antipyrine has been researched along with Cerebral Infarction in 55 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "One should consider the diagnosis of drug-induced vasospasm in patients with cerebral infarction and a history of excessive use of sumatriptan and Midrin." | 8.80 | Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin. ( Biller, J; Malkoff, MD; Meschia, JF, 1998) |
| "To investigate the protective effect of edaravone and danshensu conjugate (IM-009) on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanisms." | 7.81 | [Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanism]. ( Chen, H; Hou, S; Zhang, S, 2015) |
| "Edaravone attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia." | 7.80 | Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. ( Johshita, H; Miyazaki, H; Okamura, K; Shiokawa, Y; Tsubokawa, T, 2014) |
| "Edaravone is a free radical scavenger that protects the adjacent cortex during cerebral infarction." | 7.79 | Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model. ( Harada, K; Ikeda, S; Kamikawa, Y; Ohwatashi, A, 2013) |
| "Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction." | 7.78 | Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. ( Chen, X; Gao, M; Lei, S; Li, L; Li, W; Li, X; Liu, Y; Lu, H; Wang, N; Zhang, P; Zheng, J, 2012) |
| "Edaravone, a potent free radical scavenger, is clinically used for the treatment of cerebral infarction in Japan." | 7.75 | The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. ( Arimura, N; Biswas, KK; Hashiguchi, T; Ito, T; Iwata, M; Kawahara, K; Kikuchi, K; Kuramoto, T; Maruyama, I; Matsuda, F; Miura, N; Morimoto, Y; Nakayama, K; Nawa, Y; Oyama, Y; Shigemori, M; Tajima, Y; Takenouchi, K; Tancharoen, S; Yoshida, Y, 2009) |
| "Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction." | 7.74 | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction. ( Akuzawa, S; Bashar, AH; Fujie, M; Kazui, T; Ohishi, K; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Washiyama, N; Yamamoto, S; Yamashita, K, 2007) |
| "A 60-year-old male with cerebral infarction was admitted to our hospital and treated with edaravone." | 7.74 | A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient. ( Abe, M; Kaizu, K; Matsumoto, K, 2007) |
| " With use of this system we studied whether human serum obtained from patients with acute cerebral infarction (n = 16) would have a proliferative effect on vessels and whether an administration of a free radical scavenger, edaravone, with or without amlodipine would elicit antiproliferative effects." | 7.72 | [Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells]. ( Echizen, H; Hiraga, M; Ida, T; Kobayashi, T; Oishi, K; Uchida, MK; Yamaguchi, T, 2004) |
| "We investigated whether or not a combination of the selective thrombin inhibitor, argatroban, and the free radical scavenger, edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil." | 7.71 | Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. ( Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K, 2002) |
| "It is hypothesized that cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is induced by free radicals released from a subarachnoid clot." | 6.74 | Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage. ( Asano, K; Munakata, A; Nakano, T; Naraoka, M; Ohkuma, H; Shimamura, N, 2009) |
