antipyrine has been researched along with Acute Brain Injuries in 32 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to evaluate the protective effect of edaravone, a free radical scavenger, on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma." | 9.19 | Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial. ( Hu, W; Li, G; Luo, J; Rong, X; Tang, Y; Xu, P; Yang, J; Yang, X, 2014) |
| " This study was designed to evaluate the protective effect of edaravone, a free radical scavenger, on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma." | 5.19 | Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial. ( Hu, W; Li, G; Luo, J; Rong, X; Tang, Y; Xu, P; Yang, J; Yang, X, 2014) |
| "The edaravone-treated animals also exhibited higher rCBF in the contralateral hemisphere compared with that seen in -vehicle-treated animals." | 1.39 | Edaravone increases regional cerebral blood flow after traumatic brain injury in mice. ( Aruga, T; Dohi, K; Kiriyama, K; Miyamoto, K; Nakano, H; Ohtaki, H; Shioda, S; Song, D; Tsumuraya, T, 2013) |
| "Edaravone treatment significantly decreased hippocampal CA3 neuron loss, reduced oxidative stress, and decreased neuronal programmed cell death compared to vehicle treatment." | 1.37 | Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats. ( Chen, J; Gao, YQ; Jiang, ZL; Li, X; Li, YC; Shi, H; Vosler, PS; Wang, GH, 2011) |
| "Edaravone is a novel free radical scavenger used clinically in patients with acute cerebral infarction; however, it has not been assessed in traumatic brain injury (TBI)." | 1.36 | Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats. ( Hashimoto, S; Imano, M; Ito, H; Itoh, T; Nishida, S; Satou, T; Tsubaki, M, 2010) |
| "Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI)." | 1.35 | The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury. ( Hashimoto, S; Ito, H; Itoh, T; Nishida, S; Satou, T; Tsubaki, M, 2009) |
| "Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult." | 1.34 | Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury? ( Aruga, T; Dohi, K; Hiratsuka, K; Nakamachi, T; Nakamura, S; Ohtaki, H; Satoh, K; Shioda, S; Yofu, S; Yoshikawa, T, 2007) |
| "At 24 h, hyperemia was observed (vs." | 1.29 | Posttraumatic hyperemia in immature, mature, and aged rats: autoradiographic determination of cerebral blood flow. ( Biagas, KV; Grundl, PD; Kochanek, PM; Nemoto, EM; Schiding, JK, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 10 (31.25) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Kara, O | 1 |
| Kilitci, A | 1 |
| Miyamoto, K | 2 |
| Ohtaki, H | 4 |
| Dohi, K | 4 |
| Tsumuraya, T | 2 |
| Nakano, H | 1 |
| Kiriyama, K | 2 |
| Song, D | 2 |
| Aruga, T | 4 |
| Shioda, S | 4 |
| Satoh, K | 3 |
| Shimizu, A | 1 |
| Tang, Y | 1 |
| Rong, X | 1 |
| Hu, W | 1 |
| Li, G | 1 |
| Yang, X | 1 |
| Yang, J | 1 |
| Xu, P | 1 |
| Luo, J | 1 |
| Qin, T | 1 |
| Lei, LY | 1 |
| Li, N | 1 |
| Shi, FR | 1 |
| Chen, MH | 1 |
| Xie, L | 1 |
| Engel, DC | 1 |
| Mies, G | 1 |
| Terpolilli, NA | 1 |
| Trabold, R | 1 |
| Loch, A | 1 |
| De Zeeuw, CI | 1 |
| Weber, JT | 1 |
| Maas, AI | 1 |
| Plesnila, N | 1 |
| Itoh, T | 2 |
| Satou, T | 2 |
| Nishida, S | 2 |
| Tsubaki, M | 2 |
| Hashimoto, S | 2 |
| Ito, H | 2 |
| Imano, M | 1 |
| Gao, Y | 1 |
| Ding, XS | 1 |
| Xu, S | 1 |
| Wang, W | 1 |
| Zuo, QL | 1 |
| Kuai, F | 1 |
| Zhao, YN | 1 |
| Guo, X | 1 |
| Gao, JL | 1 |
| Chen, HH | 1 |
| Tian, YX | 1 |
| Cui, JZ | 1 |
| Lukic-Panin, V | 1 |
| Deguchi, K | 1 |
| Yamashita, T | 1 |
| Shang, J | 1 |
| Zhang, X | 1 |
| Tian, F | 1 |
| Liu, N | 1 |
| Kawai, H | 1 |
| Matsuura, T | 1 |
| Abe, K | 1 |
| Wang, GH | 1 |
| Jiang, ZL | 1 |
