antipyrine has been researched along with Aging in 62 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of aging on the metabolism of antipyrine (AP) and hexobarbital enantiomers (R-HB and S-HB) with and without phenobarbital (PB) induction was investigated in a longitudinal study in rats aged 6, 12, 24 and 30 months." | 7.69 | The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study. ( Breimer, DD; Groen, K; Jansen, EJ; van Bezooijen, CF, 1994) |
| "Our objective was to determine the effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of the anti-HIV drug zalcitabine (2',3'-dideoxycytidine; ddC) in the pigtailed macaque (Macaca nemestrina)." | 7.69 | Effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of zalcitabine (2', 3'-dideoxycytidine) in the pigtailed macaque (Macaca nemestrina). ( Nosbisch, C; Tuntland, T; Unadkat, JD, 1997) |
| "Antipyrine (1 g) was administered orally and ClAP was determined by the one-sample saliva method." | 5.29 | Effects of aging on antipyrine clearance: predictive factors of metabolizing capacity. ( Almar, MM; González-Gallego, J; González-Sastre, M; Jorquera, F; Pozuelo, M; Sansegundo, D, 1995) |
| " administration of the beta blockers, no significant increase in area under the plasma drug concentration-time curve was observed for propranolol and metoprolol as a function of age, but for atenolol, a significant increase in area under the plasma drug concentration-time curve was seen in the 24-month-old rats, due to a decrease in renal function, as bioavailability of atenolol did not change in function of age." | 5.28 | Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. ( Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ, 1990) |
| "The findings suggest that aging leads to altered disposition of antipyrine in both males and females and that the main metabolic pathways of the compound are not different in the elderly." | 3.70 | The effect of age and sex on metabolism and urinary excretion of antipyrine. ( Almar, M; González-Gallego, J; González-Sastre, M; Jorquera, F; Pozuelo, M; Sansegundo, D, 1998) |
| " The extent of cerebral ischemia during BCO was evaluated with [14C]iodoantipyrine autoradiography." | 3.69 | Resistance to cerebral ischemia in developing gerbils. ( Arai, H; Kusumoto, M; Mori, K; Sato, K, 1995) |
| "Our objective was to determine the effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of the anti-HIV drug zalcitabine (2',3'-dideoxycytidine; ddC) in the pigtailed macaque (Macaca nemestrina)." | 3.69 | Effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of zalcitabine (2', 3'-dideoxycytidine) in the pigtailed macaque (Macaca nemestrina). ( Nosbisch, C; Tuntland, T; Unadkat, JD, 1997) |
| "The influence of aging on the metabolism of phenazone (antipyrine), and the relationship between the formation of 3 phenazone metabolites and the metabolic clearance of theophylline in healthy and frail elderly women, were examined." | 3.68 | The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women. ( Breimer, DD; Groen, K; Gulati, RS; Horan, MA; Jansen, EJ; Miljkovic, B; Paramsothy, V; Roberts, NA; van Bezooijen, CF, 1993) |
| "Antipyrine was administered intravenously to young and adult female camels when water was available ad libitum and to the adult camels after 14 days of dehydration." | 2.68 | Antipyrine disposition in the dehydrated camel. ( Ben-Zvi, Z; Rubin, M; Van Creveld, C; Yagil, R, 1995) |
| "Antipyrine kinetics was studied in 93 elderly (mean age 82 years) and 23 young (mean age 29 years) volunteers." | 2.68 | Assessment of antipyrine kinetics from saliva or plasma: influence of age. ( Almar, MM; González-Gallego, J; González-Sastre, M; Jimeno, A; Jorquera, F, 1995) |
| "Antipyrine was administered orally and pharmacokinetic parameters were obtained from saliva and urine samples." | 1.31 | Physical exercise and improvement of liver oxidative metabolism in the elderly. ( García-López, J; González-Gallego, J; Jorquera, F; Mauriz, JL; Tabernero, B; Villa, JG, 2000) |
