antipyrine has been researched along with Hepatitis, Viral, Human in 7 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Hepatitis, Viral, Human: INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether natural human interferon administered under the usual therapeutic dosing scheme would inhibit the hepatic drug metabolism, we performed an antipyrine test in eight patients with chronic B or non-A, non-B hepatitis before and after a subchronic interferon therapy (6 megaunits/day for 17 +/- 4 days, mean +/- SD)." | 7.68 | Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis. ( Echizen, H; Ishizaki, T; Oda, T; Ohta, Y; Shirataki, H; Tsukamoto, K; Umeda, N, 1990) |
| "To determine whether natural human interferon administered under the usual therapeutic dosing scheme would inhibit the hepatic drug metabolism, we performed an antipyrine test in eight patients with chronic B or non-A, non-B hepatitis before and after a subchronic interferon therapy (6 megaunits/day for 17 +/- 4 days, mean +/- SD)." | 3.68 | Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis. ( Echizen, H; Ishizaki, T; Oda, T; Ohta, Y; Shirataki, H; Tsukamoto, K; Umeda, N, 1990) |
| "In 33 patients with acute hepatic encephalopathy due to toxic or viral hepatitis the following analyses were performed: (24-14C)cholic acid conjugation and sulfation, plasma phenazone clearance, galactose elimination capacity, and concentrations of glycocholic acid and glycolithocholic acid sulfate in plasma." | 3.66 | Cholic acid conjugation test and quantitative liver function in acute liver failure. ( Andreasen, PB; Bahnsen, M; Bremmelgaard, A; Christensen, E; Ranek, L, 1983) |
| "Antipyrine clearance was determined in five healthy volunteers, 10 patients with viral hepatitis and 15 patients with cirrhosis of the liver." | 1.26 | Antipyrine clearance and its correlation to routine liver function tests in patients with liver disease. ( Krausz, Y; Levy, M; Zylber-Katz, E, 1980) |
| "Antipyrine metabolism was normal or marginally impaired in patients with compensated cirrhosis or acute hepatitis, whereas it was frequently abnormal in those with chronic active hepatitis or advanced alcoholic liver disease." | 1.26 | Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism. ( Cooksley, WG; Farrell, GC; Hart, P; Powell, LW, 1978) |
| " Estimates of clearance, volume of distribution, and half-life made from either plasma or saliva samples were not statistically different in these subjects." | 1.26 | Application of salivary concentration data to pharmacokinetic studies with antipyrine. ( Blaschke, TF; Meffin, PJ; Rowland, M; Williams, RL, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bremmelgaard, A | 1 |
| Ranek, L | 2 |
| Bahnsen, M | 1 |
| Andreasen, PB | 2 |
| Christensen, E | 1 |
| Ramsøe, K | 1 |
| Krausz, Y | 1 |
| Zylber-Katz, E | 1 |
| Levy, M | 1 |
| Farrell, GC | 1 |
| Cooksley, WG | 1 |
| Hart, P | 1 |
| Powell, LW | 1 |
| Meffin, PJ | 1 |
| Williams, RL | 1 |
| Blaschke, TF | 1 |
| Rowland, M | 1 |
| Echizen, H | 1 |
| Ohta, Y | 1 |
| Shirataki, H | 1 |
| Tsukamoto, K | 1 |
| Umeda, N | 1 |
| Oda, T | 1 |
| Ishizaki, T | 1 |
| Zakhyarova, AA | 1 |
| Musabaev, EI | 1 |
| Zmyzgova, AV | 1 |
7 other studies available for antipyrine and Hepatitis, Viral, Human
| Article | Year |
|---|---|
Cholic acid conjugation test and quantitative liver function in acute liver failure.
Topics: Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Cholic Acids; Diagnosis, Differen | 1983 |
Functioning liver mass in uncomplicated and fulminant acute hepatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Alanine Transaminase; Antipyrine; Bilirubin; Chemical and Dr | 1980 |
Antipyrine clearance and its correlation to routine liver function tests in patients with liver disease.
Topics: Adult; Aged; Antipyrine; Female; Hepatitis, Viral, Human; Humans; Liver Cirrhosis; Liver Function Te | 1980 |
Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism.
Topics: Acute Disease; Antipyrine; Ascites; Biotransformation; Chemical and Drug Induced Liver Injury; Chole | 1978 |
Application of salivary concentration data to pharmacokinetic studies with antipyrine.
Topics: Acute Disease; Antipyrine; Hepatitis, Viral, Human; Humans; Kinetics; Male; Saliva | 1977 |
Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis.
Topics: Adult; Antipyrine; Chromatography, High Pressure Liquid; Female; Fever; Half-Life; Hepatitis B; Hepa | 1990 |
[A monooxygenase enzymatic system and cortisol in the serum of pregnant women with viral hepatitis].
Topics: Adult; Antipyrine; Female; Hepatitis B Surface Antigens; Hepatitis C; Hepatitis, Viral, Human; Human | 1989 |