antipyrine has been researched along with Cerebral Hemorrhage in 18 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Edaravone is widely used for treating ischemic stroke, but it is not still confirmed in intracerebral hemorrhage (ICH) as an ideal medication targeting the brain parenchyma." | 7.83 | Stereotactic Administration of Edaravone Ameliorates Collagenase-Induced Intracerebral Hemorrhage in Rat. ( Gao, M; Ge, GZ; Ji, XC; Sun, YL; Wang, QQ; Xu, RX; Yang, Y; Zhang, GZ; Zhang, HT; Zhang, Y, 2016) |
| "In present study, we evaluated acute neuroprotective effects of combined therapy with pharmacologically induced hypothermia and edaravone in a rat model of intracerebral hemorrhage (ICH)." | 7.81 | Early Combined Therapy with Pharmacologically Induced Hypothermia and Edaravone Exerts Neuroprotective Effects in a Rat Model of Intracerebral Hemorrhage. ( Liu, C; Sun, Z; Zhu, Y, 2015) |
| "Edaravone attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia." | 7.80 | Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. ( Johshita, H; Miyazaki, H; Okamura, K; Shiokawa, Y; Tsubokawa, T, 2014) |
| "To explore the effects of edaravone on the expression of matrix metalloproteinase-9 (MMP-9) posterior to cerebral hemorrhage, and to analyze the relationship between this expression and neurological deficit." | 7.80 | Beneficial effects of edaravone on the expression of serum matrix metalloproteinase-9 after cerebral hemorrhage. ( Liu, Z; Zhao, F, 2014) |
| "A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin--a combination of isometheptene mucate, dichlorophenazine and acetaminophen." | 7.75 | Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy. ( Johnston, JC, 2009) |
| " In the first, the dose-dependent effects of edaravone on ICH-induced brain injury were examined by measuring brain edema and neurologic deficits." | 7.74 | Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. ( Itano, T; Keep, RF; Kuroda, Y; Miyamoto, O; Nagao, S; Nakamura, T; Tamiya, T; Xi, G; Yamashita, S; Zhang, X, 2008) |
| " The present study was undertaken to examine whether or not the free radical scavenger, edaravone, could prevent the extravasation of tPA administered for the purpose of fibrinolysis in a rat model of thromboembolic stroke." | 7.73 | Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model. ( Harada, T; Kano, T; Katayama, Y, 2005) |
| "Edaravone is widely used for treating ischemic stroke, but it is not still confirmed in intracerebral hemorrhage (ICH) as an ideal medication targeting the brain parenchyma." | 3.83 | Stereotactic Administration of Edaravone Ameliorates Collagenase-Induced Intracerebral Hemorrhage in Rat. ( Gao, M; Ge, GZ; Ji, XC; Sun, YL; Wang, QQ; Xu, RX; Yang, Y; Zhang, GZ; Zhang, HT; Zhang, Y, 2016) |
| "In present study, we evaluated acute neuroprotective effects of combined therapy with pharmacologically induced hypothermia and edaravone in a rat model of intracerebral hemorrhage (ICH)." | 3.81 | Early Combined Therapy with Pharmacologically Induced Hypothermia and Edaravone Exerts Neuroprotective Effects in a Rat Model of Intracerebral Hemorrhage. ( Liu, C; Sun, Z; Zhu, Y, 2015) |
| "Edaravone attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia." | 3.80 | Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia. ( Johshita, H; Miyazaki, H; Okamura, K; Shiokawa, Y; Tsubokawa, T, 2014) |