| "Edaravone was administered to 27 randomly selected patients (GIa, n = 13; GIIa, n = 14) and its efficacy was studied by comparing their plasma OxLDL, S-100B, and MnSOD levels to those in patients without edaravone (GIb, n = 11, GIIb, n = 13)." | 6.71 | Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction. ( Harada, M; Itabe, H; Kitazato, KT; Matsuzaki, K; Nagahiro, S; Suzue, A; Uno, M, 2005) |
| "One should consider the diagnosis of drug-induced vasospasm in patients with cerebral infarction and a history of excessive use of sumatriptan and Midrin." | 4.80 | Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin. ( Biller, J; Malkoff, MD; Meschia, JF, 1998) |
| "To investigate the protective effect of edaravone and danshensu conjugate (IM-009) on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanisms." | 3.81 | [Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury in rats and its underlying mechanism]. ( Chen, H; Hou, S; Zhang, S, 2015) |
| "Edaravone attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia." | 3.80 | Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. ( Johshita, H; Miyazaki, H; Okamura, K; Shiokawa, Y; Tsubokawa, T, 2014) |
| "Edaravone is a free radical scavenger that protects the adjacent cortex during cerebral infarction." | 3.79 | Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model. ( Harada, K; Ikeda, S; Kamikawa, Y; Ohwatashi, A, 2013) |
| "Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction." | 3.78 | Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. ( Chen, X; Gao, M; Lei, S; Li, L; Li, W; Li, X; Liu, Y; Lu, H; Wang, N; Zhang, P; Zheng, J, 2012) |
| "To clarify the relationship between the gain in functional recovery (rehabilitation gain) and the total amount of edaravone used for acute-phase therapy for cerebral infarction at a convalescent rehabilitation hospital." | 3.76 | Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment? A retrospective study of edaravone therapy. ( Katayama, M; Shimizu, H; Unno, Y, 2010) |
| "Edaravone, a potent free radical scavenger, is clinically used for the treatment of cerebral infarction in Japan." | 3.75 | The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. ( Arimura, N; Biswas, KK; Hashiguchi, T; Ito, T; Iwata, M; Kawahara, K; Kikuchi, K; Kuramoto, T; Maruyama, I; Matsuda, F; Miura, N; Morimoto, Y; Nakayama, K; Nawa, Y; Oyama, Y; Shigemori, M; Tajima, Y; Takenouchi, K; Tancharoen, S; Yoshida, Y, 2009) |
| "Prophylactic administration of edaravone exerted a significant protective effect against postoperative neurologic dysfunction after antegrade selective cerebral perfusion in a canine model with old cerebral infarction." | 3.74 | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction. ( Akuzawa, S; Bashar, AH; Fujie, M; Kazui, T; Ohishi, K; Ohkura, K; Suzuki, K; Suzuki, T; Terada, H; Washiyama, N; Yamamoto, S; Yamashita, K, 2007) |
| "A 60-year-old male with cerebral infarction was admitted to our hospital and treated with edaravone." | 3.74 | A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient. ( Abe, M; Kaizu, K; Matsumoto, K, 2007) |
