antipyrine has been researched along with Porphyria in 9 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of heme on hepatic xenobiotic drug metabolism were investigated in eight subjects with variegate porphyria." | 7.68 | Rapid normalization of antipyrine oxidation by heme in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tenhunen, R; Tokola, O, 1992) |
| "Effects of heme on hepatic xenobiotic drug metabolism were investigated in eight subjects with variegate porphyria." | 3.68 | Rapid normalization of antipyrine oxidation by heme in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tenhunen, R; Tokola, O, 1992) |
| " The elimination of antipyrine was investigated before and after intravenous administration of haem arginate (3 mg haem kg-1 day-1 on three or four successive days) to six patients with variegate porphyria in remission." | 3.67 | Haem arginate improves hepatic oxidative metabolism in variegate porphyria. ( Himberg, JJ; Mustajoki, P; Tokola, O, 1988) |
| " Phenobarbital, which exacerbates acute intermittent porphyria in man, induces drug-oxidizing enzymes in liver." | 3.65 | Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug. ( Alvares, AP; Bickers, DR; Bradlow, HL; Kappas, A, 1977) |
| "Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kappas, A | 2 |
| Bradlow, HL | 1 |
| Bickers, DR | 1 |
| Alvares, AP | 2 |
| Anderson, KE | 1 |
| Sassa, S | 1 |
| Mustajoki, P | 2 |
| Himberg, JJ | 2 |
| Tokola, O | 2 |
| Tenhunen, R | 1 |
| Herrick, A | 1 |
| McColl, KE | 2 |
| McLellan, A | 1 |
| Moore, MR | 3 |
| Brodie, MJ | 2 |
| Goldberg, A | 3 |
| Yeung-Laiwah, AA | 1 |
| Birnie, GG | 1 |
| Thompson, GG | 1 |
| Cowger, ML | 1 |
| Labbe, RF | 1 |
| Almeyda, J | 1 |
| Levantine, A | 1 |
1 review available for antipyrine and Porphyria
| Article | Year |
|---|---|
Drug reactions. XVII. Cutaneous reactions to barbiturates, chloral hydrate and its derivatives.
Topics: Adult; Aged; Anaphylaxis; Antipyrine; Barbiturates; Chloral Hydrate; Drug Eruptions; Erythema Multif | 1972 |
8 other studies available for antipyrine and Porphyria
| Article | Year |
|---|---|
Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstenes; Antipyrine; Female; Humans; Ketosteroids; | 1977 |
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane | 1976 |
Rapid normalization of antipyrine oxidation by heme in variegate porphyria.
Topics: Adult; Aged; Antipyrine; Female; Glucaric Acid; Half-Life; Heme; Humans; Hydrocortisone; Middle Aged | 1992 |
Effect of haem arginate therapy on porphyrin metabolism and mixed function oxygenase activity in acute hepatic porphyria.
Topics: Acute Disease; Adult; Antipyrine; Arginine; Cytochrome P-450 Enzyme System; Depression, Chemical; Fe | 1987 |
Haem arginate improves hepatic oxidative metabolism in variegate porphyria.
Topics: Adult; Antipyrine; Arginine; Feces; Female; Heme; Humans; Liver; Oxidation-Reduction; Porphyrias; Po | 1988 |
Lead effects on the heme biosynthetic pathway. Relationship to toxicity.
Topics: Aminolevulinic Acid; Antipyrine; Cytochromes; Heme; Humans; Lead Poisoning; Models, Biological; Porp | 1987 |
Antipyrine metabolism in acute hepatic porphyria in relapse and remission.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Aged; Aminolevulinic Acid; Antipyrine; Cytochrome P | 1987 |
The inhibition of terminal oxidation by porphyrinogenic drugs.
Topics: Animals; Antipyrine; Barbiturates; Carbamates; Cattle; Chlordiazepoxide; Chlorobutanol; Culture Tech | 1967 |