antipyrine has been researched along with Addison Disease in 2 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Addison Disease: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The metabolic clearance rate (MCR) and plasma half-life of this material were measured before and after 6 days of rifampicin treatment (600 mg/day) in seven patients with Addison's disease due to tuberculosis." | 5.27 | Pharmacokinetics of aldosterone in patients with Addison's disease: effect of rifampicin treatment on glucocorticoid and mineralocorticoid metabolism. ( Benker, G; Mönig, H; Ohnhaus, EE; Pagel, H; Reinwein, D; Schulte, HM, 1987) |
| " The metabolic clearance rate (MCR) and plasma half-life of this material were measured before and after 6 days of rifampicin treatment (600 mg/day) in seven patients with Addison's disease due to tuberculosis." | 1.27 | Pharmacokinetics of aldosterone in patients with Addison's disease: effect of rifampicin treatment on glucocorticoid and mineralocorticoid metabolism. ( Benker, G; Mönig, H; Ohnhaus, EE; Pagel, H; Reinwein, D; Schulte, HM, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bouchard, P | 1 |
| Kuttenn, F | 1 |
| Nahoul, K | 1 |
| Mavier, P | 1 |
| Schaison, G | 1 |
| Mauvais-Jarvis, P | 1 |
| Schulte, HM | 1 |
| Mönig, H | 1 |
| Benker, G | 1 |
| Pagel, H | 1 |
| Reinwein, D | 1 |
| Ohnhaus, EE | 1 |
2 other studies available for antipyrine and Addison Disease
| Article | Year |
|---|---|
[Deviation in cortisol metabolism induced by rifampicin. Therapeutic consequences in adrenal failure (author's transl)].
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adult; Aged; Antipyrine; Enzyme Ind | 1979 |
Pharmacokinetics of aldosterone in patients with Addison's disease: effect of rifampicin treatment on glucocorticoid and mineralocorticoid metabolism.
Topics: Addison Disease; Adult; Aldosterone; Antipyrine; Female; Humans; Hydrocortisone; Male; Middle Aged; | 1987 |