antipyrine has been researched along with Injury, Ischemia-Reperfusion in 83 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a clinically approved cerebroprotective agent against ischemic stroke and amyotrophic lateral sclerosis, while new formulations that enable improvement of its physicochemical properties and biodistribution are desired." | 8.31 | Development of Edaravone Ionic Liquids and Their Application for the Treatment of Cerebral Ischemia/Reperfusion Injury. ( Fukuta, T; Ikeda-Imafuku, M; Iwao, Y, 2023) |
| " The free-radical scavenger edaravone is used in combination with the recombinant tissue plasminogen activator alteplase to treat acute ischemic stroke." | 7.81 | The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model. ( Ishii, H; Sakamoto, K; Sato, T; Yamamoto, J; Yamashita, T, 2015) |
| "To investigate the protective effect of edaravone and danshensu conjugate (IM-009) on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanisms." | 7.81 | [Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanism]. ( Chen, H; Hou, S; Zhang, S, 2015) |
| "Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction." | 7.78 | Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. ( Chen, X; Gao, M; Lei, S; Li, L; Li, W; Li, X; Liu, Y; Lu, H; Wang, N; Zhang, P; Zheng, J, 2012) |
| "To compare the protective effect of nerve growth factor (NGF) and edaravone (a free radical scavenger) pretreatment against cerebral ischemia/reperfusion (I/R) injury to nerve cells." | 7.76 | [A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury]. ( Fu, JQ; Liu, H; Wang, DF, 2010) |
| "The aim of this study is to clarify whether edaravone postconditioning had protective effect against renal ischemia/reperfusion injury and to compare the protective effect between ischemic postconditioning and edaravone postconditioning." | 7.76 | Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats. ( Li, Y; Xia, AZ; Xing, SH, 2010) |
| "To increase the survival rate of patients with acute superior mesenteric artery thromboembolism (ASMAT) treated by catheter thrombolysis, we examined the effects of delivering edaravone and asialoerythropoietin, agents with tissue-protective activities, using a rabbit autologous fibrin clot ASMAT model." | 7.76 | Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model? ( Kashiwagi, A; Murata, K; Nitta, N; Ohta, S; Seko, A; Sonoda, A; Sugimoto, T; Takahashi, M; Takemura, S; Uzu, T; Yokomaku, Y, 2010) |
| "The aim of this study was to evaluate the effects of intra-arterial administration of edaravone after superior mesenteric artery (SMA) thromboembolism in a rabbit model." | 7.75 | Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model. ( Miyagawa, Y; Murata, K; Nitta, N; Ohta, S; Seko, A; Sonoda, A; Takahashi, M; Takemura, S, 2009) |
| "We investigated the effects of edaravone, a free radical scavenger, on peripheral nerve ischemia-reperfusion injury caused by ligation of vessels supplying the sciatic and tibial nerves in rats." | 7.75 | Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury. ( Iida, H; Nagasaka, T; Shindo, K; Shiozawa, Z, 2009) |
| "To investigate the effect of edaravone on renal ischemia-reperfusion injury in rats." | 7.74 | [Protective effects of edaravone on renal ischemia-reperfusion injury in rats]. ( Huang, HY; Xu, QP; Zhang, G, 2008) |
| "Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction." | 7.74 | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction. ( Akuzawa, S; Bashar, AH; Fujie, M; Kazui, T; Ohishi, K; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Washiyama, N; Yamamoto, S; Yamashita, K, 2007) |
| "Compared to vehicle group, IR significantly decreased the PO(2) level and increased the wet-to-dry ratio, proteins in bronchoalveolar lavage (BAL), and myeloperoxidase (MPO) activity in the control group, while edaravone treatment maintained the PO(2) similar to the vehicle group and significantly reduced edema formation and neutrophil extravasation." | 7.73 | MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation. ( Akamatsu, H; Reyes, YA; Shimoyama, T; Sunamori, M, 2006) |
| "Edaravone ameliorates renal ischemia/reperfusion injury by scavenging free radicals produced in renal tubular cells and inhibiting lipid peroxidation." | 7.72 | Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. ( Doi, K; Fujita, T; Nakao, A; Noiri, E; Suzuki, Y, 2004) |
| "We investigated whether or not a combination of the selective thrombin inhibitor, argatroban, and the free radical scavenger, edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil." | 7.71 | Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. ( Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K, 2002) |
| "Edaravone was found to have a protective effect against I/R injury by directly inhibiting lipid peroxidation of the myocyte by free radicals in skeletal muscles and may also reduce the secondary edema and inflammatory infiltration incidence of oxidative stress on tissue." | 5.39 | Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb. ( Akeda, K; Hasegawa, M; Hori, K; Iino, T; Satonaka, H; Sudo, A; Tsujii, M; Uchida, A; Uemura, T, 2013) |
