antipyrine has been researched along with Constitutional Liver Dysfunction in 6 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gilbert disease was diagnosed in a 15-year-old boy on the basis of the clinical pattern and the changing drug-metabolizing capacity of the liver-enzyme apparatus, which was drug-induced." | 1.27 | Non-specific drug-metabolizing enzyme activity in Gilbert disease. ( Csanádi, J; Gyurkovits, K; Szeleczki, T; Várkonyi, A, 1984) |
| "The pharmacokinetic parameters of antipyrine (AP) were examined in 45 normal healthy subjects (18 heavy smokers, 5 mild smokers, and 22 nonsmokers) and in 12 patients with Gilbert's syndrome (GS), amongst whom 2 mild and 1 heavy smokers were included." | 1.27 | Antipyrine clearance in patients with Gilbert's syndrome. ( Chiba, K; Ishizaki, T; Sasaki, T, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Várkonyi, A | 2 |
| Szeleczki, T | 2 |
| Csanádi, J | 2 |
| Gyurkovits, K | 2 |
| Ishizaki, T | 1 |
| Chiba, K | 1 |
| Sasaki, T | 1 |
| Habior, A | 1 |
| Narang, AP | 1 |
| Datta, DV | 1 |
| Nakajima, O | 1 |
1 trial available for antipyrine and Constitutional Liver Dysfunction
| Article | Year |
|---|---|
Comparison of in-vivo and in-vitro drug metabolism in patients with Gilbert's syndrome.
Topics: Adult; Antipyrine; Bilirubin; Clinical Trials as Topic; Female; Gilbert Disease; Humans; Hyperbiliru | 1982 |
5 other studies available for antipyrine and Constitutional Liver Dysfunction
| Article | Year |
|---|---|
Non-specific drug-metabolizing enzyme activity in Gilbert disease.
Topics: Adolescent; Antipyrine; Bilirubin; Gilbert Disease; Glucaric Acid; Glucuronosyltransferase; Histocyt | 1984 |
Antipyrine clearance in patients with Gilbert's syndrome.
Topics: Adult; Antipyrine; Female; Gilbert Disease; Humans; Hyperbilirubinemia, Hereditary; Male; Metabolic | 1984 |
[Usefulness of the determination of bile acids in the blood and antipyrine elimination in the diagnosis of minimal liver damage].
Topics: Adult; Antipyrine; Bile Acids and Salts; Female; Gilbert Disease; Half-Life; Humans; Hyperbilirubine | 1983 |
[Non-specific drug-metabolizing enzyme capacity in Gilbert's disease].
Topics: Adolescent; Antipyrine; Benzhydryl Compounds; Gilbert Disease; Humans; Hyperbilirubinemia, Hereditar | 1983 |
[Gilbert's syndrome and incomplete conjugation of bilirubin].
Topics: Antipyrine; Bile; Bilirubin; Gilbert Disease; Humans; Hyperbilirubinemia, Hereditary; Isomerism | 1985 |