antipyrine has been researched along with Porphyrias in 9 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
Excerpt | Relevance | Reference |
---|---|---|
"Effects of heme on hepatic xenobiotic drug metabolism were investigated in eight subjects with variegate porphyria." | 7.68 | Rapid normalization of antipyrine oxidation by heme in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tenhunen, R; Tokola, O, 1992) |
"Effects of heme on hepatic xenobiotic drug metabolism were investigated in eight subjects with variegate porphyria." | 3.68 | Rapid normalization of antipyrine oxidation by heme in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tenhunen, R; Tokola, O, 1992) |
" The elimination of antipyrine was investigated before and after intravenous administration of haem arginate (3 mg haem kg-1 day-1 on three or four successive days) to six patients with variegate porphyria in remission." | 3.67 | Haem arginate improves hepatic oxidative metabolism in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tokola, O, 1988) |
" Phenobarbital, which exacerbates acute intermittent porphyria in man, induces drug-oxidizing enzymes in liver." | 3.65 | Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug. ( Alvares, AP; Bickers, DR; Bradlow, HL; Kappas, A, 1977) |
"Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (88.89) | 18.7374 |
1990's | 1 (11.11) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kappas, A | 2 |
Bradlow, HL | 1 |
Bickers, DR | 1 |
Alvares, AP | 2 |
Anderson, KE | 1 |
Sassa, S | 1 |
Mustajoki, P | 2 |
Himberg, JJ | 2 |
Tokola, O | 2 |
Tenhunen, R | 1 |
Herrick, A | 1 |
McColl, KE | 2 |
McLellan, A | 1 |
Moore, MR | 3 |
Brodie, MJ | 2 |
Goldberg, A | 3 |
Yeung-Laiwah, AA | 1 |
Birnie, GG | 1 |
Thompson, GG | 1 |
Cowger, ML | 1 |
Labbe, RF | 1 |
Almeyda, J | 1 |
Levantine, A | 1 |
1 review available for antipyrine and Porphyrias
Article | Year |
---|---|
Drug reactions. XVII. Cutaneous reactions to barbiturates, chloral hydrate and its derivatives.
Topics: Adult; Aged; Anaphylaxis; Antipyrine; Barbiturates; Chloral Hydrate; Drug Eruptions; Erythema Multif | 1972 |
8 other studies available for antipyrine and Porphyrias
Article | Year |
---|---|
Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstenes; Antipyrine; Female; Humans; Ketosteroids; | 1977 |
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane | 1976 |
Rapid normalization of antipyrine oxidation by heme in variegate porphyria.
Topics: Adult; Aged; Antipyrine; Female; Glucaric Acid; Half-Life; Heme; Humans; Hydrocortisone; Middle Aged | 1992 |
Effect of haem arginate therapy on porphyrin metabolism and mixed function oxygenase activity in acute hepatic porphyria.
Topics: Acute Disease; Adult; Antipyrine; Arginine; Cytochrome P-450 Enzyme System; Depression, Chemical; Fe | 1987 |
Haem arginate improves hepatic oxidative metabolism in variegate porphyria.
Topics: Adult; Antipyrine; Arginine; Feces; Female; Heme; Humans; Liver; Oxidation-Reduction; Porphyrias; Po | 1988 |
Lead effects on the heme biosynthetic pathway. Relationship to toxicity.
Topics: Aminolevulinic Acid; Antipyrine; Cytochromes; Heme; Humans; Lead Poisoning; Models, Biological; Porp | 1987 |
Antipyrine metabolism in acute hepatic porphyria in relapse and remission.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Aged; Aminolevulinic Acid; Antipyrine; Cytochrome P | 1987 |
The inhibition of terminal oxidation by porphyrinogenic drugs.
Topics: Animals; Antipyrine; Barbiturates; Carbamates; Cattle; Chlordiazepoxide; Chlorobutanol; Culture Tech | 1967 |