| "Edaravone or saline were administered after reperfusion for 30 min." | 5.36 | Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function. ( Hanai, T; Matsumoto, S; Shimizu, N; Sugimoto, K; Uemura, H, 2010) |
| "Edaravone is a synthetic radical scavenger that has been used in acute stroke." | 5.33 | A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation. ( Fujita, M; Furukawa, H; Jin, MB; Nakayama, M; Shimamura, T; Suzuki, T; Tahara, M; Taniguchi, M; Todo, S, 2005) |
| "Edaravone has been used for protection against I/R injury in patients with cerebral infarction." | 5.33 | Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. ( Horikawa, S; Ito, K; Ozasa, H, 2005) |
| "Edaravone (10 mg/kg) was delivered intravenously before ischemia and after reperfusion to prevent the neutrophil activation." | 5.33 | Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model. ( Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Sugimura, K; Takemoto, Y; Tsuchida, K; Yoshimura, R, 2006) |
| "When edaravone was administered prior to ischemia and at the time of initiation of the reperfusion, liver injury was markedly reduced." | 5.33 | Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. ( Connor, HD; Fujii, H; Kono, H; Maki, A; Mason, RP; Rusyn, I; Woods, CG, 2006) |
| "Edaravone was administered via intravenous infusion at 5 min before reperfusion was achieved by removal of the clamp." | 5.32 | Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. ( Ichikawa, H; Imamoto, E; Isozaki, Y; Katada, K; Kokura, S; Naito, Y; Okanoue, T; Takagi, T; Tomatsuri, N; Uchiyama, K; Yoshida, N; Yoshikawa, T, 2004) |
| "Antipyrine (AP) was selected as a model substrate and administered intravenously at a dose of 10 mg/kg." | 5.30 | Extrahepatic ischemia-reperfusion injury reduces hepatic oxidative drug metabolism as determined by serial antipyrine clearance. ( Barone, GW; Estes, M; Gurley, BJ; Harden, A; Polston, S; Yamashita, K, 1997) |
| " Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a clinically approved cerebroprotective agent against ischemic stroke and amyotrophic lateral sclerosis, while new formulations that enable improvement of its physicochemical properties and biodistribution are desired." | 4.31 | Development of Edaravone Ionic Liquids and Their Application for the Treatment of Cerebral Ischemia/Reperfusion Injury. ( Fukuta, T; Ikeda-Imafuku, M; Iwao, Y, 2023) |
| " The free-radical scavenger edaravone is used in combination with the recombinant tissue plasminogen activator alteplase to treat acute ischemic stroke." | 3.81 | The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model. ( Ishii, H; Sakamoto, K; Sato, T; Yamamoto, J; Yamashita, T, 2015) |
| "To investigate the protective effect of edaravone and danshensu conjugate (IM-009) on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanisms." | 3.81 | [Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanism]. ( Chen, H; Hou, S; Zhang, S, 2015) |
| " We have previously reported that edaravone, a free radical scavenger, has a cytoprotective effect on warm ischemia-reperfusion injury and improves the function of liver grafts from NHBDs in a rat model of ischemia-reperfusion." | 3.80 | Edaravone, a free radical scavenger, improves the graft viability on liver transplantation from non-heart-beating donors in pigs. ( Fujio, A; Goto, M; Hara, Y; Kashiwadate, T; Kawagishi, N; Maida, K; Miyagi, S; Miyazawa, K; Murakami, K; Nakanishi, C; Nakanishi, W; Ohuchi, N; Yamaya, H, 2014) |
| "Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction." | 3.78 | Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. ( Chen, X; Gao, M; Lei, S; Li, L; Li, W; Li, X; Liu, Y; Lu, H; Wang, N; Zhang, P; Zheng, J, 2012) |
| "In a rabbit model with aortic clamping up to 30 minutes, which consistently produces complete paraplegia in rabbits, spinal cord damage was partially reduced by topical cooling with transvertebral cooling pads or the injection of edaravone into the clamped segment of aorta, but was more effectively protected by a combined use of these two strategies." | 3.77 | New method for absolute spinal cord ischemia protection in rabbits. ( Herlambang, B; Hiyama, E; Mizukami, T; Orihashi, K; Sueda, T; Takahashi, S; Uchida, N, 2011) |
| "To increase the survival rate of patients with acute superior mesenteric artery thromboembolism (ASMAT) treated by catheter thrombolysis, we examined the effects of delivering edaravone and asialoerythropoietin, agents with tissue-protective activities, using a rabbit autologous fibrin clot ASMAT model." | 3.76 | Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model? ( Kashiwagi, A; Murata, K; Nitta, N; Ohta, S; Seko, A; Sonoda, A; Sugimoto, T; Takahashi, M; Takemura, S; Uzu, T; Yokomaku, Y, 2010) |
| "To compare the protective effect of nerve growth factor (NGF) and edaravone (a free radical scavenger) pretreatment against cerebral ischemia/reperfusion (I/R) injury to nerve cells." | 3.76 | [A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury]. ( Fu, JQ; Liu, H; Wang, DF, 2010) |