| " With use of this system we studied whether human serum obtained from patients with acute cerebral infarction (n = 16) would have a proliferative effect on vessels and whether an administration of a free radical scavenger, edaravone, with or without amlodipine would elicit antiproliferative effects." | 3.72 | [Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells]. ( Echizen, H; Hiraga, M; Ida, T; Kobayashi, T; Oishi, K; Uchida, MK; Yamaguchi, T, 2004) |
| "We investigated whether or not a combination of the selective thrombin inhibitor, argatroban, and the free radical scavenger, edaravone (MCI-186), ameliorates postischemic hypoperfusion and decreases mortality after 15 min of forebrain ischemia in the gerbil." | 3.71 | Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. ( Jin, YJ; Mima, T; Park, KC; Raicu, V; Shimizu, K, 2002) |
| "It is hypothesized that cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is induced by free radicals released from a subarachnoid clot." | 2.74 | Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage. ( Asano, K; Munakata, A; Nakano, T; Naraoka, M; Ohkuma, H; Shimamura, N, 2009) |
| "Edaravone was infused at a dose of 30 mg, twice a day, for 14 days." | 2.71 | Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. ( , 2003) |
| "Edaravone was associated with delayed evolution of infarcts and edema in patients with severe carotid-territorial stroke and decreased mortality during the acute stage." | 2.71 | Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. ( Arihiro, S; Fujii, K; Ibayashi, S; Iida, M; Kamouchi, M; Nakane, H; Okada, Y; Toyoda, K, 2004) |
| "Pretreatment with edaravone can prevent development of cognitive impairment after CEA." | 2.71 | Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy. ( Endo, H; Fukuda, T; Inoue, T; Kobayashi, M; Ogasawara, K; Ogawa, A; Terasaki, K; Yamadate, K; Yoshida, K, 2005) |
| "Edaravone was administered to 27 randomly selected patients (GIa, n = 13; GIIa, n = 14) and its efficacy was studied by comparing their plasma OxLDL, S-100B, and MnSOD levels to those in patients without edaravone (GIb, n = 11, GIIb, n = 13)." | 2.71 | Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction. ( Harada, M; Itabe, H; Kitazato, KT; Matsuzaki, K; Nagahiro, S; Suzue, A; Uno, M, 2005) |
| "Edaravone was treated twice via tail vein; after MCA occlusion and after reperfusion." | 1.43 | A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. ( Arai, K; Fujiwara, N; Lee, BJ; Lo, EH; Mandeville, ET; Pham, LD; Som, AT, 2016) |
| "He had been treated for lung cancer by chemotherapy and irradiation 3 years earlier." | 1.40 | [Case of cardiac tamponade during the treatment of acute cerebral infarction]. ( Nagasawa, H; Ono, H; Tanaka, H; Yamakawa, T, 2014) |
| "On day after discharge, he developed cerebral infarction and showed persistence of multiple left ventricular thrombi." | 1.40 | Multiple left ventricular thrombi in a patient with dilated cardiomyopathy and cerebral infarction: a case report. ( Mine, T; Miyake, H; Sato, I, 2014) |
| "Mice subjected to 2-h filamental middle cerebral artery occlusion were treated with NBO (95% O2, during the ischemia) alone, with edaravone (1." | 1.35 | Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice. ( Hara, H; Iwama, T; Nonaka, Y; Shimazawa, M; Yoshimura, S, 2008) |
| "Cerebral ischemia was induced in rats by injecting 150 mug of sodium laurate into the left internal carotid artery on day 1." | 1.35 | Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. ( Asano, T; Hitomi, A; Ikegaki, I; Satoh, S; Seto, M; Toshima, Y, 2008) |