| "To explore the effects of edaravone on the expression of matrix metalloproteinase-9 (MMP-9) posterior to cerebral hemorrhage, and to analyze the relationship between this expression and neurological deficit." | 3.80 | Beneficial effects of edaravone on the expression of serum matrix metalloproteinase-9 after cerebral hemorrhage. ( Liu, Z; Zhao, F, 2014) |
| "We demonstrate that edaravone inhibits rtPA-induced cerebral hemorrhage in the ischemic brain of rats via the inhibition of MMP-9 expression in vivo, which is substantiated by inhibition of MMP-9 expression and NF-kappaB activation in HBECs." | 3.75 | Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. ( Kinouchi, T; Kitazato, KT; Nagahiro, S; Shimada, K; Tada, Y; Uno, M; Yagi, K, 2009) |
| "A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin--a combination of isometheptene mucate, dichlorophenazine and acetaminophen." | 3.75 | Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy. ( Johnston, JC, 2009) |
| " In the first, the dose-dependent effects of edaravone on ICH-induced brain injury were examined by measuring brain edema and neurologic deficits." | 3.74 | Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. ( Itano, T; Keep, RF; Kuroda, Y; Miyamoto, O; Nagao, S; Nakamura, T; Tamiya, T; Xi, G; Yamashita, S; Zhang, X, 2008) |
| " The present study was undertaken to examine whether or not the free radical scavenger, edaravone, could prevent the extravasation of tPA administered for the purpose of fibrinolysis in a rat model of thromboembolic stroke." | 3.73 | Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model. ( Harada, T; Kano, T; Katayama, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okamura, K | 1 |
| Tsubokawa, T | 1 |
| Johshita, H | 1 |
| Miyazaki, H | 1 |
| Shiokawa, Y | 1 |
| Chen, Z | 1 |
| Zhang, J | 2 |
| Chen, Q | 1 |
| Guo, J | 1 |
| Zhu, G | 1 |
| Feng, H | 1 |
| Zhao, F | 1 |
| Liu, Z | 1 |
| Zhu, Y | 1 |
| Liu, C | 1 |
| Sun, Z | 1 |
| Zhang, Y | 1 |
| Yang, Y | 1 |
| Zhang, GZ | 1 |
| Gao, M | 1 |
| Ge, GZ | 1 |
| Wang, QQ | 1 |
| Ji, XC | 1 |
| Sun, YL | 1 |
| Zhang, HT | 1 |
| Xu, RX | 1 |
| Mishina, M | 1 |
| Komaba, Y | 1 |
| Kobayashi, S | 1 |
| Kominami, S | 1 |
| Fukuchi, T | 1 |
| Mizunari, T | 1 |
| Teramoto, A | 1 |
| Katayama, Y | 3 |
| Han, N | 1 |
| Ding, SJ | 1 |
| Wu, T | 1 |
| Zhu, YL | 1 |
| Yagi, K | 1 |
| Kitazato, KT | 1 |
| Uno, M | 1 |
| Tada, Y | 1 |
| Kinouchi, T | 1 |
| Shimada, K | 1 |
| Nagahiro, S | 2 |
| Yamashita, T | 1 |
| Kamiya, T | 1 |
| Deguchi, K | 1 |
| Inaba, T | 1 |
| Zhang, H | 1 |
| Shang, J | 1 |
| Miyazaki, K | 1 |
| Ohtsuka, A | 1 |
| Abe, K | 1 |
| Zhou, F | 1 |
| Chen, G | 1 |
| Johnston, JC | 1 |
| Shrikanth, V | 1 |
| Vanderheiden, A | 1 |
| Simha, V | 1 |
| Yang, J | 1 |
| Liu, M | 1 |
| Zhou, J | 1 |
| Zhang, S | 1 |
| Lin, S | 1 |
| Zhao, H | 1 |
| Kano, T | 1 |
| Harada, T | 1 |
| Nakamura, T | 1 |
| Kuroda, Y | 1 |
| Yamashita, S | 1 |
| Zhang, X | 1 |
| Miyamoto, O | 1 |
| Tamiya, T | 1 |
| Nagao, S | 1 |
| Xi, G | 1 |
| Keep, RF | 1 |
| Itano, T | 1 |
| Ment, LR | 1 |
| Stewart, WB | 1 |
| Duncan, CC | 1 |
| Lambrecht, R | 1 |
| Yamamoto, YL | 1 |
| Diksic, M | 1 |
| Mitsuka, S | 1 |
| Sugimoto, S | 1 |
| Feindel, W | 1 |
| Fieschi, C | 1 |
1 review available for antipyrine and Cerebral Hemorrhage
| Article | Year |
|---|---|
Edaravone for acute intracerebral haemorrhage.
