
| Grellet, J | 1 |
| Henderson, GI | 5 |
| Perez, AB | 2 |
| Yang, Y | 2 |
| Hamby, RL | 1 |
| Schenken, RS | 2 |
| Schenker, S | 6 |
| Johnson, RF | 6 |
| Herman, N | 1 |
| Arney, TL | 1 |
| Gonzalez, H | 1 |
| Johnson, HV | 1 |
| Downing, JW | 2 |
| Haugen, G | 1 |
| Stray-Pedersen, S | 1 |
| Bjøro, K | 1 |
| Pereira, CM | 1 |
| Nosbisch, C | 4 |
| Winter, HR | 1 |
| Baughman, WL | 2 |
| Unadkat, JD | 4 |
| Elliott, BD | 1 |
| Langer, O | 1 |
| Johnson, R | 1 |
| Prihoda, T | 1 |
| Barzago, MM | 2 |
| Omarini, D | 2 |
| Bortolotti, A | 1 |
| Stellari, FF | 1 |
| Lucchini, G | 1 |
| Efrati, S | 1 |
| Bonati, M | 2 |
| Stulc, J | 1 |
| Stulcová, B | 1 |
| Sibley, CP | 1 |
| Gull, I | 1 |
| Charlton, V | 1 |
| Milley, JR | 1 |
| Sweeley, JC | 1 |
| Bassily, M | 1 |
| Ghabrial, H | 1 |
| Smallwood, RA | 2 |
| Morgan, DJ | 2 |
| Ala-Kokko, TI | 2 |
| Hollmén, AI | 2 |
| Tuntland, T | 3 |
| Massarella, J | 1 |
| Schmolling, J | 2 |
| Jung, S | 2 |
| Reinsberg, J | 2 |
| Schlebusch, H | 2 |
| Lampela, E | 1 |
| Reisenberger, K | 1 |
| Egarter, C | 1 |
| Sternberger, B | 1 |
| Eckenberger, P | 1 |
| Eberle, E | 1 |
| Weissenbacher, ER | 1 |
| Giroux, M | 2 |
| Teixera, MG | 1 |
| Dumas, JC | 2 |
| Desprats, R | 2 |
| Grandjean, H | 2 |
| Houin, G | 2 |
| Staud, F | 1 |
| Fendrich, Z | 1 |
| Jindrová, O | 1 |
| Láznícek, M | 1 |
| Odinecs, A | 1 |
| Martín-Algarra, RV | 1 |
| Polache, A | 1 |
| Fernández-Villalba, E | 1 |
| Plá Delfina, JM | 1 |
| Guerri, C | 1 |
| Sastry, BV | 1 |
| Chance, MB | 1 |
| Hemontolor, ME | 1 |
| Goddijn-Wessel, TA | 1 |
| Holt, DE | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs: A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs. (NeoAKI STOP)[NCT05851222] | 4,200 participants (Anticipated) | Observational | 2023-08-01 | Not yet recruiting | |||
| Ex Vivo Study of Drugs Transfer Across the Placenta[NCT04400084] | 2,000 participants (Anticipated) | Observational | 2020-06-05 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for antipyrine and Pregnancy
| Article | Year |
|---|---|
Meta-analysis of data from human ex vivo placental perfusion studies on genotoxic and immunotoxic agents within the integrated European project NewGeneris.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; Central Nervous System Depres | 2012 |
The blood-uterine lumen barrier and its possible significance in early embryo development.
Topics: Animals; Antipyrine; Barbital; Biological Transport, Active; Blastocyst; Body Water; Electrolytes; E | 1984 |
Utility of clinical chemical determinations of drug concentrations in biological fluids.
Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramin | 1971 |
Effects of environmental chemicals on the metabolism of drugs, carcinogens, and normal body constituents in man.
Topics: 17-Ketosteroids; Alcohols; Androstanes; Animals; Antipyrine; Azo Compounds; Benzopyrenes; Bilirubin; | 1971 |
Polygenic factors controlling drug response.
Topics: Adult; Animals; Antipyrine; Caffeine; Dicumarol; Environment; Ethanol; Female; Genetic Variation; Ha | 1974 |
Recent progress in pharmacogenetics.
Topics: Adult; Aged; Alcohol Oxidoreductases; Antipyrine; Asian People; Child, Preschool; Cholinesterases; C | 1969 |
Recent progress in pharmacogenetics.
Topics: Adult; Antipyrine; Cyanides; Dicumarol; Erythrocytes; Ethnicity; Female; Glucosephosphate Dehydrogen | 1969 |
Salicylate metabolism in man.
Topics: Acylation; Adolescent; Aminopyrine; Animals; Antipyrine; Aspirin; Biotransformation; Brain; Dogs; Ep | 1971 |
4 trials available for antipyrine and Pregnancy
| Article | Year |
|---|---|
Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo.
Topics: Anticonvulsants; Antipyrine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; | 2003 |
Transplacental transfer and metabolism of buprenorphine.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biotransformation; Buprenorphine; Female | 2002 |
Prophylaxis of neonatal jaundice with maternal antipyrine treatment.
Topics: Antipyrine; Bilirubin; Clinical Trials as Topic; Female; Fetus; Follow-Up Studies; Humans; Infant, N | 1979 |
[Controlled study of the analgesic action of viminol p-OH bezoate in suppositories in post-partum pain].
Topics: Adult; Analgesics; Antipyrine; Benzyl Compounds; Clinical Trials as Topic; Drug Evaluation; Ethanola | 1972 |
226 other studies available for antipyrine and Pregnancy
| Article | Year |
|---|---|
Simultaneous LC-MS/MS quantification of SGLT2 inhibitors and antipyrine in medium and tissue from human ex vivo placenta perfusions.
Topics: Antipyrine; Canagliflozin; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Hum | 2023 |
Placental transfer and tissue accumulation of dolutegravir in the ex vivo human cotyledon perfusion model.
Topics: Antipyrine; Female; Heterocyclic Compounds, 3-Ring; HIV Integrase Inhibitors; Humans; Maternal-Fetal | 2019 |
Activities of metabolizing enzymes in human placenta.
Topics: Adult; Antipyrine; Aromatase; Catalase; Cytochrome P-450 CYP1A1; Female; Glucuronosyltransferase; Gl | 2020 |
Integration and validation of the ex vivo human placenta perfusion model.
Topics: Antipyrine; Female; Fetus; Glucose; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Materna | 2017 |
Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biomarkers, Pharmacological; Co | 2017 |
An advanced human in vitro co-culture model for translocation studies across the placental barrier.
