antipyrine has been researched along with Pancreatitis in 8 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hepatic drug metabolism was examined in patients with chronic pancreatitis and healthy controls by using a cocktail design with three different model compounds: antipyrine to express phase-I oxidation, oxazepam to express phase-II conjugation, and indocyanine green (ICG), a high-clearance compound." | 9.09 | Antipyrine, oxazepam, and indocyanine green clearance in patients with chronic pancreatitis and healthy subjects. ( Andersen, V; Larsen, S; Sonne, J, 1999) |
| "Edaravone treatment significantly reduced the elevated malondialdehyde levels in rat lungs after acute pancreatitis, suggesting an important role for free radicals in acute pancreatitis-associated lung injury." | 5.36 | Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. ( Cai, ZY; Deng, XM; Hou, J; Hu, JY; Liu, SQ; Mao, YF; Ni, X; Yang, T; Zhu, XY, 2010) |
| "Hepatic drug metabolism was examined in patients with chronic pancreatitis and healthy controls by using a cocktail design with three different model compounds: antipyrine to express phase-I oxidation, oxazepam to express phase-II conjugation, and indocyanine green (ICG), a high-clearance compound." | 5.09 | Antipyrine, oxazepam, and indocyanine green clearance in patients with chronic pancreatitis and healthy subjects. ( Andersen, V; Larsen, S; Sonne, J, 1999) |
| " Oxidative drug metabolizing capacity has been assessed by oral antipyrine and/or theophylline tests in consecutive patients with chronic pancreatitis (CP; alcoholic 24, idiopathic 47), acute pancreatitis (AP; 28) and pancreatic cancer (CA; 11)." | 5.06 | Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease. ( Acheson, DW; Braganza, JM; Houston, JB; Hunt, LP; Rose, P, 1989) |
| "Edaravone treatment significantly reduced the elevated malondialdehyde levels in rat lungs after acute pancreatitis, suggesting an important role for free radicals in acute pancreatitis-associated lung injury." | 1.36 | Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. ( Cai, ZY; Deng, XM; Hou, J; Hu, JY; Liu, SQ; Mao, YF; Ni, X; Yang, T; Zhu, XY, 2010) |
| "In 22 patients with acute pancreatitis caused by biliary calculi and 9 healthy controls the rate of hepatic elimination of phenazone was measured." | 1.28 | [Effect of acute biliary pancreatitis on liver metabolism of phenazone]. ( Becker, A; Hartleb, M; Kacperek, T; Mańczyk, I; Nowak, A; Nowakowska-Duława, E, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, T | 1 |
| Mao, YF | 1 |
| Liu, SQ | 1 |
| Hou, J | 1 |
| Cai, ZY | 1 |
| Hu, JY | 1 |
| Ni, X | 1 |
| Deng, XM | 1 |
| Zhu, XY | 1 |
| Geller, LI | 1 |
| Griaznova, MV | 1 |
| Bulgakova, OS | 1 |
| Kozlova, ZP | 1 |
| Andersen, V | 1 |
| Sonne, J | 1 |
| Larsen, S | 1 |
| Hartleb, M | 1 |
| Nowak, A | 1 |
| Nowakowska-Duława, E | 1 |
| Mańczyk, I | 1 |
| Becker, A | 1 |
| Kacperek, T | 1 |
| Acheson, DW | 2 |
| Hunt, LP | 1 |
| Rose, P | 2 |
| Houston, JB | 2 |
| Braganza, JM | 2 |
| Kogan, AS | 1 |
| Nepomniashchikh, VA | 1 |
| Lukaszyk, A | 1 |
2 trials available for antipyrine and Pancreatitis
| Article | Year |
|---|---|
Antipyrine, oxazepam, and indocyanine green clearance in patients with chronic pancreatitis and healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Chronic Disease; Coloring Agents; Female | 1999 |
Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease.
Topics: Adult; Aged; Alcohol Drinking; Antipyrine; Enzyme Induction; Female; Humans; Male; Metabolic Clearan | 1989 |
6 other studies available for antipyrine and Pancreatitis
| Article | Year |
|---|---|
Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.
Topics: Acute Lung Injury; Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; | 2010 |
[Pharmacometabolic capacity of the liver and the effect of pancreozymin in chronic hepatitis, chronic pancreatitis and diabetes mellitus].
Topics: Adult; Antipyrine; Biotransformation; Cholecystokinin; Chronic Disease; Diabetes Mellitus; Hepatitis | 1982 |
[Effect of acute biliary pancreatitis on liver metabolism of phenazone].
Topics: Acute Disease; Adult; Aged; Antipyrine; Biotransformation; Cholelithiasis; Female; Humans; Liver; Li | 1990 |
[Effect of inflammation and cholestasis on the metabolic function of the liver].
Topics: Antipyrine; Biliary Tract Diseases; Hepatitis; Humans; Inactivation, Metabolic; Inflammation; Liver; | 1987 |
[Hepatic metabolism of antipyrine in patients with acute pancreatitis].
Topics: Acute Disease; Adult; Aged; Antipyrine; Female; Humans; Inactivation, Metabolic; Kinetics; Liver; Ma | 1987 |
Induction of cytochromes P-450 in pancreatic disease: consequence, coincidence or cause?
Topics: Adolescent; Adult; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Half-Life; | 1985 |