| "In in vitro models of cerebral ischemia, exposure to hydrogen peroxide or glutamate induced cell death with overactivation of PARP, and treatment with DR2313 reduced excessive formation of poly(ADP-ribose) and cell death." | 1.33 | A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. ( Hasegawa, T; Ishikawa, M; Kakui, N; Nakajima, H; Ohkuma, K, 2005) |
| "Edaravone-treated animals showed significantly improved neurological outcome." | 1.33 | Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. ( Amemiya, S; Inaba, T; Kamiya, T; Katayama, Y; Kato, K; Nito, C; Shimazaki, K; Ueda, M, 2005) |
| "Cerebral ischemia was mechanically induced by 2-hour occlusion of the left middle cerebral artery (MCA) using an intraluminal filament followed by 24-hour reperfusion." | 1.33 | Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats. ( Hong, KW; Lee, JH; Lee, WS; Park, SY, 2005) |
| "Cerebral infarct volume and cerebral edema were measured by high-contrast silver infarct staining (SIS)." | 1.31 | Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats. ( Frietsch, T; Georgiadis, D; Kollmar, R; Kuschinsky, W; Schäbitz, WR; Schwab, S; Waschke, KF, 2002) |
| "The volume of cerebral infarction, induced by 2-h occlusion and subsequent 2-h reperfusion of MCA in Fisher-344 rats, was evaluated." | 1.30 | Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat. ( Iwai, T; Nakashima, M; Niwa, M; Uematsu, T, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.64) | 18.7374 |
| 1990's | 4 (7.27) | 18.2507 |
| 2000's | 31 (56.36) | 29.6817 |
| 2010's | 18 (32.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikeda, S | 1 |
| Harada, K | 1 |
| Ohwatashi, A | 1 |
| Kamikawa, Y | 1 |
| Okamura, K | 1 |
| Tsubokawa, T | 1 |
| Johshita, H | 1 |
| Miyazaki, H | 1 |
| Shiokawa, Y | 1 |
| Nagasawa, H | 1 |
| Ono, H | 1 |
| Tanaka, H | 1 |
| Yamakawa, T | 1 |
| Yamamoto, Y | 2 |
| Mine, T | 1 |
| Sato, I | 1 |
| Miyake, H | 1 |
| Nishihira, T | 1 |
| Suzuki, K | 2 |
| Takekawa, H | 1 |
| Nakamura, T | 1 |
| Iwasaki, A | 1 |
| Hirata, K | 1 |
| Zhang, S | 1 |
| Hou, S | 1 |
| Chen, H | 1 |
| Fujiwara, N | 1 |
| Som, AT | 1 |
| Pham, LD | 1 |
| Lee, BJ | 1 |
| Mandeville, ET | 1 |
| Lo, EH | 1 |
| Arai, K | 1 |
| Nonaka, Y | 1 |
| Shimazawa, M | 1 |
| Yoshimura, S | 1 |
| Iwama, T | 1 |
| Hara, H | 1 |
| Osaka, H | 1 |
| Okazaki, S | 1 |
| Higashi, Y | 1 |
| Munakata, A | 1 |
| Ohkuma, H | 1 |
| Nakano, T | 1 |
| Shimamura, N | 1 |
| Asano, K | 1 |
| Naraoka, M | 1 |
| Kikuchi, K | 1 |
| Kawahara, K | 1 |
| Tancharoen, S | 1 |
| Matsuda, F | 1 |
| Morimoto, Y | 1 |
| Ito, T | 1 |
| Biswas, KK | 1 |
| Takenouchi, K | 1 |
| Miura, N | 1 |
| Oyama, Y | 1 |
| Nawa, Y | 1 |
| Arimura, N | 1 |
| Iwata, M | 1 |
| Tajima, Y | 1 |
| Kuramoto, T | 1 |
| Nakayama, K | 1 |
| Shigemori, M | 1 |
| Yoshida, Y | 1 |
| Hashiguchi, T | 1 |
| Maruyama, I | 1 |
| Woitzik, J | 1 |
| Lassel, E | 1 |
| Hecht, N | 1 |
| Schneider, UC | 1 |
| Schroeck, H | 1 |
| Vajkoczy, P | 1 |
| Graf, R | 1 |
| Yamasaki, H | 1 |
| Matsubara, S | 1 |
| Sasaki, I | 1 |
| Nagahiro, S | 2 |
| Guo, Q | 1 |
| Wang, G | 1 |
| Namura, S | 1 |
| Unno, Y | 1 |
| Katayama, M | 1 |
| Shimizu, H | 1 |
| Shibata, K | 1 |
| Hashimoto, T | 1 |
| Nobe, K | 1 |
| Hasumi, K | 1 |
| Honda, K | 1 |
| Liu, N | 1 |
| Shang, J | 1 |