| " The first three months of life were characterised by a steady decrease in the apparent volume of distribution (aVd) and half-life (t0." | 1.29 | Effect of age on the pharmacokinetics of antipyrine in calves. ( Janus, K; Suszycka, J, 1996) |
| "At 24 h, hyperemia was observed (vs." | 1.29 | Posttraumatic hyperemia in immature, mature, and aged rats: autoradiographic determination of cerebral blood flow. ( Biagas, KV; Grundl, PD; Kochanek, PM; Nemoto, EM; Schiding, JK, 1996) |
| "Antipyrine (1 g) was administered orally and pharmacokinetic parameters were determined by the one-sample (24 h) and multiple-sample (3, 6, 9, 12 and 24 h) methods." | 1.29 | Accuracy of the one-sample method for determination of antipyrine clearance in elderly subjects. ( Almar, MM; González-Gallego, J; González-Sastre, M; Jorquera, F; Suarez, I, 1996) |
| " Pharmacokinetic variable values in elderly subjects did not differ in a clinically significant manner from those in younger subjects." | 1.28 | Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam. ( Karim, A; Nicholson, PA; Smith, M, 1990) |
| " administration of the beta blockers, no significant increase in area under the plasma drug concentration-time curve was observed for propranolol and metoprolol as a function of age, but for atenolol, a significant increase in area under the plasma drug concentration-time curve was seen in the 24-month-old rats, due to a decrease in renal function, as bioavailability of atenolol did not change in function of age." | 1.28 | Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. ( Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ, 1990) |
| " Absolute bioavailability of oral chlordiazepoxide was not less than 100%, and was unrelated to age or sex." | 1.28 | Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition. ( Abernethy, DR; Divoll, MK; Greenblatt, DJ; Harmatz, JS; Ochs, HR; Shader, RI, 1989) |
| " Mean triazolam elimination half-life was not significantly different between young and elderly men (3." | 1.27 | Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity. ( Abernethy, DR; Divoll, M; Greenblatt, DJ; Moschitto, LJ; Shader, RI; Smith, RB, 1983) |
| " The knowledge of pharmacokinetics give essential informations for the development of new pharmaceutical forms, adjustment of dosage regimen and recommendations for drug intake in order to minimize the variations in bioavailability and to improve compliance." | 1.27 | [Pharmacokinetics: a contribution in clinical geriatric pharmacology?]. ( Humbert, H; Kiechel, JR; Lavène, D, 1983) |
| " Absolute bioavailability was not significantly less than 100% and was not related to age." | 1.27 | Antipyrine absorption and disposition in the elderly. ( Divoll, MK; Greenblatt, DJ; Harmatz, JS; Shader, RI, 1988) |
| " 5 The findings suggest that there is a selective impairment of N-demethylation in the elderly which may have important implications for dosage of elderly patients with drugs metabolised by this route." | 1.27 | The disposition of antipyrine and its metabolites in young and elderly healthy volunteers. ( Breimer, DD; Danhof, M; Posner, J; Teunissen, MW; Whiteman, PD, 1987) |
| "The antipyrine half-life was 38." | 1.27 | Cirrhosis of the liver markedly impairs the elimination of mexiletine. ( Halinen, MO; Hietakorpi, S; Lampinen, LM; Pentikäinen, PJ, 1986) |
| "The antipyrine half-life was prolonged in 4 patients." | 1.26 | Antipyrine metabolism and liver function in patients treated with high-dose medroxyprogesterone. ( Kauppila, AJ; Rautio, A; Sotaniemi, EA; Tuimala, RJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (50.00) | 18.7374 |
| 1990's | 22 (35.48) | 18.2507 |
| 2000's | 7 (11.29) | 29.6817 |
| 2010's | 2 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, CY | 1 |
| Zha, H | 1 |
| Xia, QQ | 1 |