| Li, YC | 1 |
| Li, X | 1 |
| Shi, H | 1 |
| Gao, YQ | 1 |
| Vosler, PS | 1 |
| Chen, J | 1 |
| Yamashita, S | 1 |
| Hasuo, H | 1 |
| Tokutomi, T | 1 |
| Shigemori, M | 1 |
| Akasu, T | 1 |
| Ohta, M | 1 |
| Higashi, Y | 1 |
| Yawata, T | 1 |
| Kitahara, M | 1 |
| Nobumoto, A | 1 |
| Ishida, E | 1 |
| Tsuda, M | 1 |
| Fujimoto, Y | 1 |
| Shimizu, K | 1 |
| KOVALEVA, NT | 1 |
| ALLIEZ, J | 1 |
| MOUREN, P | 1 |
| CARCASSONNE, Y | 1 |
| AYMES, G | 1 |
| GEBHARDT, KH | 1 |
| Nakamura, H | 1 |
| Uzura, M | 1 |
| Uchida, K | 1 |
| Nakayama, H | 1 |
| Furuya, Y | 1 |
| Hayashi, T | 1 |
| Sekino, H | 1 |
| Ominato, M | 1 |
| Owada, S | 1 |
| Chen, SF | 1 |
| Richards, HK | 2 |
| Smielewski, P | 1 |
| Johnström, P | 1 |
| Salvador, R | 1 |
| Pickard, JD | 2 |
| Harris, NG | 1 |
| Zhang, LH | 1 |
| Wei, EQ | 2 |
| Maeda, T | 1 |
| Lee, SM | 2 |
| Hovda, DA | 2 |
| Ding, Q | 1 |
| Zhang, YJ | 1 |
| Zhang, WP | 1 |
| Chen, Z | 1 |
| Mihara, Y | 1 |
| Nakamura, S | 2 |
| Miyake, Y | 1 |
| Nakamachi, T | 2 |
| Yoshikawa, T | 2 |
| Yofu, S | 1 |
| Hiratsuka, K | 1 |
| Masaoka, N | 1 |
| Nakajima, Y | 1 |
| Watanabe, M | 1 |
| Hayakawa, Y | 1 |
| Nagaishi, M | 1 |
| Yamamoto, T | 1 |
| Honma, T | 1 |
| Oinuma, T | 1 |
| Nemoto, N | 1 |
| Scremin, OU | 1 |
| Li, MG | 1 |
| Scremin, AM | 1 |
| Dietrich, WD | 1 |
| Alonso, O | 1 |
| Busto, R | 1 |
| Prado, R | 1 |
| Dewanjee, S | 1 |
| Dewanjee, MK | 1 |
| Ginsberg, MD | 1 |
| Biagas, KV | 1 |
| Grundl, PD | 1 |
| Kochanek, PM | 1 |
| Schiding, JK | 1 |
| Nemoto, EM | 1 |
| Kelly, DF | 1 |
| Kozlowski, DA | 1 |
| Haddad, E | 1 |
| Echiverri, A | 1 |
| Simac, S | 1 |
| Piechnik, S | 1 |
| Milhorat, TH | 1 |
| Johnson, WD | 1 |
| Dow-Edwards, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Edaravone on Radiation-induced Temporal Lobe Necrosis in Patients With Nasopharyngeal Carcinoma After Radiotherapy[NCT01865201] | Phase 2 | 154 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for antipyrine and Acute Brain Injuries
| Article | Year |
|---|---|
Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Brain Injuries; Carcinoma; Case-Control Studies; Edaravo | 2014 |
31 other studies available for antipyrine and Acute Brain Injuries
| Article | Year |
|---|---|
Antioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Rats.
Topics: Animals; Antioxidants; Antipyrine; Brain Injuries; Cisplatin; Edaravone; Female; Free Radical Scaven | 2024 |
Edaravone increases regional cerebral blood flow after traumatic brain injury in mice.
Topics: Animals; Antipyrine; Brain; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Eda | 2013 |
Therapeutic time window for edaravone treatment of traumatic brain injury in mice.
Topics: Animals; Antipyrine; Brain Injuries; Disease Models, Animal; Edaravone; Free Radical Scavengers; Jap | 2013 |
Edaravone improves survival and neurological outcomes after CPR in a ventricular fibrillation model of rats.
Topics: Animals; Antipyrine; Brain Injuries; Cardiopulmonary Resuscitation; Disease Models, Animal; Edaravon | 2016 |
Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Biomarkers; Brain; Br | 2008 |
The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult Stem Cells; Aldehydes; Animals; Antipyrine; Behavior, Animal; Bra | 2009 |
Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antipyrine; Apoptosis; Behavior, Animal; Brain Inju | 2010 |
Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage.
Topics: Animals; Antipyrine; Blotting, Western; Brain Injuries; Edaravone; Immunohistochemistry; Male; Malon | 2009 |
[Effect of edaravone on extracellular signal-regulated kinase 1/2 pathway following severe traumatic brain injury in rats].
