Page last updated: 2024-10-22

antipyrine and Neoplasms

antipyrine has been researched along with Neoplasms in 9 studies

Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"To examine whether hepatic drug metabolism is altered in patients with cystic fibrosis (CF), we evaluated the pharmacokinetics of three model pharmacologic substrates (antipyrine, a marker of hepatic oxidative metabolism; lorazepam, a marker of hepatic glucuronosyltransferase activity; and indocyanine green (ICG), a marker of hepatic blood flow and biliary secretion) in 14 patients with CF (14."3.68Enhanced hepatic drug clearance in patients with cystic fibrosis. ( Crom, WR; Evans, WE; Kearns, GL; Mallory, GB, 1990)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19905 (55.56)18.7374
1990's3 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Bogush, TA2
Syrkin, AB1
Saltanov, AI1
Tseĭtlin, GIa2
Higuchi, T1
Nakamura, T1
Uchino, H1
Israel, BC1
Blouin, RA1
McIntyre, W1
Shedlofsky, SI1
McLean, AE1
Bukhny, AF1
Kearns, GL1
Mallory, GB1
Crom, WR1
Evans, WE1
Preiss, R1
Sohr, R1
Kittelmann, B1
Müller, E1
Haase, D1
Elfström, J1
Lindgren, S1

Reviews

2 reviews available for antipyrine and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Cancer and nutrition (review).
    Die Nahrung, 1976, Volume: 20, Issue:4

    Topics: Alcohol Drinking; Animals; Antipyrine; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Dietary Fa

1976

Trials

1 trial available for antipyrine and Neoplasms

ArticleYear
Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients.
    British journal of clinical pharmacology, 1993, Volume: 36, Issue:3

    Topics: Aged; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Hexoba

1993

Other Studies

6 other studies available for antipyrine and Neoplasms

ArticleYear
[Changes in the activity of nonspecific liver oxidases after surgery for cancer in children].
    Pediatriia, 1982, Issue:4

    Topics: Adolescent; Antipyrine; Child; Child, Preschool; Humans; Infant; Liver; Neoplasms; Oxidoreductases;

1982
Antipyrine metabolism in cancer patients.
    Cancer, 1980, Volume: 45, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Antipyrine; Half-Life; Humans; Microsomes, Liver; Middle Aged; N

1980
[The rate of antipyrine metabolism in cancer patients administered specific therapy].
    Voprosy onkologii, 1992, Volume: 38, Issue:11

    Topics: Antipyrine; Child; Child, Preschool; Half-Life; Humans; Liver; Metabolic Clearance Rate; Neoplasms;

1992
Enhanced hepatic drug clearance in patients with cystic fibrosis.
    The Journal of pediatrics, 1990, Volume: 117, Issue:6

    Topics: Adolescent; Adult; Antipyrine; Biotransformation; Cystic Fibrosis; Female; Humans; Indocyanine Green

1990
Investigations on the dose-dependent pharmacokinetics of adriamycin and its metabolites.
    International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:4

    Topics: Adult; Aged; Antipyrine; Chromatography, High Pressure Liquid; Doxorubicin; Female; Humans; Male; Mi

1989
Disappearance of phenazone from plasma in patients with obstructive jaundice.
    European journal of clinical pharmacology, 1974, Oct-04, Volume: 7, Issue:6

    Topics: Adult; Aged; Antipyrine; Bile; Biliary Tract Diseases; Cholestasis; Chromatography, Gas; Female; Hal

1974