antipyrine has been researched along with Epilepsy in 20 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 7.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "We determined changes in serum concentrations of thyroid hormones during carbamazepine (CBZ) therapy during a 5-year prospective follow-up study of 20 patients with newly diagnosed epilepsy." | 3.69 | Thyroid and myocardial function after replacement of carbamazepine by oxcarbazepine. ( Airaksinen, KE; Isojärvi, JI; Mustonen, JN; Myllylä, VV; Pakarinen, AJ; Pelkonen, O; Rautio, A, 1995) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 3.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| " Antipyrine t1/2 did not distinguish epileptics with osteomalacia from other epileptic patients and half-lives were similar in patients treated with phenytoin and a barbiturate to those in patients on phenytoin alone." | 3.66 | Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population. ( Byrne, E; Frewin, DB; Hallpike, JF; Harman, AW, 1979) |
| "Phenytoin treatment may impair the validity of the caffeine liver function test." | 1.28 | Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. ( Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T, 1989) |
| " Significant positive correlations were found between the dosage of CBZ, DPH, PMD and PB and both indices of enzyme induction." | 1.27 | A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. ( Hedges, A; Makki, KA; Perucca, E; Richens, A; Ruprah, M; Wilson, JF, 1984) |
| "Felodipine is a dihydropyridine calcium antagonist, structurally related to nifedipine, which undergoes extensive first-pass hepatic metabolism and normally has an oral bioavailability of 15%." | 1.27 | Reduced felodipine bioavailability in patients taking anticonvulsants. ( Capewell, S; Critchley, JA; Freestone, S; Pottage, A; Prescott, LF, 1988) |
| " The half-life of chlorpropamide was significantly shorter in the patients (34." | 1.27 | Pharmacokinetics of chlorpropamide in epileptic patients: effects of enzyme induction and urine pH on chlorpropamide elimination. ( Kärkkäinen, S; Lehtovaara, R; Neuvonen, PJ, 1987) |
| " Of the generally used measures of enzyme induction (oral clearance, oral half-life and intravenous half-life) oral clearance was the most closely related to the intravenous clearance of antipyrine (r = 0." | 1.27 | Pharmacokinetics of antipyrine in epileptic patients. ( Richens, A; Rimmer, EM; Routledge, PA; Tsanaclis, LM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (85.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Vasconcelos, AP | 1 |
| Bouilleret, V | 1 |
| Riban, V | 1 |
| Wasterlain, C | 1 |
| Nehlig, A | 1 |
| Miyamoto, R | 1 |
| Shimakawa, S | 1 |
| Suzuki, S | 1 |
| Ogihara, T | 1 |
| Tamai, H | 1 |
| Perucca, E | 1 |
| Hedges, A | 2 |
| Makki, KA | 2 |
| Ruprah, M | 1 |
| Wilson, JF | 1 |
| Richens, A | 3 |
| Chiba, K | 1 |
| Ishizaki, T | 1 |
| Tabuchi, T | 1 |
| Wagatsuma, T | 1 |
| Nakazawa, Y | 1 |
| Goldberg, DM | 1 |
| Isojärvi, JI | 1 |
| Airaksinen, KE | 1 |
| Mustonen, JN | 1 |
| Pakarinen, AJ | 1 |
| Rautio, A | 1 |
| Pelkonen, O | 1 |
| Myllylä, VV | 1 |
| Oxley, J | 1 |
| Monks, A | 1 |
| Byrne, E | 1 |
| Harman, AW | 1 |
| Frewin, DB | 1 |
| Hallpike, JF | 1 |
| Sotaniemi, EA | 2 |
| Pelkonen, RO | 1 |
| Ahokas, J | 1 |
| Pirttiaho, HI | 2 |
| Ahlqvist, J | 1 |
| Ahokas, JT | 1 |
| Pitkänen, U | 1 |
| Petruch, F | 3 |
| Schüppel, RV | 3 |
| Welch, RM | 2 |
| DeAngelis, RL | 2 |
| Wingfield, M | 1 |
| Farmer, TW | 2 |
| Wietholtz, H | 1 |
| Zysset, T | 1 |
| Kreiten, K | 1 |
| Kohl, D | 1 |
| Büchsel, R | 1 |
| Matern, S | 1 |
| Capewell, S | 1 |
| Freestone, S | 1 |
| Critchley, JA | 1 |
| Pottage, A | 1 |
| Prescott, LF | 1 |
| Acheson, DW | 1 |
| Uden, S | 1 |
| Braganza, JM | 1 |
| Brown, SW | 1 |
| Houston, JB | 1 |
| Neuvonen, PJ | 1 |
| Kärkkäinen, S | 1 |
| Lehtovaara, R | 1 |
| Rimmer, EM | 1 |
| Routledge, PA | 1 |
| Tsanaclis, LM | 1 |
| Steinhilber, G | 1 |
1 review available for antipyrine and Epilepsy
| Article | Year |
|---|---|
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
19 other studies available for antipyrine and Epilepsy
| Article | Year |
|---|---|
Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches.