Topics: Antipyrine; Biological Transport; Cell Line; Coculture Techniques; Endothelial Cells; Female; Humans | 2018 |
Transport kinetics of chromium in perfused human placental lobule in late gestation:
Topics: Adult; Antipyrine; Biological Transport; Chromium; Female; Humans; Maternal-Fetal Exchange; Placenta | 2019 |
Kinetics of silica nanoparticles in the human placenta.
Topics: Antipyrine; Biological Transport; Cell Line; Cell Survival; Female; Humans; Kinetics; Maternal-Fetal | 2015 |
Characterization of transplacental transfer of paroxetine in perfused human placenta: development of a pharmacokinetic model to evaluate tapered dosing.
Topics: Antidepressive Agents, Second-Generation; Antipyrine; Female; Fetus; Humans; Kinetics; Maternal-Feta | 2013 |
Edaravone mitigates hexavalent chromium-induced oxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the rat ovary in F1 offspring.
Topics: Animals; Animals, Suckling; Antipyrine; Apoptosis; Dose-Response Relationship, Drug; Edaravone; Estr | 2014 |
Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia.
Topics: Antipyrine; Cell Hypoxia; Cell Line; Cobalt; Edaravone; Female; Free Radical Scavengers; Gene Expres | 2014 |
Criteria and challenges of the human placental perfusion – Data from a large series of perfusions.
Topics: Antipyrine; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Perfusion; Placenta; Pregn | 2015 |
Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biological Transport; Carrier Proteins; Chromat | 2008 |
The metabolism and transplacental transfer of oseltamivir in the ex vivo human model.
Topics: Antipyrine; Antiviral Agents; Female; Fetus; Humans; Maternal-Fetal Exchange; Models, Biological; Os | 2008 |
Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta.
Topics: Acrylamides; Adult; Antipyrine; Chromatography, High Pressure Liquid; DNA; Epoxy Compounds; Female; | 2008 |
Antisepsis and asepsis since Semmelweis.
Topics: Antipyrine; History, 19th Century; Pregnancy; Puerperal Infection | 1947 |
Transport kinetics of cisplatin in the perfused human placental lobule in vitro.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antipyrine; Chorionic Villi; | 2008 |
Transplacental pharmacokinetics of diclofenac in perfused human placenta.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Chromatography, High Pressure Liquid; Diclofena | 2009 |
The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta.
Topics: Antipyrine; Biological Transport; Female; HIV Protease Inhibitors; Humans; In Vitro Techniques; Mate | 2009 |
The impact of cocaine and heroin on the placental transfer of methadone.
Topics: Antipyrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbon Radioisotopes; Cocaine; | 2009 |
Changes of expression of glucose transporters in the fetal lamb brain after MCI-186 administration to the maternal circulation with 10-min persistent umbilical cord occlusion.
Topics: Animals; Antipyrine; Arterial Occlusive Diseases; Brain; Drug Evaluation, Preclinical; Edaravone; Fe | 2009 |
Modeling placental transport: correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion.
Topics: Antipyrine; Benzoic Acid; Caffeine; Cell Line; Cell Membrane Permeability; Female; Glycine; Glyphosa | 2009 |
The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta.
Topics: Antipyrine; Biological Transport, Active; Cimetidine; Female; Humans; Maternal-Fetal Exchange; Metfo | 2010 |
Quality assessment of a placental perfusion protocol.
Topics: Animal Testing Alternatives; Antipyrine; Equipment Design; Female; Humans; In Vitro Techniques; Mate | 2010 |
Gene network analysis to determine the effects of antioxidant treatment in a rat model of neonatal hypoxic-ischemic encephalopathy.
Topics: Animals; Animals, Newborn; Antioxidants; Antipyrine; Disease Models, Animal; Edaravone; Female; Free | 2010 |
Transfer of bisphenol A across the human placenta.
Topics: Air Pollutants, Occupational; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Benzhydryl Compou | 2010 |
Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study.
Topics: Antipyrine; Female; Halogenated Diphenyl Ethers; Humans; Maternal-Fetal Exchange; Perfusion; Placent | 2010 |
Transfer of PAMAM dendrimers across human placenta: prospects of its use as drug carrier during pregnancy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biological Transport; Dendrimers; Drug Carriers | 2011 |
Placental transfer of the insulin analog glargine in the ex vivo perfused placental cotyledon model.
Topics: Antipyrine; Female; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Glargine; Ins | 2011 |
Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Di | 2012 |
Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion.
Topics: Adenocarcinoma; Antipyrine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cas | 2011 |
The transfer of 6-mercaptopurine in the dually perfused human placenta.
Topics: Antipyrine; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Mercaptopurine; Perfusion; | 2011 |
Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD.
Topics: 14-3-3 Proteins; Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Pr | 2012 |
Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats.
Topics: Animals; Animals, Newborn; Antipyrine; Brain; Edaravone; Female; Free Radical Scavengers; Hypoxia-Is | 2002 |
Effect of ursodeoxycholic acid on the impairment induced by maternal cholestasis in the rat placenta-maternal liver tandem excretory pathway.
Topics: Animals; Antipyrine; Cell Membrane; Cholestasis; DNA Primers; Female; Gene Expression; Glycocholic A | 2003 |
Excretion of foetal bilirubin by the rat placenta-maternal liver tandem.
Topics: Animals; Antipyrine; Bilirubin; Biological Transport; Cell Membrane; Female; Fetus; Liver; Maternal- | 2003 |
The volume of distribution of inulin, antipyrine, and radiosodium during normal and toxemic pregnancy and during the puerperium.
Topics: Antipyrine; Electrolytes; Female; Humans; Inulin; Postpartum Period; Pre-Eclampsia; Pregnancy | 1953 |
Transfer of sodium and iodo-antipyrine across guinea pig placenta with an in situ perfusion technique.
Topics: Antipyrine; Female; Guinea Pigs; Humans; Iodine; Iodine Radioisotopes; Placenta; Pregnancy; Sodium; | 1960 |
EFFECT OF SOME THERAPEUTIC AGENTS ON THE DEVELOPING RAT FETUS.
Topics: Abnormalities, Drug-Induced; Animals; Antipyrine; Aspirin; Chloral Hydrate; Dimenhydrinate; Female; | 1965 |
Developmental effects of propyphenazone in analgesic and antipyretic combination with caffeine or paracetamol.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antipyrine; Caffeine; Dose-R | 2004 |
Transplacental passage of vancomycin in the ex vivo human perfusion model.
Topics: Anti-Bacterial Agents; Antipyrine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Femal | 2004 |
Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Edaravone; Energy Metabolism; Female; Fetal Hypoxia; Fre | 2005 |
Effects of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across the human placenta.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antipyrine; Drug Evaluation, Preclinical; Fem | 2005 |
The production of hydroxyl radicals in the fetal lamb brain resulting from occlusion of the umbilical circulation and the transplacental effect of MCI-186 to inhibit hydroxyl radical production.
