antipyrine has been researched along with Liver Cirrhosis, Alcoholic in 19 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Liver Cirrhosis, Alcoholic: FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was undertaken to determine whether or not spironolactone could induce drug-metabolizing enzymes in patients with ascites due to alcoholic cirrhosis of the liver." | 9.05 | Spironolactone and enzyme induction in patients with alcoholic cirrhosis. ( Dhumeaux, D; Joanne, C; Miguet, JP; Thebault-Lucas, A; Vuitton, D, 1980) |
| "The metabolism of antipyrine to each of its three major metabolites 4-hydroxy-, 3-methylhydroxy- and norantipyrine has previously been demonstrated to be differentially affected in alcoholic cirrhosis." | 7.68 | Antipyrine elimination in patients with alcoholic and non-alcoholic cirrhosis. ( Heidemann, HT; Hoffmann, K; Wensing, G, 1993) |
| "We determined the clearance of antipyrine before, and during, the administration of propranolol in eight male patients with alcoholic cirrhosis and a recent episode of gastrointestinal bleeding." | 7.66 | Propranolol does not further decrease the clearance of antipyrine in patients with alcoholic cirrhosis. ( Bercoff, E; Larrey, D; Lebrec, D; Pessayre, D, 1983) |
| "Chronic alcohol abuse, as well as liver disease, induces a decrease of hepatic GSH." | 5.29 | Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis. ( De Girolamo, V; Del Vecchio Blanco, C; Disalvo, D; Guerriero, C; Loguercio, C; Piscopo, P, 1996) |
| " The elimination half-life of antipyrine in patients with alcoholic liver cirrhosis was significantly longer than in the healthy subjects (P less than 0." | 5.27 | Antipyrine clearance and metabolite formation in patients with alcoholic cirrhosis. ( Breimer, DD; Janssens, AR; Koch, CW; Spoelstra, P; Teunissen, MW; van Duyn, W; Weeda, B, 1984) |
| "The effect of zinc supplementation on antipyrine clearance was evaluated in 14 outpatients with stable alcoholic liver disease, of whom nine had biopsy proven alcoholic cirrhosis." | 5.08 | Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease. ( Andreasen, PB; Feldman, M; Friis, H; Grønbaek, K; Sonne, J, 1996) |
| "The present study was undertaken to determine whether or not spironolactone could induce drug-metabolizing enzymes in patients with ascites due to alcoholic cirrhosis of the liver." | 5.05 | Spironolactone and enzyme induction in patients with alcoholic cirrhosis. ( Dhumeaux, D; Joanne, C; Miguet, JP; Thebault-Lucas, A; Vuitton, D, 1980) |
| "The metabolism of antipyrine to each of its three major metabolites 4-hydroxy-, 3-methylhydroxy- and norantipyrine has previously been demonstrated to be differentially affected in alcoholic cirrhosis." | 3.68 | Antipyrine elimination in patients with alcoholic and non-alcoholic cirrhosis. ( Heidemann, HT; Hoffmann, K; Wensing, G, 1993) |
| "Medroxyprogesterone acetate (MPA) elimination rate was investigated in 25 patients with primary biliary cirrhosis, alcoholic cirrhosis and fatty liver." | 3.67 | Liver function and medroxyprogesterone acetate elimination in man. ( Rautio, A, 1984) |
| " Comparison was also made with pericellular collagen in liver biopsies and with insulin sensitivity assessed by the euglycemic clamp technique and with conventional liver function tests including oral antipyrine test." | 3.67 | Carbohydrate intolerance associated with reduced hepatic glucose phosphorylating and releasing enzyme activities and peripheral insulin resistance in alcoholics with liver cirrhosis. ( Arranto, AJ; Kairaluoma, M; Keinänen, K; Lahtela, JT; Sotaniemi, EA, 1985) |
| "We determined the clearance of antipyrine before, and during, the administration of propranolol in eight male patients with alcoholic cirrhosis and a recent episode of gastrointestinal bleeding." | 3.66 | Propranolol does not further decrease the clearance of antipyrine in patients with alcoholic cirrhosis. ( Bercoff, E; Larrey, D; Lebrec, D; Pessayre, D, 1983) |