| "The aim of this study is to clarify whether edaravone postconditioning had protective effect against renal ischemia/reperfusion injury and to compare the protective effect between ischemic postconditioning and edaravone postconditioning." | 3.76 | Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats. ( Li, Y; Xia, AZ; Xing, SH, 2010) |
| "The aim of this study was to evaluate the effects of intra-arterial administration of edaravone after superior mesenteric artery (SMA) thromboembolism in a rabbit model." | 3.75 | Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model. ( Miyagawa, Y; Murata, K; Nitta, N; Ohta, S; Seko, A; Sonoda, A; Takahashi, M; Takemura, S, 2009) |
| "We demonstrate that edaravone inhibits rtPA-induced cerebral hemorrhage in the ischemic brain of rats via the inhibition of MMP-9 expression in vivo, which is substantiated by inhibition of MMP-9 expression and NF-kappaB activation in HBECs." | 3.75 | Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. ( Kinouchi, T; Kitazato, KT; Nagahiro, S; Shimada, K; Tada, Y; Uno, M; Yagi, K, 2009) |
| "We investigated the effects of edaravone, a free radical scavenger, on peripheral nerve ischemia-reperfusion injury caused by ligation of vessels supplying the sciatic and tibial nerves in rats." | 3.75 | Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury. ( Iida, H; Nagasaka, T; Shindo, K; Shiozawa, Z, 2009) |
| "To investigate the effect of edaravone on renal ischemia-reperfusion injury in rats." | 3.74 | [Protective effects of edaravone on renal ischemia-reperfusion injury in rats]. ( Huang, HY; Xu, QP; Zhang, G, 2008) |
| "Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction." | 3.74 | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction. ( Akuzawa, S; Bashar, AH; Fujie, M; Kazui, T; Ohishi, K; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Washiyama, N; Yamamoto, S; Yamashita, K, 2007) |
| " We investigated the effects of edaravone (Mitsubishi Pharma Co, Tokyo, Japan), a free radical scavenger, on spinal ischemia-reperfusion injury in a rabbit model." | 3.73 | Experimental study on the protective effects of edaravone against ischemic spinal cord injury. ( Bashar, AH; Ikeda, Y; Kazui, T; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Umemura, K; Washiyama, N; Yamashita, K; Yasuike, J, 2005) |
| "Compared to vehicle group, IR significantly decreased the PO(2) level and increased the wet-to-dry ratio, proteins in bronchoalveolar lavage (BAL), and myeloperoxidase (MPO) activity in the control group, while edaravone treatment maintained the PO(2) similar to the vehicle group and significantly reduced edema formation and neutrophil extravasation." | 3.73 | MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation. ( Akamatsu, H; Reyes, YA; Shimoyama, T; Sunamori, M, 2006) |
| "The effects of ozagrel (CAS 82571-53-7), a thromboxane A2-synthetase inhibitor, and norphenazone (CAS 89-25-8), a free-radical scavenger, on cerebral infarction were assessed using the suture-induced middle cerebral artery occlusion (MCAO) model and a microthrombosis model." | 3.72 | Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. ( Ichikawa, K; Imamura, T; Kiguchi, S; Kobayashi, K; Kojima, M; Yamazaki, Y, 2003) |
| "Edaravone ameliorates renal ischemia/reperfusion injury by scavenging free radicals produced in renal tubular cells and inhibiting lipid peroxidation." | 3.72 | Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney. ( Doi, K; Fujita, T; Nakao, A; Noiri, E; Suzuki, Y, 2004) |
| "We investigated whether or not a combination of the selective thrombin inhibitor, argatroban, and the free radical scavenger, edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil." | 3.71 | Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. ( Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K, 2002) |
| " Most importantly, 3d possessed a very high absolute bioavailability and was rapidly distributed in brain tissue to keep high plasma drug concentration for the treatment of ischemic strokes." | 1.42 | Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent. ( Lan, Z; Lei, M; Li, J; Liang, Z; Xu, W; Xu, X; Zhang, X; Zhao, C, 2015) |
| "Edaravone was found to have a protective effect against I/R injury by directly inhibiting lipid peroxidation of the myocyte by free radicals in skeletal muscles and may also reduce the secondary edema and inflammatory infiltration incidence of oxidative stress on tissue." | 1.39 | Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb. ( Akeda, K; Hasegawa, M; Hori, K; Iino, T; Satonaka, H; Sudo, A; Tsujii, M; Uchida, A; Uemura, T, 2013) |
| "Edaravone is a brain-penetrant free radical scavenger that is known to ameliorate postischemic neuronal dysfunction." | 1.37 | Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation. ( Hayakari, R; Imaizumi, T; Ishikawa, A; Itoh, K; Kosaka, K; Matsumiya, T; Metoki, N; Mimura, J; Ota, K; Satoh, K; Tanji, K; Yoshida, H, 2011) |
| "To validate this new model of reperfusion injury, we used two well characterized neuroprotectants, estrogen and edaravone." | 1.36 | A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery. ( Connell, BJ; Saleh, TM, 2010) |
| "Edaravone or saline were administered after reperfusion for 30 min." | 1.36 | Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function. ( Hanai, T; Matsumoto, S; Shimizu, N; Sugimoto, K; Uemura, H, 2010) |
