antipyrine has been researched along with Lead Poisoning in 6 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Lead Poisoning: Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Among the latter, 2 were normal and 8 had biochemical evidence of lead poisoning but no clinical expression of plumbism." | 3.65 | Drug metabolism in normal children, lead-poisoned children, and normal adults. ( Alvares, AP; Kapelner, S; Kappas, A; Sassa, S, 1975) |
| " However, chronic administration of lead to weanling rats caused no significant changes in hepatic cytochrome P-450 levels or in the microsomal oxidative enzymes over a 12-wk period." | 1.26 | Lead intoxication: effects on cytochrome P-450-mediated hepatic oxidations. ( Alvares, AP; Anderson, KE; Fischbein, A; Kappas, A; Sassa, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fischbein, A | 2 |
| Alvares, AP | 3 |
| Anderson, KE | 2 |
| Sassa, S | 3 |
| Kappas, A | 3 |
| Meredith, PA | 2 |
| Campbell, BC | 2 |
| Moore, MR | 3 |
| Goldberg, A | 3 |
| Kapelner, S | 1 |
| Brodie, MJ | 1 |
| Thompson, GG | 1 |
| Yeung-Laiwah, AA | 1 |
6 other studies available for antipyrine and Lead Poisoning
| Article | Year |
|---|---|
Lead intoxication among demolition workers: the effect of lead on the hepatic cytochrome P-450 system in humans.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme System; Edetic Acid; Half-Life; Humans; Lead Poisoning; L | 1977 |
The effects of industrial lead poisoning on cytochrome P450 mediated phenazone (antipyrine) hydroxylation.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme System; Edetic Acid; Humans; Hydroxylation; Lead Poisonin | 1977 |
Drug metabolism in normal children, lead-poisoned children, and normal adults.
Topics: Adult; Age Factors; Antipyrine; Child; Child, Preschool; Edetic Acid; Female; Half-Life; Humans; Inf | 1975 |
Haem biosynthesis and hydroxylation of phenazone during lead intoxication.
Topics: Adult; Antipyrine; Chelating Agents; Half-Life; Heme; Humans; Hydroxylation; Lead; Lead Poisoning; M | 1976 |
Lead intoxication: effects on cytochrome P-450-mediated hepatic oxidations.
Topics: Adult; Aniline Hydroxylase; Animals; Antipyrine; Body Weight; Cytochrome P-450 Enzyme System; Ethylm | 1976 |
Lead effects on the heme biosynthetic pathway. Relationship to toxicity.
Topics: Aminolevulinic Acid; Antipyrine; Cytochromes; Heme; Humans; Lead Poisoning; Models, Biological; Porp | 1987 |