antipyrine has been researched along with Chronic Hepatitis in 11 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether hepatic metabolic function affects the response to interferon treatment, we measured antipyrine clearance (APC) in 85 patients with chronic active hepatitis C and compared the results with treatment outcome." | 9.08 | Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C. ( Byth, K; Coverdale, S; Farrell, GC; Field, J; Liddle, C; Lin, R, 1995) |
| "To determine whether natural human interferon administered under the usual therapeutic dosing scheme would inhibit the hepatic drug metabolism, we performed an antipyrine test in eight patients with chronic B or non-A, non-B hepatitis before and after a subchronic interferon therapy (6 megaunits/day for 17 +/- 4 days, mean +/- SD)." | 7.68 | Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis. ( Echizen, H; Ishizaki, T; Oda, T; Ohta, Y; Shirataki, H; Tsukamoto, K; Umeda, N, 1990) |
| "To determine whether hepatic metabolic function affects the response to interferon treatment, we measured antipyrine clearance (APC) in 85 patients with chronic active hepatitis C and compared the results with treatment outcome." | 5.08 | Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C. ( Byth, K; Coverdale, S; Farrell, GC; Field, J; Liddle, C; Lin, R, 1995) |
| "We sought to ascertain whether response to alpha interferon treatment could be predicted among patients with chronic active hepatitis C, and whether antipyrine clearance estimations would determine changes in liver function with this disease." | 5.07 | Prediction of response to interferon in patients with chronic active hepatitis C, and evidence that this improves hepatic metabolic function. ( Coverdale, S; Farrell, GC; Lin, R, 1991) |
| "To determine whether natural human interferon administered under the usual therapeutic dosing scheme would inhibit the hepatic drug metabolism, we performed an antipyrine test in eight patients with chronic B or non-A, non-B hepatitis before and after a subchronic interferon therapy (6 megaunits/day for 17 +/- 4 days, mean +/- SD)." | 3.68 | Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis. ( Echizen, H; Ishizaki, T; Oda, T; Ohta, Y; Shirataki, H; Tsukamoto, K; Umeda, N, 1990) |
| "Antipyrine (AP) clearance was determined in 23 cases with liver cirrhosis (LC), 12 with chronic active hepatitis (CAH), 12 with hepatocellular carcinoma (mcHCC), 20 with non-hepatic diseases and 70 healthy controls." | 3.67 | [Evaluation of antipyrine clearance in chronic liver diseases]. ( Wang, JL; Yuan, SY; Zhang, F, 1989) |
| "Antipyrine clearance was positively correlated with serum albumin (r2 = 0." | 2.69 | Antipyrine clearance in chronic and neoplastic liver diseases: a study of 518 patients. ( Castellano, R; Di Rocco, P; Gasbarrini, G; Grieco, A; Marcoccia, S; Matera, A; Ragazzoni, E; Vecchio, FM, 1998) |
| "Antipyrine clearance was measured before and 1 day after administration of a single intramuscular dose of recombinant human leukocyte alpha A interferon." | 1.27 | Inhibition of antipyrine metabolism by interferon. ( Farrell, GC; Williams, SJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farrell, G | 1 |
| Zaluzny, L | 1 |
| Baird-Lambert, J | 1 |
| Cvejic, M | 1 |
| Buchanan, N | 1 |
| Habior, A | 1 |
| Coverdale, S | 2 |
| Byth, K | 1 |
| Field, J | 1 |
| Liddle, C | 1 |
| Lin, R | 2 |
| Farrell, GC | 3 |
| Bauer, LA | 1 |
| O'Sullivan, T | 1 |
| Reiss, WG | 1 |
| Horn, JR | 1 |
| Opheim, K | 1 |
| Strandness, DE | 1 |
| Carithers, RL | 1 |
| Grieco, A | 1 |
| Castellano, R | 1 |
| Matera, A | 1 |
| Marcoccia, S | 1 |
| Di Rocco, P | 1 |
| Ragazzoni, E | 1 |
| Vecchio, FM | 1 |
| Gasbarrini, G | 1 |
| Soto Alvarez, J | 1 |
| Alsar Ortiz, MJ | 1 |
| Echizen, H | 1 |
| Ohta, Y | 1 |
| Shirataki, H | 1 |
| Tsukamoto, K | 1 |
| Umeda, N | 1 |
| Oda, T | 1 |
| Ishizaki, T | 1 |
| Wang, JL | 1 |
| Zhang, F | 1 |
| Yuan, SY | 1 |
| Villeneuve, JP | 1 |
| Thibeault, MJ | 1 |
| Ampelas, M | 1 |
| Fortunet-Fouin, H | 1 |
| LaMarre, L | 1 |
| Côté, J | 1 |
| Pomier-Layrargues, G | 1 |
| Huet, PM | 1 |
| Williams, SJ | 1 |
3 trials available for antipyrine and Chronic Hepatitis
| Article | Year |
|---|---|
Antipyrine clearance and response to interferon treatment in patients with chronic active hepatitis C.
Topics: Adult; Aged; Alanine Transaminase; Antipyrine; Antiviral Agents; Female; Hepatitis C; Hepatitis, Chr | 1995 |
Antipyrine clearance in chronic and neoplastic liver diseases: a study of 518 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipyrine; Carcinoma, Hepatocellular; Evaluation Studie | 1998 |
Prediction of response to interferon in patients with chronic active hepatitis C, and evidence that this improves hepatic metabolic function.
Topics: Adult; Aged; Antipyrine; Chi-Square Distribution; Female; Hepatitis C; Hepatitis, Chronic; Humans; I | 1991 |
8 other studies available for antipyrine and Chronic Hepatitis
| Article | Year |
|---|---|
Impaired elimination of metronidazole in decompensated chronic liver disease.
Topics: Adult; Aged; Antipyrine; Female; Half-Life; Hepatitis, Chronic; Humans; Liver Diseases, Alcoholic; M | 1983 |
[Endogenous bile acids in the blood as a functional test in chronic liver diseases. I. Comparison with the antipyrine elimination test].
Topics: Adult; Aged; Antipyrine; Bile Acids and Salts; Chronic Disease; Female; Hepatitis B; Hepatitis, Chro | 1982 |
Liver blood flow, antipyrine clearance, and antipyrine metabolite formation clearance in patients with chronic active hepatitis and alcoholic cirrhosis.
Topics: Adult; Antipyrine; Female; Half-Life; Hepatitis B; Hepatitis C; Hepatitis, Chronic; Humans; Liver Ci | 1994 |
[The assessment of liver microsomal oxidative capacity via caffeine and antipyrine elimination in patients with chronic active hepatitis: preliminary results].
Topics: Adult; Antipyrine; Caffeine; Female; Hepatitis, Chronic; Humans; Liver Function Tests; Male; Microso | 1992 |
Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis.
Topics: Adult; Antipyrine; Chromatography, High Pressure Liquid; Female; Fever; Half-Life; Hepatitis B; Hepa | 1990 |
[Evaluation of antipyrine clearance in chronic liver diseases].
Topics: Adolescent; Adult; Antipyrine; Carcinoma, Hepatocellular; Hepatitis, Chronic; Humans; Liver Cirrhosi | 1989 |
Drug disposition in patients with HBsAg-positive chronic liver disease.
Topics: Adult; Aminopyrine; Antipyrine; Female; Hepatitis; Hepatitis B Surface Antigens; Hepatitis, Chronic; | 1987 |
Inhibition of antipyrine metabolism by interferon.
Topics: Adult; Antipyrine; Female; Hepatitis B; Hepatitis, Chronic; Humans; Interferon Type I; Liver; Longit | 1986 |