| "Treatment with serofendic acid (1-30 nmol) reduced the infarct volume in a dose-dependent manner." | 1.35 | Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats. ( Akaike, A; Katsuki, H; Kume, T; Nakamura, T; Niidome, T; Sugimoto, H, 2008) |
| "Edaravone pretreatment reduced markedly the productions of ROS-HR and MDA and increased the activities of GSH-PX and SOD." | 1.35 | Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model. ( Chen, D; Chen, Y; Gu, H; Qiu, W; Zheng, L; Zhou, J, 2008) |
| "Edaravone was intravenously administered to rats just before reperfusion and partial (70%) hepatectomy was performed just after reperfusion." | 1.34 | Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats. ( Hiranuma, S; Horikawa, S; Ito, K; Koike, Y; Noda, Y; Ozasa, H, 2007) |
| "Edaravone is a newly developed radical scavenging agent that has been used for protection against I/R injury in patients with cerebral infarction." | 1.33 | Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder. ( Hanai, T; Levin, RM; Matsumoto, S; Shimizu, N; Sugiyama, T; Uemura, H; Yoshioka, N, 2005) |
| "Edaravone is a synthetic radical scavenger that has been used in acute stroke." | 1.33 | A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation. ( Fujita, M; Furukawa, H; Jin, MB; Nakayama, M; Shimamura, T; Suzuki, T; Tahara, M; Taniguchi, M; Todo, S, 2005) |
| "Edaravone (10 mg/kg) was delivered intravenously before ischemia and after reperfusion to prevent the neutrophil activation." | 1.33 | Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model. ( Funao, K; Hayama, T; Kawahito, Y; Matsuyama, M; Nakatani, T; Sano, H; Sugimura, K; Takemoto, Y; Tsuchida, K; Yoshimura, R, 2006) |
| "Edaravone-treated animals showed significantly improved neurological outcome." | 1.33 | Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. ( Amemiya, S; Inaba, T; Kamiya, T; Katayama, Y; Kato, K; Nito, C; Shimazaki, K; Ueda, M, 2005) |
| "When edaravone was administered prior to ischemia and at the time of initiation of the reperfusion, liver injury was markedly reduced." | 1.33 | Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. ( Connor, HD; Fujii, H; Kono, H; Maki, A; Mason, RP; Rusyn, I; Woods, CG, 2006) |
| "Edaravone has been used for protection against I/R injury in patients with cerebral infarction." | 1.33 | Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. ( Horikawa, S; Ito, K; Ozasa, H, 2005) |
| "Edaravone was administered via intravenous infusion at 5 min before reperfusion was achieved by removal of the clamp." | 1.32 | Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. ( Ichikawa, H; Imamoto, E; Isozaki, Y; Katada, K; Kokura, S; Naito, Y; Okanoue, T; Takagi, T; Tomatsuri, N; Uchiyama, K; Yoshida, N; Yoshikawa, T, 2004) |
| "Antipyrine (AP) was selected as a model substrate and administered intravenously at a dose of 10 mg/kg." | 1.30 | Extrahepatic ischemia-reperfusion injury reduces hepatic oxidative drug metabolism as determined by serial antipyrine clearance. ( Barone, GW; Estes, M; Gurley, BJ; Harden, A; Polston, S; Yamashita, K, 1997) |
| "Metabolic disruption resulted from cerebral ischemia and post-ischemia reperfusion injury was studied using proton magnetic resonance spectroscopy (1H MRS)." | 1.30 | [In vitro evaluation of metabolic change in forebrain ischemia model of rat using proton magnetic resonance spectroscopy]. ( Tanaka, N, 1997) |
| "The volume of cerebral infarction, induced by 2-h occlusion and subsequent 2-h reperfusion of MCA in Fisher-344 rats, was evaluated." | 1.30 | Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat. ( Iwai, T; Nakashima, M; Niwa, M; Uematsu, T, 1999) |
| "Pretreatment with mannitol prevented postischemic obstruction of the microcirculation during 5 minutes of recirculation after 30 minutes of severe temporary ischemia, but the EEG signals did not recover." | 1.28 | Effect of mannitol on local cerebral blood flow after temporary complete cerebral ischemia in rats. ( Shirane, R; Weinstein, PR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (9.64) | 18.2507 |
| 2000's | 47 (56.63) | 29.6817 |
| 2010's | 27 (32.53) | 24.3611 |
| 2020's | 1 (1.20) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuta, T | 1 |
| Ikeda-Imafuku, M | 1 |
| Iwao, Y | 1 |
| Xu, YP | 1 |
| Han, F | 1 |
| Tan, J | 1 |
| Hori, K | 1 |
| Tsujii, M | 1 |
| Iino, T | 1 |
| Satonaka, H | 1 |
| Uemura, T | 1 |
| Akeda, K | 1 |
| Hasegawa, M | 2 |
| Uchida, A | 1 |
| Sudo, A | 1 |
| Ergenoglu, M | 1 |
| Erbaş, O | 1 |
| Akdemir, A | 1 |
| Yeniel, AÖ | 1 |
| Yildirim, N | 1 |
| Oltulu, F | 1 |
| Aktuğ, H | 1 |
| Taskiran, D | 1 |
| Connell, BJ | 2 |
| Saleh, MC | 1 |
| Kucukkaya, I | 1 |
| Abd-El-Aziz, AS | 1 |
| Khan, BV | 1 |
| Saleh, TM | 2 |
| Miyazawa, K | 1 |
| Miyagi, S | 2 |
| Maida, K | 1 |
| Murakami, K | 1 |
| Fujio, A | 1 |
| Kashiwadate, T | 1 |
| Nakanishi, W | 1 |
| Hara, Y | 1 |
| Nakanishi, C | 1 |
| Yamaya, H | 1 |
| Kawagishi, N | 1 |
| Goto, M | 1 |
| Ohuchi, N | 1 |
| Uchiyama, M | 1 |
| Tojo, K | 1 |
| Yazawa, T | 1 |
| Ota, S | 1 |