Topics: Animals; Antipyrine; Brain; Catechols; Edaravone; Female; Free Radical Scavengers; Hydroxybenzoates; | 2006 |
Maternal-fetal transport and disposition of copper, iron, molybdenum, selenium and zinc in experimentally induced diabetic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diabetes Mellitus, Experimental; Femal | 2006 |
MCI-186 administered to the maternal circulation inhibits fetal brain injury resulting from total umbilical cord occlusion in the chronically instrumented fetal lamb.
Topics: Animals; Antipyrine; Brain Injuries; Edaravone; Female; Fetal Hypoxia; Free Radical Scavengers; Mate | 2006 |
Placental transfer of quetiapine in relation to P-glycoprotein activity.
Topics: Acridines; Alleles; Antipsychotic Agents; Antipyrine; ATP Binding Cassette Transporter, Subfamily B, | 2007 |
Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta.
Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Female; Humans; Kinetics; Models, B | 2007 |
Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Female; Humans; Hypoglycemic Agents; Maternal-F | 2008 |
Maternal-fetal transport kinetics of carboplatin in the perfused human placental lobule: in vitro study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antipyrine; Biological Availa | 2007 |
Theoretical and experimental study of transplacental diffusion.
Topics: Animals; Antipyrine; Biological Transport; Blood Circulation; Cell Membrane Permeability; Female; Fe | 1967 |
Protein binding of human fetal and maternal plasmas to salicylate.
Topics: Antipyrine; Biological Transport, Active; Blood Proteins; Cell Membrane Permeability; Chlorides; Dex | 1967 |
Diffusion of certain weak organic acids and bases across the bovine mammary gland membrane after systemic administration.
Topics: Aminohippuric Acids; Animals; Antipyrine; Benzoates; Biological Transport; Cattle; Creatine; Ephedri | 1967 |
Transplacental transfer of beta-adrenergic drugs studied by an in vitro perfusion method of an isolated human placental lobule.
Topics: Adrenergic beta-Antagonists; Albuterol; Antipyrine; Female; Fenoterol; Glucose; Hexoprenaline; Human | 1983 |
Flow-dependent transfer of antipyrine in the human placenta in vitro.
Topics: Antipyrine; Biological Transport; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Perf | 1983 |
Placental calcium and phosphorus transfer in the guinea pig: lack of effect of modulators of Ca-ATPase and alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Animals; Antipyrine; Calcium; Calcium-Transporting ATPases; Ethacrynic Acid; F | 1983 |
Complex, dynamically interacting host factors that affect the disposition of drugs and carcinogens.
Topics: Animals; Antipyrine; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Enzyme | 1982 |
[Preliminary in vitro study of the transplacental passage of spiramycin].
Topics: Antipyrine; Female; Fetus; Humans; In Vitro Techniques; Kinetics; Leucomycins; Maternal-Fetal Exchan | 1983 |
Metabolic balance of the ovine fetus during the fed and fasted states.
Topics: Amino Acids; Ammonia; Animals; Antipyrine; Blood Glucose; Blood Urea Nitrogen; Fasting; Female; Feta | 1984 |
Effect of fetal intravascular 4-aminoantipyrine infusions on myometrial activity (contractures) at 125 to 143 days' gestation in the pregnant sheep.
Topics: Ampyrone; Animals; Antipyrine; Dinoprost; Electromyography; Female; Fetal Blood; Fetus; Infusions, P | 1984 |
Genetic and environmental regulation of aryl hydrocarbon hydroxylase in man: studies with liver, lung, placenta, and lymphocytes.
Topics: Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Enzyme Induction; Female; Human | 1984 |
Selection of subjects for investigation of host factors affecting drug response: a method to identify new pharmacogenetic conditions.
Topics: Adolescent; Adult; Antipyrine; Female; Humans; Male; Middle Aged; Pedigree; Pharmacogenetics; Phenot | 1984 |
Sources of interindividual variations in acetaminophen and antipyrine metabolism.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Antipyrine; Biotransformation; Chromatograph | 1984 |
Transfer of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 across the perfused human placenta.
Topics: Antipyrine; Blood; Calcifediol; Calcitriol; Electrophoresis; Female; Humans; In Vitro Techniques; Ma | 1984 |
Transfer and metabolism of norepinephrine studied from maternal-to-fetal and fetal-to-maternal sides in the in vitro perfused human placental lobe.
Topics: Antipyrine; Clorgyline; Female; Glucose; Humans; In Vitro Techniques; Lactates; Lactic Acid; Mandeli | 1984 |
Non-steady state placental transfer of highly diffusible molecules.
Topics: Animals; Antipyrine; Ethanol; Female; Homeostasis; Maternal-Fetal Exchange; Models, Biological; Plac | 1984 |
Transfer of urea, sodium, and chloride across the perfused human placenta.
Topics: Animals; Antipyrine; Chlorides; Female; Fetus; Haplorhini; Humans; Maternal-Fetal Exchange; Molecula | 1981 |
Effect of maternal ketoacidemia on the pregnant ewe and the fetus.
Topics: 3-Hydroxybutyric Acid; Amniotic Fluid; Animals; Antipyrine; Diabetic Ketoacidosis; Female; Fetus; He | 1982 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; | 1982 |
A new recycling technique for human placental cotyledon perfusion: application to studies of the fetomaternal transfer of glucose, inulin, and antipyrine.
Topics: Animals; Antipyrine; Carbon Radioisotopes; Female; Fetus; Glucose; Humans; In Vitro Techniques; Inul | 1983 |
Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twins.
Topics: Antipyrine; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Humans; Kinetics; Male; Pregn | 1981 |
Elementary pharmacokinetics in clinical practice 4: genetic, environmental and age influences on pharmacokinetics.
Topics: 4-Aminobenzoic Acid; Acetyltransferases; Adult; Age Factors; Aged; Antipyrine; Biopharmaceutics; Chi | 1981 |
Effect of maternal serum insulin on umbilical extraction of glucose and lactate in fed and fasted sheep.
Topics: Animals; Antipyrine; Blood Glucose; Fasting; Female; Fetal Blood; Insulin; Lactates; Maternal-Fetal | 1982 |
Placental transfer as a function of uterine blood flow.
Topics: Animals; Antipyrine; Ethanol; Female; Maternal-Fetal Exchange; Mathematics; Placenta; Pregnancy; Reg | 1982 |
Cardiovascular and biochemical effects of infusion of beta hydroxybutyrate into the fetal lamb.
Topics: 3-Hydroxybutyric Acid; Amniotic Fluid; Animals; Antipyrine; Blood Pressure; Female; Fetal Heart; Fet | 1982 |
Transplacental diffusion of ethanol under steady state conditions.
