antimony-sodium-gluconate and Facial-Dermatoses

A 61-year-old man presented with erysipelas-like cutaneous leishmaniasis.

Topics: Antimony Sodium Gluconate; Antiprotozoal Agents; Cellulitis; Diagnosis, Differential; Disease Progression; DNA, Protozoan; Endemic Diseases; Erysipelas; Eyelid Diseases; Facial Dermatoses; Humans; Hypokalemia; Leishmania donovani; Leishmaniasis, Cutaneous; Long QT Syndrome; Male; Middle Aged; Pancytopenia; Spain; Travel

Limited data are available regarding topical and systemic therapies for Leishmania tropica in children.. We sought to characterize the clinical presentation and evaluate the efficacy and safety of topical and systemic treatments in pediatric patients infected with L tropica.. A retrospective study was performed on 47 children with L tropica cutaneous leishmaniasis. Treatments included topical or systemic therapy with liposomal amphotericin B or pentavalent antimony.. Seventy patients with L tropica cutaneous leishmaniasis were treated at our center between 2008 and 2012, of which 47 (67%) were children. The average age of the pediatric population was 8.8 years, and the face was the most common site of involvement (76%). The average number of lesions was 2.6. 24 children (51%) required systemic therapy. The patients were treated with 3 to 5 mg/kg/d of intravenous liposomal amphotericin B, and a response was observed in 83% of the patients within 3 months.. This was a retrospective study.. The disease burden of L tropica in children is high, and because of facial involvement and a low response to topical therapies, systemic therapy is often required. In our experience, liposomal amphotericin B treatment in children is safe and effective and is required for a considerably shorter duration than treatment with pentavalent antimony.

Topics: Administration, Cutaneous; Administration, Intravenous; Adolescent; Amphotericin B; Antimony Sodium Gluconate; Child; Child, Preschool; Cryotherapy; Facial Dermatoses; Female; Humans; Infant; Injections, Intralesional; Leishmania tropica; Leishmaniasis, Cutaneous; Male; Paromomycin; Retrospective Studies; Trypanocidal Agents

Topics: Adolescent; Antimony Sodium Gluconate; Antiprotozoal Agents; Biopsy; Combined Modality Therapy; Cryotherapy; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Leishmaniasis, Cutaneous; Saudi Arabia; Syria; Travel

Topics: Aged; Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Biopsy; Chronic Disease; Dermatitis, Atopic; Facial Dermatoses; Female; Humans; Leishmania donovani; Leishmania infantum; Leishmaniasis; Treatment Outcome

Topics: Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Child; Cicatrix; Facial Dermatoses; France; Humans; Leishmania infantum; Leishmaniasis, Cutaneous; Male

Topics: Antimony Sodium Gluconate; Antiprotozoal Agents; Facial Dermatoses; Female; Humans; Itraconazole; Leishmaniasis, Cutaneous; Middle Aged; Treatment Outcome

Topics: Adolescent; Antimony Sodium Gluconate; Antiprotozoal Agents; Biopsy; Diagnosis, Differential; Emigration and Immigration; Facial Dermatoses; Humans; Leishmaniasis, Cutaneous; Male; Mexico; Physical Examination; Texas

The incidence of leishmaniasis is increasing globally due to population and environmental changes. Ease of worldwide travel and immigrant populations means that the UK surgeon is more likely to encounter cutaneous lesions. Two cases are presented and treatment options discussed.

Topics: Antimony Sodium Gluconate; Antiprotozoal Agents; Carcinoma, Basal Cell; Child; Cryotherapy; Facial Dermatoses; Female; Humans; Leishmaniasis, Cutaneous; Middle Aged; Skin Neoplasms

Topics: Afghanistan; Antimony Sodium Gluconate; Antiprotozoal Agents; Child; Facial Dermatoses; Female; Humans; Leishmaniasis, Cutaneous; Lip Diseases; London

Topics: Adult; Antimony Sodium Gluconate; Antiprotozoal Agents; Facial Dermatoses; Humans; Injections; Leishmaniasis, Cutaneous; Male; Travel

Visceral leishmaniasis (VL) is endemic in several areas in the Sudan. The disease is associated with depressed cellular immunity. Tinea versicolor is a normal commensal of the skin which can become pathogenic particularly in patients with depressed cell-mediated immunity. Patients with VL have a high prevalence of tinea versicolor.. One hundred and thirty patients with parasitologic confirmation of VL were screened for tinea versicolor infection. In the suspected cases the diagnosis was made by demonstrating the fungal hyphae and spores in skin scrapings. All patients were treated with sodium stibogluconate.. Of the 130 patients with VL, 10.8% were found to have severe tinea versicolor. The fungal infection developed or became worse with the start of VL. After successful treatment of VL, the tinea lesions disappeared completely or decreased in severity.. Depressed cell-mediated immunity that is a feature of VL is the probable underlying cause for fungal infection. Tinea infection during the course of VL is to be distinguished from lesions of post-kala-azar dermal leishmaniasis.

Topics: Adolescent; Adult; Antimony Sodium Gluconate; Child; Diagnosis, Differential; Facial Dermatoses; Female; Follow-Up Studies; Humans; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Male; Opportunistic Infections; Remission Induction; Sudan; Time Factors; Tinea Versicolor

The case of a 15-year-old boy with recurrent cutaneous leishmaniasis is reported. Species identification was based on results of serotyping and isoenzyme analysis. The patient did not respond to rifampin combined with isoniazid or to ketoconazole. Subsequent therapy with systemic sodium antimony gluconate resulted in complete regression of the lesions.

Topics: Adolescent; Antimony Sodium Gluconate; Facial Dermatoses; Gluconates; Humans; Injections, Intramuscular; Leishmaniasis; Male; Recurrence