| Goto, T | 1 |
| Kurahashi, K | 1 |
| Chiazza, F | 1 |
| Chegaev, K | 1 |
| Rogazzo, M | 1 |
| Cutrin, JC | 1 |
| Benetti, E | 1 |
| Lazzarato, L | 1 |
| Fruttero, R | 1 |
| Collino, M | 1 |
| Yamashita, T | 1 |
| Sato, T | 1 |
| Sakamoto, K | 1 |
| Ishii, H | 1 |
| Yamamoto, J | 1 |
| Zhang, S | 1 |
| Hou, S | 1 |
| Chen, H | 1 |
| Lan, Z | 1 |
| Xu, X | 1 |
| Xu, W | 1 |
| Li, J | 1 |
| Liang, Z | 1 |
| Zhang, X | 1 |
| Lei, M | 1 |
| Zhao, C | 1 |
| Zhang, DY | 1 |
| Kang, SS | 1 |
| Zhang, ZW | 1 |
| Wu, R | 1 |
| Zhang, G | 1 |
| Xu, QP | 1 |
| Huang, HY | 1 |
| Song, Y | 1 |
| Gong, YY | 1 |
| Xie, ZG | 1 |
| Li, CH | 1 |
| Gu, Q | 1 |
| Wu, XW | 1 |
| Nakamura, A | 1 |
| Akamatsu, Y | 1 |
| Fukumori, T | 1 |
| Sekiguchi, S | 1 |
| Satomi, S | 1 |
| Qiu, W | 1 |
| Gu, H | 1 |
| Zheng, L | 1 |
| Zhou, J | 1 |
| Chen, D | 1 |
| Chen, Y | 1 |
| Xu, JZ | 1 |
| Shen, BZ | 1 |
| Li, Y | 2 |
| Zhang, T | 1 |
| Xu, WH | 1 |
| Liu, XW | 1 |
| Lu, HG | 1 |
| Liu, H | 2 |
| Wang, DF | 3 |
| Fu, JQ | 2 |
| Yagi, K | 1 |
| Kitazato, KT | 1 |
| Uno, M | 1 |
| Tada, Y | 1 |
| Kinouchi, T | 1 |
| Shimada, K | 1 |
| Nagahiro, S | 1 |
| Sonoda, A | 2 |
| Nitta, N | 2 |
| Seko, A | 2 |
| Ohta, S | 2 |
| Takemura, S | 2 |
| Miyagawa, Y | 1 |
| Takahashi, M | 3 |
| Murata, K | 2 |
| Yamazaki, K | 1 |
| Miwa, S | 1 |
| Toyokuni, S | 1 |
| Nemoto, S | 1 |
| Oriyanhan, W | 1 |
| Takaba, K | 1 |
| Saji, Y | 1 |
| Marui, A | 1 |
| Nishina, T | 1 |
| Ikeda, T | 1 |
| Komeda, M | 1 |
| Sugimoto, T | 1 |
| Uzu, T | 1 |
| Yokomaku, Y | 1 |
| Kashiwagi, A | 1 |
| Watanabe, M | 1 |
| Masaoka, N | 1 |
| Nakajima, Y | 1 |
| Nagaishi, M | 1 |
| Yamamoto, T | 2 |
| Iida, H | 1 |
| Nagasaka, T | 1 |
| Shindo, K | 1 |
| Shiozawa, Z | 1 |
| Tamamura, M | 1 |
| Saito, M | 1 |
| Kinoshita, Y | 1 |
| Shimizu, S | 1 |
| Satoh, I | 1 |
| Shomori, K | 1 |
| Dimitriadis, F | 1 |
| Satoh, K | 2 |
| Guo, Q | 1 |
| Wang, G | 1 |
| Namura, S | 1 |
| Matsumoto, S | 2 |
| Hanai, T | 2 |
| Shimizu, N | 2 |
| Sugimoto, K | 1 |
| Uemura, H | 2 |
| Xia, AZ | 1 |
| Xing, SH | 1 |
| Yoshida, H | 1 |
| Mimura, J | 1 |
| Imaizumi, T | 1 |
| Matsumiya, T | 1 |
| Ishikawa, A | 1 |
| Metoki, N | 1 |
| Tanji, K | 1 |
| Ota, K | 1 |
| Hayakari, R | 1 |
| Kosaka, K | 1 |
| Itoh, K | 1 |
| Takano, T | 1 |
| Yonemitsu, Y | 2 |
| Saito, S | 1 |
| Itoh, H | 1 |
| Onohara, T | 2 |
| Fukuda, A | 1 |
| Takai, M | 1 |
| Maehara, Y | 3 |
| Herlambang, B | 1 |
| Orihashi, K | 1 |
| Mizukami, T | 1 |
| Takahashi, S | 1 |
| Uchida, N | 1 |
| Hiyama, E | 1 |
| Sueda, T | 1 |
| Ogishima, H | 1 |
| Nakamura, S | 1 |
| Nakanishi, T | 1 |
| Imai, S | 1 |
| Kakino, M | 1 |
| Ishizuka, F | 1 |
| Tsuruma, K | 1 |
| Shimazawa, M | 1 |
| Hara, H | 1 |
| Zhang, P | 1 |
| Li, W | 1 |
| Li, L | 1 |
| Wang, N | 1 |
| Li, X | 1 |
| Gao, M | 1 |
| Zheng, J | 1 |
| Lei, S | 1 |
| Chen, X | 1 |
| Lu, H | 1 |
| Liu, Y | 1 |
| Kara, M | 1 |
| Daglioglu, YK | 1 |
| Kuyucu, Y | 1 |
| Tuli, A | 1 |
| Tap, O | 1 |
| Lu, RY | 1 |
| Luo, DF | 1 |
| Xiao, SH | 1 |
| Yang, LH | 1 |
| Zhao, J | 1 |
| Ji, EN | 1 |
| Tao, EX | 1 |
| Xing, YG | 1 |
| Zhu, FY | 1 |
| Luan, P | 1 |
| Liu, J | 1 |
| Yao, N | 1 |
| Song, X | 1 |
| Liu, XL | 1 |
| Shimoda, M | 1 |
| Iwasaki, Y | 1 |
| Okada, T | 1 |
| Kubota, K | 1 |
| Ninomiya, M | 2 |
| Shimada, M | 2 |
| Harada, N | 2 |
| Shiotani, S | 1 |
| Hiroshige, S | 1 |
| Soejima, Y | 2 |
| Suehiro, T | 2 |
| Sugimachi, K | 1 |
| Okatani, Y | 1 |
| Wakatsuki, A | 1 |
| Enzan, H | 1 |
| Miyahara, Y | 1 |
| Imamura, T | 1 |
| Kiguchi, S | 1 |
| Kobayashi, K | 2 |
| Ichikawa, K | 1 |
| Yamazaki, Y | 1 |
| Kojima, M | 1 |
| Tomatsuri, N | 1 |
| Yoshida, N | 1 |
| Takagi, T | 1 |
| Katada, K | 1 |
| Isozaki, Y | 1 |
| Imamoto, E | 1 |
| Uchiyama, K | 1 |
| Kokura, S | 1 |
| Ichikawa, H | 1 |
| Naito, Y | 1 |
| Okanoue, T | 1 |
| Yoshikawa, T | 1 |
| Doi, K | 2 |
| Suzuki, Y | 1 |
| Nakao, A | 1 |
| Fujita, T | 1 |
| Noiri, E | 1 |
| Yamawaki, M | 1 |
| Sasaki, N | 1 |
| Shimoyama, M | 1 |
| Miake, J | 1 |
| Ogino, K | 1 |
| Igawa, O | 1 |
| Tajima, F | 1 |
| Shigemasa, C | 1 |
| Hisatome, I | 1 |
| Irie, H | 1 |
| Kato, T | 1 |
| Ikebe, K | 1 |
| Tsuchida, T | 1 |
| Oniki, Y | 1 |
| Takagi, K | 1 |
| Ito, K | 2 |
| Ozasa, H | 2 |
| Horikawa, S | 2 |
| Amemiya, S | 1 |
| Kamiya, T | 1 |
| Nito, C | 1 |
| Inaba, T | 1 |
| Kato, K | 1 |
| Ueda, M | 1 |
| Shimazaki, K | 1 |
| Katayama, Y | 1 |
| Yokota, A | 1 |
| Nakai, A | 1 |
| Taniuchi, Y | 1 |
| Okuda, N | 1 |
| Nakai, M | 1 |
| Takeshita, T | 1 |
| Suzuki, F | 1 |
| Hashikura, Y | 1 |
| Ise, H | 1 |
| Ishida, A | 1 |
| Nakayama, J | 1 |
| Miyagawa, S | 1 |
| Ikeda, U | 1 |
| Tahara, M | 2 |
| Nakayama, M | 1 |
| Jin, MB | 1 |
| Fujita, M | 1 |
| Suzuki, T | 3 |
| Taniguchi, M | 2 |
| Shimamura, T | 1 |
| Furukawa, H | 1 |
| Todo, S | 2 |
| Hashizume, K | 1 |
| Ueda, T | 1 |
| Shimizu, H | 1 |
| Mori, A | 1 |
| Yozu, R | 1 |
| Zhang, N | 1 |
| Komine-Kobayashi, M | 1 |
| Tanaka, R | 1 |
| Liu, M | 1 |
| Mizuno, Y | 1 |
| Urabe, T | 1 |
| Yoshioka, N | 1 |
| Sugiyama, T | 1 |
| Levin, RM | 1 |
| Kaneko, K | 1 |
| Fujii, T | 1 |
| Onimaru, M | 1 |
| Jin, CH | 1 |
| Inoue, M | 1 |
| Sueishi, K | 1 |