Topics: Animals; Antipyrine; Ethanol; Female; Fetal Blood; Homeostasis; Maternal-Fetal Exchange; Placenta; P | 1980 |
Transfer of Salbutamol in the human placenta in vitro.
Topics: Albuterol; Antipyrine; Biological Transport; Diffusion; Female; Humans; Inulin; Maternal-Fetal Excha | 1981 |
Investigation of [14C] linoleic acid conversion into [14C] arachidonic acid and placental transfer of linoleic and palmitic acids across the perfused human placenta.
Topics: Antipyrine; Arachidonic Acids; Biological Transport; Carbon Radioisotopes; Female; Humans; In Vitro | 1981 |
Effects of acetylcholine on the clearance of [3H]-antipyrine in bilaterally perfused lobules of human term placenta.
Topics: Acetylcholine; Antipyrine; Cell Membrane Permeability; Female; Humans; In Vitro Techniques; Metaboli | 1980 |
Carbamazepine and its metabolites in human perfused placenta and in maternal and cord blood.
Topics: Antipyrine; Biological Transport; Blood; Carbamazepine; Chromatography, Gas; Chromatography, High Pr | 1995 |
[A prospective study of antipyrine pharmacokinetics in pregnancy].
Topics: Adult; Antipyrine; Female; Humans; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Thir | 1995 |
[Placental penetration of cefpirome (HR 810): study of fetal concentrations after in vitro infusions of human placenta at term].
Topics: Antipyrine; Bacterial Infections; Cefpirome; Cephalosporins; Female; Humans; Infant, Newborn; Matern | 1994 |
Transfer of dideoxyinosine across the human isolated placenta.
Topics: Antipyrine; Biological Transport; Chromatography, High Pressure Liquid; Didanosine; Female; Glucose; | 1994 |
Bupivacaine transfer across the human term placenta. A study using the dual perfused human placental model.
Topics: Antipyrine; Bupivacaine; Female; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Maternal-F | 1995 |
Effect of phenazone (antipyrine) on the prostanoid formation in human umbilical arteries perfused in vitro.
Topics: Antipyrine; Arachidonic Acids; Female; Humans; In Vitro Techniques; Indomethacin; Pregnancy; Prostag | 1995 |
Transplacental pharmacokinetics of dideoxyinosine in pigtailed macaques.
Topics: Amniotic Fluid; Animals; Antipyrine; Chromatography, High Pressure Liquid; Didanosine; Female; Fetus | 1994 |
Comparative placental transport of oral hypoglycemic agents in humans: a model of human placental drug transfer.
Topics: Administration, Oral; Analysis of Variance; Antipyrine; Biological Transport; Chlorpropamide; Chroma | 1994 |
Mefloquine transfer during in vitro human placenta perfusion.
Topics: Antipyrine; Biological Transport; Female; Glucose; Humans; In Vitro Techniques; Lactates; Lactic Aci | 1994 |
Evidence for active maternal-fetal transport of Na+ across the placenta of the anaesthetized rat.
Topics: Anesthesia; Animals; Antipyrine; Biological Transport, Active; Cold Temperature; Diffusion; Diuretic | 1993 |
Effects of antipyrine on umbilical and regional metabolism in late gestation in the fetal lamb.
Topics: Animals; Antipyrine; Female; Fetus; Glucose; Hindlimb; Lactates; Lactic Acid; Osmolar Concentration; | 1993 |
High-performance liquid chromatographic measurement of leucine and alpha-ketoisocaproate in whole blood: application to fetal protein metabolism.
Topics: Animals; Antipyrine; Carbon Dioxide; Chromatography, High Pressure Liquid; Female; Fetal Proteins; K | 1993 |
Determinants of placental drug transfer: studies in the isolated perfused human placenta.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cimetidine; Diclofenac; Female; Histamine H2 An | 1995 |
Transfer of lidocaine and bupivacaine across the isolated perfused human placenta.
Topics: Anesthetics, Local; Antipyrine; Bupivacaine; Female; Humans; Hydrogen-Ion Concentration; In Vitro Te | 1995 |
Mechanism and rate of placental transfer of zalcitabine (2',3'-dideoxycytidine) in Macaca nemestrina.
Topics: Amniotic Fluid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Antiviral Agents; Catt | 1996 |
Digoxin transfer across the isolated placenta is influenced by maternal and fetal albumin concentrations.
Topics: Anti-Arrhythmia Agents; Antipyrine; Culture Media; Digoxin; Female; Humans; In Vitro Techniques; Mat | 1996 |
Diffusion characteristics of placental preparations affect the digoxin passage across the isolated placental lobule.
Topics: Anti-Arrhythmia Agents; Antipyrine; Diffusion; Digoxin; Female; Humans; In Vitro Techniques; Materna | 1997 |
Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta.
Topics: Adrenergic alpha-Agonists; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Antipyrine; Biological | 1997 |
Placental passage of angiotensin-converting enzyme inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antipyrine; Enalapril; Female; Gas Chromatography-Mass Spe | 1996 |
Influence of maternal blood flow on the placental transfer of three opioids--fentanyl, alfentanil, sufentanil.
Topics: Alfentanil; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biological Tran | 1997 |
Phenytoin transfer across the in situ perfused rat term placenta.
Topics: Analgesics; Animals; Anticonvulsants; Antipyrine; Blood Proteins; Chemical Phenomena; Chemistry, Phy | 1997 |
Effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of zalcitabine (2', 3'-dideoxycytidine) in the pigtailed macaque (Macaca nemestrina).
Topics: Aging; Animals; Animals, Newborn; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyri | 1997 |
In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens.
Topics: Amniotic Fluid; Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Femal | 1998 |
Influence of chronic alcohol intake on intestinal taurine and antipyrine transport in pregnant rats.
Topics: Animals; Antipyrine; Diffusion; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Intestinal Absorp | 1998 |
Formation and retention of cotinine during placental transfer of nicotine in human placental cotyledon.
Topics: Adult; Antipyrine; Cotinine; Female; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Nicotine; | 1998 |
The role of nitro-reduction and nitric oxide in the toxicity of chloramphenicol.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Antipyrine; Blood Vessels; Chloramphenicol; Drug I | 1999 |
Transfer of methohexital across the perfused human placenta.
Topics: Adolescent; Adult; Albumins; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2000 |
Somatic and skeleton development of rat foetuses following in-utero exposure to isopropylantipyrine (propyphenazone) during the second trimester of gestation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Embryonic and Fetal Development; Femal | 2000 |
Ex vivo human placental transfer of trovafloxacin.
Topics: Anti-Infective Agents; Antipyrine; Carbon Isotopes; Chromatography, High Pressure Liquid; Diffusion; | 2000 |
The effects of uterine and umbilical blood flows on the transfer of propofol across the human placenta during in vitro perfusion.