| Yuan, Y | 1 |
| Liang, XY | 1 |
| Li, JH | 1 |
| Guo, ZY | 1 |
| Li, JJ | 1 |
| Koyanagi, T | 1 |
| Yamaura, Y | 1 |
| Yano, K | 1 |
| Kim, S | 1 |
| Yamazaki, H | 1 |
| Adam, D | 1 |
| Federspil, P | 1 |
| Lukes, M | 1 |
| Petrowicz, O | 1 |
| SCHWAB, M | 1 |
| DISSMANN, W | 1 |
| DISSMANN, T | 1 |
| SCHUBERT, W | 1 |
| Wen, J | 2 |
| Watanabe, K | 2 |
| Ma, M | 2 |
| Yamaguchi, K | 1 |
| Tachikawa, H | 1 |
| Kodama, M | 2 |
| Aizawa, Y | 2 |
| Schneider, AR | 1 |
| Teuber, G | 1 |
| Paul, K | 1 |
| Nikodem, A | 1 |
| Duesterhoeft, M | 1 |
| Caspary, WF | 1 |
| Stein, J | 1 |
| Greenblatt, DJ | 6 |
| Divoll, M | 3 |
| Abernethy, DR | 5 |
| Moschitto, LJ | 1 |
| Smith, RB | 1 |
| Shader, RI | 6 |
| Kiechel, JR | 1 |
| Lavène, D | 1 |
| Humbert, H | 1 |
| Rapin, JR | 1 |
| Le Poncin-Lafitte, M | 1 |
| Lespinasse, P | 1 |
| Ochs, HR | 3 |
| Pfeifer, S | 1 |
| Feely, J | 1 |
| Pereira, L | 1 |
| Guy, E | 1 |
| Hockings, N | 1 |
| Wootton, R | 1 |
| Flecknell, PA | 1 |
| Royston, JP | 1 |
| John, M | 1 |
| Harmatz, JS | 4 |
| Danhof, M | 2 |
| Idle, JR | 1 |
| Teunissen, MW | 2 |
| Sloan, TP | 1 |
| Breimer, DD | 5 |
| Smith, RL | 1 |
| Mucklow, JC | 1 |
| Fraser, HS | 1 |
| Groen, K | 3 |
| Brouwer, A | 1 |
| Schijff, G | 1 |
| Jansen, EJ | 3 |
| van Bezooijen, CF | 5 |
| Ben-Zvi, Z | 1 |
| Rubin, M | 1 |
| Van Creveld, C | 1 |
| Yagil, R | 1 |
| Kusumoto, M | 1 |
| Arai, H | 1 |
| Mori, K | 1 |
| Sato, K | 1 |
| Grundl, PD | 2 |
| Biagas, KV | 2 |
| Kochanek, PM | 2 |
| Schiding, JK | 2 |
| Barmada, MA | 1 |
| Nemoto, EM | 2 |
| Horan, MA | 1 |
| Roberts, NA | 1 |
| Gulati, RS | 1 |
| Miljkovic, B | 1 |
| Paramsothy, V | 1 |
| Jorquera, F | 5 |
| Almar, MM | 3 |
| Jimeno, A | 1 |
| González-Sastre, M | 4 |
| González-Gallego, J | 5 |
| Janus, K | 1 |
| Suszycka, J | 1 |
| Pozuelo, M | 2 |
| Sansegundo, D | 2 |
| Suarez, I | 1 |
| Sotaniemi, EA | 2 |
| Arranto, AJ | 1 |
| Pelkonen, O | 1 |
| Pasanen, M | 1 |
| Lindahl, A | 1 |
| Krondahl, E | 1 |
| Grudén, AC | 1 |
| Ungell, AL | 1 |
| Lennernäs, H | 1 |
| Tuntland, T | 1 |
| Nosbisch, C | 1 |
| Unadkat, JD | 1 |
| Almar, M | 1 |
| Klawuhn, D | 1 |
| Staufenbiel, R | 1 |
| Mauriz, JL | 1 |
| Tabernero, B | 1 |
| García-López, J | 1 |
| Villa, JG | 1 |
| Meijer, EP | 2 |
| Coolen, SA | 2 |
| Bast, A | 2 |
| Westerterp, KR | 2 |
| Richey, DP | 1 |
| Bender, AD | 1 |
| Stevenson, IH | 2 |
| Wood, AJ | 1 |
| Vestal, RE | 3 |
| Wilkinson, GR | 1 |
| Branch, RA | 1 |
| Shand, DG | 1 |
| Rautio, A | 1 |
| Kauppila, AJ | 1 |
| Tuimala, RJ | 1 |
| Norris, AH | 1 |
| Tobin, JD | 1 |
| Cohen, BH | 1 |
| Shock, NW | 1 |
| Andres, R | 1 |
| Clarke, CR | 1 |
| Lochner, FK | 1 |
| Bellamy, J | 1 |
| Waite, NM | 1 |
| Rybak, MJ | 1 |
| Krakovsky, DJ | 1 |
| Steinberg, JD | 1 |
| Warbasse, LH | 1 |
| Edwards, DJ | 1 |
| Nicholson, PA | 1 |
| Karim, A | 1 |
| Smith, M | 1 |
| Jakobsen, J | 1 |
| Nedergaard, M | 1 |
| Aarslew-Jensen, M | 1 |
| Diemer, NH | 1 |
| Van Geel, CA | 1 |
| Belpaire, FM | 1 |
| de Smet, F | 1 |
| Vynckier, LJ | 1 |
| Vermeulen, AM | 1 |
| Rosseel, MT | 1 |
| Bogaert, MG | 1 |
| Chauvelot-Moachon, L | 1 |
| Divoll, MK | 2 |
| Nehlig, A | 1 |
| Pereira de Vasconcelos, A | 1 |
| Boyet, S | 1 |
| Fischer-Nielsen, A | 1 |
| Poulsen, HE | 1 |
| Hansen, BA | 1 |
| Tygstrup, N | 1 |
| Keiding, S | 1 |
| Henderson, DJ | 1 |
| Posner, J | 1 |
| Whiteman, PD | 1 |
| Pentikäinen, PJ | 1 |
| Hietakorpi, S | 1 |
| Halinen, MO | 1 |
| Lampinen, LM | 1 |
| Locniskar, A | 1 |
| Petrin, A | 1 |
| Hospador, MA | 1 |
| Grosso, LS | 1 |
| Manthei, RW | 1 |
| Kennedy, C | 1 |
| Grave, GD | 1 |
| Juhle, JW | 1 |
| Sokoloff, L | 1 |
| O'Malley, K | 1 |
| Crooks, J | 1 |
| Lehrer, GM | 1 |
| Bornstein, MB | 1 |
| Klinger, W | 1 |
| Kusch, T | 1 |
| Neugebauer, A | 1 |
| Splinter, FK | 1 |
| Ankermann, H | 1 |
3 reviews available for antipyrine and Aging
| Article | Year |
|---|---|
Pharmacokinetic consequences of aging.