| Suzuki, K | 2 |
| Kazui, T | 2 |
| Terada, H | 2 |
| Umemura, K | 1 |
| Ikeda, Y | 1 |
| Bashar, AH | 2 |
| Yamashita, K | 3 |
| Washiyama, N | 2 |
| Ohkura, K | 2 |
| Yasuike, J | 1 |
| Reyes, YA | 1 |
| Shimoyama, T | 1 |
| Akamatsu, H | 1 |
| Sunamori, M | 1 |
| Wen, J | 2 |
| Watanabe, K | 2 |
| Ma, M | 2 |
| Yamaguchi, K | 1 |
| Tachikawa, H | 1 |
| Kodama, M | 2 |
| Aizawa, Y | 2 |
| Hu, X | 1 |
| Ge, QF | 1 |
| Zhang, L | 1 |
| Lu, YB | 1 |
| Wei, EQ | 1 |
| Kono, H | 1 |
| Woods, CG | 1 |
| Maki, A | 1 |
| Connor, HD | 1 |
| Mason, RP | 1 |
| Rusyn, I | 1 |
| Fujii, H | 1 |
| Wu, T | 1 |
| Ding, XS | 1 |
| Wang, W | 1 |
| Wu, J | 2 |
| Akao, T | 1 |
| Takeyoshi, I | 1 |
| Totsuka, O | 1 |
| Arakawa, K | 1 |
| Muraoka, M | 1 |
| Konno, K | 1 |
| Matsumoto, K | 1 |
| Morishita, Y | 1 |
| Matsuyama, M | 1 |
| Hayama, T | 1 |
| Funao, K | 1 |
| Tsuchida, K | 1 |
| Takemoto, Y | 1 |
| Sugimura, K | 1 |
| Kawahito, Y | 1 |
| Sano, H | 1 |
| Nakatani, T | 1 |
| Yoshimura, R | 1 |
| Uchinami, M | 1 |
| Yoshida, M | 1 |
| Sasaki, H | 1 |
| Tamagawa, K | 1 |
| Horiuchi, T | 1 |
| Tanaka, K | 2 |
| Yamamoto, S | 1 |
| Ohishi, K | 1 |
| Akuzawa, S | 1 |
| Fujie, M | 1 |
| Hiranuma, S | 1 |
| Noda, Y | 1 |
| Koike, Y | 1 |
| Nakamura, T | 1 |
| Kume, T | 1 |
| Katsuki, H | 1 |
| Niidome, T | 1 |
| Sugimoto, H | 1 |
| Akaike, A | 1 |
| Watanabe, T | 2 |
| Masaki, Y | 1 |
| Kumano, K | 1 |
| He, N | 1 |
| Suyama, I | 1 |
| Endo, T | 1 |
| Gartshore, G | 1 |
| Dawson, D | 1 |
| Patterson, J | 1 |
| Macrae, IM | 1 |
| Gurley, BJ | 1 |
| Barone, GW | 1 |
| Polston, S | 1 |
| Estes, M | 1 |
| Harden, A | 1 |
| Tanaka, N | 1 |
| Yuki, S | 1 |
| Mitsuka, M | 1 |
| Saito, KI | 1 |
| Kogure, K | 1 |
| Tsuchidate, R | 1 |
| He, QP | 1 |
| Smith, ML | 1 |
| Siesjö, BK | 1 |
| Nakashima, M | 1 |
| Niwa, M | 1 |
| Iwai, T | 1 |
| Uematsu, T | 1 |
| Wu, TW | 1 |
| Zeng, LH | 1 |
| Fung, KP | 1 |
| Wijnen, MH | 1 |
| Coolen, SA | 1 |
| Vader, HL | 1 |
| Reijenga, JC | 1 |
| Huf, FA | 1 |
| Roumen, RM | 1 |
| Zhao, W | 1 |
| Busto, R | 1 |
| Truettner, J | 1 |
| Ginsberg, MD | 1 |
| Kimura, T | 1 |
| Sako, K | 1 |
| Kusakabe, M | 1 |
| Tanaka, T | 1 |
| Nakada, T | 1 |
| Jin, YJ | 1 |
| Mima, T | 1 |
| Raicu, V | 1 |
| Park, KC | 1 |
| Shimizu, K | 1 |
| Shirane, R | 1 |
| Weinstein, PR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Open-Label Comparison Study on the Efficacy and Safety of Argatroban Monotherapy With Argatroban-Edaravone Combination Therapy[NCT00153946] | Phase 4 | 814 participants (Actual) | Interventional | 2004-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
83 other studies available for antipyrine and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Development of Edaravone Ionic Liquids and Their Application for the Treatment of Cerebral Ischemia/Reperfusion Injury.
Topics: Animals; Antipyrine; Brain Ischemia; Edaravone; Free Radical Scavengers; Ionic Liquids; Ischemic Str | 2023 |
Edaravone protects the retina against ischemia/reperfusion‑induced oxidative injury through the PI3K/Akt/Nrf2 pathway.
Topics: Animals; Antioxidants; Antipyrine; Cell Membrane; Cell Survival; Edaravone; Gene Expression Regulati | 2017 |
Protective effect of edaravone for tourniquet-induced ischemia-reperfusion injury on skeletal muscle in murine hindlimb.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hindlimb; Male; Mice; Mice, Inbred C57BL; M | 2013 |
Attenuation of ischemia/reperfusion-induced ovarian damage in rats: does edaravone offer protection?
Topics: Animals; Antipyrine; Caspase 3; Edaravone; Female; Free Radical Scavengers; Glutathione; Immunohisto | 2013 |
UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia/reperfusion.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Drug Combinations; Male; Neocort | 2014 |
Edaravone, a free radical scavenger, improves the graft viability on liver transplantation from non-heart-beating donors in pigs.
Topics: Adenosine; Allopurinol; Animals; Antipyrine; Biomarkers; Cold Ischemia; Cytoprotection; Edaravone; F | 2014 |
Edaravone prevents lung injury induced by hepatic ischemia-reperfusion.
Topics: Acute Lung Injury; Alanine Transaminase; Animals; Antipyrine; Aspartate Aminotransferases; Cytokines | 2015 |
A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion.
Topics: Acetylglucosamine; Acute-Phase Proteins; Animals; Antipyrine; Creatinine; Disease Models, Animal; Ed | 2015 |
The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Fibrinolysis; Fibrinolytic Agents; Free Radi | 2015 |
[Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury
in rats and its underlying mechanism].
Topics: Animals; Antipyrine; Brain Edema; Brain Ischemia; Cerebral Infarction; Edaravone; Lactates; Malondia | 2015 |
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent.
Topics: Animals; Antioxidants; Antipyrine; Behavior, Animal; Benzofurans; Biological Availability; Brain; Ca | 2015 |
Edaravone enhances the viability of ischemia/reperfusion flaps.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Graft Survival; Ischemic Preconditioning; Ma | 2017 |
[Protective effects of edaravone on renal ischemia-reperfusion injury in rats].
