Page last updated: 2024-10-22

antipyrine and Allergy, Drug

antipyrine has been researched along with Allergy, Drug in 32 studies

Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.

Research Excerpts

ExcerptRelevanceReference
"Controlled oral challenge with nonsteroidal anti-inflammatory drugs (NSAIDs) is the only definite way to detect safe NSAIDs in patients with NSAID-induced anaphylactoid reactions."2.71Safety of the new selective cyclooxygenase type 2 inhibitors rofecoxib and celecoxib in patients with anaphylactoid reactions to nonsteroidal anti-inflammatory drugs. ( Conde, J; Delgado, J; Florido, JF; López-Pascual, E; Nieto, MA; Ortega, N; Quiralte, J; Sáenz de San Pedro, B, 2004)
"Propyphenazone is a sensitizing agent in susceptible individuals and can elicit IgE-mediated anaphylaxis."1.32IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone. ( Bohle, B; Ebner, C; Ebner, H; Ferreira, F; Grubmayr, K; Himly, M; Jahn-Schmid, B; Pittertschatscher, K, 2003)
"Antipyrine is a pyrazole derivative used extensively as a marker for hepatic drug metabolizing enzyme activity."1.28Allergic reaction to antipyrine, a marker of hepatic enzyme activity. ( McCrea, JB; Rocci, ML; Vlasses, PH, 1989)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199026 (81.25)18.7374
1990's2 (6.25)18.2507
2000's3 (9.38)29.6817
2010's1 (3.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Steiner, M1
Harrer, A1
Lang, R1
Schneider, M1
Ferreira, T1
Hawranek, T1
Himly, M2
Jahn-Schmid, B1
Pittertschatscher, K1
Bohle, B1
Grubmayr, K1
Ferreira, F1
Ebner, H1
Ebner, C1
GHOSH, M1
TERZANI, A1
ROBINSON, HM1
ICHIMARU, M1
CHIBU, K1
Quiralte, J1
Delgado, J1
Sáenz de San Pedro, B1
López-Pascual, E1
Nieto, MA1
Ortega, N1
Florido, JF1
Conde, J1
Patanè, S1
Marte, F1
Di Bella, G1
Chiofalo, S1
Currò, A1
Coglitore, S1
Landwehr, AJ1
van Ketel, WG1
Kadar, D1
Kalow, W1
Rubio-Martínez, A1
García-Erce, JA1
Salvador, C1
Gómez-Arteta, E1
Gimeno, JJ1
Lochmann, O1
Benes, J1
Výmola, F1
Pokorný, J1
Perl, S1
Tabarelli-Poplawski, S1
Uehleke, H1
Naess, K1
Zhu, D1
Becker, WM1
Schulz, KH2
Schubeler, K1
Schlaak, M1
McCrea, JB1
Vlasses, PH1
Rocci, ML1
Brattig, NW1
Diao, GJ1
Berg, PA1
Mihatsch, MJ1
Kowalski, ML1
Rozniecki, J1
Ortuno, J1
Botella, J1
Trigger, DJ1
Vesell, ES1
Lüders, G1
Monro, P1
Kono, R1
Kogoj, F1
Samter, M1
Beers, RF1
Hartl, W1
Puxeddu, A1
Schmidt, P1
Tritsch, H1
Haustein, UF1

Reviews

2 reviews available for antipyrine and Allergy, Drug

ArticleYear
Recent progress in pharmacogenetics.
    Advances in pharmacology, 1969, Volume: 7

    Topics: Adult; Aged; Alcohol Oxidoreductases; Antipyrine; Asian People; Child, Preschool; Cholinesterases; C

1969
[Notes on fixed exanthemas].
    Medicinski glasnik, 1967, Volume: 21, Issue:12

    Topics: Antipyrine; Bromine; Drug Hypersensitivity; Exanthema; Humans; Quinine

1967

Trials

1 trial available for antipyrine and Allergy, Drug

ArticleYear
Safety of the new selective cyclooxygenase type 2 inhibitors rofecoxib and celecoxib in patients with anaphylactoid reactions to nonsteroidal anti-inflammatory drugs.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 93, Issue:4

    Topics: Adult; Aged; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Celecoxib; Cyclooxyge