Topics: Adult; Algorithms; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Bl | 2001 |
Placental transfer of SR49059 in the human dually perfused cotyledon in vitro.
Topics: Adult; Antidiuretic Hormone Receptor Antagonists; Antipyrine; Biological Transport; Chromatography, | 2001 |
Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrin | 2001 |
Absence of placental transfer of pentasaccharide (Fondaparinux, Arixtra) in the dually perfused human cotyledon in vitro.
Topics: Adult; Anticoagulants; Antipyrine; Enoxaparin; Female; Fetal Blood; Fondaparinux; Humans; In Vitro T | 2002 |
Effects of prenatal exposure to combination of acetaminophen, isopropylantipyrine and caffeine on intrauterine development in rats.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2002 |
Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cartilage, Articular; Cyclooxygenase I | 2002 |
Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes.
Topics: Adolescent; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Culture Media; Dicuma | 1976 |
Antipyrine for prophylaxis of neonatal jaundice.
Topics: Antipyrine; Female; Humans; Infant, Newborn; Jaundice, Neonatal; Pregnancy; Prenatal Care | 1979 |
The antipyrine test in clinical pharmacology: conceptions and misconceptions.
Topics: Animals; Antipyrine; Biotransformation; Dogs; Environment; Female; Genetics; Half-Life; Haplorhini; | 1979 |
Search for single gene effects in multifactorial inheritance in pharmacogenetics.
Topics: Amobarbital; Antipyrine; Enzymes; Female; Genes; Humans; Male; Pregnancy; Twins, Dizygotic; Twins, M | 1978 |
Placental transfer of water and nonelectrolytes during a single circulatory passage.
Topics: Animals; Antipyrine; Biological Transport; Female; Guinea Pigs; Lipids; Maternal-Fetal Exchange; Mol | 1979 |
Insulin effect on fetal glucose utilization.
Topics: Animals; Antipyrine; Female; Fetus; Glucose; Insulin; Pregnancy; Regional Blood Flow; Sheep; Umbilic | 1978 |
The transfer and metabolism of corticosteroids in the perfused human placenta.
Topics: Antipyrine; Betamethasone; Dexamethasone; Female; Humans; Hydrocortisone; In Vitro Techniques; Place | 1978 |
Placental clearance of antipyrine and urea during hypoxia and adrenaline infusions in sheep [proceedings].
Topics: Animals; Antipyrine; Epinephrine; Female; Hypoxia; Placenta; Pregnancy; Sheep; Urea | 1977 |
Uterine blood flow, oxygen consumption, and maternal plasma estradiol and progestins following fetal death.
Topics: Animals; Antipyrine; Arteries; Estradiol; Female; Fetal Death; Oxygen; Oxygen Consumption; Pregnancy | 1976 |
Permeability of human chorion laeve to diazepam and meperidine.
Topics: Aminohippuric Acids; Antipyrine; Cell Membrane Permeability; Chorion; Diazepam; Diffusion; Extraembr | 1976 |
Serial measurements of plasma half-lives and urinary excretion of antipyrine in low-birth-weight infants.
Topics: Antipyrine; Birth Weight; Female; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pre | 1975 |
Transfer of heparin across the human perfused placental lobule.
Topics: Antipyrine; Cell Membrane Permeability; Chorionic Gonadotropin; Creatinine; Female; Fetal Blood; Hep | 1992 |
A comparison of parameters used to standardize results from in vitro perfusions of human placentae.
Topics: Antipyrine; Biological Transport, Active; Creatinine; Female; gamma-Glutamyltransferase; Glucose; Hu | 1992 |
Passage of S(+) and R(-) gamma-vinyl-GABA across the human isolated perfused placenta.
Topics: Aminocaproates; Anticonvulsants; Antipyrine; Female; Humans; In Vitro Techniques; Leucine; Perfusion | 1992 |
Acyclovir transport by the human placenta.
Topics: Acyclovir; Antipyrine; Biological Transport; Female; Humans; Maternal-Fetal Exchange; Metabolic Clea | 1992 |
Effect of inorganic mercury on in vitro placental nutrient transfer and oxygen consumption.
Topics: 3-O-Methylglucose; Amino Acids; Aminoisobutyric Acids; Antipyrine; Biological Transport; Edema; Fema | 1992 |
In situ perfusion in the rabbit: effects of different umbilical flow rates on placental transfer of compounds.
Topics: Analysis of Variance; Animals; Antipyrine; Female; Kinetics; Maternal-Fetal Exchange; Perfusion; Pre | 1992 |
Parathion transfer and acetylcholinesterase activity in an in-vitro perfused term human placenta.
Topics: Acetylcholinesterase; Antipyrine; Female; Glucose; Humans; In Vitro Techniques; Maternal-Fetal Excha | 1992 |
Transplacental transfer of ritodrine and its effect on placental glucose and oxygen consumption in an in vitro human placental cotyledon perfusion.
Topics: Antipyrine; Drug Evaluation, Preclinical; Female; Glucose; Humans; In Vitro Techniques; Maternal-Fet | 1991 |
Regional cerebral blood flow during hypoxia-ischemia in the immature rat: comparison of iodoantipyrine and iodoamphetamine as radioactive tracers.
Topics: Amphetamines; Animals; Antipyrine; Autoradiography; Brain; Brain Ischemia; Cerebrovascular Circulati | 1991 |
Effect of hypoinsulinemia and hyperglycemia on fetal glucose utilization.
Topics: Animals; Antipyrine; Blood Glucose; Female; Fetal Blood; Fetus; Glucose; Glucose Clamp Technique; Hy | 1990 |
The influence of zinc-binding ligands in fetal circulation on zinc clearance across the in situ perfused guinea pig placenta.
Topics: Animals; Antipyrine; Female; Fetus; Guinea Pigs; Ligands; Maternal-Fetal Exchange; Metabolic Clearan | 1991 |
Measurement of leucine and alpha-ketoisocaproic acid fluxes in the fetal/placental unit.
Topics: Animals; Antipyrine; Carbon Isotopes; Female; Fetus; Keto Acids; Leucine; Maternal-Fetal Exchange; P | 1991 |
A prostacyclin analogue crosses the in vitro perfused human placenta and improves transfer in some pathologic states.
Topics: Antipyrine; Diabetes Mellitus, Type 1; Epoprostenol; Female; Humans; Hypertension; Ibuprofen; In Vit | 1991 |
Transfer of cyclosporine in the perfused human placenta.
Topics: Antipyrine; Cyclosporins; Female; Humans; Maternal-Fetal Exchange; Molecular Weight; Placenta; Pregn | 1990 |
Estimation of glucose kinetics in fetal-maternal studies: potential errors, solutions, and limitations.
