antipyrine has been researched along with Inflammation in 30 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was designed to evaluate the cardioprotective potential of edaravone on oxidative stress, anti-apoptotic, anti-inflammatory and ultrastructure findings in isoproterenol (ISO) induced myocardial infarction (MI) in rats." | 7.81 | Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence. ( Akhtar, M; Akhtar, MS; Ali, J; Haque, SE; Hassan, MQ; Najmi, AK, 2015) |
| "Intrathecally administered edaravone, a free radical scavenger, had analgesic effects on inflammatory-induced acute and facilitated pain but not on acute thermal pain, without any behavioural side-effects." | 7.73 | Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats. ( Nishiyama, T; Ogawa, M, 2005) |
| "Plasma concentrations after oral administration of the high extraction drug propranolol are increased in patients and animals with inflammation." | 7.67 | Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat. ( Belpaire, FM; Bogaert, MG; Chindavijak, B; de Smet, F; Fraeyman, N, 1989) |
| "A decrease of the hepatic intrinsic clearance could contribute to the increase of the plasma concentrations of alpha 1-acid glycoprotein-bound drugs such as propranolol in animals and humans with inflammation." | 7.67 | Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes. ( Belpaire, FM; Bogaert, MG; Chindavijak, B, 1988) |
| "When edaravone was administered prior to ischemia and at the time of initiation of the reperfusion, liver injury was markedly reduced." | 5.33 | Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. ( Connor, HD; Fujii, H; Kono, H; Maki, A; Mason, RP; Rusyn, I; Woods, CG, 2006) |
| "The present study was designed to evaluate the cardioprotective potential of edaravone on oxidative stress, anti-apoptotic, anti-inflammatory and ultrastructure findings in isoproterenol (ISO) induced myocardial infarction (MI) in rats." | 3.81 | Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence. ( Akhtar, M; Akhtar, MS; Ali, J; Haque, SE; Hassan, MQ; Najmi, AK, 2015) |
| "Intrathecally administered edaravone, a free radical scavenger, had analgesic effects on inflammatory-induced acute and facilitated pain but not on acute thermal pain, without any behavioural side-effects." | 3.73 | Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats. ( Nishiyama, T; Ogawa, M, 2005) |
| "Fifty-one consecutive children with sepsis and six critically ill children without sepsis were enrolled and given 18 mg/kg antipyrine per NG." | 3.72 | Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. ( Burckart, GJ; Carcillo, JA; Doughty, L; Frye, RF; Kaplan, SS; Kofos, D; Sasser, H, 2003) |
| "Plasma concentrations after oral administration of the high extraction drug propranolol are increased in patients and animals with inflammation." | 3.67 | Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat. ( Belpaire, FM; Bogaert, MG; Chindavijak, B; de Smet, F; Fraeyman, N, 1989) |
| "A decrease of the hepatic intrinsic clearance could contribute to the increase of the plasma concentrations of alpha 1-acid glycoprotein-bound drugs such as propranolol in animals and humans with inflammation." | 3.67 | Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes. ( Belpaire, FM; Bogaert, MG; Chindavijak, B, 1988) |