Topics: Animals; Antipyrine; Brain; Cerebral Cortex; Cerebrovascular Circulation; Convulsants; Disease Model | 2005 |
Edaravone prevents kainic acid-induced neuronal death.
Topics: Aldehydes; Animals; Antipyrine; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Edaravon | 2008 |
A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients.
Topics: Anticonvulsants; Antipyrine; Carbamazepine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half- | 1984 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; | 1982 |
Thyroid and myocardial function after replacement of carbamazepine by oxcarbazepine.
Topics: Adolescent; Adult; Anticonvulsants; Antipyrine; Carbamazepine; Cytochrome P-450 Enzyme System; Echoc | 1995 |
Lack of hepatic enzyme inducing effect of sodium valproate.
Topics: Adult; Antipyrine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half-Life; Humans; Liver; Male | 1979 |
Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population.
Topics: Adult; Antipyrine; Barbiturates; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Male; Micros | 1979 |
Drug metabolism in epileptics: in vivo and in vitro correlations.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme System; Epilepsy; Female; Half-Life; Humans; In Vitro Tec | 1978 |
Liver size and indices of drug metabolism in epileptics.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme System; Epilepsy; Female; Humans; Kinetics; Liver; Male; | 1978 |
[Effects of anticonvulsive treatment on drug elimination in man. Induction of liver hydroxylating enzyme system by diphenylhydantoin and carbamazepine].
Topics: Adult; Antipyrine; Bilirubin; Carbamazepine; Creatinine; Epilepsy; Female; Half-Life; Humans; Hydrox | 1975 |
Elimination of antipyrine from saliva as a measure of metabolism in man.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Antipyrine; Epilepsy; Half-Life; Humans; Kinetics; Midd | 1975 |
Effect of anticonvulsant drugs on the drug metabolism in man as measured by the elimination rate of antipyrine from saliva.
Topics: Anticonvulsants; Antipyrine; Epilepsy; Humans; Saliva | 1975 |
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism.
Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme | 1989 |
Reduced felodipine bioavailability in patients taking anticonvulsants.
Topics: Administration, Oral; Adult; Anticonvulsants; Antipyrine; Biological Availability; Drug Administrati | 1988 |
Theophylline and antipyrine disposition in smoking and non-smoking epileptic subjects.
Topics: Adult; Antipyrine; Epilepsy; Female; Half-Life; Humans; Male; Middle Aged; Smoking; Theophylline | 1987 |
Pharmacokinetics of chlorpropamide in epileptic patients: effects of enzyme induction and urine pH on chlorpropamide elimination.
Topics: Adult; Anticonvulsants; Antipyrine; Chlorpropamide; Enzyme Induction; Epilepsy; Female; Half-Life; H | 1987 |
Pharmacokinetics of antipyrine in epileptic patients.
Topics: Administration, Oral; Adolescent; Adult; Antipyrine; Biological Availability; Epilepsy; Female; Half | 1986 |
[Enhanced drug hydroxylation in man under diphenyl-hydantoin therapy].
Topics: Administration, Oral; Antipyrine; Biodegradation, Environmental; Creatinine; Epilepsy; Epilepsy, Ton | 1974 |
Effect of diphenylhydantoin on hepatic drug hydroxylation.
Topics: Adult; Antipyrine; Bilirubin; Colorimetry; Creatinine; Epilepsy; Half-Life; Humans; Hydroxylation; J | 1974 |