antipyrine has been researched along with Brain Injuries in 32 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to evaluate the protective effect of edaravone, a free radical scavenger, on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma." | 9.19 | Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial. ( Hu, W; Li, G; Luo, J; Rong, X; Tang, Y; Xu, P; Yang, J; Yang, X, 2014) |
| " This study was designed to evaluate the protective effect of edaravone, a free radical scavenger, on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma." | 5.19 | Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial. ( Hu, W; Li, G; Luo, J; Rong, X; Tang, Y; Xu, P; Yang, J; Yang, X, 2014) |
| "The edaravone-treated animals also exhibited higher rCBF in the contralateral hemisphere compared with that seen in -vehicle-treated animals." | 1.39 | Edaravone increases regional cerebral blood flow after traumatic brain injury in mice. ( Aruga, T; Dohi, K; Kiriyama, K; Miyamoto, K; Nakano, H; Ohtaki, H; Shioda, S; Song, D; Tsumuraya, T, 2013) |
| "Edaravone treatment significantly decreased hippocampal CA3 neuron loss, reduced oxidative stress, and decreased neuronal programmed cell death compared to vehicle treatment." | 1.37 | Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats. ( Chen, J; Gao, YQ; Jiang, ZL; Li, X; Li, YC; Shi, H; Vosler, PS; Wang, GH, 2011) |
| "Edaravone is a novel free radical scavenger used clinically in patients with acute cerebral infarction; however, it has not been assessed in traumatic brain injury (TBI)." | 1.36 | Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats. ( Hashimoto, S; Imano, M; Ito, H; Itoh, T; Nishida, S; Satou, T; Tsubaki, M, 2010) |
| "Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI)." | 1.35 | The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury. ( Hashimoto, S; Ito, H; Itoh, T; Nishida, S; Satou, T; Tsubaki, M, 2009) |
| "Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult." | 1.34 | Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury? ( Aruga, T; Dohi, K; Hiratsuka, K; Nakamachi, T; Nakamura, S; Ohtaki, H; Satoh, K; Shioda, S; Yofu, S; Yoshikawa, T, 2007) |
| "At 24 h, hyperemia was observed (vs." | 1.29 | Posttraumatic hyperemia in immature, mature, and aged rats: autoradiographic determination of cerebral blood flow. ( Biagas, KV; Grundl, PD; Kochanek, PM; Nemoto, EM; Schiding, JK, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 10 (31.25) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Kara, O | 1 |
| Kilitci, A | 1 |
| Miyamoto, K | 2 |
| Ohtaki, H | 4 |
| Dohi, K | 4 |
| Tsumuraya, T | 2 |
| Nakano, H | 1 |
| Kiriyama, K | 2 |
| Song, D | 2 |
| Aruga, T | 4 |
| Shioda, S | 4 |
| Satoh, K | 3 |
| Shimizu, A | 1 |
| Tang, Y | 1 |
| Rong, X | 1 |
| Hu, W | 1 |
| Li, G | 1 |
| Yang, X | 1 |
| Yang, J | 1 |
| Xu, P | 1 |
| Luo, J | 1 |
| Qin, T | 1 |
| Lei, LY | 1 |
| Li, N | 1 |
| Shi, FR | 1 |
| Chen, MH | 1 |
| Xie, L | 1 |
| Engel, DC | 1 |
| Mies, G | 1 |
| Terpolilli, NA | 1 |
| Trabold, R | 1 |
| Loch, A | 1 |
| De Zeeuw, CI | 1 |
| Weber, JT | 1 |
| Maas, AI | 1 |
| Plesnila, N | 1 |
| Itoh, T | 2 |
| Satou, T | 2 |
| Nishida, S | 2 |
| Tsubaki, M | 2 |
| Hashimoto, S | 2 |
| Ito, H | 2 |
| Imano, M | 1 |
| Gao, Y | 1 |
| Ding, XS | 1 |
| Xu, S | 1 |
| Wang, W | 1 |
| Zuo, QL | 1 |
| Kuai, F | 1 |
| Zhao, YN | 1 |
| Guo, X | 1 |
| Gao, JL | 1 |
| Chen, HH | 1 |
| Tian, YX | 1 |
| Cui, JZ | 1 |
| Lukic-Panin, V | 1 |
| Deguchi, K | 1 |
| Yamashita, T | 1 |
| Shang, J | 1 |
| Zhang, X | 1 |
| Tian, F | 1 |
| Liu, N | 1 |
| Kawai, H | 1 |
| Matsuura, T | 1 |
| Abe, K | 1 |
| Wang, GH | 1 |
| Jiang, ZL | 1 |
