antimony-sodium-gluconate and Kidney-Diseases

The aim of this study was to investigate the factors associated with acute kidney injury (AKI) in patients with visceral leishmaniasis (VL). The study patients had a diagnosis of VL and were admitted to a tertiary hospital. A multivariate analysis was performed to analyze the risk factors for AKI. A total of 224 patients were included. The mean age was 36 +/- 15 years. AKI was observed in 33.9% of cases. Risk factors associated with AKI were male gender (odds ratio [OR] = 2.2; P = 0.03), advanced age (OR = 1.05; P < 0.001), and jaundice (OR = 2.9; P = 0.002). There was an association between amphotericin B use and AKI (OR = 18.4; P < 0.0001), whereas glucantime use was associated with lower incidence of AKI compared with amphotericin B use (OR = 0.05; P < 0.0001). Mortality was 13.3%, and it was higher in AKI patients (30.2%). Therefore, factors associated with AKI were male gender, advanced age, and jaundice. Amphotericin B was an important cause of AKI in VL.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Antimony Sodium Gluconate; Antiprotozoal Agents; Female; Humans; Kidney Diseases; Leishmaniasis, Visceral; Male; Meglumine; Meglumine Antimoniate; Middle Aged; Organometallic Compounds; Risk Factors; Young Adult

We studied 27 patients presenting with renal dysfunction after Stibamate therapy. Eighteen patients were proved cases of Kala Azar, others of PUO. Out of 10 cases in whom Kidney biopsy was done, 6 had tubular necrosis, one had mild mesangial proliferation and 3 had normal picture.

Topics: Adolescent; Adult; Antimony Sodium Gluconate; Blood Urea Nitrogen; Creatinine; Female; Fever of Unknown Origin; Glomerular Mesangium; Glomerulonephritis; Humans; Kidney Diseases; Kidney Tubular Necrosis, Acute; Leishmaniasis, Visceral; Male; Middle Aged; Proteinuria; Sodium

Topics: Adolescent; Adult; Antimony Sodium Gluconate; Gluconates; Humans; Kidney Diseases; Leishmaniasis, Mucocutaneous

Topics: Adult; Antimony; Antimony Sodium Gluconate; Antiprotozoal Agents; Female; Gluconates; Humans; Kidney Diseases; Kidney Tubules; Leishmaniasis, Mucocutaneous; Male; Meglumine; Meglumine Antimoniate; Middle Aged; Organometallic Compounds

Thirty-five golden hamsters infected with Leishmania donovani were treated with Pentostam and followed up to determine the effect of treatment on the development of secondary amyloidosis. Seventy untreated golden hamsters infected with L. donovani were followed up as controls to determine the pattern of development of secondary amyloidosis. Amyloid developed in all animals treated and untreated. The treatment significantly prolonged the survival time, but did not inhibit the development of renal amyloid in animals shown by biopsy to be free from renal amyloid at the time of treatment. When amyloid was present in kidney at the time of treatment it progressed invariably to renal failure.

Topics: Amyloidosis; Animals; Antimony Sodium Gluconate; Cricetinae; Kidney Diseases; Leishmaniasis; Mesocricetus