Topics: Animals; Antipyrine; Blood Glucose; Carbon Radioisotopes; Epinephrine; Female; Fetal Blood; Glucose; | 1990 |
Maternal to fetal transfer of free fatty acids in the in situ perfused rabbit placenta.
Topics: Animals; Antipyrine; Blood Pressure; Fatty Acids, Nonesterified; Female; Infusions, Intravenous; Mat | 1990 |
The effect of zinc levels in fetal circulation on zinc clearance across the in situ perfused guinea pig placenta.
Topics: Animals; Antipyrine; Female; Fetus; Guinea Pigs; Maternal-Fetal Exchange; Microscopy, Electron; Perf | 1990 |
Azidothymidine (zidovudine) transport by the human placenta.
Topics: Antipyrine; Biological Transport; Female; Humans; Kinetics; Placenta; Pregnancy; Zidovudine | 1990 |
Effect of umbilical perfusate pH and controlled maternal hypotension on placental drug transfer in the rabbit.
Topics: Anesthesia, Obstetrical; Animals; Antipyrine; Bupivacaine; Chromatography, Gas; Female; Hydrogen-Ion | 1990 |
Effects of pH on antipyrine transfer across the human placenta ex vivo.
Topics: Adult; Antipyrine; Female; Fetus; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Models, B | 1990 |
Thiamine-transfer by human placenta: normal transport and effects of ethanol.
Topics: Antipyrine; Biological Transport, Active; Chromatography, High Pressure Liquid; Ethanol; Female; Hum | 1990 |
Placental-fetal glucose exchange and placental glucose consumption in pregnant sheep.
Topics: Animals; Antipyrine; Blood Glucose; Female; Fetal Blood; Fetus; Glucose; Glucose Clamp Technique; In | 1990 |
Clearance of compounds of different molecular size in the human placenta in vitro.
Topics: Aminohippuric Acids; Antipyrine; Cell Membrane; Dextrans; Diffusion; Female; Humans; In Vitro Techni | 1985 |
[A monooxygenase enzymatic system and cortisol in the serum of pregnant women with viral hepatitis].
Topics: Adult; Antipyrine; Female; Hepatitis B Surface Antigens; Hepatitis C; Hepatitis, Viral, Human; Human | 1989 |
Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta.
Topics: Animals; Antipyrine; Female; Humans; In Vitro Techniques; Male; Maternal-Fetal Exchange; Metabolic C | 1989 |
Does insulin affect placental glucose metabolism and transfer?
Topics: 3-O-Methylglucose; Antipyrine; Female; Glucose; Humans; Insulin; Lactates; Lactic Acid; Maternal-Fet | 1989 |
Dilution kinetics of chemicals used for estimation of water content of body compartments in perinatal medicine.
Topics: Amniotic Fluid; Animals; Antipyrine; Body Water; Bromides; Evans Blue; Extracellular Space; Female; | 1989 |
Effect of inhibiting prostaglandin synthesis in pregnant sheep with 4-aminoantipyrine under normothermic and hyperthermic conditions.
Topics: Ampyrone; Animals; Antipyrine; Blood Gas Analysis; Blood Glucose; Body Temperature; Dinoprost; Dinop | 1989 |
Effect of adrenaline on placental transfer of bupivacaine in the perfused in situ rabbit placenta.
Topics: Animals; Antipyrine; Blood Pressure; Bupivacaine; Epinephrine; Female; Placenta; Pregnancy; Rabbits | 1989 |
Transplacental clearance and blood flows of bovine gravid uterus at several stages of gestation.
Topics: Animals; Antipyrine; Blood; Cattle; Deuterium; Deuterium Oxide; Female; Gestational Age; Metabolic C | 1987 |
A comparative evaluation of the transport of H2-receptor antagonists by the human and baboon placenta.
Topics: Adolescent; Adult; Animals; Antipyrine; Biological Transport; Cimetidine; Famotidine; Female; Histam | 1988 |
Transplacental diffusion and blood flow of gravid bovine uterus.
Topics: Analysis of Variance; Animals; Antipyrine; Cattle; Deuterium; Deuterium Oxide; Diffusion; Electromag | 1985 |
Establishment of gradients of riboflavin, L-lysine and alpha-aminoisobutyric acid across the perfused human placenta.
Topics: Aminoisobutyric Acids; Antipyrine; Female; Humans; Lysine; Maternal-Fetal Exchange; Perfusion; Place | 1986 |
Cyclooxygenase inhibition reduces placental transfer: reversal by carbacyclin.
Topics: Antipyrine; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Ibuprofen; Indomethacin; Matern | 1987 |
Blood flow redistribution during isocapnic hypoxia in foetal lamb.
Topics: Animals; Antipyrine; Blood Circulation; Carbon Dioxide; Female; Fetal Blood; Fetus; Hypoxia; Organ S | 1988 |
Enhanced glucose metabolism and impaired placental function in hypoxic pregnant rats.
Topics: Animals; Antipyrine; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Female; Fluorine Radioisot | 1988 |
Pregnancy-specific changes of antipyrine pharmacokinetics correlate inversely with changes of estradiol/progesterone plasma concentration ratios.
Topics: Adult; Antipyrine; Estradiol; Female; Humans; Pregnancy; Progesterone | 1988 |
Effect of antipyrine on prostaglandin levels and uterine and umbilical blood flow.
Topics: 6-Ketoprostaglandin F1 alpha; Ampyrone; Animals; Antipyrine; Depression, Chemical; Dinoprost; Dinopr | 1986 |
Low clearance of cimetidine across the human placenta.
Topics: Antipyrine; Cimetidine; Female; Humans; Leucine; Maternal-Fetal Exchange; Mathematics; Metabolic Cle | 1987 |
Restriction of placental size in sheep enhances efficiency of placental transfer of antipyrine, 3-O-methyl-D-glucose but not of urea.
Topics: 3-O-Methylglucose; Animals; Antipyrine; Embryonic and Fetal Development; Female; Fetal Blood; Gestat | 1987 |
The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies.
Topics: Antibodies, Monoclonal; Antipyrine; Cotinine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Syste | 1986 |
Body water estimates in intrauterine-growth-retarded versus normally grown baboon neonates.
Topics: Animals; Animals, Newborn; Antipyrine; Birth Weight; Blood Volume; Body Water; Bromides; Erythrocyte | 1986 |
Effect of fetal and maternal intravascular antipyrine infusion on maternal plasma prostaglandin concentrations in the pregnant sheep at 104 to 127 days' gestation.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antipyrine; Chromatography, High Pressure Liquid; Dinoprost; | 1986 |
Transfer of fentanyl across the rabbit placenta. Effect of umbilical flow and concurrent drug administration.