Topics: Adult; Aged; Aging; Aminopyrine; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agent | 1977 |
Factors influencing antipyrine elimination.
Topics: Aging; Anemia, Hypochromic; Antipyrine; Chemical Phenomena; Chemistry; Drug Interactions; Half-Life; | 1977 |
Aging and determinants of hepatic drug clearance.
Topics: Adult; Aged; Aging; Animals; Antipyrine; Female; Humans; Liver; Liver Circulation; Male; Middle Aged | 1989 |
5 trials available for antipyrine and Aging
| Article | Year |
|---|---|
Therapeutic properties and tolerance of procaine and phenazone containing ear drops in infants and very young children.
Topics: Aging; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Child; Child, Presch | 2009 |
Patient age is a strong independent predictor of 13C-aminopyrine breath test results: a comparative study with histology, duplex-Doppler and a laboratory index in patients with chronic hepatitis C virus infection.
Topics: Adult; Aged; Aging; Antipyrine; Aspartate Aminotransferases; Breath Tests; Female; Hepatitis C, Chro | 2006 |
Antipyrine disposition in the dehydrated camel.
Topics: Aging; Animals; Antipyrine; Camelus; Chromatography, High Pressure Liquid; Cross-Over Studies; Dehyd | 1995 |
Assessment of antipyrine kinetics from saliva or plasma: influence of age.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antip | 1995 |
Influence of subject age on the inhibition of oxidative metabolism by ciprofloxacin.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antipyrine; Ciprofloxacin; Edaravone; Female; Humans; Male; O | 1991 |
54 other studies available for antipyrine and Aging
| Article | Year |
|---|---|
Expression of angiotensin II and its receptors in activated microglia in experimentally induced cerebral ischemia in the adult rats.
Topics: Aging; Angiotensin II; Animals; Antipyrine; Blotting, Western; Brain Ischemia; Cerebral Cortex; Edar | 2013 |
Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
Topics: Acetaminophen; Age Factors; Aging; Albumins; Animals; Antipyrine; Blood Proteins; Diazepam; Diphenhy | 2014 |
[EFFECT OF AGE ON THE BODY FLUID SPACE].
Topics: Adolescent; Aging; Antipyrine; Body Fluids; Bromides; Geriatrics; Physiology | 1963 |
Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats.
Topics: Aging; Animals; Antioxidants; Antipyrine; Blotting, Western; Brain; Cerebral Infarction; Edaravone; | 2006 |
Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury.
Topics: Aging; Animals; Antipyrine; Apoptosis; Blotting, Western; Brain Ischemia; Cell Survival; Disease Mod | 2007 |
Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity.
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Antipyrine; Female; Half-Life; Humans; Kinetics; Liver; Mal | 1983 |
[Pharmacokinetics: a contribution in clinical geriatric pharmacology?].
Topics: Administration, Oral; Adult; Aged; Aging; Antipyrine; Dihydroergotoxine; Female; Geriatrics; Humans; | 1983 |
Simultaneous study of cerebral blood flow, vascular bed and deoxyglucose in aged rats. Effects of two dihydrogenated rye ergot alkaloids.
