antipyrine has been researched along with Liver Neoplasms in 16 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the functional activity of a liver with solid metastases from primary colorectal cancer, antipyrine metabolism was studied after the drug was administered orally (18 mg/kg body weight) to 55 healthy volunteers, 62 patients with well-compensated cirrhosis, and 42 patients with small (Class A) or massive (Class B) metastatic liver involvement." | 7.68 | Antipyrine metabolism in patients with liver metastases from colorectal cancer. ( Astone, A; Barone, C; Cassano, A; Castellano, R; Coletta, P; Gambassi, G; Grieco, A; Ragazzoni, E, 1992) |
| "The antipyrine metabolizing capacity was studied in 12 patients with cirrhosis of the liver and 12 with cirrhosis and hepatocellular carcinoma (HCC)." | 7.67 | Antipyrine clearance per unit liver volume in cirrhotics with and without hepatocellular carcinoma indicating a correlation with histological change of the liver. ( Kawata, S; Minami, Y; Miyoshi, S; Noda, S; Tarui, S, 1989) |
| "To assess the functional activity of a liver with solid metastases from primary colorectal cancer, antipyrine metabolism was studied after the drug was administered orally (18 mg/kg body weight) to 55 healthy volunteers, 62 patients with well-compensated cirrhosis, and 42 patients with small (Class A) or massive (Class B) metastatic liver involvement." | 3.68 | Antipyrine metabolism in patients with liver metastases from colorectal cancer. ( Astone, A; Barone, C; Cassano, A; Castellano, R; Coletta, P; Gambassi, G; Grieco, A; Ragazzoni, E, 1992) |
| "The antipyrine metabolizing capacity was studied in 12 patients with cirrhosis of the liver and 12 with cirrhosis and hepatocellular carcinoma (HCC)." | 3.67 | Antipyrine clearance per unit liver volume in cirrhotics with and without hepatocellular carcinoma indicating a correlation with histological change of the liver. ( Kawata, S; Minami, Y; Miyoshi, S; Noda, S; Tarui, S, 1989) |
| "Antipyrine (AP) clearance was determined in 23 cases with liver cirrhosis (LC), 12 with chronic active hepatitis (CAH), 12 with hepatocellular carcinoma (mcHCC), 20 with non-hepatic diseases and 70 healthy controls." | 3.67 | [Evaluation of antipyrine clearance in chronic liver diseases]. ( Wang, JL; Yuan, SY; Zhang, F, 1989) |
| "Antipyrine clearance was positively correlated with serum albumin (r2 = 0." | 2.69 | Antipyrine clearance in chronic and neoplastic liver diseases: a study of 518 patients. ( Castellano, R; Di Rocco, P; Gasbarrini, G; Grieco, A; Marcoccia, S; Matera, A; Ragazzoni, E; Vecchio, FM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vesell, ES | 1 |
| Kairaluoma, MI | 1 |
| Mokka, RE | 2 |
| Sotaniemi, EA | 2 |
| Huttunen, R | 2 |
| Laitinen, S | 1 |
| Larmi, TK | 1 |
| Johansson, SL | 1 |
| Grieco, A | 2 |
| Castellano, R | 2 |
| Matera, A | 1 |
| Marcoccia, S | 1 |
| Di Rocco, P | 1 |
| Ragazzoni, E | 2 |
| Vecchio, FM | 1 |
| Gasbarrini, G | 1 |
| Burke, D | 1 |
| Carnochan, P | 1 |
| Glover, C | 1 |
| Allen-Mersh, TG | 1 |
| Kjartansson, I | 1 |
| Pelkonen, RO | 1 |
| Viljakainen, E | 1 |
| Barone, C | 1 |
| Coletta, P | 1 |
| Cassano, A | 1 |
| Astone, A | 1 |
| Gambassi, G | 1 |
| Robertz-Vaupel, GM | 1 |
| Lindecken, KD | 1 |
| Edeki, T | 1 |
| Funke, C | 1 |
| Belwon, S | 1 |
| Dengler, HJ | 1 |
| Van Hillegersberg, R | 1 |
| Kort, WJ | 1 |
| ten Kate, FJ | 1 |
| Terpstra, OT | 1 |
| Aitio, A | 1 |
| Aitio, ML | 1 |
| Camus, AM | 1 |
| Cardis, E | 1 |
| Bartsch, H | 1 |
| Noda, S | 2 |
| Kawata, S | 2 |
| Miyoshi, S | 2 |
| Minami, Y | 1 |
| Tarui, S | 1 |
| Wang, JL | 1 |
| Zhang, F | 1 |
| Yuan, SY | 1 |
| Preiss, R | 1 |
| Matthias, M | 1 |
| Sohr, R | 1 |
| Brockmann, B | 1 |
| Hüller, H | 1 |
| Ito, N | 1 |
| Imai, Y | 1 |
| Saitoh, R | 1 |
| Tamura, S | 1 |
| Inada, M | 1 |
| Inui, Y | 1 |
| Matsuda, Y | 1 |
| Homeida, MM | 1 |
| Daneshmend, TK | 1 |
| Ali, EM | 1 |
| Yousif-Elkadaru, AG | 1 |
| Arbab, BM | 1 |
1 trial available for antipyrine and Liver Neoplasms
| Article | Year |
|---|---|
Antipyrine clearance in chronic and neoplastic liver diseases: a study of 518 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipyrine; Carcinoma, Hepatocellular; Evaluation Studie | 1998 |
15 other studies available for antipyrine and Liver Neoplasms
| Article | Year |
|---|---|
Complex, dynamically interacting host factors that affect the disposition of drugs and carcinogens.