Topics: Analgesics; Animals; Antipyrine; Bupivacaine; Female; Fentanyl; Fetal Blood; Kinetics; Maternal-Feta | 1986 |
Effect of flow rate ratio on the diffusion of antipyrine and 3H2O in the isolated dually in vitro perfused lobe of the human placenta.
Topics: Antipyrine; Blood Flow Velocity; Diffusion; Female; Humans; In Vitro Techniques; Maternal-Fetal Exch | 1985 |
Placental transfer of bupivacaine, pethidine and lignocaine in the rabbit. Effect of umbilical flow rate and protein content.
Topics: Animals; Antipyrine; Blood Flow Velocity; Blood Proteins; Bupivacaine; Female; Lidocaine; Maternal-F | 1985 |
Effect of hypoxia and pregnancy on antipyrine metabolism in isolated perfused rat livers.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Female; Kinetics; Liver; Metabolic Clearance Ra | 1985 |
A rat model for the study of transplacental pharmacokinetics and its assessment with antipyrine and aminoisobutyric acid.
Topics: Aminoisobutyric Acids; Anesthesia; Animals; Antipyrine; Dose-Response Relationship, Drug; Female; Ki | 1985 |
Transfer of riboflavin by the perfused human placenta.
Topics: Antipyrine; Biological Transport, Active; Female; Flavin Mononucleotide; Glucose; Humans; In Vitro T | 1985 |
Genetic control of drug levels and of the induction of drug-metabolizing enzymes in man: individual variability in the extent of allopurinol and nortriptyline inhibition of drug metabolism.
Topics: Adult; Allopurinol; Aniline Compounds; Animals; Antipyrine; Coffee; Cytochromes; Dicumarol; Ethanol; | 1971 |
Genetic control of dicumarol levels in man.
Topics: Adult; Antipyrine; Caffeine; Centrifugation; Coffee; Dicumarol; Female; Genetics, Medical; Humans; M | 1968 |
Umbilical blood flow, cardiac output, and organ blood flow in the immature baboon fetus.
Topics: Acid-Base Equilibrium; Animals; Antipyrine; Blood Pressure; Brain; Cardiac Output; Digestive System; | 1973 |
The permeation of drugs across the placental barrier.
Topics: Aniline Compounds; Antipyrine; Barbiturates; Female; Guanidines; Humans; In Vitro Techniques; Lipids | 1968 |
Validation of the antipyrine method for measuring fetal umbilical blood flow.
Topics: Animals; Antipyrine; Electromagnetic Phenomena; Evaluation Studies as Topic; Female; Fetus; Osmolar | 1967 |
Suitability of pig placenta for investigation of placental transfer.
Topics: Animals; Antipyrine; Carbon Radioisotopes; Chorion; Diffusion; Female; Maternal-Fetal Exchange; Perm | 1974 |
Transfer across perfused human placenta. 3. Effect of chain length on transfer of free fatty acids.
Topics: Antipyrine; Caproates; Caprylates; Carbon Radioisotopes; Chromatography, Thin Layer; Colorimetry; Fa | 1974 |
Uterine blood flow and oxygen consumption in the unrestrained pregnant ewe.
Topics: Animals; Antipyrine; Blood Flow Velocity; Female; Gestational Age; Oxygen Consumption; Pregnancy; Pr | 1972 |
Ethanol metabolism: regulation by genetic factors in normal volunteers under a controlled environment and the effect of chronic ethanol administration.
Topics: Adult; Alcohol Drinking; Alcoholism; Antipyrine; Environment; Ethanol; Female; Genetics, Medical; Ge | 1972 |
Changes in blood flow in the component structures of the dog brain during postnatal maturation.
Topics: Aging; Animals; Antipyrine; Blood Pressure; Brain; Carbon Dioxide; Carbon Isotopes; Cerebrovascular | 1972 |
Transfer across the perfused human placenta of antipyrine, sodium and leucine.
Topics: Antipyrine; Biological Transport; Carbon Isotopes; Chromatography; Female; Humans; In Vitro Techniqu | 1972 |
Transfer across perfused human placenta. II. Free fatty acids.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Antipyrine; Carbon Isotopes; Chromatography, Thin Layer | 1973 |
Diffusion mechanisms across human placental tissue.
Topics: Aminohippuric Acids; Antipyrine; Biological Transport, Active; Cell Membrane Permeability; Energy Tr | 1973 |
Mammary blood flow and glucose uptake in lactating cows given dexamethasone.
Topics: Animals; Antipyrine; Blood Glucose; Calcium; Cattle; Dexamethasone; Fatty Acids, Nonesterified; Fema | 1973 |
Use of the guinea-pig foetal placenta, perfused in situ, as a model to study the placental transfer of pharmacological substances.
Topics: Acid-Base Equilibrium; Animals; Antipyrine; Blood Pressure; Female; Guinea Pigs; Maternal-Fetal Exch | 1973 |
Placental transfer of antipyrine and thiocyanate and their use in determining maternal and fetal body fluids in a maintained pregnancy.
Topics: Animals; Antipyrine; Body Fluids; Female; Fetus; Gestational Age; Goats; Maternal-Fetal Exchange; Pl | 1973 |
Physicochemical factors in maternal-fetal distribution of drugs.
Topics: Amphetamine; Aniline Compounds; Animals; Antipyrine; Aspirin; Atropine; Benzoates; Caffeine; Carbon | 1973 |
The influence of high maternal plasma glucose levels, and maternal blood flow on the placental transfer of glucose in the guinea pig.
Topics: Animals; Antipyrine; Biological Transport, Active; Blood Glucose; Cell Membrane; Female; Guinea Pigs | 1973 |
Interindividual differences in pharmacokinetics in man: clinical importance.
Topics: Administration, Oral; Antipyrine; Drug Interactions; Female; Humans; Kinetics; Male; Nortriptyline; | 1973 |
Umbilical blood flow in late gestation: a comparison of simultaneous measurements with two different techniques.
Topics: Animals; Antipyrine; Blood Flow Velocity; Blood Pressure; Body Temperature; Female; Fetal Heart; Fet | 1974 |
Proceedings: A comparison of the effect of a reduction in maternal blood flow on the placental transfer of glucose and amino nitrogen from mother to foetus.
Topics: Acid-Base Equilibrium; Amino Acids; Animals; Antipyrine; Blood Glucose; Blood Pressure; Female; Feta | 1974 |
Effect of cesarean section on neonatal body water spaces.
Topics: Age Factors; Anesthesia, General; Anesthesia, Obstetrical; Antipyrine; Birth Weight; Body Compositio | 1971 |
The use of an indicator diffusion procedure to measure the uterine blood flow in sows during the estrous cycle and pregnancy.