| "Inflammation is the immune response to a harmful stimulus, and its purpose is to destroy foreign agents so that the affected site can be repair." | 1.91 | The ( da Rosa, JS; Dalmarco, EM; de Campos-Buzzi, F; Fratoni, E; Maciel, TDRG; Nascimento, MVPDS; Theindl, LC, 2023) |
| "Edaravone was treated twice via tail vein; after MCA occlusion and after reperfusion." | 1.43 | A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. ( Arai, K; Fujiwara, N; Lee, BJ; Lo, EH; Mandeville, ET; Pham, LD; Som, AT, 2016) |
| "These results support the critical role of NO in the microcirculation and suggest that free-radical scavenging increases the bioavailability of NO in the microcirculation via eNOS upregulation." | 1.39 | Effect of a free radical scavenger on nitric oxide release in microvessels. ( Sakamoto, K; Totani, N; Yamamoto, J; Yamanishi, H; Yamashita, T, 2013) |
| "Edaravone treatment significantly decreased hippocampal CA3 neuron loss, reduced oxidative stress, and decreased neuronal programmed cell death compared to vehicle treatment." | 1.37 | Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats. ( Chen, J; Gao, YQ; Jiang, ZL; Li, X; Li, YC; Shi, H; Vosler, PS; Wang, GH, 2011) |
| "When edaravone was administered prior to ischemia and at the time of initiation of the reperfusion, liver injury was markedly reduced." | 1.33 | Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. ( Connor, HD; Fujii, H; Kono, H; Maki, A; Mason, RP; Rusyn, I; Woods, CG, 2006) |
| " This increase was paralleled by increases in the absorption rate constant AUC and antipyrine bioavailability." | 1.32 | Membrane permeability and antipyrine absorption in a rat model of ischemic colitis. ( Ishitobi, Y; Kawashima, S; Koga, K; Murakami, M; Taniguchi, M, 2004) |
| " From these observations it is concluded that a specific pharmacokinetic behaviour of acidic NSAID leading to high concentrations in inflamed tissue is a decisive aspect of their anti-inflammatory action." | 1.26 | Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: evidence for the importance of pharmacokinetics. ( Brune, K; Glatt, M; Graf, P, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (43.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 10 (33.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Fratoni, E | 1 |
| Theindl, LC | 1 |
| da Rosa, JS | 1 |
| Nascimento, MVPDS | 1 |
| Maciel, TDRG | 1 |
| de Campos-Buzzi, F | 1 |
| Dalmarco, EM | 1 |
| Zhang, X | 1 |
| Xu, F | 1 |
| Liu, L | 1 |
| Feng, L | 1 |
| Wu, X | 2 |
| Shen, Y | 1 |
| Sun, Y | 1 |
| Xu, Q | 1 |
| Hashimoto, T | 1 |
| Shibata, K | 1 |
| Ohata, H | 1 |
| Hasumi, K | 1 |
| Honda, K | 1 |
| Jiao, SS | 1 |
| Yao, XQ | 1 |
| Liu, YH | 1 |
| Wang, QH | 1 |
| Zeng, F | 1 |
| Lu, JJ | 1 |
| Liu, J | 1 |
| Zhu, C | 1 |
| Shen, LL | 1 |
| Liu, CH | 1 |
| Wang, YR | 1 |
| Zeng, GH | 1 |
| Parikh, A | 1 |
| Chen, J | 2 |
| Liang, CR | 1 |
| Xiang, Y | 1 |
| Bu, XL | 1 |
| Deng, J | 1 |
| Li, J | 1 |
| Xu, J | 1 |
| Zeng, YQ | 1 |
| Xu, X | 1 |
| Xu, HW | 1 |
| Zhong, JH | 1 |
| Zhou, HD | 1 |
| Zhou, XF | 1 |
| Wang, YJ | 1 |
| Hassan, MQ | 1 |
| Akhtar, MS | 1 |
| Akhtar, M | 1 |
| Ali, J | 1 |
| Haque, SE | 1 |
| Najmi, AK | 1 |
| Jangra, A | 1 |
| Sriram, CS | 1 |
| Dwivedi, S | 1 |
| Gurjar, SS | 1 |
| Hussain, MI | 1 |
| Borah, P | 1 |
| Lahkar, M | 1 |
| Fujiwara, N | 1 |
| Som, AT | 1 |
| Pham, LD | 1 |