| Tian, F | 1 |
| Nishi, H | 1 |
| Abe, K | 5 |
| Kamiya, T | 2 |
| Ohara, T | 1 |
| Nagakane, Y | 1 |
| Tanaka, E | 1 |
| Morii, F | 1 |
| Koizumi, T | 1 |
| Zhang, P | 1 |
| Li, W | 1 |
| Li, L | 1 |
| Wang, N | 1 |
| Li, X | 1 |
| Gao, M | 1 |
| Zheng, J | 1 |
| Lei, S | 1 |
| Chen, X | 1 |
| Lu, H | 1 |
| Liu, Y | 1 |
| Lu, RY | 1 |
| Luo, DF | 1 |
| Xiao, SH | 1 |
| Yang, LH | 1 |
| Zhao, J | 1 |
| Ji, EN | 1 |
| Tao, EX | 1 |
| Xing, YG | 1 |
| Zhu, FY | 1 |
| Luan, P | 1 |
| Liu, J | 1 |
| Shinohara, Y | 1 |
| Inoue, S | 1 |
| Kollmar, R | 1 |
| Frietsch, T | 1 |
| Georgiadis, D | 1 |
| Schäbitz, WR | 1 |
| Waschke, KF | 1 |
| Kuschinsky, W | 1 |
| Schwab, S | 1 |
| Otori, T | 1 |
| Greenberg, JH | 1 |
| Welsh, FA | 1 |
| Takabatake, Y | 1 |
| Uno, E | 1 |
| Wakamatsu, K | 1 |
| Yamazaki, N | 1 |
| Hashimoto, N | 1 |
| Tsuchiya, Y | 1 |
| Yamaguchi, T | 1 |
| Ida, T | 1 |
| Kobayashi, T | 1 |
| Hiraga, M | 1 |
| Oishi, K | 1 |
| Uchida, MK | 1 |
| Echizen, H | 1 |
| Toyoda, K | 1 |
| Fujii, K | 1 |
| Kamouchi, M | 1 |
| Nakane, H | 1 |
| Arihiro, S | 1 |
| Okada, Y | 1 |
| Ibayashi, S | 1 |
| Iida, M | 1 |
| Nakajima, H | 1 |
| Kakui, N | 1 |
| Ohkuma, K | 1 |
| Ishikawa, M | 1 |
| Hasegawa, T | 1 |
| Fushimi, H | 1 |
| Amemiya, S | 1 |
| Nito, C | 1 |
| Inaba, T | 1 |
| Kato, K | 1 |
| Ueda, M | 1 |
| Shimazaki, K | 1 |
| Katayama, Y | 1 |
| Lee, JH | 1 |
| Park, SY | 1 |
| Lee, WS | 1 |
| Hong, KW | 1 |
| Ogasawara, K | 1 |
| Yamadate, K | 1 |
| Kobayashi, M | 1 |
| Endo, H | 1 |
| Fukuda, T | 1 |
| Yoshida, K | 1 |
| Terasaki, K | 1 |
| Inoue, T | 1 |
| Ogawa, A | 1 |
| Uno, M | 1 |
| Kitazato, KT | 1 |
| Suzue, A | 1 |
| Matsuzaki, K | 1 |
| Harada, M | 1 |
| Itabe, H | 1 |
| Wen, J | 1 |
| Watanabe, K | 1 |
| Ma, M | 1 |
| Yamaguchi, K | 1 |
| Tachikawa, H | 1 |
| Kodama, M | 1 |
| Aizawa, Y | 1 |
| Suzuki, T | 1 |
| Kazui, T | 1 |
| Yamamoto, S | 1 |
| Washiyama, N | 1 |
| Ohkura, K | 1 |
| Ohishi, K | 1 |
| Bashar, AH | 1 |
| Yamashita, K | 1 |
| Terada, H | 1 |
| Akuzawa, S | 1 |
| Fujie, M | 1 |
| Abe, M | 1 |
| Kaizu, K | 1 |
| Matsumoto, K | 1 |
| Niyaz, M | 1 |
| Numakawa, T | 1 |
| Matsuki, Y | 1 |
| Kumamaru, E | 1 |
| Adachi, N | 1 |
| Kitazawa, H | 1 |
| Kunugi, H | 1 |
| Kudo, M | 1 |
| Satoh, S | 1 |
| Toshima, Y | 1 |
| Hitomi, A | 1 |
| Ikegaki, I | 1 |
| Seto, M | 1 |
| Asano, T | 1 |
| Le Poncin-Lafitte, M | 1 |
| Grosdemouge, C | 1 |
| Roy-Billon, C | 1 |
| Duterte, D | 1 |
| Rapin, JR | 1 |
| Wittlich, F | 1 |
| Kohno, K | 1 |
| Mies, G | 1 |
| Norris, DG | 1 |
| Hoehn-Berlage, M | 1 |
| Grundl, PD | 1 |
| Biagas, KV | 1 |
| Kochanek, PM | 1 |
| Schiding, JK | 1 |
| Barmada, MA | 1 |
| Nemoto, EM | 1 |
| Meschia, JF | 1 |
| Malkoff, MD | 1 |
| Biller, J | 1 |
| Nakashima, M | 1 |
| Niwa, M | 1 |
| Iwai, T | 1 |
| Uematsu, T | 1 |
| MacGregor, DG | 1 |
| Carswell, HV | 1 |
| Graham, DI | 1 |
| McCulloch, J | 1 |
| Macrae, IM | 1 |
| Rossberg, MI | 1 |
| Murphy, SJ | 1 |
| Traystman, RJ | 1 |
| Hurn, PD | 2 |
| Vannucci, SJ | 1 |
| Willing, LB | 1 |
| Goto, S | 1 |
| Alkayed, NJ | 1 |
| Brucklacher, RM | 1 |
| Wood, TL | 1 |
| Towfighi, J | 1 |
| Simpson, IA | 1 |
| Kimura, T | 1 |
| Sako, K | 1 |
| Tanaka, K | 1 |
| Kusakabe, M | 1 |
| Tanaka, T | 1 |
| Nakada, T | 1 |
| Jin, YJ | 1 |
| Mima, T | 1 |
| Raicu, V | 1 |
| Park, KC | 1 |
| Shimizu, K | 1 |
