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antipyrine and Anoxia, Brain

antipyrine has been researched along with Anoxia, Brain in 9 studies

Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.

Research Excerpts

ExcerptRelevanceReference
"Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, reduces brain edema in patients with acute ischemic stroke."3.74Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia. ( Imaizumi, T; Ishikawa, A; Matsumiya, T; Metoki, N; Satoh, K; Taima, K; Toki, T; Yamashita, K; Yoshida, H, 2007)
"Pretreatment with edaravone can prevent development of cognitive impairment after CEA."2.71Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy. ( Endo, H; Fukuda, T; Inoue, T; Kobayashi, M; Ogasawara, K; Ogawa, A; Terasaki, K; Yamadate, K; Yoshida, K, 2005)
"Edaravone treatment (3mg/kg, i."1.40A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion. ( Arai, K; Liang, AC; Maki, T; Miyamoto, N; Pham, LD, 2014)
"Cerebral ischemia was mechanically induced by 2-hour occlusion of the left middle cerebral artery (MCA) using an intraluminal filament followed by 24-hour reperfusion."1.33Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats. ( Hong, KW; Lee, JH; Lee, WS; Park, SY, 2005)
"During cerebral hypoxia-ischemia (unilateral common carotid artery ligation and hypoxia with 8% oxygen), blood flows to all regions of the ipsilateral cerebral hemisphere were not different from control at 10 and 20 min."1.28Regional cerebral blood flow during hypoxia-ischemia in the immature rat: comparison of iodoantipyrine and iodoamphetamine as radioactive tracers. ( Bryan, RM; Ringel, M; Vannucci, RC, 1991)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's2 (22.22)18.2507
2000's3 (33.33)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miyamoto, N1
Pham, LD1
Maki, T1
Liang, AC1
Arai, K1
Somekawa-Kondo, T1
Yamaguchi, K1
Ishitsuka, Y1
Ito, S1
Tanaka, K1
Irikura, M1
Moriuchi, H1
Takahama, K1
Ando, Y1
Yamazaki, T1
Irie, T1
Lee, JH1
Park, SY1
Lee, WS1
Hong, KW1
Ogasawara, K1
Yamadate, K1
Kobayashi, M1
Endo, H1
Fukuda, T1
Yoshida, K1
Terasaki, K1
Inoue, T1
Ogawa, A1
Ishikawa, A1
Yoshida, H1
Metoki, N1
Toki, T1
Imaizumi, T1
Matsumiya, T1
Yamashita, K1
Taima, K1
Satoh, K1
Fabricius, M1
Lauritzen, M1
Ringel, M1
Bryan, RM1
Vannucci, RC3
Lyons, DT2
Vasta, F2

Trials

1 trial available for antipyrine and Anoxia, Brain

ArticleYear
Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy.
    Surgical neurology, 2005, Volume: 64, Issue:4

    Topics: Aged; Antipyrine; Carotid Artery, Internal; Carotid Stenosis; Cerebral Infarction; Cerebrovascular C

2005

Other Studies

8 other studies available for antipyrine and Anoxia, Brain

ArticleYear
A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion.
    Neuroscience letters, 2014, Jun-24, Volume: 573

    Topics: Animals; Antipyrine; Blood-Brain Barrier; Carotid Artery, Common; Carotid Stenosis; Cell Death; Cell

2014
Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:1

    Topics: Aminophylline; Animals; Antipyrine; CA1 Region, Hippocampal; Creatine Kinase, BB Form; Disease Model

2013
Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats.
    Neurological research, 2005, Volume: 27, Issue:5

    Topics: Animals; Antioxidants; Antipyrine; Aspirin; bcl-2-Associated X Protein; Blotting, Western; Brain Ede

2005
Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia.
    Neuroscience research, 2007, Volume: 59, Issue:4

    Topics: Antipyrine; Astrocytes; Blood-Brain Barrier; Brain Edema; Cell Nucleus; Cells, Cultured; Cerebral Ar

2007
Laser-Doppler evaluation of rat brain microcirculation: comparison with the [14C]-iodoantipyrine method suggests discordance during cerebral blood flow increases.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:1

    Topics: Animals; Antipyrine; Carbon Radioisotopes; Cerebral Cortex; Cerebrovascular Circulation; Hypoxia, Br

1996
Regional cerebral blood flow during hypoxia-ischemia in the immature rat: comparison of iodoantipyrine and iodoamphetamine as radioactive tracers.
    Brain research. Developmental brain research, 1991, Apr-24, Volume: 59, Issue:2

    Topics: Amphetamines; Animals; Antipyrine; Autoradiography; Brain; Brain Ischemia; Cerebrovascular Circulati

1991
Regional cerebral blood flow during hypoxia-ischemia in immature rats.
    Stroke, 1988, Volume: 19, Issue:2

    Topics: Animals; Animals, Newborn; Antipyrine; Autoradiography; Brain; Brain Ischemia; Carbon Radioisotopes;

1988
Autoradiographic determination of regional cerebral blood flow in the immature rat.
    Pediatric research, 1987, Volume: 21, Issue:5

    Topics: Animals; Antipyrine; Autoradiography; Brain Ischemia; Cerebrovascular Circulation; Hypoxia, Brain; R

1987