| Lee, BJ | 1 |
| Mandeville, ET | 1 |
| Lo, EH | 1 |
| Arai, K | 1 |
| Kato, S | 1 |
| Hussein, MH | 1 |
| Kakita, H | 1 |
| Goto, T | 1 |
| Daoud, GA | 1 |
| Kato, T | 1 |
| Sugiura, T | 1 |
| Nobata, M | 1 |
| Nakajima, Y | 1 |
| Endo, T | 1 |
| Mizuno, K | 1 |
| Ito, T | 1 |
| Kato, I | 1 |
| Suzuki, S | 1 |
| Togari, H | 1 |
| Miyazaki, Y | 1 |
| Kaikita, K | 1 |
| Endo, M | 1 |
| Horio, E | 1 |
| Miura, M | 1 |
| Tsujita, K | 1 |
| Hokimoto, S | 1 |
| Yamamuro, M | 1 |
| Iwawaki, T | 1 |
| Gotoh, T | 1 |
| Ogawa, H | 1 |
| Oike, Y | 1 |
| Wang, GH | 1 |
| Jiang, ZL | 1 |
| Li, YC | 1 |
| Li, X | 1 |
| Shi, H | 1 |
| Gao, YQ | 1 |
| Vosler, PS | 1 |
| Yamashita, T | 1 |
| Sakamoto, K | 1 |
| Yamanishi, H | 1 |
| Totani, N | 1 |
| Yamamoto, J | 1 |
| Carcillo, JA | 1 |
| Doughty, L | 1 |
| Kofos, D | 1 |
| Frye, RF | 1 |
| Kaplan, SS | 1 |
| Sasser, H | 1 |
| Burckart, GJ | 1 |
| VAN CAUWENBERGE, H | 1 |
| LECOMTE, J | 1 |
| LAPIERE, C | 1 |
| BARATTINI, MA | 1 |
| HIEMEYER, V | 1 |
| WAGNER-JAUREGG, T | 1 |
| JAHN, U | 1 |
| BUECH, O | 1 |
| WHITEHOUSE, MW | 2 |
| BOSTROEM, H | 1 |
| BERNTSEN, K | 1 |
| DORFMAN, RI | 1 |
| DORFMAN, AS | 1 |
| Koga, K | 1 |
| Ishitobi, Y | 1 |
| Kawashima, S | 1 |
| Taniguchi, M | 1 |
| Murakami, M | 1 |
| Nishiyama, T | 1 |
| Ogawa, M | 1 |
| Zhang, N | 1 |
| Komine-Kobayashi, M | 1 |
| Tanaka, R | 1 |
| Liu, M | 1 |
| Mizuno, Y | 1 |
| Urabe, T | 1 |
| Kono, H | 1 |
| Woods, CG | 1 |
| Maki, A | 1 |
| Connor, HD | 1 |
| Mason, RP | 1 |
| Rusyn, I | 1 |
| Fujii, H | 1 |
| Skjelbred, P | 1 |
| Løkken, P | 1 |
| Brune, K | 1 |
| Graf, P | 1 |
| Glatt, M | 1 |
| Belpaire, FM | 3 |
| de Smet, F | 1 |
| Chindavijak, B | 3 |
| Fraeyman, N | 1 |
| Bogaert, MG | 3 |
| Kogan, AS | 1 |
| Nepomniashchikh, VA | 1 |
1 trial available for antipyrine and Inflammation
| Article | Year |
|---|---|
Phenazone versus placebo: effects on post-operative course.
Topics: Adult; Antipyrine; Body Temperature; Double-Blind Method; Edema; Female; Humans; Inflammation; Male; | 1980 |
29 other studies available for antipyrine and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
The
Topics: Anti-Inflammatory Agents; Antipyrine; Cytokines; Humans; Immunity; Inflammation; Interleukin-13; Int | 2023 |
(+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway.
Topics: Animals; Antipyrine; Camphanes; Cell Differentiation; Cells, Cultured; Colitis; Colon; Cytokines; De | 2017 |
Altered gene expression in an embolic stroke model after thrombolysis with tissue plasminogen activator and Stachybotrys microspora triprenyl phenol-7.
Topics: Animals; Antioxidants; Antipyrine; Benzopyrans; Calgranulin A; Disease Models, Animal; Edaravone; Fr | 2014 |
Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits.
Topics: Administration, Oral; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antipyrine; Behavi | 2015 |
Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; C-Reactive Protein; Caspase 3; Creatine Kinase, MB For | 2015 |
Sodium Phenylbutyrate and Edaravone Abrogate Chronic Restraint Stress-Induced Behavioral Deficits: Implication of Oxido-Nitrosative, Endoplasmic Reticulum Stress Cascade, and Neuroinflammation.
Topics: Animals; Antipyrine; Chronic Disease; Depression; Dose-Response Relationship, Drug; Edaravone; Endop | 2017 |
A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model.