| Dietrich, WD | 1 |
| Busto, R | 1 |
| Ginsberg, MD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Nerve Growth Factor or Edaravone on Alcohol-induced Brain Injury[NCT03968042] | Phase 2 | 150 participants (Anticipated) | Interventional | 2019-06-30 | Recruiting | ||
| Multicenter Randomized Open-Label Comparison Study on the Efficacy and Safety of Argatroban Monotherapy With Argatroban-Edaravone Combination Therapy[NCT00153946] | Phase 4 | 814 participants (Actual) | Interventional | 2004-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for antipyrine and Cerebral Infarction
| Article | Year |
|---|---|
[Concept, pathophysiology and treatment for branch atheromatous disease].
Topics: Antipyrine; Arginine; Cerebral Infarction; Cilostazol; Clopidogrel; Contraindications; Drug Therapy, | 2014 |
Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress.
Topics: Acute Disease; Antipyrine; Cerebral Infarction; Edaravone; Endothelium, Vascular; Free Radical Scave | 2009 |
[Future neuroprotective strategies in the post-thrombolysis era--neurovascular unit protection and vascular endothelial protection].
Topics: Amines; Animals; Antipyrine; Cerebral Infarction; Cyclohexanecarboxylic Acids; Edaravone; Endotheliu | 2011 |
[Concept of branch atheromatous disease (BAD) and its clinical significance].
Topics: Antipyrine; Arginine; Cerebral Infarction; Cilostazol; Drug Therapy, Combination; Edaravone; Humans; | 2010 |
[Gene therapy and neuroprotection for cerebral infarction].
Topics: Adenoviridae; Animals; Antipyrine; Cerebral Infarction; Cerebrovascular Circulation; Edaravone; Free | 2003 |
[Treatment of cerebral infarction patients with IGT].
Topics: Antidepressive Agents; Antipyrine; Atorvastatin; Cerebral Infarction; Edaravone; Free Radical Scaven | 2005 |
[Edaravone].
Topics: Antipyrine; Cerebral Infarction; Edaravone; Free Radical Scavengers; Humans | 2006 |
Reversible segmental cerebral arterial vasospasm and cerebral infarction: possible association with excessive use of sumatriptan and Midrin.
Topics: Acetaminophen; Adult; Antipyrine; Cerebral Infarction; Chloral Hydrate; Drug Combinations; Drug Ther | 1998 |
5 trials available for antipyrine and Cerebral Infarction
| Article | Year |
|---|---|
Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage.
Topics: Antipyrine; Cerebral Infarction; Comorbidity; Edaravone; Female; Free Radical Scavengers; Humans; Ja | 2009 |
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antipyrine; Cerebral Infarction; Double-Blind Method; | 2003 |
Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion.
Topics: Aged; Antipyrine; Atrial Fibrillation; Brain Edema; Carotid Artery Thrombosis; Carotid Artery, Inter | 2004 |
Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy.
Topics: Aged; Antipyrine; Carotid Artery, Internal; Carotid Stenosis; Cerebral Infarction; Cerebrovascular C | 2005 |
Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Astrocytes; Biomarkers; Cerebral Infarction; Edaravone; | 2005 |
42 other studies available for antipyrine and Cerebral Infarction
| Article | Year |
|---|---|
Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model.
Topics: Animals; Antipyrine; Cerebral Infarction; Edaravone; Free Radical Scavengers; Hemiplegia; Intracrani | 2013 |
Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia.