| " The histological changes associated with the therapy were investigated by comparing liver biopsies before and after phenobarbital and medroxyprogesterone acetate treatment, known inducers of hepatic microsomal enzyme system, in eight alcoholics with cirrhosis and two control groups, subjects with normal liver and endstage alcoholic cirrhosis." | 3.66 | Pericellular collagen in alcoholics with liver cirrhosis. ( Arranto, AJ; Rautio, A; Sotaniemi, EA, 1982) |
| " Hepatic microsomal reserve, defined as the difference between the basal and phenobarbital-stimulated ABT, was therefore studied in eight healthy control subjects and 12 patients with stable alcoholic cirrhosis." | 3.66 | Decreased hepatic microsomal reserve in patients with cirrhosis. Studies using aminopyrine as model drug. ( Hepner, GW; Piken, E, 1979) |
| "Chronic alcohol abuse, as well as liver disease, induces a decrease of hepatic GSH." | 1.29 | Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis. ( De Girolamo, V; Del Vecchio Blanco, C; Disalvo, D; Guerriero, C; Loguercio, C; Piscopo, P, 1996) |
| " The elimination half-life of antipyrine in patients with alcoholic liver cirrhosis was significantly longer than in the healthy subjects (P less than 0." | 1.27 | Antipyrine clearance and metabolite formation in patients with alcoholic cirrhosis. ( Breimer, DD; Janssens, AR; Koch, CW; Spoelstra, P; Teunissen, MW; van Duyn, W; Weeda, B, 1984) |
| " The average biological half-life after oral administration of 1 g paracetamol was significantly prolonged in patients with hepatic cirrhosis compared to the controls (3." | 1.26 | Paracetamol (acetaminophen) clearance in patients with cirrhosis of the liver. ( Andreasen, PB; Hutters, L, 1979) |
| "Antipyrine (AP) serves as a model drug for drugs which are eliminated independently of liver blood flow and lorcainide (L) elimination as a model for drugs which depend on liver blood flow." | 1.26 | Alterations in the disposition of differently cleared drugs in patients with cirrhosis. ( Fischer, C; Klotz, U; Müller, WA; Müller-Seydlitz, P; Schulz, J, 1979) |
| "Antipyrine metabolism was normal or marginally impaired in patients with compensated cirrhosis or acute hepatitis, whereas it was frequently abnormal in those with chronic active hepatitis or advanced alcoholic liver disease." | 1.26 | Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism. ( Cooksley, WG; Farrell, GC; Hart, P; Powell, LW, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (73.68) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rautio, A | 2 |
| Teunissen, MW | 1 |
| Spoelstra, P | 1 |
| Koch, CW | 1 |
| Weeda, B | 1 |
| van Duyn, W | 1 |
| Janssens, AR | 1 |
| Breimer, DD | 1 |
| Larrey, D | 1 |
| Lebrec, D | 1 |
| Bercoff, E | 1 |
| Pessayre, D | 1 |
| Arranto, AJ | 2 |
| Sotaniemi, EA | 2 |
| Horváth, T | 1 |
| Pár, A | 1 |
| Past, T | 1 |
| Tapsonyi, Z | 1 |
| Ruzsa, C | 1 |
| Kádas, I | 1 |
| Jávor, T | 1 |
| Miguet, JP | 2 |
| Vuitton, D | 1 |
| Thebault-Lucas, A | 1 |
| Joanne, C | 2 |
| Dhumeaux, D | 2 |
| Bauer, LA | 1 |
| O'Sullivan, T | 1 |
| Reiss, WG | 1 |
| Horn, JR | 1 |
| Opheim, K | 1 |
| Strandness, DE | 1 |
| Carithers, RL | 1 |
| Rector, WG | 1 |
| Everson, GT | 1 |
| Robertson, AD | 1 |
| Wensing, G | 1 |
| Hoffmann, K | 1 |
| Heidemann, HT | 1 |
| Grønbaek, K | 1 |
| Friis, H | 1 |
| Feldman, M | 1 |
| Sonne, J | 1 |
| Andreasen, PB | 2 |
| Loguercio, C | 1 |
| Piscopo, P | 1 |
| Guerriero, C | 1 |
| De Girolamo, V | 1 |
| Disalvo, D | 1 |
| Del Vecchio Blanco, C | 1 |
| Hutters, L | 1 |
| Klotz, U | 1 |
| Fischer, C | 1 |
| Müller-Seydlitz, P | 1 |
| Schulz, J | 1 |
| Müller, WA | 1 |
| Piken, E | 1 |
| Hepner, GW | 1 |
| Farrell, GC | 1 |
| Cooksley, WG | 1 |
| Hart, P | 1 |
| Powell, LW | 1 |
| Allemand, H | 1 |
| Debruyne, D | 1 |
| Gram, LF | 1 |
| Grollier, G | 1 |
| Camsonne, R | 1 |
| Agron, L | 1 |
| Dao, MT | 1 |
| Lacotte, J | 1 |
| Bigot, MC | 1 |
| Moulin, M | 1 |
| MacGilchrist, AJ | 1 |
| Birnie, GG | 1 |
| Cook, A | 1 |
| Scobie, G | 1 |
| Murray, T | 1 |
| Watkinson, G | 1 |
| Brodie, MJ | 1 |
| Keinänen, K | 1 |
| Lahtela, JT | 1 |
| Kairaluoma, M | 1 |
2 trials available for antipyrine and Liver Cirrhosis, Alcoholic
| Article | Year |
|---|---|
Spironolactone and enzyme induction in patients with alcoholic cirrhosis.
