Page last updated: 2024-10-22

antipyrine and Anoxemia

antipyrine has been researched along with Anoxemia in 23 studies

Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.

Research Excerpts

ExcerptRelevanceReference
"To investigate the mechanism of the pulmonary injury in rats caused by chronic intermittent hypoxia (CIH) and to investigate the intervention effect of Edaravone."7.81[The pulmonary injury in rats caused by chronic intermittent hypoxia and the intervention effect of Edaravone]. ( Kou, Y; Tan, X; Wang, H; Xie, B; Zhang, J; Zhang, M, 2015)
"We studied antipyrine metabolism in rats with different resistance to hypoxia during adaptation to cold stress."7.71Urine antipyrine metabolites in rats with different resistance to hypoxia subjected to cold stress. ( Gichev, YP; Grek, OR; Guseva, EO; Sharapov, VI, 2001)
"Experiments in rats with different sensitivity to hypobaric hypoxia established bimodal distribution of antipyrine and isoniazide half-lives."7.68[The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency]. ( Grek, OR; Kolpakov, MA; Sharapov, VI, 1993)
"Local cerebral blood flow (CBF) was measured in rats, using an autoradiographic technique with 14C-iodoantipyrine as diffusible tracer, in situations with low, normal and high flow rates (phenobarbital anesthesia, analgesia with 75% N2O, and hypoxia, respectively)."7.66Local versus regional cerebral blood flow in the rat at high (hypoxia) and low (phenobarbital anesthesia) flow rates. ( Abdul-Rahman, A; Dahlgren, N; Ingvar, M; Rehncrona, S; Siesjö, BK, 1979)
"To investigate the mechanism of the pulmonary injury in rats caused by chronic intermittent hypoxia (CIH) and to investigate the intervention effect of Edaravone."3.81[The pulmonary injury in rats caused by chronic intermittent hypoxia and the intervention effect of Edaravone]. ( Kou, Y; Tan, X; Wang, H; Xie, B; Zhang, J; Zhang, M, 2015)
"We studied antipyrine metabolism in rats with different resistance to hypoxia during adaptation to cold stress."3.71Urine antipyrine metabolites in rats with different resistance to hypoxia subjected to cold stress. ( Gichev, YP; Grek, OR; Guseva, EO; Sharapov, VI, 2001)
"Experiments in rats with different sensitivity to hypobaric hypoxia established bimodal distribution of antipyrine and isoniazide half-lives."3.68[The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency]. ( Grek, OR; Kolpakov, MA; Sharapov, VI, 1993)
"Local cerebral blood flow (CBF) was measured in rats, using an autoradiographic technique with 14C-iodoantipyrine as diffusible tracer, in situations with low, normal and high flow rates (phenobarbital anesthesia, analgesia with 75% N2O, and hypoxia, respectively)."3.66Local versus regional cerebral blood flow in the rat at high (hypoxia) and low (phenobarbital anesthesia) flow rates. ( Abdul-Rahman, A; Dahlgren, N; Ingvar, M; Rehncrona, S; Siesjö, BK, 1979)
"Treatment with edaravone significantly increased the number of NSPCs and newly generated neurons in the subgranular zone (p < ."1.40Pre- and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats. ( Chen, X; Gao, M; He, X; Lei, S; Li, W; Li, X; Liu, Y; Lu, H; Qi, C; Wang, N; Wang, X; Zhang, J; Zhang, P; Zheng, J, 2014)
"In vivo, rat transient middle cerebral artery occlusion (MCAO) model was established."1.38Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model. ( Ding, XS; Gu, XS; Han, Q; Huang, H; Huang, HF; Liu, XF; Shen, LH; Wu, EB; Ye, M; Zhang, C, 2012)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19909 (39.13)18.7374
1990's5 (21.74)18.2507
2000's6 (26.09)29.6817
2010's3 (13.04)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lei, S1
Zhang, P1
Li, W1
Gao, M1
He, X1
Zheng, J1
Li, X1
Wang, X1
Wang, N1
Zhang, J2
Qi, C1
Lu, H1
Chen, X1
Liu, Y1
Kou, Y1
Xie, B1
Wang, H1
Tan, X1
Zhang, M1
Kaur, C2
Sivakumar, V2
Yip, GW1
Ling, EA2
Li, JJ1
Lu, J1
Wu, CY1
Martínez-Romero, R1
Cañuelo, A1
Martínez-Lara, E1
Javier Oliver, F1
Cárdenas, S1
Siles, E1
Shen, LH1
Ye, M1
Ding, XS1
Han, Q1
Zhang, C1
Liu, XF1
Huang, H1
Wu, EB1
Huang, HF1
Gu, XS1
Qi, X1
Okuma, Y1
Hosoi, T1
Nomura, Y1
Itoh, Y1
Takaoka, R1
Ohira, M1
Abe, T1
Tanahashi, N1
Suzuki, N1
Sharapov, VI4
Kolpakov, MA1
Grek, OR3
Chen, JL1
Wei, L1
Bereczki, D1
Hans, FJ1
Otsuka, T1
Acuff, V1
Richardson, G1
Patlak, C1
Fenstermacher, J1
Watanabe, Y1
Kusuoka, H1
Fukuchi, K1
Fujiwara, T1
Nishimura, T1
Gichev, IuP1
Guseva, EO2
Grek, OP1
Gichev, YP1
Abdul-Rahman, A1
Dahlgren, N1
Ingvar, M1
Rehncrona, S1
Siesjö, BK1
Walker, DW1
Merkle, P1
Bindewald, H1
Breitig, D1
Lampé, LG1
Vojcek, L1
Princzkel, E1
Csömör, S1
Sakuragawa, N1
Matsui, A1
Matsuzaka, T1
Kono, Y1
Ido, T1
Ishiwata, K1
Kawashima, K1
Ochsenfahrt, H1
Winne, D1
Hechtman, HB1
Weisel, RD1
Vito, L1
Ali, J1
Berger, RL1
Reynolds, ML2
Young, M2
Hopins, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hemodynamics and Extravascular Lung Water in Acute Lung Injury: A Prospective Randomized Controlled Multicentered Trial of Goal Directed Treatment of EVLW Versus Standard Management for the Treatment of Acute Lung Injury[NCT00624650]Phase 233 participants (Actual)Interventional2008-02-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