Topics: Animals; Antipyrine; Blood Glucose; Brain; Cerebral Hemorrhage; Cerebral Infarction; Edaravone; Free | 2014 |
[Case of cardiac tamponade during the treatment of acute cerebral infarction].
Topics: Acute Disease; Adenocarcinoma; Anterior Cerebral Artery; Antipyrine; Aspirin; Cardiac Tamponade; Cer | 2014 |
Multiple left ventricular thrombi in a patient with dilated cardiomyopathy and cerebral infarction: a case report.
Topics: Aged; Anticoagulants; Antipyrine; Cardiomyopathy, Dilated; Cerebral Infarction; Edaravone; Heart Dis | 2014 |
[Lateral medullary infarction presenting with truncal lateropulsion and decreased pain and temperature sensation below T10 sensory level].
Topics: Antipyrine; Arginine; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Edaravone; Free R | 2014 |
[Protective effect of novel edaravone and danshensu conjugate on focal cerebral ischemia-reperfusion injury
in rats and its underlying mechanism].
Topics: Animals; Antipyrine; Brain Edema; Brain Ischemia; Cerebral Infarction; Edaravone; Lactates; Malondia | 2015 |
A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model.
Topics: Animals; Antipyrine; Brain Edema; Cerebral Infarction; Cytokines; Edaravone; Free Radical Scavengers | 2016 |
Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice.
Topics: Animals; Antipyrine; Blood Pressure; Cell Death; Cerebral Infarction; Disease Models, Animal; Edarav | 2008 |
[Outcome assessment in treatment of edaravone in childhood ischemic stroke].
Topics: Adolescent; Antipyrine; Cerebral Infarction; Child; Child, Preschool; Edaravone; Female; Free Radica | 2008 |
The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.
Topics: Active Transport, Cell Nucleus; Animals; Antipyrine; Apoptosis; Butadienes; Cell Hypoxia; Cell Nucle | 2009 |
Ischemia independent lesion evolution during focal stroke in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; | 2009 |
Retinal artery embolization during carotid angioplasty and carotid artery stenting: case report.
Topics: Aged; Angioplasty, Balloon; Anticoagulants; Antipyrine; Aspirin; Carotid Artery, External; Carotid S | 2009 |
Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice.
Topics: Animals; Antipyrine; Arterial Occlusive Diseases; Autoradiography; Brain Ischemia; Capillaries; Cere | 2010 |
Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment? A retrospective study of edaravone therapy.
Topics: Aged; Aged, 80 and over; Antipyrine; Cerebral Infarction; Dose-Response Relationship, Drug; Edaravon | 2010 |
Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice.
Topics: Aldehydes; Animals; Antipyrine; Benzopyrans; Brain; Cerebral Infarction; Disease Models, Animal; Eda | 2011 |
In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice.
Topics: Animals; Annexin A5; Antipyrine; Apoptosis; Autophagy; Blood-Brain Barrier; Blotting, Western; Cereb | 2011 |
Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury.
Topics: Analysis of Variance; Animals; Antipyrine; Bromodeoxyuridine; Cerebral Infarction; Cerebral Ventricl | 2012 |
[Therapeutic time window for ischemic stroke].
Topics: Antipyrine; Cerebral Infarction; Edaravone; Fibrinolytic Agents; Free Radical Scavengers; Humans; Ti | 2011 |
Kallikrein gene transfer induces angiogenesis and further improves regional cerebral blood flow in the early period after cerebral ischemia/reperfusion in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Carbon Isotopes; Cerebral Infarction; | 2012 |
Cost-effectiveness analysis of the neuroprotective agent edaravone for noncardioembolic cerebral infarction.
Topics: Aged; Antipyrine; Cerebral Infarction; Computer Simulation; Cost Savings; Cost-Benefit Analysis; Dru | 2013 |
Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats.
Topics: Acid-Base Equilibrium; Animals; Antipyrine; Autoradiography; Brain Edema; Brain Ischemia; Cerebral I | 2002 |
Cortical spreading depression causes a long-lasting decrease in cerebral blood flow and induces tolerance to permanent focal ischemia in rat brain.