Topics: Amines; Animals; Antipyrine; Arteries; Blood Flow Velocity; Diffusion; Dye Dilution Technique; Estru | 1969 |
The circulation of the fetus in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow.
Topics: Animals; Antipyrine; Blood Circulation; Cardiac Output; Female; Fetus; Mathematics; Methods; Microsp | 1967 |
In vitro permeability of different layers of the human placenta to carbohydrates and urea.
Topics: Amnion; Animals; Antipyrine; Arabinose; Colorimetry; Female; Haplorhini; Humans; In Vitro Techniques | 1966 |
Clearance of inert molecules, Na, and Cl ions across the primate placenta.
Topics: Animals; Antipyrine; Blood; Cell Membrane Permeability; Chlorides; Diffusion; Female; Gestational Ag | 1968 |
The supply of O2 to the primate fetus with two different O2 tensions and anesthetics.
Topics: Animals; Antipyrine; Blood; Carbon Dioxide; Female; Halothane; Haplorhini; Hydrogen-Ion Concentratio | 1969 |
Placental clearance and fetal oxygenation.
Topics: Altitude; Animals; Antipyrine; Blood Transfusion, Intrauterine; Female; Fetus; Haplorhini; Maternal- | 1970 |
Distribution of the circulation in the normal and asphyxiated fetal primate.
Topics: Acid-Base Equilibrium; Animals; Antipyrine; Asphyxia; Blood Circulation; Cardiac Output; Cerebrovasc | 1970 |
Umbilical blood flow, fetal oxygen consumption and placental diffusion clearance of antipyrine in the baboon.
Topics: Acid-Base Equilibrium; Animals; Antipyrine; Bicarbonates; Blood Pressure Determination; Body Tempera | 1972 |
Studies with triamterene, a substituted pteridine. Unusual brain to plasma ratio in mammals.
Topics: Adipose Tissue; Animals; Antipyrine; Biological Transport; Body Fluids; Brain; Carbon Isotopes; Eye; | 1972 |
Fetal oxygen consumption, carbon dioxide production, and glucose uptake in a chronic sheep preparation.
Topics: Animals; Antipyrine; Autoanalysis; Blood Flow Velocity; Blood Gas Analysis; Blood Glucose; Body Weig | 1972 |
Effects of sulpyrin on mitosis.
Topics: Abnormalities, Drug-Induced; Animals; Antipyrine; Female; Fetus; Methylamines; Mice; Mitosis; Pregna | 1972 |
Placental transfer of diphenylhydantoin in the goat.
Topics: Amniotic Fluid; Animals; Antipyrine; Blood Chemical Analysis; Blood Proteins; Chromatography, Gas; E | 1972 |
Metabolic interactions among environmental chemicals and drugs.
Topics: Animals; Antipyrine; Barbiturates; Bilirubin; Carcinogens; Drug Interactions; Environment; Environme | 1972 |
The transfer of free alpha-amino nitrogen across the placental membrane in the guinea-pig.
Topics: Amino Acids; Animals; Antimetabolites; Antipyrine; Biological Transport, Active; Cyanides; Female; G | 1971 |
A method for the estimation of the umbilical blood flow in unstressed sheep and goates with some results of its application.
Topics: Animals; Antipyrine; Blood; Blood Flow Velocity; Female; Fetus; Goats; Methods; Oxygen Consumption; | 1968 |
Pathophysiological factors influencing drug kinetics.
Topics: Absorption; Age Factors; Antipyrine; Chloral Hydrate; Environmental Exposure; Ethanol; Female; Human | 1971 |
Blood flow in the reproductive organs of the mouse after hypophysectomy, after gonadotrophin treatment, during the oestrous cycle and during early pregnancy.
Topics: Animals; Antipyrine; Brain; Estrus; Female; Genitalia, Female; Gonadotropins, Equine; Hypophysectomy | 1969 |
Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man.
Topics: Adult; Alcohol Drinking; Antipyrine; Coffee; Female; Genetics, Medical; Humans; Male; Metabolic Clea | 1969 |
[Aspects of iatrogenic pharmacology and toxicology at the fetal level].
Topics: Aminopyrine; Amitriptyline; Animals; Anti-Bacterial Agents; Antipyrine; Diazepam; Dogs; Female; Feta | 1969 |
Effect on newborn rats of perinatal exposure to phenobarbital.
Topics: Acetaminophen; Animals; Animals, Newborn; Antipyrine; Brain; Female; Hexobarbital; Microsomes, Liver | 1970 |
The influence of blood flow and hypoxia on free alpha-amino nitrogen transfer across the placental membrane.
Topics: Amines; Animals; Antipyrine; Biological Transport, Active; Blood Pressure; Female; Fetus; Guinea Pig | 1970 |
Effect of exteriorization of the sheep fetus on its cardiovascular function.
Topics: Acid-Base Equilibrium; Animals; Antipyrine; Blood Flow Velocity; Blood Pressure Determination; Carbo | 1967 |
[On the use of a spasmolytic, analgesic and sedative combination in the treatment of obstetrico-gynecologic diseases].
Topics: Abortion, Septic; Abortion, Threatened; Adolescent; Adult; Antipyrine; Ethylamines; Female; Genital | 1967 |
Distribution of uterine blood flow in the pregnant sheep.
Topics: Animals; Antipyrine; Embryonic and Fetal Development; Female; Gestational Age; Hysterosalpingography | 1968 |
The effect of maternal oxygen inhalation upon fetal oxygenation.
Topics: Animals; Antipyrine; Blood Flow Velocity; Carbon Dioxide; Female; Fetus; Hydrogen-Ion Concentration; | 1968 |
Comparison of four methods for measuring mammary blood flow in conscious goats.
Topics: Animals; Antipyrine; Blood Flow Velocity; Female; Goats; Lactation; Mammary Glands, Animal; Methods; | 1968 |
Genetic control of drug levels in man: antipyrine.
Topics: Adult; Analysis of Variance; Antipyrine; Female; Genetics, Medical; Humans; Male; Middle Aged; Pheny | 1968 |
Mammary blood flow and ketone body metabolism in normal, fasted, and ketotic cows.
Topics: Acetates; Acetoacetates; Acidosis; Animals; Antipyrine; Blood Glucose; Cattle; Fasting; Fatty Acids, | 1968 |
Measurement of umbilical arterial blood flow to the sheep placenta and fetus in utero. Distribution to cotyledons and the intercotyledonary chorion.
Topics: Animals; Antipyrine; Extraembryonic Membranes; Female; Maternal-Fetal Exchange; Placenta; Pregnancy; | 1968 |
Effect of varying umbilical blood O2 affinity on umbilical vein Po2.
Topics: Animals; Antipyrine; Blood Circulation; Exchange Transfusion, Whole Blood; Female; Hydrogen-Ion Conc | 1969 |