23 other studies available for antipyrine and Anoxemia

ArticleYear
Pre- and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats.
    ASN neuro, 2014, Volume: 6, Issue:6

    Topics: Animals; Animals, Newborn; Antipyrine; Apoptosis; CA1 Region, Hippocampal; Cell Death; Cells, Cultur

2014
[The pulmonary injury in rats caused by chronic intermittent hypoxia and the intervention effect of Edaravone].
    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2015, Volume: 29, Issue:19

    Topics: Angiotensin II; Animals; Antipyrine; Edaravone; Free Radical Scavengers; Hypoxia; Lung; Lung Injury;

2015
Expression of syndecan-2 in the amoeboid microglial cells and its involvement in inflammation in the hypoxic developing brain.
    Glia, 2009, Volume: 57, Issue:3

    Topics: Age Factors; Animals; Animals, Newborn; Antipyrine; Cell Movement; Cells, Cultured; Corpus Callosum;

2009
Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells.
    Neuroscience, 2009, Feb-18, Volume: 158, Issue:4

    Topics: Angiotensin II; Animals; Animals, Newborn; Antibodies; Antipyrine; Cell Hypoxia; Cells, Cultured; Co

2009
Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF.
    Journal of neurochemistry, 2009, Volume: 111, Issue:1

    Topics: Analysis of Variance; Animals; Antipyrine; Brain; Disease Models, Animal; Edaravone; Enzyme Inhibito

2009
Protective effects of MCI-186 on transplantation of bone marrow stromal cells in rat ischemic stroke model.
    Neuroscience, 2012, Oct-25, Volume: 223

    Topics: Analysis of Variance; Animals; Animals, Newborn; Antipyrine; Brain; Brain Infarction; Brain-Derived

2012
Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1

    Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cells, Cultured; Edaravone; Endoplasmic Reticulum; F

2004
Reactive oxygen species generated by mitochondrial injury in human brain microvessel endothelial cells.
    Clinical hemorheology and microcirculation, 2006, Volume: 34, Issue:1-2

    Topics: Antipyrine; Brain; Brain Ischemia; Cerebrovascular Circulation; Edaravone; Endothelium, Vascular; Fr

2006
[The effect of acute hypoxia on antipyrine and isoniazid pharmacokinetics in rats with different resistances to oxygen deficiency].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:7

