antipyrine has been researched along with Adrenal Hyperplasia, Congenital in 2 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Antipyrine (AP) metabolism was studied in four adult patients with congenital adrenal hyperplasia (CAH) due to classical 21-hydroxylase deficiency and in four (adult) patients with CAH due to non-classical 21-hydroxylase deficiency." | 7.67 | Antipyrine clearance in congenital adrenal hyperplasia. ( Conney, AH; Loche, S; New, MI; Rifkind, AB; Stoner, E, 1986) |
| "Antipyrine salivary clearance and half-life and the rate of formation of three principal metabolites of antipyrine (4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine) were assessed in nine children with congenital adrenal hyperplasia, six of whom were salt-losers and three of whom were non-salt-losers." | 7.67 | Antipyrine clearance and metabolite formation in children with congenital adrenal hyperplasia. ( Breimer, DD; Bruining, GJ; De Jongh, BM; Tenkate-Westerhof, EW; Teunissen, MW, 1985) |
| "Antipyrine (AP) metabolism was studied in four adult patients with congenital adrenal hyperplasia (CAH) due to classical 21-hydroxylase deficiency and in four (adult) patients with CAH due to non-classical 21-hydroxylase deficiency." | 3.67 | Antipyrine clearance in congenital adrenal hyperplasia. ( Conney, AH; Loche, S; New, MI; Rifkind, AB; Stoner, E, 1986) |
| "Antipyrine salivary clearance and half-life and the rate of formation of three principal metabolites of antipyrine (4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine) were assessed in nine children with congenital adrenal hyperplasia, six of whom were salt-losers and three of whom were non-salt-losers." | 3.67 | Antipyrine clearance and metabolite formation in children with congenital adrenal hyperplasia. ( Breimer, DD; Bruining, GJ; De Jongh, BM; Tenkate-Westerhof, EW; Teunissen, MW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loche, S | 1 |
| Rifkind, AB | 1 |
| Stoner, E | 1 |
| Conney, AH | 1 |
| New, MI | 1 |
| Teunissen, MW | 1 |
| Bruining, GJ | 1 |
| De Jongh, BM | 1 |
| Tenkate-Westerhof, EW | 1 |
| Breimer, DD | 1 |
2 other studies available for antipyrine and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Antipyrine clearance in congenital adrenal hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; Antipyrine; Half-Life; Humans; Liver; Metabolic Clearance Rate | 1986 |
Antipyrine clearance and metabolite formation in children with congenital adrenal hyperplasia.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Antipyrine; Biotransformation; Child; Cytochrome P-450 | 1985 |