Topics: Aging; Animals; Antipyrine; Carbon Radioisotopes; Carotid Arteries; Cerebral Cortex; Deoxy Sugars; D | 1984 |
Antipyretic analgesic drugs as models for studies of drug disposition in old age.
Topics: Acetaminophen; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Biotransformation; | 1983 |
[Drugs and organisms (III)--Effect of age on pharmacokinetic parameters and biotransformation].
Topics: Adult; Aging; Antipyrine; Biotransformation; Child; Creatinine; Female; Humans; Infant; Infant, Newb | 1983 |
Factors affecting the response to inhibition of drug metabolism by cimetidine--dose response and sensitivity of elderly and induced subjects.
Topics: Adult; Aged; Aging; Antipyrine; Cimetidine; Dose-Response Relationship, Drug; Female; Humans; Male; | 1984 |
The tissue-blood partition coefficient of iodoantipyrine in pig brain and its change with age.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Antipyrine; Brain; Swine | 1983 |
Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity.
Topics: Adult; Aged; Aging; Antipyrine; Benzodiazepines; Female; Half-Life; Humans; Kinetics; Male; Middle A | 1982 |
Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation.
Topics: Aging; Antipyrine; Body Weight; Debrisoquin; Female; Half-Life; Humans; Hydroxylation; Isoquinolines | 1981 |
The effects of age and smoking upon antipyrine metabolism.
Topics: Adolescent; Adult; Aging; Antipyrine; Female; Humans; Male; Middle Aged; Sex Factors; Smoking | 1980 |
The influence of dietary restriction on the metabolism of theophylline and antipyrine in the ageing female BN/BiRij rat.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Energy Intake; Female; Rats; Theophyllin | 1995 |
Resistance to cerebral ischemia in developing gerbils.
Topics: Aging; Animals; Antipyrine; Body Temperature; Brain; Brain Ischemia; Cell Death; Cerebrovascular Cir | 1995 |
Early cerebrovascular response to head injury in immature and mature rats.
Topics: Aging; Animals; Antipyrine; Blood Pressure; Body Temperature; Body Water; Brain; Brain Chemistry; Ce | 1994 |
The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Longitud | 1994 |
The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antipyrine; Chromatography, High Pressure Liquid; Female; Fra | 1993 |
Effect of age on the pharmacokinetics of antipyrine in calves.
Topics: Aging; Animals; Antipyrine; Cattle; Edaravone; Female; Half-Life; Metabolic Clearance Rate; Time Fac | 1996 |
Effects of aging on antipyrine clearance: predictive factors of metabolizing capacity.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Body Hei | 1995 |
Posttraumatic hyperemia in immature, mature, and aged rats: autoradiographic determination of cerebral blood flow.
Topics: Adult; Aging; Animals; Antipyrine; Autoradiography; Brain; Brain Injuries; Carbon Radioisotopes; Cer | 1996 |
Accuracy of the one-sample method for determination of antipyrine clearance in elderly subjects.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antip | 1996 |
Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions.
Topics: Adult; Aged; Aging; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area | 1997 |
Is the jejunal permeability in rats age-dependent?
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Atenolol; Glucose; Jejunum; Mal | 1997 |
Effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of zalcitabine (2', 3'-dideoxycytidine) in the pigtailed macaque (Macaca nemestrina).
Topics: Aging; Animals; Animals, Newborn; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyri | 1997 |
The effect of age and sex on metabolism and urinary excretion of antipyrine.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal | 1998 |
[Estimation of body composition based on total body water determination using phenazone for assessment of body fat gain in cattle. 2. Relationship between body fat content and back fat thickness].
Topics: Adipose Tissue; Aging; Animals; Antipyrine; Body Composition; Body Water; Cattle; Female; Male; Regr | 1998 |
Physical exercise and improvement of liver oxidative metabolism in the elderly.
Topics: Aged; Aging; Antipyrine; Female; Half-Life; Humans; Kidney; Liver; Middle Aged; Oxidation-Reduction; | 2000 |
Exercise training and oxidative stress in the elderly as measured by antipyrine hydroxylation products.
Topics: Aging; Antipyrine; Chromatography, High Pressure Liquid; Exercise; Female; Gas Chromatography-Mass S | 2001 |
Exercise-induced oxidative stress in older adults as measured by antipyrine oxidation.
Topics: Aging; Antipyrine; Bicycling; Exercise; Female; Free Radicals; Humans; Hydroxylation; Male; Malondia | 2001 |
Effect of aging and cigarette smoking on antipyrine and indocyanine green elimination.