Topics: Animals; Antipyrine; Edaravone; Kidney; Male; Malondialdehyde; Random Allocation; Rats; Rats, Spragu | 2008 |
Edaravone (MCI-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Electroretinography; Free Radical Scavengers; In Situ Nic | 2008 |
A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
Topics: Animals; Antipyrine; Aspartate Aminotransferases; Bile; Cadaver; Edaravone; Free Radical Scavengers; | 2008 |
Pretreatment with edaravone reduces lung mitochondrial damage in an infant rabbit ischemia-reperfusion model.
Topics: Acute Lung Injury; Animals; Animals, Suckling; Antipyrine; Constriction; Disease Models, Animal; Eda | 2008 |
Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model.
Topics: Animals; Antipyrine; Disease Models, Animal; Dogs; Edaravone; Lipid Peroxidation; Lung; Lung Transpl | 2008 |
[A comparison of protective effect of propofol and edaravone pretreatment against cerebral ischemia-reperfusion injury].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Eda | 2008 |
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
Topics: Animals; Antipyrine; Blood Pressure; Blotting, Western; Brain Ischemia; Cells, Cultured; Cerebral He | 2009 |
Edaravone prevents bowel infarction after acute superior mesenteric artery thromboembolism using autologous fibrin clots in a rabbit model.
Topics: Animals; Anticoagulants; Antipyrine; Case-Control Studies; Disease Models, Animal; Edaravone; Fibrin | 2009 |
Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Heart; Heart Arrest, Induced; In Vitro Tech | 2009 |
Does the concomitant intra-arterial injection of asialoerythropoietin and edaravone mitigate ischaemic mucosal damage after acute superior mesenteric artery thromboembolism in a rabbit autologous fibrin clot model?
Topics: Animals; Antipyrine; Asialoglycoproteins; Catheterization; Disease Models, Animal; Drug Combinations | 2010 |
Changes of expression of glucose transporters in the fetal lamb brain after MCI-186 administration to the maternal circulation with 10-min persistent umbilical cord occlusion.
Topics: Animals; Antipyrine; Arterial Occlusive Diseases; Brain; Drug Evaluation, Preclinical; Edaravone; Fe | 2009 |
Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury.
Topics: Animals; Antipyrine; Behavior, Animal; Edaravone; Edema; Electrophysiology; Free Radical Scavengers; | 2009 |
Protective effect of edaravone, a free-radical scavenger, on ischaemia-reperfusion injury in the rat testis.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Oxidative Stress; Rats; Rats, Sprague | 2010 |
Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice.
Topics: Animals; Antipyrine; Arterial Occlusive Diseases; Autoradiography; Brain Ischemia; Capillaries; Cere | 2010 |
Effect of edaravone on ischemia/reperfusion injury in rat urinary bladder--changes in smooth muscle cell phenotype and contractile function.
Topics: Animals; Antipyrine; Dose-Response Relationship, Drug; Edaravone; Electric Stimulation; Free Radical | 2010 |
[A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury].
Topics: Animals; Animals, Newborn; Antipyrine; Apoptosis; Brain Ischemia; Cells, Cultured; Disease Models, A | 2010 |
A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery.
Topics: Animals; Antipyrine; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship | 2010 |
Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Creatinine; Edaravo | 2010 |
Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.
Topics: Abietanes; Antioxidants; Antipyrine; Astrocytes; Cell Survival; Cells, Cultured; Drug Synergism; Eda | 2011 |
A somatostatin analogue, octreotide, ameliorates intestinal ischemia-reperfusion injury through the early induction of heme oxygenase-1.
Topics: Animals; Antipyrine; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Heme Oxygenase-1; Intest | 2012 |
New method for absolute spinal cord ischemia protection in rabbits.
Topics: Animals; Antipyrine; Aorta; Biomarkers; Combined Modality Therapy; Constriction; Disease Models, Ani | 2011 |
Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina.
Topics: Animals; Antipyrine; Blood Flow Velocity; Carotid Artery, External; Cell Count; Cerebrovascular Circ | 2011 |
Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury.
Topics: Analysis of Variance; Animals; Antipyrine; Bromodeoxyuridine; Cerebral Infarction; Cerebral Ventricl | 2012 |
The effect of edaravone on ischemia-reperfusion injury in rat ovary.
Topics: Animals; Antipyrine; Edaravone; Female; Free Radical Scavengers; Ovarian Diseases; Ovary; Postoperat | 2012 |
Kallikrein gene transfer induces angiogenesis and further improves regional cerebral blood flow in the early period after cerebral ischemia/reperfusion in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Carbon Isotopes; Cerebral Infarction; | 2012 |
[Neuroprotective effects of combined pretreatment with edaravone and propofol on neonatal rat cerebral cortical neurons with ischemia/reperfusion injury in vitro].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Eda | 2012 |
Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model.
Topics: Animals; Antipyrine; Apoptosis; Biomarkers; Cytoprotection; Disease Models, Animal; Edaravone; Free | 2012 |
Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Free Radical Scavengers; In Situ Nick-End Labeling; Ische | 2002 |
Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver.
Topics: Animals; Antipyrine; Edaravone; Electron Transport; Free Radical Scavengers; Glutathione Peroxidase; | 2003 |
Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger.
Topics: Animals; Antipyrine; Edaravone; Enzyme Inhibitors; Free Radical Scavengers; Infarction, Middle Cereb | 2003 |
Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats.
Topics: Animals; Antipyrine; Cytokines; Edaravone; Free Radical Scavengers; Hemoglobins; Intestinal Mucosa; | 2004 |
The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury.
Topics: Animals; Antipyrine; Cold Temperature; Edaravone; Free Radical Scavengers; Hydroxyl Radical; Interle | 2004 |
Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.
Topics: Animals; Antipyrine; Cell Line; Edaravone; Free Radical Scavengers; Humans; Kidney; Kidney Tubules, | 2004 |
Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes.
Topics: Action Potentials; Animals; Antipyrine; Cell Death; Cells, Cultured; Edaravone; Flow Cytometry; Free | 2004 |
Antioxidant effect of MCI-186, a new Free-Radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model.
Topics: Amputation, Surgical; Animals; Antioxidants; Antipyrine; Body Water; Edaravone; Enzymes; Free Radica | 2004 |
Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat.
Topics: Animals; Antipyrine; Disease Progression; Edaravone; Interleukin-6; Intestines; Ischemia; Lung; Male | 2005 |
Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Brain Edema; Brain Ischemia; Cerebral Co | 2005 |
Maternal treatment with MCI-186 does not improve delayed deterioration of cellular bioenergetic state and mitochondrial activity following transient intrauterine ischemia in the fetal rat brain.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Edaravone; Energy Metabolism; Female; Fetal Hypoxia; Fre | 2005 |
MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats.