Topics: Adaptation, Physiological; Animals; Antipyrine; Autoradiography; Brain; Brain Ischemia; Cerebral Inf | 2003 |
[The clinical effect of combination therapy with edaravone and sodium ozagrel for acute cerebral infarction].
Topics: Aged; Antipyrine; Cerebral Infarction; Drug Therapy, Combination; Edaravone; Female; Fibrinolytic Ag | 2003 |
[Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells].
Topics: Acute Disease; Aged; Amlodipine; Animals; Antioxidants; Antipyrine; Basilar Artery; Calcium Channel | 2004 |
A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats.
Topics: Animals; Antipyrine; Brain; Brain Ischemia; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured | 2005 |
Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Brain Edema; Brain Ischemia; Cerebral Co | 2005 |
Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats.
Topics: Animals; Antioxidants; Antipyrine; Aspirin; bcl-2-Associated X Protein; Blotting, Western; Brain Ede | 2005 |
Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats.
Topics: Aging; Animals; Antioxidants; Antipyrine; Blotting, Western; Brain; Cerebral Infarction; Edaravone; | 2006 |
Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction.
Topics: Analysis of Variance; Animals; Antipyrine; Blood Chemical Analysis; Cardiopulmonary Bypass; Cerebral | 2007 |
A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient.
Topics: Acute Kidney Injury; Antipyrine; Cerebral Infarction; Disseminated Intravascular Coagulation; Edarav | 2007 |
MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling.
Topics: Animals; Animals, Newborn; Antipyrine; Brain Edema; Butadienes; Cell Death; Cells, Cultured; Cerebra | 2007 |
Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipyrine; Blood Flow Velocity; Brain Ische | 2008 |
[Cerebral blood flow, metabolism and learning after a cerebral infarction in the rat (author's transl)].
Topics: Animals; Antipyrine; Avoidance Learning; Brain; Brain Edema; Cerebral Infarction; Cerebrovascular Ci | 1981 |
Quantitative measurement of regional blood flow with gadolinium diethylenetriaminepentaacetate bolus track NMR imaging in cerebral infarcts in rats: validation with the iodo[14C]antipyrine technique.
Topics: Animals; Antipyrine; Blood Pressure; Brain; Carbon Dioxide; Carbon Radioisotopes; Cerebral Infarctio | 1995 |
Early cerebrovascular response to head injury in immature and mature rats.
Topics: Aging; Animals; Antipyrine; Blood Pressure; Body Temperature; Body Water; Brain; Brain Chemistry; Ce | 1994 |
Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat.
Topics: Animals; Antipyrine; Brain; Caudate Nucleus; Cerebral Infarction; Cyclic N-Oxides; Disease Models, A | 1999 |
Impaired cerebral autoregulation 24 h after induction of transient unilateral focal ischaemia in the rat.
Topics: Animals; Antipyrine; Blood Pressure; Brain; Carbon Radioisotopes; Cerebellum; Cerebral Cortex; Cereb | 2000 |
LY353381.HCl, a selective estrogen receptor modulator, and experimental stroke.
Topics: Animals; Antipyrine; Autoradiography; Brain Ischemia; Carbon Radioisotopes; Cerebral Infarction; Cer | 2000 |
Experimental stroke in the female diabetic, db/db, mouse.
Topics: Animals; Antipyrine; Autoradiography; Brain; Carbon Radioisotopes; Cerebral Infarction; Cerebrovascu | 2001 |
Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil.
Topics: Adenosine Triphosphate; Animals; Antipyrine; Astrocytes; Body Temperature; Cerebral Cortex; Cerebral | 2002 |
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils.
Topics: Animals; Anticoagulants; Antipyrine; Arginine; Body Water; Brain Edema; Brain Ischemia; Cerebral Inf | 2002 |
Effect of the serotonin antagonist ketanserin on the hemodynamic and morphological consequences of thrombotic infarction.
Topics: Animals; Antipyrine; Autoradiography; Carbon Radioisotopes; Cerebral Infarction; Cerebrovascular Cir | 1989 |