antipyrine has been researched along with Malaria in 3 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Antipyrine and metronidazole were administered as a cocktail to young (4 weeks old) male Wistar rats (N = 12 for each treatment) to investigate the effect of malaria infection due to the rodent parasite Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of the two compounds in vivo." | 7.68 | Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat. ( Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO; Ward, SA, 1993) |
| "We have shown that malaria infection can impair selectively the formation of antipyrine metabolites in the rat." | 7.68 | The effect of malaria infection on antipyrine metabolite formation in the rat. ( Edwards, G; Mansor, SM; Ward, SA, 1991) |
| "Antipyrine and metronidazole were administered as a cocktail to young (4 weeks old) male Wistar rats (N = 12 for each treatment) to investigate the effect of malaria infection due to the rodent parasite Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of the two compounds in vivo." | 3.68 | Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat. ( Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO; Ward, SA, 1993) |
| "We have shown that malaria infection can impair selectively the formation of antipyrine metabolites in the rat." | 3.68 | The effect of malaria infection on antipyrine metabolite formation in the rat. ( Edwards, G; Mansor, SM; Ward, SA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kokwaro, GO | 1 |
| Ismail, S | 1 |
| Glazier, AP | 1 |
| Ward, SA | 2 |
| Edwards, G | 2 |
| Mansor, SM | 1 |
| Dupont, V | 1 |
| Vachon, F | 1 |
| Emile, J | 1 |
| Carbon, C | 1 |
3 other studies available for antipyrine and Malaria
| Article | Year |
|---|---|
Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat.
Topics: Animals; Antipyrine; Body Temperature; Disease Models, Animal; Endotoxins; Fever; Lipopolysaccharide | 1993 |
The effect of malaria infection on antipyrine metabolite formation in the rat.
Topics: Animals; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Malaria; Male; Microsomes, L | 1991 |
[Cerebral malaria with deep coma and acute renal insufficiency. Cure after 6 days of respiratory resuscitation associated with specific treatment of the malaria].
Topics: Acute Kidney Injury; Antipyrine; Brain Diseases; Coma; Humans; Malaria; Male; Middle Aged; Neurologi | 1967 |