Topics: Animals; Antipyrine; Apoptosis; Brain Injuries; Disease Models, Animal; Edaravone; Male; Mitogen-Act | 2010 |
Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage.
Topics: Acetylglucosamine; Animals; Antipyrine; Blood-Brain Barrier; Brain Injuries; Cerebral Cortex; Collag | 2010 |
Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.
Topics: Animals; Antipyrine; Apoptosis; Astrocytes; Blood-Brain Barrier; Body Water; Brain Injuries; Colorin | 2011 |
Edaravone attenuates impairment of synaptic plasticity in granule cell layer of the dentate gyrus following traumatic brain injury.
Topics: Animals; Antipyrine; Brain Injuries; Dentate Gyrus; Edaravone; Electric Stimulation; Excitatory Post | 2011 |
Attenuation of axonal injury and oxidative stress by edaravone protects against cognitive impairments after traumatic brain injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Brain Injuries; Cognition; Cognition Disorders; De | 2013 |
[Commotional experimental hypertension].
Topics: Antipyrine; Brain; Brain Injuries; Humans; Hypertension | 1952 |
[Post-commotional Korsakoff syndrome with initial mesodiencephalic dysrhythmia; systematic failure of recognition through elective retrograde amnesia].
Topics: Amnesia; Amnesia, Retrograde; Antipyrine; Brain; Brain Injuries; Electroencephalography; Humans; Kor | 1953 |
[Posttraumatic subjective syndrome with hybrid post cervical sympathetic commotional syndrome (Pierre-Marie; Barre-Lieou)].
Topics: Antipyrine; Brain; Brain Injuries; Cervical Plexus; Disease; Horner Syndrome; Wounds and Injuries | 1955 |
[Review of post-commotional brain injuries and the length of therapy].
Topics: Antipyrine; Brain; Brain Injuries; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Humans | 1957 |
Effects of edaravone on experimental brain injury in view of free radical reaction.
Topics: Animals; Antipyrine; Body Water; Brain; Brain Edema; Brain Injuries; Edaravone; Electron Spin Resona | 2003 |
Relationship between flow-metabolism uncoupling and evolving axonal injury after experimental traumatic brain injury.
Topics: Amyloid beta-Protein Precursor; Animals; Antipyrine; Autoradiography; Axons; Brain Injuries; Carbon | 2004 |
ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats.
Topics: Animals; Antipyrine; Brain; Brain Injuries; Cerebral Cortex; Chromones; Edaravone; Leukotriene Antag | 2005 |
Restoration of cerebral vasoreactivity by an L-type calcium channel blocker following fluid percussion brain injury.
Topics: Animals; Antipyrine; Blood Pressure; Brain Injuries; Calcium; Calcium Channel Blockers; Calcium Chan | 2005 |
Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice.
Topics: Animals; Antioxidants; Antipyrine; Brain; Brain Injuries; Chromones; Edaravone; Ketamine; Male; Memb | 2006 |
Alkoxyl radical-scavenging activity of edaravone in patients with traumatic brain injury.
Topics: Adult; Alcohols; Antipyrine; Brain Injuries; Edaravone; Electron Spin Resonance Spectroscopy; Female | 2006 |
Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Topics: alpha-Tocopherol; Animals; Antioxidants; Antipyrine; Blood; Brain Injuries; Edaravone; Free Radical | 2007 |
MCI-186 administered to the maternal circulation inhibits fetal brain injury resulting from total umbilical cord occlusion in the chronically instrumented fetal lamb.
Topics: Animals; Antipyrine; Brain Injuries; Edaravone; Female; Fetal Hypoxia; Free Radical Scavengers; Mate | 2006 |
Cortical contusion induces trans-hemispheric reorganization of blood flow maps.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Brain Injuries; | 2007 |
Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: a double-label autoradiographic study in rats.
Topics: Animals; Antipyrine; Autoradiography; Blood Platelets; Brain Injuries; Carbon Radioisotopes; Cerebro | 1996 |
Posttraumatic hyperemia in immature, mature, and aged rats: autoradiographic determination of cerebral blood flow.
Topics: Adult; Aging; Animals; Antipyrine; Autoradiography; Brain; Brain Injuries; Carbon Radioisotopes; Cer | 1996 |
Ethanol reduces metabolic uncoupling following experimental head injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Brain Injuries; Carbo | 2000 |
Uncoupling of cerebral blood flow and metabolism after cerebral contusion in the rat.
Topics: Animals; Antipyrine; Autoradiography; Brain; Brain Chemistry; Brain Injuries; Carbon Radioisotopes; | 2001 |
Relationship between oedema, blood pressure, and blood flow following local brain injury.
Topics: Animals; Antipyrine; Blood Pressure; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Male; | 1989 |