antipyrine has been researched along with Cirrhoses, Experimental Liver in 5 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated to what extent antipyrine clearance and metabolite formation are impaired in two models of liver cirrhosis in the rat, namely micronodular cirrhosis induced by chronic exposure to phenobarbital/CCl4 and biliary cirrhosis induced by bile duct ligation." | 3.68 | Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition. ( Buters, JT; Reichen, J; Zysset, T, 1993) |
| "Antipyrine extraction was decreased by 90% in acute liver injury, compared with 33% in cirrhosis, suggesting a much greater reduction of microsomal enzyme activity in the former group." | 1.29 | Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat. ( Fenyves, D; Gariépy, L; Villeneuve, JP, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buters, JT | 1 |
| Zysset, T | 1 |
| Reichen, J | 1 |
| Fenyves, D | 1 |
| Gariépy, L | 1 |
| Villeneuve, JP | 1 |
| Geraghty, JG | 1 |
| Angerson, WJ | 1 |
| Carter, DC | 1 |
| Fischer-Nielsen, A | 1 |
| Poulsen, HE | 1 |
| Hansen, BA | 1 |
| Hage, E | 1 |
| Keiding, S | 1 |
| Hashimoto, H | 1 |
5 other studies available for antipyrine and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition.
Topics: Animals; Antipyrine; Bile Acids and Salts; Breath Tests; Carbon Tetrachloride; Lipids; Liver Cirrhos | 1993 |
Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat.
Topics: Animals; Antipyrine; Carbon Tetrachloride; Chlorpromazine; In Vitro Techniques; Liver; Liver Circula | 1993 |
A study of regional gastric mucosal blood flow in a rat model of hepatic cirrhosis.
Topics: Animals; Antipyrine; Autoradiography; Gastric Mucosa; Liver Cirrhosis, Experimental; Male; Muscles; | 1992 |
CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment.
Topics: Animals; Antipyrine; Carbon Tetrachloride; Galactose; Liver; Liver Cirrhosis, Experimental; Male; Ph | 1991 |
[Studies on metabolic characteristics of cirrhotic rat hepatocytes using primary culture].
Topics: Animals; Antipyrine; Carbon Tetrachloride Poisoning; Cells, Cultured; DNA; Epidermal Growth Factor; | 1990 |