antipyrine has been researched along with Peptic Ulcer in 7 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metabolism of antipyrine was studied in 12 patients with gastric carcinoma and 5 control subjects with peptic ulcer matched for sex, body weight, height, and smoking history." | 3.66 | Microsomal enzymes in patients with gastric carcinoma as determined by plasma half-life of antipyrine. ( Higuchi, T; Nakamura, T; Uchino, H, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Staiger, C | 1 |
| Simon, B | 1 |
| Walter, E | 1 |
| Kather, H | 1 |
| Sebestyén, G | 1 |
| Gergely, V | 1 |
| Virág, S | 1 |
| Mészáros, Z | 1 |
| Higuchi, T | 1 |
| Nakamura, T | 1 |
| Uchino, H | 1 |
| Gachályi, B | 1 |
| Vas, A | 1 |
| Csillag, K | 1 |
| Nagy, B | 1 |
| Kocsis, F | 1 |
| Káldor, A | 1 |
| Adamska-Dyniewska, I | 1 |
| Tkaczewski, W | 1 |
| Jabłkowski, M | 1 |
| Chojnacki, J | 1 |
| Kettner, W | 1 |
| Schröter, U | 1 |
| Banditt, P | 1 |
| Walther, H | 1 |
| Welch, RM | 1 |
| Harrison, YE | 1 |
| Burns, JJ | 1 |
1 trial available for antipyrine and Peptic Ulcer
| Article | Year |
|---|---|
[The acetylator phenotype affects the antipyrine metabolism inhibiting action of cimetidine].
Topics: Acetylation; Antipyrine; Cimetidine; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male | 1986 |
6 other studies available for antipyrine and Peptic Ulcer
| Article | Year |
|---|---|
Influence of ranitidine on antipyrine pharmacokinetics in healthy volunteers.
Topics: Antipyrine; Drug Interactions; Furans; Humans; Peptic Ulcer; Ranitidine | 1980 |
Investigation of the interaction between Probon and indomethacin in rats.
Topics: Animals; Antipyrine; Drug Interactions; Drug Therapy, Combination; Female; Indomethacin; Male; Pepti | 1983 |
Microsomal enzymes in patients with gastric carcinoma as determined by plasma half-life of antipyrine.
Topics: Antipyrine; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Peptic Ulc | 1978 |
[Effect of combined therapy with cimetidine and (+)-cyanidanol-3 on the hepatic clearance of antipyrine].
Topics: Adolescent; Adult; Antipyrine; Catechin; Cimetidine; Drug Therapy, Combination; Female; Humans; Live | 1986 |
[Effect of histamine H2 receptor blockers on hepatic elimination of drugs].
Topics: Adult; Antipyrine; Cimetidine; Half-Life; Humans; Liver; Male; Metabolic Clearance Rate; Peptic Ulce | 1985 |
Implications of enzyme induction in drug toxicity studies.
Topics: Animals; Antipyrine; Diphenhydramine; Dogs; Enzyme Induction; Female; Haplorhini; Liver; Male; Micro | 1967 |