antipyrine has been researched along with Bile Duct Obstruction in 8 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The investigation of detoxicating function of the liver in 85 patients has shown that the indices of antipyrine clearance in patients with one-month-long parenchymatous jaundice and obstructive cholestasis were reliably different." | 7.67 | [Differential diagnosis of jaundice based on antipyrine metabolism]. ( Kogan, AS; Nepomniashchikh, VA, 1986) |
| "The investigation of detoxicating function of the liver in 85 patients has shown that the indices of antipyrine clearance in patients with one-month-long parenchymatous jaundice and obstructive cholestasis were reliably different." | 3.67 | [Differential diagnosis of jaundice based on antipyrine metabolism]. ( Kogan, AS; Nepomniashchikh, VA, 1986) |
| "Patients with acute hepatitis and patients with compensated or decompensated cirrhosis of the liver have a decreased plasma clearance of hexobarbital." | 3.66 | [Drug metabolism in patients with liver disease (author's transl)]. ( Epping, J; Fuchshofen-Röckel, M; Heusler, H; Richter, E; Zilly, W, 1980) |
| " Discriminant analysis of the basal data revealed that plasma bilirubin, proteins and antipyrine half-life taken together had a strong association with mortality." | 1.28 | Antipyrine clearance: prognostic marker for obstructive jaundice. ( Bapat, RD; Dahanukar, SA; Desai, NK; Nayak, VK; Nazareth, HM; Rege, NN; Someshwar, V, 1990) |
| "Antipyrine metabolism was normal or marginally impaired in patients with compensated cirrhosis or acute hepatitis, whereas it was frequently abnormal in those with chronic active hepatitis or advanced alcoholic liver disease." | 1.26 | Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism. ( Cooksley, WG; Farrell, GC; Hart, P; Powell, LW, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Serrano, MA | 1 |
| Macias, RI | 1 |
| Vallejo, M | 1 |
| Briz, O | 1 |
| Bravo, A | 1 |
| Pascual, MJ | 1 |
| St-Pierre, MV | 1 |
| Stieger, B | 1 |
| Meier, PJ | 1 |
| Marin, JJ | 1 |
| Richter, E | 1 |
| Epping, J | 1 |
| Fuchshofen-Röckel, M | 1 |
| Heusler, H | 1 |
| Zilly, W | 1 |
| Farrell, GC | 1 |
| Cooksley, WG | 1 |
| Hart, P | 1 |
| Powell, LW | 1 |
| Nazareth, HM | 1 |
| Rege, NN | 1 |
| Nayak, VK | 1 |
| Desai, NK | 1 |
| Someshwar, V | 1 |
| Dahanukar, SA | 1 |
| Bapat, RD | 1 |
| Migneco, G | 1 |
| Mascarella, A | 1 |
| Tripi, S | 1 |
| La Cascia, C | 1 |
| Navetta, A | 1 |
| Kogan, AS | 1 |
| Nepomniashchikh, VA | 1 |
| McPherson, GA | 1 |
| Benjamin, IS | 1 |
| Boobis, AR | 1 |
| Blumgart, LH | 1 |
| Elfström, J | 1 |
| Lindgren, S | 1 |
8 other studies available for antipyrine and Bile Duct Obstruction
| Article | Year |
|---|---|
Effect of ursodeoxycholic acid on the impairment induced by maternal cholestasis in the rat placenta-maternal liver tandem excretory pathway.
Topics: Animals; Antipyrine; Cell Membrane; Cholestasis; DNA Primers; Female; Gene Expression; Glycocholic A | 2003 |
[Drug metabolism in patients with liver disease (author's transl)].
Topics: Acute Disease; Adult; Antipyrine; Biological Availability; Biotransformation; Cholestasis; Female; H | 1980 |
Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism.
Topics: Acute Disease; Antipyrine; Ascites; Biotransformation; Chemical and Drug Induced Liver Injury; Chole | 1978 |
Antipyrine clearance: prognostic marker for obstructive jaundice.
Topics: Adult; Aged; Antipyrine; Cholestasis; Female; Humans; Liver; Liver Function Tests; Male; Middle Aged | 1990 |
[Cytolytic episodes during cirrhosis].
Topics: Antipyrine; Anxiety Disorders; Barbiturates; Caffeine; Cholestasis; Drug Therapy, Combination; Femal | 1986 |
[Differential diagnosis of jaundice based on antipyrine metabolism].
Topics: Antipyrine; Cholestasis; Diagnosis, Differential; Humans; Jaundice | 1986 |
Antipyrine elimination in patients with obstructive jaundice: a predictor of outcome.
Topics: Adult; Aged; Antipyrine; Bilirubin; Cholestasis; Chromatography, High Pressure Liquid; Drainage; Hal | 1985 |
Disappearance of phenazone from plasma in patients with obstructive jaundice.
Topics: Adult; Aged; Antipyrine; Bile; Biliary Tract Diseases; Cholestasis; Chromatography, Gas; Female; Hal | 1974 |