Page last updated: 2024-10-22

antipyrine and Porphyrias

antipyrine has been researched along with Porphyrias in 9 studies

Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.

Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.

Research Excerpts

ExcerptRelevanceReference
"Effects of heme on hepatic xenobiotic drug metabolism were investigated in eight subjects with variegate porphyria."7.68Rapid normalization of antipyrine oxidation by heme in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tenhunen, R; Tokola, O, 1992)
"Effects of heme on hepatic xenobiotic drug metabolism were investigated in eight subjects with variegate porphyria."3.68Rapid normalization of antipyrine oxidation by heme in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tenhunen, R; Tokola, O, 1992)
" The elimination of antipyrine was investigated before and after intravenous administration of haem arginate (3 mg haem kg-1 day-1 on three or four successive days) to six patients with variegate porphyria in remission."3.67Haem arginate improves hepatic oxidative metabolism in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tokola, O, 1988)
" Phenobarbital, which exacerbates acute intermittent porphyria in man, induces drug-oxidizing enzymes in liver."3.65Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug. ( Alvares, AP; Bickers, DR; Bradlow, HL; Kappas, A, 1977)
"Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)."1.26Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19908 (88.89)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kappas, A2
Bradlow, HL1
Bickers, DR1
Alvares, AP2
Anderson, KE1
Sassa, S1
Mustajoki, P2
Himberg, JJ2
Tokola, O2
Tenhunen, R1
Herrick, A1
McColl, KE2
McLellan, A1
Moore, MR3
Brodie, MJ2
Goldberg, A3
Yeung-Laiwah, AA1
Birnie, GG1
Thompson, GG1
Cowger, ML1
Labbe, RF1
Almeyda, J1
Levantine, A1

Reviews

1 review available for antipyrine and Porphyrias

ArticleYear
Drug reactions. XVII. Cutaneous reactions to barbiturates, chloral hydrate and its derivatives.
    The British journal of dermatology, 1972, Volume: 86, Issue:3

    Topics: Adult; Aged; Anaphylaxis; Antipyrine; Barbiturates; Chloral Hydrate; Drug Eruptions; Erythema Multif

1972

Other Studies

8 other studies available for antipyrine and Porphyrias

ArticleYear
Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug.
    The Journal of clinical investigation, 1977, Volume: 59, Issue:1

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstenes; Antipyrine; Female; Humans; Ketosteroids;

1977
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
    Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:1

    Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane

1976
Rapid normalization of antipyrine oxidation by heme in variegate porphyria.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:3

    Topics: Adult; Aged; Antipyrine; Female; Glucaric Acid; Half-Life; Heme; Humans; Hydrocortisone; Middle Aged

1992
Effect of haem arginate therapy on porphyrin metabolism and mixed function oxygenase activity in acute hepatic porphyria.
    Lancet (London, England), 1987, Nov-21, Volume: 2, Issue:8569

    Topics: Acute Disease; Adult; Antipyrine; Arginine; Cytochrome P-450 Enzyme System; Depression, Chemical; Fe

1987
Haem arginate improves hepatic oxidative metabolism in variegate porphyria.
    British journal of clinical pharmacology, 1988, Volume: 26, Issue:6

    Topics: Adult; Antipyrine; Arginine; Feces; Female; Heme; Humans; Liver; Oxidation-Reduction; Porphyrias; Po

1988
Lead effects on the heme biosynthetic pathway. Relationship to toxicity.
    Annals of the New York Academy of Sciences, 1987, Volume: 514

    Topics: Aminolevulinic Acid; Antipyrine; Cytochromes; Heme; Humans; Lead Poisoning; Models, Biological; Porp

1987
Antipyrine metabolism in acute hepatic porphyria in relapse and remission.
    British journal of clinical pharmacology, 1987, Volume: 23, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Aged; Aminolevulinic Acid; Antipyrine; Cytochrome P

1987
The inhibition of terminal oxidation by porphyrinogenic drugs.
    Biochemical pharmacology, 1967, Volume: 16, Issue:11

    Topics: Animals; Antipyrine; Barbiturates; Carbamates; Cattle; Chlordiazepoxide; Chlorobutanol; Culture Tech

1967