2004

Other Studies

29 other studies available for antipyrine and Allergy, Drug

ArticleYear
Basophil activation test for investigation of IgE-mediated mechanisms in drug hypersensitivity.
    Journal of visualized experiments : JoVE, 2011, Sep-16, Issue:55

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Basophils; Chromatography, Gel; Chromatography,

2011
IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone.
    The Journal of allergy and clinical immunology, 2003, Volume: 111, Issue:4

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Drug Hypersensitivity; Enzym

2003
Side-effect of dichloralphenazone.
    British medical journal, 1963, Mar-02, Volume: 1, Issue:5330

    Topics: Antipyrine; Chloral Hydrate; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions;

1963
[DAMAGE FROM THERAPY].
    La Clinica terapeutica, 1963, Oct-15, Volume: 27

    Topics: Adrenal Cortex Hormones; Anemia; Anemia, Aplastic; Anticoagulants; Antipyrine; Blood Group Incompati

1963
DRUG ERUPTIONS.
    Journal of the Iowa Medical Society, 1964, Volume: 54

    Topics: Antipyrine; Barbiturates; Dermatitis, Contact; Drug Eruptions; Drug Hypersensitivity; Penicillins; P

1964
[CASE OF AGRANULOCYTOSIS SHOWING A LEUKEMOID REACTION DURING THE RECOVERY PHASE].
    Naika. Internal medicine, 1964, Volume: 14

    Topics: Adrenal Cortex Hormones; Agranulocytosis; Antipyrine; Blood; Bone Marrow Examination; Chloramphenico

1964
Acute myocardial infarction and Kounis syndrome.
    International journal of cardiology, 2009, May-15, Volume: 134, Issue:2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Drug Hypersensitivity; Female; Flavoxate;

2009
Delayed-type allergy to phenazone in a patient with erythema multiforme.
    Contact dermatitis, 1982, Volume: 8, Issue:4

    Topics: Adult; Antipyrine; Drug Hypersensitivity; Erythema Multiforme; Humans; Hypersensitivity, Delayed; Ma

1982
Acute and latent leukopenic reaction to antipyrine.
    Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:6

    Topics: Adult; Antipyrine; Drug Hypersensitivity; Humans; Hypersensitivity, Immediate; Leukopenia; Male; Tim

1980
Autoimmune haemolytic anaemia induced by propyphenazone.
    Vox sanguinis, 1998, Volume: 75, Issue:3

    Topics: Adult; Anemia, Hemolytic, Autoimmune; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoimmun

1998
Observation of antibody activity against antibiotics in patients with atopic disease.
    Journal of hygiene, epidemiology, microbiology, and immunology, 1978, Volume: 22, Issue:3

    Topics: Analgesics; Anti-Bacterial Agents; Antibodies; Antipyrine; Asthma; Drug Hypersensitivity; Hemaggluti

1978
Anaphylaxis after dichloralphenazone treatment.
    British medical journal, 1977, Nov-05, Volume: 2, Issue:6096

    Topics: Aged; Anaphylaxis; Antipyrine; Chloral Hydrate; Drug Combinations; Drug Hypersensitivity; Humans; Ma

1977
Irreversible binding of 3-14C-antipyrine to hepatic protein in vivo and in metabolizing liver microsomes.
    Naunyn-Schmiedeberg's archives of pharmacology, 1977, Volume: 297, Issue:1

    Topics: Agranulocytosis; Animals; Antipyrine; Drug Hypersensitivity; Hydroxylation; Liver; Male; Mice; Micro

1977
[Phenazone. Anaphylactic shock after peroral administration. Danger of cross allergy?].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1977, Aug-30, Volume: 97, Issue:24

    Topics: Administration, Oral; Antipyrine; Drug Hypersensitivity; Humans

1977
Detection of IgE antibodies specific for 1-phenyl-2,3-dimethyl-3-pyrazoline-5-one by RAST: a serological diagnostic method for sensitivity to pyrazoline drugs.
    Asian Pacific journal of allergy and immunology, 1992, Volume: 10, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Dipyrone; Drug Hypersensitivity; F

1992
Allergic reaction to antipyrine, a marker of hepatic enzyme activity.
    DICP : the annals of pharmacotherapy, 1989, Volume: 23, Issue:1