| Li, YC | 1 |
| Li, X | 1 |
| Shi, H | 1 |
| Gao, YQ | 1 |
| Vosler, PS | 1 |
| Chen, J | 1 |
| Yamashita, S | 1 |
| Hasuo, H | 1 |
| Tokutomi, T | 1 |
| Shigemori, M | 1 |
| Akasu, T | 1 |
| Ohta, M | 1 |
| Higashi, Y | 1 |
| Yawata, T | 1 |
| Kitahara, M | 1 |
| Nobumoto, A | 1 |
| Ishida, E | 1 |
| Tsuda, M | 1 |
| Fujimoto, Y | 1 |
| Shimizu, K | 1 |
| KOVALEVA, NT | 1 |
| ALLIEZ, J | 1 |
| MOUREN, P | 1 |
| CARCASSONNE, Y | 1 |
| AYMES, G | 1 |
| GEBHARDT, KH | 1 |
| Nakamura, H | 1 |
| Uzura, M | 1 |
| Uchida, K | 1 |
| Nakayama, H | 1 |
| Furuya, Y | 1 |
| Hayashi, T | 1 |
| Sekino, H | 1 |
| Ominato, M | 1 |
| Owada, S | 1 |
| Chen, SF | 1 |
| Richards, HK | 2 |
| Smielewski, P | 1 |
| Johnström, P | 1 |
| Salvador, R | 1 |
| Pickard, JD | 2 |
| Harris, NG | 1 |
| Zhang, LH | 1 |
| Wei, EQ | 2 |
| Maeda, T | 1 |
| Lee, SM | 2 |
| Hovda, DA | 2 |
| Ding, Q | 1 |
| Zhang, YJ | 1 |
| Zhang, WP | 1 |
| Chen, Z | 1 |
| Mihara, Y | 1 |
| Nakamura, S | 2 |
| Miyake, Y | 1 |
| Nakamachi, T | 2 |
| Yoshikawa, T | 2 |
| Yofu, S | 1 |
| Hiratsuka, K | 1 |
| Masaoka, N | 1 |
| Nakajima, Y | 1 |
| Watanabe, M | 1 |
| Hayakawa, Y | 1 |
| Nagaishi, M | 1 |
| Yamamoto, T | 1 |
| Honma, T | 1 |
| Oinuma, T | 1 |
| Nemoto, N | 1 |
| Scremin, OU | 1 |
| Li, MG | 1 |
| Scremin, AM | 1 |
| Dietrich, WD | 1 |
| Alonso, O | 1 |
| Busto, R | 1 |
| Prado, R | 1 |
| Dewanjee, S | 1 |
| Dewanjee, MK | 1 |
| Ginsberg, MD | 1 |
| Biagas, KV | 1 |
| Grundl, PD | 1 |
| Kochanek, PM | 1 |
| Schiding, JK | 1 |
| Nemoto, EM | 1 |
| Kelly, DF | 1 |
| Kozlowski, DA | 1 |
| Haddad, E | 1 |
| Echiverri, A | 1 |
| Simac, S | 1 |
| Piechnik, S | 1 |
| Milhorat, TH | 1 |
| Johnson, WD | 1 |
| Dow-Edwards, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Edaravone on Radiation-induced Temporal Lobe Necrosis in Patients With Nasopharyngeal Carcinoma After Radiotherapy[NCT01865201] | Phase 2 | 154 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for antipyrine and Brain Injuries
| Article | Year |
|---|---|
Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Brain Injuries; Carcinoma; Case-Control Studies; Edaravo | 2014 |
31 other studies available for antipyrine and Brain Injuries
| Article | Year |
|---|---|
Antioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Rats.
Topics: Animals; Antioxidants; Antipyrine; Brain Injuries; Cisplatin; Edaravone; Female; Free Radical Scaven | 2024 |
Edaravone increases regional cerebral blood flow after traumatic brain injury in mice.
Topics: Animals; Antipyrine; Brain; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Eda | 2013 |
Therapeutic time window for edaravone treatment of traumatic brain injury in mice.
Topics: Animals; Antipyrine; Brain Injuries; Disease Models, Animal; Edaravone; Free Radical Scavengers; Jap | 2013 |
Edaravone improves survival and neurological outcomes after CPR in a ventricular fibrillation model of rats.
Topics: Animals; Antipyrine; Brain Injuries; Cardiopulmonary Resuscitation; Disease Models, Animal; Edaravon | 2016 |
Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Biomarkers; Brain; Br | 2008 |
The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult Stem Cells; Aldehydes; Animals; Antipyrine; Behavior, Animal; Bra | 2009 |
Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antipyrine; Apoptosis; Behavior, Animal; Brain Inju | 2010 |
Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage.
Topics: Animals; Antipyrine; Blotting, Western; Brain Injuries; Edaravone; Immunohistochemistry; Male; Malon | 2009 |
[Effect of edaravone on extracellular signal-regulated kinase 1/2 pathway following severe traumatic brain injury in rats].
