antipyrine has been researched along with Hepatitis C in 7 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether hepatic metabolic function affects the response to interferon treatment, we measured antipyrine clearance (APC) in 85 patients with chronic active hepatitis C and compared the results with treatment outcome." | 9.08 | Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C. ( Byth, K; Coverdale, S; Farrell, GC; Field, J; Liddle, C; Lin, R, 1995) |
| "Our aim was to study whether chronic hepatitis C affects the three metabolic pathways of the model drug antipyrine differently." | 7.69 | Antipyrine clearance and metabolite excretion in patients with chronic hepatitis C. ( Ali, HA; Ali, MA; Døssing, M; el-Yazigi, A; Ernst, P; Khan, B; Raines, DA; Saour, J; Sieck, JO, 1995) |
| "To determine whether natural human interferon administered under the usual therapeutic dosing scheme would inhibit the hepatic drug metabolism, we performed an antipyrine test in eight patients with chronic B or non-A, non-B hepatitis before and after a subchronic interferon therapy (6 megaunits/day for 17 +/- 4 days, mean +/- SD)." | 7.68 | Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis. ( Echizen, H; Ishizaki, T; Oda, T; Ohta, Y; Shirataki, H; Tsukamoto, K; Umeda, N, 1990) |
| "To determine whether hepatic metabolic function affects the response to interferon treatment, we measured antipyrine clearance (APC) in 85 patients with chronic active hepatitis C and compared the results with treatment outcome." | 5.08 | Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C. ( Byth, K; Coverdale, S; Farrell, GC; Field, J; Liddle, C; Lin, R, 1995) |
| "We sought to ascertain whether response to alpha interferon treatment could be predicted among patients with chronic active hepatitis C, and whether antipyrine clearance estimations would determine changes in liver function with this disease." | 5.07 | Prediction of response to interferon in patients with chronic active hepatitis C, and evidence that this improves hepatic metabolic function. ( Coverdale, S; Farrell, GC; Lin, R, 1991) |
| "Our aim was to study whether chronic hepatitis C affects the three metabolic pathways of the model drug antipyrine differently." | 3.69 | Antipyrine clearance and metabolite excretion in patients with chronic hepatitis C. ( Ali, HA; Ali, MA; Døssing, M; el-Yazigi, A; Ernst, P; Khan, B; Raines, DA; Saour, J; Sieck, JO, 1995) |
| "To determine whether natural human interferon administered under the usual therapeutic dosing scheme would inhibit the hepatic drug metabolism, we performed an antipyrine test in eight patients with chronic B or non-A, non-B hepatitis before and after a subchronic interferon therapy (6 megaunits/day for 17 +/- 4 days, mean +/- SD)." | 3.68 | Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis. ( Echizen, H; Ishizaki, T; Oda, T; Ohta, Y; Shirataki, H; Tsukamoto, K; Umeda, N, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 6 (85.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coverdale, S | 2 |
| Byth, K | 1 |
| Field, J | 1 |
| Liddle, C | 1 |
| Lin, R | 2 |
| Farrell, GC | 2 |
| Ali, HA | 1 |
| el-Yazigi, A | 2 |
| Sieck, JO | 2 |
| Ali, MA | 1 |
| Raines, DA | 2 |
| Saour, J | 2 |
| Ernst, P | 2 |
| Khan, B | 1 |
| Døssing, M | 2 |
| Ali, H | 1 |
| Bauer, LA | 1 |
| O'Sullivan, T | 1 |
| Reiss, WG | 1 |
| Horn, JR | 1 |
| Opheim, K | 1 |
| Strandness, DE | 1 |
| Carithers, RL | 1 |
| Echizen, H | 1 |
| Ohta, Y | 1 |
| Shirataki, H | 1 |
| Tsukamoto, K | 1 |
| Umeda, N | 1 |
| Oda, T | 1 |
| Ishizaki, T | 1 |
| Zakhyarova, AA | 1 |
| Musabaev, EI | 1 |
| Zmyzgova, AV | 1 |
3 trials available for antipyrine and Hepatitis C
| Article | Year |
|---|---|
Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C.
Topics: Adult; Aged; Alanine Transaminase; Antipyrine; Antiviral Agents; Female; Hepatitis C; Hepatitis, Chr | 1995 |
Elimination of antipyrine and its metabolites in interferon treated hepatitis C.
Topics: Administration, Oral; Adult; Antipyrine; Chromatography, High Pressure Liquid; Dose-Response Relatio | 1994 |
Prediction of response to interferon in patients with chronic active hepatitis C, and evidence that this improves hepatic metabolic function.
Topics: Adult; Aged; Antipyrine; Chi-Square Distribution; Female; Hepatitis C; Hepatitis, Chronic; Humans; I | 1991 |
4 other studies available for antipyrine and Hepatitis C
| Article | Year |
|---|---|
Antipyrine clearance and metabolite excretion in patients with chronic hepatitis C.
Topics: Adult; Antipyrine; Chronic Disease; Edaravone; Female; Hepatitis C; Humans; Male; Middle Aged; Refer | 1995 |
Liver blood flow, antipyrine clearance, and antipyrine metabolite formation clearance in patients with chronic active hepatitis and alcoholic cirrhosis.
Topics: Adult; Antipyrine; Female; Half-Life; Hepatitis B; Hepatitis C; Hepatitis, Chronic; Humans; Liver Ci | 1994 |
Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis.
Topics: Adult; Antipyrine; Chromatography, High Pressure Liquid; Female; Fever; Half-Life; Hepatitis B; Hepa | 1990 |
[A monooxygenase enzymatic system and cortisol in the serum of pregnant women with viral hepatitis].
Topics: Adult; Antipyrine; Female; Hepatitis B Surface Antigens; Hepatitis C; Hepatitis, Viral, Human; Human | 1989 |