    Topics: Acute Disease; Animals; Antipyrine; Atmosphere Exposure Chambers; Disease Susceptibility; Half-Life;

1993
Virtually unaltered permeability-surface area products imply little capillary recruitment in brain with hypoxia.
    Microcirculation (New York, N.Y. : 1994), 1994, Volume: 1, Issue:1

    Topics: 3-O-Methylglucose; Animals; Antipyrine; Autoradiography; Blood Flow Velocity; Blood-Brain Barrier; B

1994
[Activity of liver monooxygenase system in rats with low and high resistance to hypoxia].
    Biulleten' eksperimental'noi biologii i meditsiny, 1996, Volume: 122, Issue:9

    Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Cytochromes b5; Diazepam; Hypoxia; Male; Micros

1996
Contribution of hypoxia to the development of cardiomyopathy in hamsters.
    Cardiovascular research, 1997, Volume: 35, Issue:2

    Topics: Animals; Antipyrine; Autoradiography; Cardiomyopathy, Dilated; Cricetinae; Hypoxia; Iodine Radioisot

1997
[Antipyrine pharmacokinetics in rats with various resistance to hypoxia during cold stress].
    Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 126, Issue:11

    Topics: Acute Disease; Animals; Antipyrine; Cold Temperature; Hypoxia; Male; Rats; Rats, Wistar; Species Spe

1998
Urine antipyrine metabolites in rats with different resistance to hypoxia subjected to cold stress.
    Bulletin of experimental biology and medicine, 2001, Volume: 131, Issue:3

    Topics: Adaptation, Physiological; Animals; Antipyrine; Cold Temperature; Hypoxia; Male; Rats; Rats, Wistar;

2001
Local versus regional cerebral blood flow in the rat at high (hypoxia) and low (phenobarbital anesthesia) flow rates.
    Acta physiologica Scandinavica, 1979, Volume: 106, Issue:1

    Topics: Anesthesia, General; Animals; Antipyrine; Autoradiography; Carbon Radioisotopes; Cerebrovascular Cir

1979
Placental clearance of antipyrine and urea during hypoxia and adrenaline infusions in sheep [proceedings].
    The Journal of physiology, 1977, Volume: 271, Issue:2

    Topics: Animals; Antipyrine; Epinephrine; Female; Hypoxia; Placenta; Pregnancy; Sheep; Urea

1977
[Functional and metabolic changes of the mucosa during the occlusion of the small bowel of the rat (author's transl)].
    Langenbecks Archiv fur Chirurgie, 1975, Sep-10, Volume: 338, Issue:4

    Topics: Alkaline Phosphatase; Animals; Antipyrine; Aspartate Aminotransferases; Biological Transport; Glucos

1975
Blood flow redistribution during isocapnic hypoxia in foetal lamb.
    Acta physiologica Hungarica, 1988, Volume: 71, Issue:4

    Topics: Animals; Antipyrine; Blood Circulation; Carbon Dioxide; Female; Fetal Blood; Fetus; Hypoxia; Organ S

1988
Enhanced glucose metabolism and impaired placental function in hypoxic pregnant rats.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1988, Volume: 15, Issue:6

    Topics: Animals; Antipyrine; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Female; Fluorine Radioisot

1988
[Intestinal blood flow and absorption of drugs].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 260, Issue:2

    Topics: Aminopyrine; Aniline Compounds; Animals; Antipyrine; Biological Transport, Active; Carbon Isotopes;

1968
The independence of pulmonary shunting and pulmonary edema.
    Surgery, 1973, Volume: 74, Issue:2

    Topics: Antipyrine; Cardiac Catheterization; Cardiac Surgical Procedures; Chemotherapy, Cancer, Regional Per

1973
The transfer of free alpha-amino nitrogen across the placental membrane in the guinea-pig.
    The Journal of physiology, 1971, Volume: 214, Issue:3

    Topics: Amino Acids; Animals; Antimetabolites; Antipyrine; Biological Transport, Active; Cyanides; Female; G

1971
The influence of blood flow and hypoxia on free alpha-amino nitrogen transfer across the placental membrane.
    The Journal of physiology, 1970, Volume: 207, Issue:1

    Topics: Amines; Animals; Antipyrine; Biological Transport, Active; Blood Pressure; Female; Fetus; Guinea Pig

1970