antipyrine has been researched along with Neoplasms in 9 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether hepatic drug metabolism is altered in patients with cystic fibrosis (CF), we evaluated the pharmacokinetics of three model pharmacologic substrates (antipyrine, a marker of hepatic oxidative metabolism; lorazepam, a marker of hepatic glucuronosyltransferase activity; and indocyanine green (ICG), a marker of hepatic blood flow and biliary secretion) in 14 patients with CF (14." | 3.68 | Enhanced hepatic drug clearance in patients with cystic fibrosis. ( Crom, WR; Evans, WE; Kearns, GL; Mallory, GB, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Bogush, TA | 2 |
| Syrkin, AB | 1 |
| Saltanov, AI | 1 |
| Tseĭtlin, GIa | 2 |
| Higuchi, T | 1 |
| Nakamura, T | 1 |
| Uchino, H | 1 |
| Israel, BC | 1 |
| Blouin, RA | 1 |
| McIntyre, W | 1 |
| Shedlofsky, SI | 1 |
| McLean, AE | 1 |
| Bukhny, AF | 1 |
| Kearns, GL | 1 |
| Mallory, GB | 1 |
| Crom, WR | 1 |
| Evans, WE | 1 |
| Preiss, R | 1 |
| Sohr, R | 1 |
| Kittelmann, B | 1 |
| Müller, E | 1 |
| Haase, D | 1 |
| Elfström, J | 1 |
| Lindgren, S | 1 |
2 reviews available for antipyrine and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Cancer and nutrition (review).
Topics: Alcohol Drinking; Animals; Antipyrine; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Dietary Fa | 1976 |
1 trial available for antipyrine and Neoplasms
| Article | Year |
|---|---|
Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients.
Topics: Aged; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Hexoba | 1993 |
6 other studies available for antipyrine and Neoplasms
| Article | Year |
|---|---|
[Changes in the activity of nonspecific liver oxidases after surgery for cancer in children].
Topics: Adolescent; Antipyrine; Child; Child, Preschool; Humans; Infant; Liver; Neoplasms; Oxidoreductases; | 1982 |
Antipyrine metabolism in cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Antipyrine; Half-Life; Humans; Microsomes, Liver; Middle Aged; N | 1980 |
[The rate of antipyrine metabolism in cancer patients administered specific therapy].
Topics: Antipyrine; Child; Child, Preschool; Half-Life; Humans; Liver; Metabolic Clearance Rate; Neoplasms; | 1992 |
Enhanced hepatic drug clearance in patients with cystic fibrosis.
Topics: Adolescent; Adult; Antipyrine; Biotransformation; Cystic Fibrosis; Female; Humans; Indocyanine Green | 1990 |
Investigations on the dose-dependent pharmacokinetics of adriamycin and its metabolites.
Topics: Adult; Aged; Antipyrine; Chromatography, High Pressure Liquid; Doxorubicin; Female; Humans; Male; Mi | 1989 |
Disappearance of phenazone from plasma in patients with obstructive jaundice.
Topics: Adult; Aged; Antipyrine; Bile; Biliary Tract Diseases; Cholestasis; Chromatography, Gas; Female; Hal | 1974 |