Topics: Animals; Antipyrine; Apoptosis; Brain Injuries; Disease Models, Animal; Edaravone; Male; Mitogen-Act | 2010 |
Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage.
Topics: Acetylglucosamine; Animals; Antipyrine; Blood-Brain Barrier; Brain Injuries; Cerebral Cortex; Collag | 2010 |
Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.
Topics: Animals; Antipyrine; Apoptosis; Astrocytes; Blood-Brain Barrier; Body Water; Brain Injuries; Colorin | 2011 |
Edaravone attenuates impairment of synaptic plasticity in granule cell layer of the dentate gyrus following traumatic brain injury.
Topics: Animals; Antipyrine; Brain Injuries; Dentate Gyrus; Edaravone; Electric Stimulation; Excitatory Post | 2011 |
Attenuation of axonal injury and oxidative stress by edaravone protects against cognitive impairments after traumatic brain injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Brain Injuries; Cognition; Cognition Disorders; De | 2013 |
[Commotional experimental hypertension].
Topics: Antipyrine; Brain; Brain Injuries; Humans; Hypertension | 1952 |
[Post-commotional Korsakoff syndrome with initial mesodiencephalic dysrhythmia; systematic failure of recognition through elective retrograde amnesia].
Topics: Amnesia; Amnesia, Retrograde; Antipyrine; Brain; Brain Injuries; Electroencephalography; Humans; Kor | 1953 |
[Posttraumatic subjective syndrome with hybrid post cervical sympathetic commotional syndrome (Pierre-Marie; Barre-Lieou)].
Topics: Antipyrine; Brain; Brain Injuries; Cervical Plexus; Disease; Horner Syndrome; Wounds and Injuries | 1955 |
[Review of post-commotional brain injuries and the length of therapy].
Topics: Antipyrine; Brain; Brain Injuries; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Humans | 1957 |
Effects of edaravone on experimental brain injury in view of free radical reaction.
Topics: Animals; Antipyrine; Body Water; Brain; Brain Edema; Brain Injuries; Edaravone; Electron Spin Resona | 2003 |
Relationship between flow-metabolism uncoupling and evolving axonal injury after experimental traumatic brain injury.
Topics: Amyloid beta-Protein Precursor; Animals; Antipyrine; Autoradiography; Axons; Brain Injuries; Carbon | 2004 |
ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats.
Topics: Animals; Antipyrine; Brain; Brain Injuries; Cerebral Cortex; Chromones; Edaravone; Leukotriene Antag | 2005 |
Restoration of cerebral vasoreactivity by an L-type calcium channel blocker following fluid percussion brain injury.
Topics: Animals; Antipyrine; Blood Pressure; Brain Injuries; Calcium; Calcium Channel Blockers; Calcium Chan | 2005 |
Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice.
Topics: Animals; Antioxidants; Antipyrine; Brain; Brain Injuries; Chromones; Edaravone; Ketamine; Male; Memb | 2006 |
Alkoxyl radical-scavenging activity of edaravone in patients with traumatic brain injury.
Topics: Adult; Alcohols; Antipyrine; Brain Injuries; Edaravone; Electron Spin Resonance Spectroscopy; Female | 2006 |
Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Topics: alpha-Tocopherol; Animals; Antioxidants; Antipyrine; Blood; Brain Injuries; Edaravone; Free Radical | 2007 |
MCI-186 administered to the maternal circulation inhibits fetal brain injury resulting from total umbilical cord occlusion in the chronically instrumented fetal lamb.
Topics: Animals; Antipyrine; Brain Injuries; Edaravone; Female; Fetal Hypoxia; Free Radical Scavengers; Mate | 2006 |
Cortical contusion induces trans-hemispheric reorganization of blood flow maps.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Brain Injuries; | 2007 |
Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: a double-label autoradiographic study in rats.
Topics: Animals; Antipyrine; Autoradiography; Blood Platelets; Brain Injuries; Carbon Radioisotopes; Cerebro | 1996 |
Posttraumatic hyperemia in immature, mature, and aged rats: autoradiographic determination of cerebral blood flow.
Topics: Adult; Aging; Animals; Antipyrine; Autoradiography; Brain; Brain Injuries; Carbon Radioisotopes; Cer | 1996 |
Ethanol reduces metabolic uncoupling following experimental head injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Brain Injuries; Carbo | 2000 |
Uncoupling of cerebral blood flow and metabolism after cerebral contusion in the rat.
Topics: Animals; Antipyrine; Autoradiography; Brain; Brain Chemistry; Brain Injuries; Carbon Radioisotopes; | 2001 |
Relationship between oedema, blood pressure, and blood flow following local brain injury.
Topics: Animals; Antipyrine; Blood Pressure; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Male; | 1989 |