Topics: Adult; Aged; Aging; Alcohol Drinking; Antipyrine; Coffee; Half-Life; Humans; Indocyanine Green; Live | 1979 |
Antipyrine metabolism and liver function in patients treated with high-dose medroxyprogesterone.
Topics: Adult; Aged; Aging; Antipyrine; Female; Half-Life; Humans; Liver; Liver Function Tests; Medroxyproge | 1979 |
Antipyrine metabolism in man: influence of age, alcohol, caffeine, and smoking.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Alcohol Drinking; Antipyrine; Body Water; Caffeine; Cof | 1975 |
Pharmacokinetics of gentamicin and antipyrine in the horse--effect of advancing age.
Topics: Aging; Animals; Antipyrine; Gentamicins; Horses | 1992 |
Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam.
Topics: Adult; Aged; Aging; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diazepam; Drug | 1990 |
Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats.
Topics: Aging; Animals; Antipyrine; Autoradiography; Brain; Carbon Radioisotopes; Cerebrovascular Circulatio | 1990 |
The effect of age on the oxidative metabolism of antipyrine by uninduced microsomal fractions of rat liver.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Edaravone; In Vitro Techniques; Isoenzym | 1990 |
Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat.
Topics: Aging; Animals; Antipyrine; Atenolol; Male; Metabolic Clearance Rate; Metoprolol; Orosomucoid; Propr | 1990 |
Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition.
Topics: Adult; Aging; Antipyrine; Body Weight; Chlordiazepoxide; Female; Half-Life; Humans; Injections, Intr | 1989 |
Postnatal changes in local cerebral blood flow measured by the quantitative autoradiographic [14C]iodoantipyrine technique in freely moving rats.
Topics: Aging; Animals; Animals, Newborn; Antipyrine; Autoradiography; Carbon Radioisotopes; Cerebrovascular | 1989 |
Age dependence of rat liver function measurements.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Galactose; Glutathione; Liver; Male; Rat | 1989 |
The effect of age on antipyrine metabolism by liver microsomes isolated from phenobarbital-treated rats.
Topics: Aging; Animals; Antipyrine; Male; Microsomes, Liver; Phenobarbital; Rats | 1989 |
Antipyrine absorption and disposition in the elderly.
Topics: Adult; Aged; Aging; Antipyrine; Female; Food; Half-Life; Humans; Intestinal Absorption; Male | 1988 |
The disposition of antipyrine and its metabolites in young and elderly healthy volunteers.
Topics: Adult; Aged; Aging; Antipyrine; Biotransformation; Female; Half-Life; Humans; Kinetics; Male; Saliva | 1987 |
Cirrhosis of the liver markedly impairs the elimination of mexiletine.
Topics: Adult; Aging; Antipyrine; Blood Proteins; Humans; Injections, Intravenous; Kinetics; Liver Cirrhosis | 1986 |
Age, sex, and nitrazepam kinetics: relation to antipyrine disposition.
Topics: Administration, Oral; Adult; Aged; Aging; Antipyrine; Blood Proteins; Chromatography, Gas; Female; H | 1985 |
[Pharmacokinetics of drugs in the elderly].
Topics: Adult; Age Factors; Aged; Aging; Antipyrine; Digoxin; Dihydrostreptomycin Sulfate; Glomerular Filtra | 1974 |
Influence of age and diet on the induction of microsomal enzymes in the mouse.
Topics: Aging; Animals; Antipyrine; Benzopyrenes; Biotransformation; Caseins; Cytochromes; Dietary Proteins; | 1971 |
Changes in blood flow in the component structures of the dog brain during postnatal maturation.
Topics: Aging; Animals; Antipyrine; Blood Pressure; Brain; Carbon Dioxide; Carbon Isotopes; Cerebrovascular | 1972 |
Drug metabolism in a geriatric population.
Topics: Adult; Aged; Aging; Antipyrine; Half-Life; Humans; Phenylbutazone | 1971 |
Glucose metabolism in rat cerebellum tissue cultures as a functioion of age.
Topics: Aging; Animals; Antipyrine; Cerebellum; Culture Techniques; Glucose; Lactates; Methods; Rats; Time F | 1968 |
[Studies of the mechanism of enzyme induction. XIV. Effect of age on the activity and inducibility of phenazone hydroxylases, aminophenazone-N-demethylase, codeine-O-demethylase and nitroreductase of the rat liver].
Topics: Age Factors; Aging; Aminopyrine; Animals; Animals, Newborn; Antipyrine; Barbiturates; Codeine; Enzym | 1968 |