antipyrine has been researched along with Acute Liver Injury, Drug-Induced in 38 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Salivary antipyrine clearance was measured in 15 patients with psoriasis receiving methotrexate and related to liver biopsy changes and routine liver function tests, to determine whether antipyrine clearance could be used as a non-invasive method for monitoring liver function." | 3.67 | The use of antipyrine clearance to measure liver damage in psoriatic patients receiving methotrexate. ( Collins, M; Lawrence, CM; Paramsothy, J; Sharif, H; Shaw, P; Strange, R, 1988) |
| "In 33 patients with acute hepatic encephalopathy due to toxic or viral hepatitis the following analyses were performed: (24-14C)cholic acid conjugation and sulfation, plasma phenazone clearance, galactose elimination capacity, and concentrations of glycocholic acid and glycolithocholic acid sulfate in plasma." | 3.66 | Cholic acid conjugation test and quantitative liver function in acute liver failure. ( Andreasen, PB; Bahnsen, M; Bremmelgaard, A; Christensen, E; Ranek, L, 1983) |
| "Drug-metabolizing capacity has been assessed by serial measurements of the plasma antipyrine half life in 11 patients with severe barbiturate intoxication and in 17 patients with acute hepatic necrosis due to paracetamol overdosage." | 3.65 | Abnormal drug metabolism after barbiturate and paracetamol overdose. ( Forrest, JA; Prescott, LF; Roscoe, P; Stevenson, IH, 1974) |
| "Edaravone was injected into mice 30 min before and 4 h after GalN/LPS injection." | 1.40 | Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines. ( Deng, XM; Du, YX; Yu, QH; Zong, L, 2014) |
| "When antipyrine was administered to the intragastric group, a reduction of total body clearances and an increase in half-lives and areas under the curve were observed in relation to a reduction of oxidation capacities." | 1.29 | Assessment of hepatic insufficiency model in the rabbit using carbon tetrachloride intoxication. ( Alvinerie, M; Delrat, P; Dupin, S; Galtier, P; Houin, G; Saivin, S; Tufenkji, AE; Voigt, JJ, 1994) |
| "Antipyrine metabolism was normal or marginally impaired in patients with compensated cirrhosis or acute hepatitis, whereas it was frequently abnormal in those with chronic active hepatitis or advanced alcoholic liver disease." | 1.26 | Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism. ( Cooksley, WG; Farrell, GC; Hart, P; Powell, LW, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (63.16) | 18.7374 |
| 1990's | 7 (18.42) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 4 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Zong, L | 1 |
| Yu, QH | 1 |
| Du, YX | 1 |
| Deng, XM | 1 |
| Abe, M | 1 |
| Kumagi, T | 1 |
| Nakanishi, S | 1 |
| Yamagami, T | 1 |
| Michitaka, K | 1 |
| Abe, K | 1 |
| Okura, I | 1 |
| Yamashita, H | 1 |
| Horiike, N | 1 |
| Onji, M | 1 |
| Tada, S | 1 |
| Nakamoto, N | 1 |
| Kameyama, K | 1 |
| Tsunematsu, S | 1 |
| Kumagai, N | 1 |
| Saito, H | 1 |
| Ishii, H | 1 |
| TERZANI, A | 1 |
| KURZ, H | 1 |
| Kingreen, JC | 1 |
| Breger, G | 1 |
| Guzelian, PS | 1 |
| Vranian, G | 1 |
| Boylan, JJ | 1 |
| Cohn, WJ | 1 |
| Blanke, RV | 1 |
| Kloss, MW | 1 |
| Griffeth, LK | 1 |
| Rosen, GM | 1 |
| Rauckman, EJ | 1 |
| Bremmelgaard, A | 1 |
| Ranek, L | 3 |
| Bahnsen, M | 1 |
| Andreasen, PB | 2 |
| Christensen, E | 1 |
| Knights, KM | 1 |