Topics: Antipyrine; Cerebral Hemorrhage; Edaravone; Free Radical Scavengers; Humans; Randomized Controlled T | 2011 |
17 other studies available for antipyrine and Cerebral Hemorrhage
| Article | Year |
|---|---|
Edaravone, a free radical scavenger, attenuates cerebral infarction and hemorrhagic infarction in rats with hyperglycemia.
Topics: Animals; Antipyrine; Blood Glucose; Brain; Cerebral Hemorrhage; Cerebral Infarction; Edaravone; Free | 2014 |
Neuroprotective effects of edaravone after intraventricular hemorrhage in rats.
Topics: Animals; Antipyrine; Brain Edema; Cerebral Hemorrhage; Cognition Disorders; Edaravone; Free Radical | 2014 |
Beneficial effects of edaravone on the expression of serum matrix metalloproteinase-9 after cerebral hemorrhage.
Topics: Adult; Aged; Antipyrine; Cerebral Hemorrhage; Edaravone; Female; Free Radical Scavengers; Glasgow Co | 2014 |
Early Combined Therapy with Pharmacologically Induced Hypothermia and Edaravone Exerts Neuroprotective Effects in a Rat Model of Intracerebral Hemorrhage.
Topics: Animals; Antipyrine; Apoptosis Regulatory Proteins; Blood-Brain Barrier; Blotting, Western; Brain Ed | 2015 |
Stereotactic Administration of Edaravone Ameliorates Collagenase-Induced Intracerebral Hemorrhage in Rat.
Topics: Animals; Antipyrine; Apoptosis; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Collagenases; | 2016 |
Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism.
Topics: Aged; Aged, 80 and over; Antipyrine; Cerebral Hemorrhage; Dose-Response Relationship, Drug; Edaravon | 2008 |
Correlation of free radical level and apoptosis after intracerebral hemorrhage in rats.
Topics: Analysis of Variance; Animals; Antipyrine; Apoptosis; Cerebral Hemorrhage; Disease Models, Animal; D | 2008 |
Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
Topics: Animals; Antipyrine; Blood Pressure; Blotting, Western; Brain Ischemia; Cells, Cultured; Cerebral He | 2009 |
Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain.
Topics: Animals; Antipyrine; Basement Membrane; Brain Ischemia; Cerebral Hemorrhage; Edaravone; Free Radical | 2009 |
Edaravone reduces brain oedema and attenuates cell death after intracerebral haemorrhage in mice.
Topics: Animals; Antipyrine; Brain; Brain Edema; Cell Death; Cerebral Hemorrhage; Collagenases; Disease Mode | 2009 |
Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy.
Topics: Acetaminophen; Analgesics; Antipyrine; Cerebral Hemorrhage; Chloral Hydrate; Drug Combinations; Fema | 2009 |
Spontaneous intracerebral hemorrhage associated with ingestion of isometheptine containing anti-migraine medication.
Topics: Acetaminophen; Adult; Antipyrine; Cerebral Hemorrhage; Chloral Hydrate; Drug Combinations; Emergency | 2011 |
Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model.
Topics: Analysis of Variance; Animals; Antipyrine; Blood Vessels; Cerebral Hemorrhage; Disease Models, Anima | 2005 |
Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage.
Topics: Acute Disease; Animals; Antipyrine; Basal Ganglia; Brain Edema; Cerebral Cortex; Cerebral Hemorrhage | 2008 |
Beagle puppy model of intraventricular hemorrhage.
Topics: Animals; Animals, Newborn; Antipyrine; Autoradiography; Cerebral Hemorrhage; Cerebral Ventricles; Ce | 1982 |
Neurotoxicity after intracarotid 1,3-bis(2-chloroethyl)-1-nitrosourea administration in the rat: hemodynamic changes studied by double-tracer autoradiography.
Topics: Aminobutyrates; Amygdala; Animals; Antipyrine; Autoradiography; Blood-Brain Barrier; Carbon Radioiso | 1991 |
Regional cerebral blood flow in acute apoplexy, including pharmacodynamic studies.
Topics: Acute Disease; Animals; Antipyrine; Autoradiography; Blood Pressure; Carbon Dioxide; Carbon Isotopes | 1968 |