antipyrine has been researched along with Diabetes Mellitus, Type 1 in 7 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Edaravone is a potent scavenger of hydroxyl radicals and attenuates oxidative damage-related neurodegenerative diseases." | 1.35 | The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice. ( Ago, Y; Fukudome, D; Kawasaki, T; Matsuda, M; Matsuda, T, 2008) |
| "Antipyrine is a useful marker drug for cytochrome P-450 dependent hepatic drug metabolism." | 1.28 | Hepatic drug metabolism is increased in poorly controlled insulin-dependent diabetes mellitus. ( Goldstein, S; Saenger, P; Simpson, A, 1990) |
| "Antipyrine elimination was studied in 11 type I and 10 type II diabetic patients and 2 age-matched control groups." | 1.28 | Differential effect of type I and type II diabetes mellitus on antipyrine elimination. ( Adithan, C; Bapna, JS; Chandrasekar, S; Danda, D; Shashindran, CH; Swaminathan, RP, 1989) |
| " Thus, the drug-metabolizing capacity in diabetics seems to be markedly reduced, and drug dosage might have to take account of this fact." | 1.27 | [Antipyrine clearance as a measure of drug metabolism in patients with diabetes mellitus]. ( Dennin, DE; Oltmanns, D; Pentz, R; Siegers, CP, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukudome, D | 1 |
| Matsuda, M | 1 |
| Kawasaki, T | 1 |
| Ago, Y | 1 |
| Matsuda, T | 1 |
| Oltmanns, D | 1 |
| Dennin, DE | 1 |
| Pentz, R | 1 |
| Siegers, CP | 1 |
| Sotaniemi, EA | 1 |
| Pelkonen, O | 1 |
| Arranto, AJ | 1 |
| Tapanainen, P | 1 |
| Rautio, A | 1 |
| Pasanen, M | 1 |
| Kuhn, DC | 1 |
| Walenga, RW | 1 |
| Stuart, MJ | 1 |
| Goldstein, S | 1 |
| Simpson, A | 1 |
| Saenger, P | 1 |
| Adithan, C | 1 |
| Danda, D | 1 |
| Shashindran, CH | 1 |
| Bapna, JS | 1 |
| Swaminathan, RP | 1 |
| Chandrasekar, S | 1 |
| Zysset, T | 1 |
| Wietholtz, H | 1 |
1 trial available for antipyrine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Blood Glu | 2002 |
6 other studies available for antipyrine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice.
Topics: Animals; Antipyrine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Edar | 2008 |
[Antipyrine clearance as a measure of drug metabolism in patients with diabetes mellitus].
Topics: Adolescent; Adult; Aged; Antipyrine; Diabetes Mellitus, Type 1; Fatty Liver; Humans; Liver Cirrhosis | 1984 |
A prostacyclin analogue crosses the in vitro perfused human placenta and improves transfer in some pathologic states.
Topics: Antipyrine; Diabetes Mellitus, Type 1; Epoprostenol; Female; Humans; Hypertension; Ibuprofen; In Vit | 1991 |
Hepatic drug metabolism is increased in poorly controlled insulin-dependent diabetes mellitus.
Topics: Adolescent; Adult; Antipyrine; Child; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Glycated | 1990 |
Differential effect of type I and type II diabetes mellitus on antipyrine elimination.
Topics: Adolescent; Adult; Antipyrine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitu | 1989 |
Differential effect of type I and type II diabetes on antipyrine disposition in man.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Biotransformation; Diabetes Mellitus, Type 1; Diabetes M | 1988 |