Topics: Animals; Antipyrine; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Enzyme | 1982 |
Effect of surgery on liver function in patients with liver cancer.
Topics: Adult; Aged; Antipyrine; Female; Fluorouracil; Humans; Ligation; Liver; Liver Function Tests; Liver | 1982 |
Carcinogenicity of analgesics: long-term treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen).
Topics: Acetaminophen; Adenocarcinoma; Analgesics; Animals; Antipyrine; Caffeine; Carcinogens; Carcinoma, Sq | 1981 |
Correlation between tumour blood flow and fluorouracil distribution in a hypovascular liver metastasis model.
Topics: Animals; Antimetabolites, Antineoplastic; Antipyrine; Calibration; Colorectal Neoplasms; Fluorouraci | 2000 |
Tumour circulation. An experimental study in the rat with a comparison of different methods for estimation of tumour blood flow.
Topics: Angiography; Animals; Antipyrine; Carcinoma, Hepatocellular; Iodine Radioisotopes; Liver Neoplasms; | 1976 |
Impairment of drug metabolism in patients with liver cancer.
Topics: Adult; Aged; Alkaline Phosphatase; Antipyrine; Aspartate Aminotransferases; Benzopyrene Hydroxylase; | 1977 |
Antipyrine metabolism in patients with liver metastases from colorectal cancer.
Topics: Adult; Aged; Antipyrine; Colorectal Neoplasms; Female; Humans; Liver Cirrhosis; Liver Function Tests | 1992 |
Disposition of antipyrine in patients with extensive metastatic liver disease.
Topics: Adenocarcinoma; Aged; Antipyrine; Colorectal Neoplasms; Edaravone; Female; Humans; Liver Neoplasms; | 1992 |
Water-jet-cooled Nd:YAG laser coagulation: selective destruction of rat liver metastases.
Topics: Adenocarcinoma; Alanine Transaminase; Aluminum Silicates; Animals; Antipyrine; Aspartate Aminotransf | 1991 |
Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepato | 1991 |
Antipyrine clearance per unit liver volume in cirrhotics with and without hepatocellular carcinoma indicating a correlation with histological change of the liver.
Topics: Adult; Aged; Antipyrine; Carcinoma, Hepatocellular; Female; Humans; Liver; Liver Cirrhosis; Liver Fu | 1989 |
[Evaluation of antipyrine clearance in chronic liver diseases].
Topics: Adolescent; Adult; Antipyrine; Carcinoma, Hepatocellular; Hepatitis, Chronic; Humans; Liver Cirrhosi | 1989 |
Pharmacokinetics of adriamycin, adriamycinol, and antipyrine in patients with moderate tumor involvement of the liver.
Topics: Adult; Antipyrine; Breast Neoplasms; Carcinoma, Hepatocellular; Doxorubicin; Female; Humans; Liver F | 1987 |
[Alterations of urinary excretion of antipyrine metabolites in patients with cirrhosis of the liver].
Topics: Antipyrine; Carcinoma, Hepatocellular; Edaravone; Female; Humans; Liver Cirrhosis; Liver Neoplasms; | 1987 |
Assessment of oxidative metabolism in adults with hepatocellular carcinoma in the Sudan.
Topics: Adult; Antipyrine; Carcinoma, Hepatocellular; Female; Humans; Kinetics; Liver; Liver Function Tests; | 1986 |