| Gourlay, GK | 1 |
| Hall, P | 1 |
| Cousins, MJ | 1 |
| Bien, E | 1 |
| Skorka, G | 1 |
| Buntrock, P | 1 |
| Ramsøe, K | 1 |
| Liubchenko, PN | 1 |
| Gorenkov, RV | 1 |
| Bendikov, EA | 1 |
| Petrakov, AV | 1 |
| Delrat, P | 1 |
| Dupin, S | 1 |
| Galtier, P | 1 |
| Alvinerie, M | 1 |
| Voigt, JJ | 1 |
| Tufenkji, AE | 1 |
| Saivin, S | 1 |
| Houin, G | 1 |
| Shedlofsky, SI | 1 |
| Israel, BC | 1 |
| McClain, CJ | 1 |
| Hill, DB | 1 |
| Blouin, RA | 1 |
| Boothe, DM | 1 |
| Cullen, JM | 1 |
| Calvin, JA | 1 |
| Jenkins, WL | 1 |
| Brown, SA | 1 |
| Green, RA | 1 |
| Corrier, DE | 1 |
| Dalhoff, K | 1 |
| Poulsen, HE | 1 |
| Brøsen, K | 1 |
| Flachs, H | 1 |
| Loft, S | 1 |
| Wantzin, P | 1 |
| Zhu, M | 1 |
| Lin, KF | 1 |
| Yeung, RY | 1 |
| Li, RC | 1 |
| Burdan, F | 1 |
| Siezieniewska, Z | 1 |
| Urbanowicz, Z | 1 |
| Mach, T | 1 |
| Barylak, H | 1 |
| Ladefoged, O | 1 |
| Streeter, AJ | 1 |
| Timbrell, JA | 1 |
| Sotaniemi, EA | 1 |
| Hokkanen, OT | 1 |
| Ahokas, JT | 1 |
| Pelkonen, RO | 1 |
| Ahlqvist, J | 1 |
| Farrell, GC | 1 |
| Cooksley, WG | 1 |
| Hart, P | 1 |
| Powell, LW | 1 |
| Prescott, LF | 2 |
| Forrest, JA | 2 |
| Adjepon-Yamoah, KK | 1 |
| Finlayson, ND | 1 |
| Kelleher, J | 1 |
| McLachlan, MS | 1 |
| Walker, BE | 1 |
| Dixon, MF | 1 |
| Losowsky, MS | 1 |
| Tanaka, E | 1 |
| Etoh, H | 1 |
| Ishikawa, A | 1 |
| Nakano, M | 1 |
| Misawa, S | 1 |
| Siegmund, W | 1 |
| Franke, G | 1 |
| Baumgarten, R | 1 |
| Fengler, JD | 1 |
| Krüger, R | 1 |
| Reichardt, R | 1 |
| Chindavijak, B | 1 |
| Belpaire, FM | 1 |
| Bogaert, MG | 1 |
| Lutz, W | 1 |
| Stankiewicz, A | 1 |
| Krajewska, B | 1 |
| Paramsothy, J | 1 |
| Strange, R | 1 |
| Sharif, H | 1 |
| Collins, M | 1 |
| Shaw, P | 1 |
| Lawrence, CM | 1 |
| Altmann, HW | 1 |
| Roscoe, P | 1 |
| Stevenson, IH | 1 |
| Saratikov, AS | 1 |
| Gibelgaus, LG | 1 |
| Pritchep, TR | 1 |
| Korolenko, TA | 1 |
| Kondakova, EA | 1 |
| Kanetaka, T | 1 |
| Oda, T | 1 |
2 reviews available for antipyrine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
[Antipyrine elimination in acute toxic hepatitis in rats].
Topics: Acute Disease; Animals; Antipyrine; Biotransformation; Carbon Tetrachloride Poisoning; Chemical and | 1978 |
Drug metabolism in liver disease.
Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H | 1975 |
36 other studies available for antipyrine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines.
Topics: Alanine Transaminase; Animals; Antipyrine; Apoptosis; Aspartate Aminotransferases; Caspase 3; Caspas | 2014 |
Drug-induced hepatitis with hepatic granuloma due to saridon.
Topics: Adult; Antipyrine; Biopsy, Needle; Caffeine; Chemical and Drug Induced Liver Injury; Dose-Response R | 2002 |
Clinical usefulness of edaravone for acute liver injury.
Topics: Animals; Antipyrine; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Edarav | 2003 |
[DAMAGE FROM THERAPY].
Topics: Adrenal Cortex Hormones; Anemia; Anemia, Aplastic; Anticoagulants; Antipyrine; Blood Group Incompati | 1963 |
[THE PERMEATION OF POISONS INTO THE LIVER].
Topics: Aminopyrine; Animals; Antipyrine; Barbiturates; Chemical and Drug Induced Liver Injury; Ethylamines; | 1964 |
[Pellagra in morazone abuse].
Topics: Adult; Analgesics, Opioid; Antipyrine; Chemical and Drug Induced Liver Injury; Female; Humans; Male; | 1984 |
Liver structure and function in patients poisoned with chlordecone (Kepone).