Topics: Adult; Aged; Antipyrine; Body Weight; Drug Interactions; Enzyme Induction; Female; Furosemide; Human | 1980 |
Lack of effect of zinc supplementation on antipyrine clearance in alcoholic liver disease.
Topics: Adjuvants, Immunologic; Adult; Aged; Alkaline Phosphatase; Antipyrine; Bilirubin; Factor VII; Female | 1996 |
17 other studies available for antipyrine and Liver Cirrhosis, Alcoholic
| Article | Year |
|---|---|
Liver function and medroxyprogesterone acetate elimination in man.
Topics: Antipyrine; Fatty Liver; Female; Humans; Liver; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Biliary | 1984 |
Antipyrine clearance and metabolite formation in patients with alcoholic cirrhosis.
Topics: Adult; Aged; Antipyrine; Glucuronates; Humans; Liver Cirrhosis, Alcoholic; Metabolic Clearance Rate; | 1984 |
Propranolol does not further decrease the clearance of antipyrine in patients with alcoholic cirrhosis.
Topics: Adult; Antipyrine; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis, Alcoholic; Male; Metabolic | 1983 |
Pericellular collagen in alcoholics with liver cirrhosis.
Topics: Adult; Antipyrine; Collagen; Humans; Liver; Liver Cirrhosis, Alcoholic; Male; Medroxyprogesterone; M | 1982 |
Drug metabolism in alcoholic liver disease.
Topics: Acetylation; Adult; Antipyrine; Fatty Liver, Alcoholic; Female; Glucaric Acid; Humans; Hydroxylation | 1982 |
Liver blood flow, antipyrine clearance, and antipyrine metabolite formation clearance in patients with chronic active hepatitis and alcoholic cirrhosis.
Topics: Adult; Antipyrine; Female; Half-Life; Hepatitis B; Hepatitis C; Hepatitis, Chronic; Humans; Liver Ci | 1994 |
Sodium retention does not occur at a critical threshold of liver function in alcoholic cirrhosis.
Topics: Antipyrine; Ascites; Blood Volume; Caffeine; Cholic Acid; Cholic Acids; Humans; Liver; Liver Cirrhos | 1994 |
Antipyrine elimination in patients with alcoholic and non-alcoholic cirrhosis.
Topics: Adult; Antipyrine; Female; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Bil | 1993 |
Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis.
Topics: Adult; Aged; Alcoholism; Antipyrine; Female; Glutathione; Humans; Injections, Intravenous; Liver Cir | 1996 |
Paracetamol (acetaminophen) clearance in patients with cirrhosis of the liver.
Topics: Acetaminophen; Adult; Aged; Antipyrine; Female; Half-Life; Humans; Kinetics; Liver Cirrhosis; Liver | 1979 |
Alterations in the disposition of differently cleared drugs in patients with cirrhosis.
Topics: Acetanilides; Adult; Aged; Anti-Arrhythmia Agents; Antipyrine; Benzeneacetamides; Humans; Liver; Liv | 1979 |
Decreased hepatic microsomal reserve in patients with cirrhosis. Studies using aminopyrine as model drug.
Topics: Adult; Aminopyrine; Antipyrine; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Microsomes, Liver; | 1979 |
Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism.
Topics: Acute Disease; Antipyrine; Ascites; Biotransformation; Chemical and Drug Induced Liver Injury; Chole | 1978 |
[The metabolic clearance rate of antipyrine: a good index for the assessment of the hepatic drug-oxidizing function in cirrhotic patients (author's transl)].
Topics: Adult; Antipyrine; Female; Humans; Liver; Liver Cirrhosis, Alcoholic; Male; Metabolic Clearance Rate | 1978 |
Quinidine disposition in relation to antipyrine elimination and debrisoquine phenotype in alcoholic patients with and without cirrhosis.
Topics: Adult; Aged; Alcoholism; Antipyrine; Chromatography, Liquid; Debrisoquin; Female; Half-Life; Humans; | 1989 |
Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis.
Topics: Adult; Antipyrine; Benzodiazepines; Endoscopy; Flicker Fusion; Half-Life; Humans; Hypnotics and Seda | 1986 |
Carbohydrate intolerance associated with reduced hepatic glucose phosphorylating and releasing enzyme activities and peripheral insulin resistance in alcoholics with liver cirrhosis.
Topics: Adult; Aged; Antipyrine; Blood Glucose; Collagen; Glucokinase; Glucose; Glucose-6-Phosphatase; Hexok | 1985 |