antipyrine has been researched along with Acute Edematous Pancreatitis in 8 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hepatic drug metabolism was examined in patients with chronic pancreatitis and healthy controls by using a cocktail design with three different model compounds: antipyrine to express phase-I oxidation, oxazepam to express phase-II conjugation, and indocyanine green (ICG), a high-clearance compound." | 9.09 | Antipyrine, oxazepam, and indocyanine green clearance in patients with chronic pancreatitis and healthy subjects. ( Andersen, V; Larsen, S; Sonne, J, 1999) |
| "Edaravone treatment significantly reduced the elevated malondialdehyde levels in rat lungs after acute pancreatitis, suggesting an important role for free radicals in acute pancreatitis-associated lung injury." | 5.36 | Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. ( Cai, ZY; Deng, XM; Hou, J; Hu, JY; Liu, SQ; Mao, YF; Ni, X; Yang, T; Zhu, XY, 2010) |
| "Hepatic drug metabolism was examined in patients with chronic pancreatitis and healthy controls by using a cocktail design with three different model compounds: antipyrine to express phase-I oxidation, oxazepam to express phase-II conjugation, and indocyanine green (ICG), a high-clearance compound." | 5.09 | Antipyrine, oxazepam, and indocyanine green clearance in patients with chronic pancreatitis and healthy subjects. ( Andersen, V; Larsen, S; Sonne, J, 1999) |
| " Oxidative drug metabolizing capacity has been assessed by oral antipyrine and/or theophylline tests in consecutive patients with chronic pancreatitis (CP; alcoholic 24, idiopathic 47), acute pancreatitis (AP; 28) and pancreatic cancer (CA; 11)." | 5.06 | Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease. ( Acheson, DW; Braganza, JM; Houston, JB; Hunt, LP; Rose, P, 1989) |
| "Edaravone treatment significantly reduced the elevated malondialdehyde levels in rat lungs after acute pancreatitis, suggesting an important role for free radicals in acute pancreatitis-associated lung injury." | 1.36 | Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. ( Cai, ZY; Deng, XM; Hou, J; Hu, JY; Liu, SQ; Mao, YF; Ni, X; Yang, T; Zhu, XY, 2010) |
| "In 22 patients with acute pancreatitis caused by biliary calculi and 9 healthy controls the rate of hepatic elimination of phenazone was measured." | 1.28 | [Effect of acute biliary pancreatitis on liver metabolism of phenazone]. ( Becker, A; Hartleb, M; Kacperek, T; Mańczyk, I; Nowak, A; Nowakowska-Duława, E, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, T | 1 |
| Mao, YF | 1 |
| Liu, SQ | 1 |
| Hou, J | 1 |
| Cai, ZY | 1 |
| Hu, JY | 1 |
| Ni, X | 1 |
| Deng, XM | 1 |
| Zhu, XY | 1 |
| Geller, LI | 1 |
| Griaznova, MV | 1 |
| Bulgakova, OS | 1 |
| Kozlova, ZP | 1 |
| Andersen, V | 1 |
| Sonne, J | 1 |
| Larsen, S | 1 |
| Hartleb, M | 1 |
| Nowak, A | 1 |
| Nowakowska-Duława, E | 1 |
| Mańczyk, I | 1 |
| Becker, A | 1 |
| Kacperek, T | 1 |
| Acheson, DW | 2 |
| Hunt, LP | 1 |
| Rose, P | 2 |
| Houston, JB | 2 |
| Braganza, JM | 2 |
| Kogan, AS | 1 |
| Nepomniashchikh, VA | 1 |
| Lukaszyk, A | 1 |
2 trials available for antipyrine and Acute Edematous Pancreatitis
| Article | Year |
|---|---|
Antipyrine, oxazepam, and indocyanine green clearance in patients with chronic pancreatitis and healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Chronic Disease; Coloring Agents; Female | 1999 |
Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease.
Topics: Adult; Aged; Alcohol Drinking; Antipyrine; Enzyme Induction; Female; Humans; Male; Metabolic Clearan | 1989 |
6 other studies available for antipyrine and Acute Edematous Pancreatitis
| Article | Year |
|---|---|
Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.
Topics: Acute Lung Injury; Animals; Antipyrine; Disease Models, Animal; Edaravone; Free Radical Scavengers; | 2010 |
[Pharmacometabolic capacity of the liver and the effect of pancreozymin in chronic hepatitis, chronic pancreatitis and diabetes mellitus].
Topics: Adult; Antipyrine; Biotransformation; Cholecystokinin; Chronic Disease; Diabetes Mellitus; Hepatitis | 1982 |
[Effect of acute biliary pancreatitis on liver metabolism of phenazone].
Topics: Acute Disease; Adult; Aged; Antipyrine; Biotransformation; Cholelithiasis; Female; Humans; Liver; Li | 1990 |
[Effect of inflammation and cholestasis on the metabolic function of the liver].
Topics: Antipyrine; Biliary Tract Diseases; Hepatitis; Humans; Inactivation, Metabolic; Inflammation; Liver; | 1987 |
[Hepatic metabolism of antipyrine in patients with acute pancreatitis].
Topics: Acute Disease; Adult; Aged; Antipyrine; Female; Humans; Inactivation, Metabolic; Kinetics; Liver; Ma | 1987 |
Induction of cytochromes P-450 in pancreatic disease: consequence, coincidence or cause?
Topics: Adolescent; Adult; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Half-Life; | 1985 |