Topics: Alanine Transaminase; Aldehydes; Animals; Antipyrine; Chemokines; Cytokines; Edaravone; Free Radical | 2005 |
A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation.
Topics: Animals; Antipyrine; Dogs; Edaravone; Female; Free Radical Scavengers; Kidney; Kidney Function Tests | 2005 |
Effect of the free radical scavenger MCI-186 on spinal cord reperfusion after transient ischemia in the rabbit.
Topics: Animals; Antipyrine; Cell Death; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavenger | 2005 |
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyrine; | 2005 |
Edaravone protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Rats; Rats, Sprague-Dawley; Reperfusi | 2005 |
A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia.
Topics: Angiogenesis Inducing Agents; Animals; Antipyrine; Edaravone; Fibroblast Growth Factor 2; Free Radic | 2006 |
Experimental study on the protective effects of edaravone against ischemic spinal cord injury.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Male; Rabbits; Reperfusion Injury; Spinal C | 2005 |
MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation.
Topics: Animals; Antipyrine; Bronchoalveolar Lavage Fluid; Cold Ischemia; Disease Models, Animal; Edaravone; | 2006 |
Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats.
Topics: Aging; Animals; Antioxidants; Antipyrine; Blotting, Western; Brain; Cerebral Infarction; Edaravone; | 2006 |
[Homeostatic conditions affect the protective effect of edaravone on ischemic injury in neurons].
Topics: Animals; Animals, Newborn; Antipyrine; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Edaravone; Gl | 2006 |
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage.
Topics: Acute Disease; Animals; Antipyrine; Edaravone; Electron Spin Resonance Spectroscopy; Free Radicals; | 2006 |
MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) attenuated simulated ischemia/reperfusion injury in cultured rat hippocampal cells.
Topics: Animals; Antipyrine; Apoptosis; Calcium; Cells, Cultured; Edaravone; Hippocampus; Malondialdehyde; M | 2006 |
Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs.
Topics: Animals; Antipyrine; Dogs; Edaravone; Free Radical Scavengers; Lung; Lung Transplantation; Reperfusi | 2006 |
Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model.
Topics: Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; Male; Rats; Rats, I | 2006 |
Edaravone reduces ischemia-reperfusion injury mediators in rat liver.
Topics: Animals; Antipyrine; Aspartate Aminotransferases; E-Selectin; Edaravone; Free Radical Scavengers; Li | 2007 |
Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction.
Topics: Analysis of Variance; Animals; Antipyrine; Blood Chemical Analysis; Cardiopulmonary Bypass; Cerebral | 2007 |
Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury.
Topics: Aging; Animals; Antipyrine; Apoptosis; Blotting, Western; Brain Ischemia; Cell Survival; Disease Mod | 2007 |
Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats.
Topics: Animals; Antipyrine; Edaravone; Free Radical Scavengers; Gene Expression Regulation; Hepatectomy; In | 2007 |
Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats.
Topics: Animals; Antipyrine; Body Weight; Brain Ischemia; Cerebrovascular Circulation; Diterpenes; Dose-Resp | 2008 |
The novel antioxidant edaravone: from bench to bedside.
Topics: Animals; Anti-Inflammatory Agents; Antipyrine; Drug Evaluation, Preclinical; Edaravone; Free Radical | 2008 |
Protective effects of MCI-186 on cold kidney preservation/reperfusion injury in the rat.
Topics: Animals; Antipyrine; Creatinine; Edaravone; Free Radical Scavengers; Hypertonic Solutions; In Vitro | 1996 |
Topographic profile of reperfusion into MCA territory following endothelin-1-induced transient focal cerebral ischaemia.
Topics: Animals; Antipyrine; Autoradiography; Cerebral Arteries; Cerebrovascular Circulation; Collateral Cir | 1996 |
Extrahepatic ischemia-reperfusion injury reduces hepatic oxidative drug metabolism as determined by serial antipyrine clearance.
Topics: Animals; Antipyrine; Dogs; Interleukin-1; Interleukin-6; Intestines; Kidney; Liver; Male; Oxidation- | 1997 |
[In vitro evaluation of metabolic change in forebrain ischemia model of rat using proton magnetic resonance spectroscopy].
Topics: Acetates; Animals; Antipyrine; Brain; Brain Ischemia; Choline; Edaravone; Free Radical Scavengers; L | 1997 |
Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Death; Edaravone; Free Radical Scavengers; Hippocampus; Hy | 1997 |
Regional cerebral blood flow during and after 2 hours of middle cerebral artery occlusion in the rat.
Topics: Animals; Antipyrine; Autoradiography; Cerebral Arteries; Cerebrovascular Circulation; Constriction; | 1997 |
Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat.
Topics: Animals; Antipyrine; Brain; Caudate Nucleus; Cerebral Infarction; Cyclic N-Oxides; Disease Models, A | 1999 |
MCI-186: further histochemical and biochemical evidence of neuroprotection.
Topics: Animals; Antipyrine; Brain; Brain Infarction; Creatine Kinase; Cytochrome c Group; Edaravone; Free R | 2000 |
Antioxidants reduce oxidative stress in claudicants.
Topics: Aged; Antioxidants; Antipyrine; Ascorbic Acid; Exercise Test; Female; Humans; Intermittent Claudicat | 2001 |
Simultaneous measurement of cerebral blood flow and mRNA signals: pixel-based inter-modality correlational analysis.
Topics: Algorithms; Animals; Antipyrine; Autoradiography; Brain; Brain Ischemia; Carbon Radioisotopes; Cereb | 2001 |
Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil.
Topics: Adenosine Triphosphate; Animals; Antipyrine; Astrocytes; Body Temperature; Cerebral Cortex; Cerebral | 2002 |
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils.
Topics: Animals; Anticoagulants; Antipyrine; Arginine; Body Water; Brain Edema; Brain Ischemia; Cerebral Inf | 2002 |
Effect of mannitol on local cerebral blood flow after temporary complete cerebral ischemia in rats.
Topics: Animals; Antipyrine; Autoradiography; Blood Gas Analysis; Blood Pressure; Carbon Radioisotopes; Cere | 1992 |