antimony-sodium-gluconate and Proteinuria

Twelve dogs naturally infected with Leishmania infantum were treated subcutaneously with aminosidine at a dose of 10 mg kg-1 per day for four weeks. Antimonial compounds were used as reference drugs in twelve Leishmania-infected dogs. Eleven of the twelve dogs submitted to aminosidine therapy responded within 30 days. The treatment with the aminoglycoside antibiotic presented a marked decrease of anti-Leishmania antibody titres than the controls. Aminosidine also reduced urinary protein, serum IgG, and circulating immune complex concentrations. Side effects were observed only in a dog with pre-existent renal lesions. This study proved that aminosidine is an effective, tolerable and safe drug for the treatment of canine leishmaniasis and that it could be used as a suitable substitute for antimonial therapy.

Topics: Amebicides; Animals; Antibodies, Protozoan; Antigen-Antibody Complex; Antigens, Protozoan; Antimony Sodium Gluconate; Antiprotozoal Agents; Dog Diseases; Dogs; Female; Immunoglobulin G; Leishmania infantum; Leishmaniasis, Visceral; Male; Paromomycin; Proteinuria; Time Factors

We studied 27 patients presenting with renal dysfunction after Stibamate therapy. Eighteen patients were proved cases of Kala Azar, others of PUO. Out of 10 cases in whom Kidney biopsy was done, 6 had tubular necrosis, one had mild mesangial proliferation and 3 had normal picture.

Topics: Adolescent; Adult; Antimony Sodium Gluconate; Blood Urea Nitrogen; Creatinine; Female; Fever of Unknown Origin; Glomerular Mesangium; Glomerulonephritis; Humans; Kidney Diseases; Kidney Tubular Necrosis, Acute; Leishmaniasis, Visceral; Male; Middle Aged; Proteinuria; Sodium