Topics: Adolescent; Adult; Antipyrine; Biopsy; Chemical and Drug Induced Liver Injury; Chlordecone; gamma-Gl | 1980 |
Effect of acute cocaine administration on the metabolism of antipyrine in vivo.
Topics: Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System | 1983 |
Cholic acid conjugation test and quantitative liver function in acute liver failure.
Topics: Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Cholic Acids; Diagnosis, Differen | 1983 |
The predictive value of changes in antipyrine pharmacokinetics in halothane and paracetamol induced hepatic necrosis in rats.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Halothane; Ki | 1983 |
[Hepatotoxicological studies of pyrazolone derivatives on rats. Part 2: The study of propyphenazone and phenazone (author's transl)].
Topics: Aminopyrine N-Demethylase; Animals; Antipyrine; Body Weight; Chemical and Drug Induced Liver Injury; | 1981 |
Functioning liver mass in uncomplicated and fulminant acute hepatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Alanine Transaminase; Antipyrine; Bilirubin; Chemical and Dr | 1980 |
[Functional state of the liver in workers exposed to multi-component chemical mixture in the production of plastic construction materials].
Topics: Adult; Antipyrine; Chemical and Drug Induced Liver Injury; Construction Materials; Diethylhexyl Phth | 1995 |
Assessment of hepatic insufficiency model in the rabbit using carbon tetrachloride intoxication.
Topics: Alanine Transaminase; Animals; Antipyrine; Aspartate Aminotransferases; Biotransformation; Carbon Te | 1994 |
Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.
Topics: Administration, Oral; Adult; Antipyrine; C-Reactive Protein; Chemical and Drug Induced Liver Injury; | 1994 |
Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease.
Topics: Analysis of Variance; Animals; Antipyrine; Caffeine; Chemical and Drug Induced Liver Injury; Chromat | 1994 |
Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis.
Topics: Adult; Aged; Antipyrine; Chemical and Drug Induced Liver Injury; Complement C3; Female; Halothane; H | 1993 |
Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; Carbon Tetrachloride | 1999 |
Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrin | 2001 |
The effect of carbon tetrachloride (CCl4) induced liver damage on the volume of distribution, the elimination half-life and body clearance of antipyrine and warfarin in rabbits.
Topics: Animals; Antipyrine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Half-Li | 1979 |
The effect of dichloralphenazone pretreatment on paracetamol hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Chloral Hydrate; Cytochr | 1979 |
Hepatic injury and drug metabolism in patients with alpha-methyldopa-induced liver damage.
Topics: Adult; Aged; Antipyrine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Fem | 1977 |
Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism.
Topics: Acute Disease; Antipyrine; Ascites; Biotransformation; Chemical and Drug Induced Liver Injury; Chole | 1978 |
Portal venous infusion of paracetamol and antipyrine in the rat.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Injections, I | 1977 |
Influence of liver damage on antipyrine metabolite formation in rats.
Topics: 1-Naphthylisothiocyanate; Animals; Antipyrine; Carbon Tetrachloride; Chemical and Drug Induced Liver | 1991 |
Kinetics of antipyrine and sulfamethazine in patients recovered from dihydralazine-hepatitis.
Topics: Acetylation; Adult; Aged; Antipyrine; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; | 1989 |
In-vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine-induced inflammation.
Topics: Aminopyrine N-Demethylase; Animals; Antipyrine; Biotransformation; Chemical and Drug Induced Liver I | 1987 |
[Evaluation of the functional status of hepatic microsomal enzymes in workers exposed to carbon dioxide and vinyl chloride by using the antipyrine test].
Topics: Adult; Antipyrine; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Fun | 1987 |
The use of antipyrine clearance to measure liver damage in psoriatic patients receiving methotrexate.
Topics: Adult; Antipyrine; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Dise | 1988 |
Morphological changes in the liver due to phenazone and its derivatives.
Topics: Antipyrine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fatty Liver; Granulom | 1986 |
Abnormal drug metabolism after barbiturate and paracetamol overdose.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Amobarbital; Antipyrine; Barbiturates; Bilirubin; | 1974 |
Effect of some pyrazolone derivatives on lysosomes of rat liver.
Topics: Acid Phosphatase; Aminobenzoates; Analgesics; Animals; Antipyrine; Carbon Tetrachloride Poisoning; C | 1974 |
Toxic liver injuries.
Topics: Anti-Bacterial Agents; Antipyrine; Antitubercular Agents; Biopsy; Carbon Tetrachloride Poisoning; Ce | 1973 |