Topics: Animals; Antipyrine; Brain Edema; Cerebral Infarction; Cytokines; Edaravone; Free Radical Scavengers | 2016 |
Edaravone, a novel free radical scavenger, reduces high-mobility group box 1 and prolongs survival in a neonatal sepsis model.
Topics: Animals; Animals, Newborn; Antioxidants; Antipyrine; Blood Pressure; Body Weight; Cyclic N-Oxides; E | 2009 |
C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation.
Topics: Animals; Antipyrine; Apoptosis; Cells, Cultured; Chemokines; Cytokines; Disease Models, Animal; DNA- | 2011 |
Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.
Topics: Animals; Antipyrine; Apoptosis; Astrocytes; Blood-Brain Barrier; Body Water; Brain Injuries; Colorin | 2011 |
Effect of a free radical scavenger on nitric oxide release in microvessels.
Topics: Acetylcholine; Animals; Antipyrine; Aorta, Abdominal; Disease Models, Animal; Edaravone; Free Radica | 2013 |
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.
Topics: Adolescent; Age Factors; Analysis of Variance; Antipyrine; Case-Control Studies; Child; Child, Presc | 2003 |
[Anti-inflammatory properties of two antipyrine derivatives].
Topics: Anti-Inflammatory Agents; Antipyrine; Inflammation | 1959 |
[Research on the analgesic and antiinflammatory action of 4 alpha-dimethylaminopropionylamino-antipyrine].
Topics: Analgesia; Analgesics; Anti-Inflammatory Agents; Antipyrine; Humans; Inflammation; Pain Management | 1961 |
[Comparative studies on the antiphlogistic effect of nicotinoamide-phenyl-dimethylpyrazolone and its combination with prednisone].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Antipyrine; Humans; Inflammation; Niacin; Niacin | 1963 |
[The antiphlogistic testing of known antirheumatics on kaolin-induced rat paw edema].
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Antipyrine; Azoles; Edema; | 1962 |
A BIOCHEMICAL DISTINCTION BETWEEN NON-STEROID ANTI-INFLAMMATORY AND ANALGESIC DRUGS.
Topics: Acetaminophen; Acetanilides; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Ag | 1963 |
BIOCHEMICAL PROPERTIES OF ANTI-INFLAMMATORY DRUGS-II. SOME EFFECTS ON SULPHATE-35S METABOLISM IN VIVO.
Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antipyrine; Autoradio | 1964 |
ANTI-INFLAMMATORY ACTIVITY ON NONSTEROIDAL AGENTS IN A RAT GRANULOMA ASSAY.
Topics: Adrenalectomy; Anti-Inflammatory Agents; Antipyrine; Biological Assay; Chlorpheniramine; Granuloma; | 1965 |
Membrane permeability and antipyrine absorption in a rat model of ischemic colitis.
Topics: Animals; Antipyrine; Area Under Curve; Biological Availability; Cell Membrane Permeability; Colitis, | 2004 |
Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats.
Topics: Animals; Antipyrine; Behavior, Animal; Disease Models, Animal; Disinfectants; Dose-Response Relation | 2005 |
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyrine; | 2005 |
Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage.
Topics: Acute Disease; Animals; Antipyrine; Edaravone; Electron Spin Resonance Spectroscopy; Free Radicals; | 2006 |
Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: evidence for the importance of pharmacokinetics.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Carrageenan; | 1976 |
Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat.
Topics: Administration, Oral; Animals; Antipyrine; Inflammation; Injections, Intravenous; Male; Metoprolol; | 1989 |
Effect of inflammation and proadifen on the disposition of antipyrine, lignocaine and propranolol in rat isolated perfused liver.
Topics: Animals; Antipyrine; In Vitro Techniques; Inflammation; Lidocaine; Liver; Male; Proadifen; Propranol | 1987 |
Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes.
Topics: Animals; Antipyrine; Inflammation; Lidocaine; Liver; Male; Proadifen; Propranolol; Rats; Rats, Inbre | 1988 |
[Effect of inflammation and cholestasis on the metabolic function of the liver].
Topics: Antipyrine; Biliary Tract Diseases; Hepatitis; Humans; Inactivation, Metabolic; Inflammation; Liver; | 1987 |