antipyrine has been researched along with Obesity in 14 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare caffeine pharmacokinetics (200 mg single oral dose) between obese and lean subjects and in obese subjects prior to and following weight reduction." | 9.08 | Caffeine pharmacokinetics in obesity and following significant weight reduction. ( Berry, EM; Caraco, Y; Levy, M; Zylber-Katz, E, 1995) |
| "In addition, obesity is associated with a slight prolongation of antipyrine t1/2 whereas its CL0 is unaltered." | 5.29 | Antipyrine disposition in obesity: evidence for negligible effect of obesity on hepatic oxidative metabolism. ( Berry, EM; Caraco, Y; Levy, M; Zylber-Katz, E, 1995) |
| "To compare caffeine pharmacokinetics (200 mg single oral dose) between obese and lean subjects and in obese subjects prior to and following weight reduction." | 5.08 | Caffeine pharmacokinetics in obesity and following significant weight reduction. ( Berry, EM; Caraco, Y; Levy, M; Zylber-Katz, E, 1995) |
| " The elimination half-life increased to 1." | 1.28 | Influence of a very low calorie diet on the clearance of oxazepam and antipyrine in man. ( Andreasen, F; Dragsted, J; Døssing, M; Loft, S; Sonne, J, 1989) |
| "Seventeen patients with intestinal shunt for obesity and 11 control patients were given 15 mg phenazone per kg perorally to estimate the rate of absorption and hepatic metabolism of phenazone." | 1.26 | Drug absorption and hepatic drug metabolism in patients with different types of intestinal shunt operation for obesity. A study with phenazone. ( Andreasen, PB; Danö, P; Greisen, G; Kirk, H, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brouwer, KL | 1 |
| Kostenbauder, HB | 1 |
| McNamara, PJ | 1 |
| Blouin, RA | 1 |
| Abernethy, DR | 1 |
| Greenblatt, DJ | 1 |
| Divoll, M | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
| Caraco, Y | 2 |
| Zylber-Katz, E | 2 |
| Berry, EM | 2 |
| Levy, M | 2 |
| Rath, R | 2 |
| Reidenberg, MM | 2 |
| Andreasen, PB | 1 |
| Danö, P | 1 |
| Kirk, H | 1 |
| Greisen, G | 1 |
| Vesell, ES | 1 |
| O'Malley, K | 1 |
| Stevenson, IH | 1 |
| West, M | 1 |
| Raison, JM | 1 |
| Achimastos, AM | 1 |
| Safar, ME | 1 |
| Sonne, J | 1 |
| Dragsted, J | 1 |
| Loft, S | 1 |
| Døssing, M | 1 |
| Andreasen, F | 1 |
| Chojnowska-Jezierska, J | 1 |
| Kowalczyk-Gawrysiak, L | 1 |
| Tkaczewski, W | 1 |
| Lantzsch, W | 1 |
| Seige, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I, Open-Label Study to Evaluate Potential Pharmacokinetic of Orally Administered Oseltamivir in Healthy Obese Thai Adult Subjects[NCT01049763] | Phase 1 | 24 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for antipyrine and Obesity
| Article | Year |
|---|---|
[Possibilities for the determination of fat portion in body weight].
Topics: Adipose Tissue; Antipyrine; Body Composition; Body Water; Body Weight; Densitometry; Ethanol; Extrac | 1974 |
1 trial available for antipyrine and Obesity
| Article | Year |
|---|---|
Caffeine pharmacokinetics in obesity and following significant weight reduction.
Topics: Administration, Oral; Adolescent; Adult; Antipyrine; Body Mass Index; Caffeine; Female; Humans; Male | 1995 |
12 other studies available for antipyrine and Obesity
| Article | Year |
|---|---|
Phenobarbital in the genetically obese Zucker rat. II. In vivo and in vitro assessments of microsomal enzyme induction.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Me | 1984 |
Alterations in drug distribution and clearance due to obesity.
Topics: Adult; Antipyrine; Diazepam; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; | 1981 |
Antipyrine disposition in obesity: evidence for negligible effect of obesity on hepatic oxidative metabolism.
Topics: Adolescent; Adult; Antipyrine; Female; Half-Life; Humans; Liver; Male; Metabolic Clearance Rate; Mid | 1995 |
[Possibilities for determining body composition of man in relation to obesity].
Topics: Adipose Tissue; Antipyrine; Body Composition; Body Constitution; Body Water; Creatinine; Evaluation | 1976 |
Obesity and fasting--effects on drug metabolism and drug action in man.
Topics: Adult; Animals; Antipyrine; Atropine; Blood Proteins; Fasting; Female; Humans; Isoniazid; Obesity; P | 1977 |
Drug absorption and hepatic drug metabolism in patients with different types of intestinal shunt operation for obesity. A study with phenazone.
Topics: Adult; Antipyrine; Female; Humans; Intestinal Absorption; Intestine, Small; Liver; Male; Methods; Mi | 1977 |
Unaltered metabolism of antipyrine and tolbutamide in fasting man.
Topics: Administration, Oral; Adult; Antipyrine; Fasting; Female; Half-Life; Humans; Injections, Intravenous | 1975 |
The effect of fenfluramine on disposition and rate of antipyrine elimination.
Topics: Adolescent; Adult; Animals; Antipyrine; Body Height; Body Weight; Female; Fenfluramine; Half-Life; H | 1975 |
Sex-dependence of body fat distribution in patients with obesity and hypertension.
Topics: Adipose Tissue; Adult; Antipyrine; Blood Pressure; Body Fluids; Female; Humans; Hypertension; Inulin | 1992 |
Influence of a very low calorie diet on the clearance of oxazepam and antipyrine in man.
Topics: Adult; Antipyrine; Body Weight; Chromatography, High Pressure Liquid; Diet, Reducing; Energy Intake; | 1989 |
[Effect of a low-calorie diet on serum lipid levels and metabolic function of the liver in obese women during the climacteric period].
Topics: Antipyrine; Biotransformation; Climacteric; Diet, Reducing; Energy Intake; Female; Humans; Lipids; L | 1989 |
[Blood flow through human adipose subcutaneous tissue in relation to obesity under various conditions].
Topics: Adipose Tissue; Antipyrine; Blood Flow Velocity; Body Weight; Female; Humans; Iodine Isotopes; Obesi | 1971 |