    Topics: Acute Disease; Adult; Antipyrine; Drug Hypersensitivity; Humans; Liver; Male

1989
The specificity of the lymphocyte transformation test in a patient with hypersensitivity reactions to pyrazolone compounds. A 10-week follow-up study before and after rechallenge.
    European journal of clinical pharmacology, 1988, Volume: 35, Issue:1

    Topics: Adult; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Concanavalin A; Drug Hypers

1988
Does pyrazolone-induced renal injury exist?
    Agents and actions. Supplements, 1986, Volume: 19

    Topics: Acute Kidney Injury; Aged; Aminopyrine; Analgesics; Animals; Antipyrine; Cats; Dose-Response Relatio

1986
[Development of aspirin tolerance in hypersensitive persons. I. Methods of development of tolerance, aspirin refraction time and cross tolerance to other drugs].
    Polskie Archiwum Medycyny Wewnetrznej, 1986, Volume: 75, Issue:1

    Topics: Antipyrine; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Tolerance; Humans; Indomet

1986
Recurrent acute renal failure induced by phenazone hypersensitivity.
    Lancet (London, England), 1973, Dec-29, Volume: 2, Issue:7844

    Topics: Acute Kidney Injury; Adult; Anaphylaxis; Antipyrine; Biopsy; Blood Urea Nitrogen; Drug Hypersensitiv

1973
Reaction after dichloralphenazone.
    Lancet (London, England), 1967, Jan-14, Volume: 1, Issue:7481

    Topics: Antipyrine; Chloral Hydrate; Drug Hypersensitivity; Humans

1967
[Pathogenesis of drug allergic reactions on the skin].
    Archiv fur klinische und experimentelle Dermatologie, 1970, Volume: 237, Issue:1

    Topics: Antipyrine; Arteritis; Capillaries; Drug Eruptions; Drug Hypersensitivity; gamma-Globulins; Humans;

1970
Iatrogenic encephalopathy.
    Postgraduate medical journal, 1970, Volume: 46, Issue:535

    Topics: Adult; Antipyrine; Brain Diseases; Chloral Hydrate; Chlorine; Chlorpromazine; Dermatitis, Exfoliativ

1970
[Autopsy findings of anaphylactic shock and poisoning by the use of pyrazolone derivatives].
    Rinsho byori. The Japanese journal of clinical pathology, 1973, Volume: 21, Issue:5

    Topics: Adolescent; Adult; Aged; Aminopyrine; Anaphylaxis; Antipyrine; Autopsy; Child; Child, Preschool; Dru

1973
Concerning the nature of intolerance to aspirin.
    The Journal of allergy, 1967, Volume: 40, Issue:5

    Topics: Aminopyrine; Antipyrine; Aspirin; Asthma; Chemoreceptor Cells; Drug Hypersensitivity; Edema; Histami

1967
[On the problem of specificity of drug-allergic immune reactions by aminophenazone-containing antirheumatic aents].
    Klinische Wochenschrift, 1966, Jan-01, Volume: 44, Issue:1

    Topics: Aminopyrine; Animals; Antigen-Antibody Reactions; Antipyrine; Complement Fixation Tests; Drug Hypers

1966
[Fixed exanthema due to 3 different drugs with separate localization. Contribution to the problem of barbiturate allergy].
    Zeitschrift fur Haut- und Geschlechtskrankheiten, 1967, Jul-15, Volume: 42, Issue:14

    Topics: Antipyrine; Barbiturates; Drug Hypersensitivity; Exanthema; Female; Humans; Middle Aged; Phenobarbit

1967
[Histological picture report No. 203. Lyell syndrome].
    Zeitschrift fur Haut- und Geschlechtskrankheiten, 1968, Apr-15, Volume: 43, Issue:8

    Topics: Antipyrine; Child, Preschool; Drug Hypersensitivity; Female; Humans; Infant; Penicillins; Phenolphth

1968
[A fixed drug exanthema simulating the clinical picture of erythema exsudativum multiforme majus].
    Allergie und Asthma, 1965, Volume: 11, Issue:6

    Topics: Adult; Aminopyrine; Antipyrine; Diagnosis, Differential; Drug Hypersensitivity; Exanthema; Female; H

1965