anticodon and Carcinoma--Ehrlich-Tumor

anticodon has been researched along with Carcinoma--Ehrlich-Tumor* in 2 studies

Other Studies

2 other study(ies) available for anticodon and Carcinoma--Ehrlich-Tumor

Article	Year
Changes of post-transcriptional modification of wye base in tumor-specific tRNAPhe. Nucleic acids research, 1982, Oct-25, Volume: 10, Issue:20 Nucleotide sequences of normal mouse liver tRNAPhe and tumor-specific tRNAPhes isolated from Ehrlich ascites tumor and neuroblastoma cells were examined by post-labeling techniques. The results showed that their sequences are identical, except for changes in post-transcriptional modifications that are located in the anticodon region. Normal mouse liver tRNAPhe contained Cm32, Gm34 and YOH37. On the other hand, tumor-specific tRNAPhes were found in one of two possible configurations: 1) Cm32, Gm34 and YOH37 (under-modified YOH) or 2) C32, G34 and m1G37. The ratio of the two forms of tRNAPhes differed in different tumor cells; Ehrlich ascites tumor tRNAPhe had mainly YOH-containing tRNAPhe whereas neuroblastoma tRNAPhe has predominantly m1G-containing tRNAPhe. It was concluded that tumor-specific tRNAPhes are products of different extents of modification, rather than of new tRNA transcription. Topics: Animals; Anticodon; Base Sequence; Carcinoma, Ehrlich Tumor; Guanine; Liver; Mice; Neoplasms, Experimental; Neuroblastoma; Nucleic Acid Conformation; RNA Processing, Post-Transcriptional; RNA, Transfer, Amino Acyl	1982
Detection of unique tRNA species in tumor tissues by Escherichia coli guanine insertion enzyme. Proceedings of the National Academy of Sciences of the United States of America, 1978, Volume: 75, Issue:9 The guanine insertion enzyme from Escherichia coli catalyzes exchange of guanine located at the first position of the anticodon of tRNA with radioactive guanine (N. Okada and S. Nishimura, unpublished data). tRNA isolated from various tumors, including slowly growing Morris hepatoma 7794A, incorporated considerable guanine with E. coli guanine insertion enzyme, whereas tRNA isolated from all normal tissues so far tested, except regenerating rat liver, incorporated scarcely any. In the rat ascites hepatoma AH7974, the guanine was mostly incorporated into minor isoaccepting species of tRNAAsp that contained the guanine residue instead of Q base in the first position of the anticodon. This is a sensitive and easy method for identifying unique tRNA species in tumor tissues. Topics: Animals; Anticodon; Base Sequence; Carcinoma, Ehrlich Tumor; Cell Line; Escherichia coli; Guanine; Liver Neoplasms, Experimental; Pentosyltransferases; RNA, Neoplasm; RNA, Transfer; Transferases	1978

Article

Year

Changes of post-transcriptional modification of wye base in tumor-specific tRNAPhe.

Nucleic acids research, 1982, Oct-25, Volume: 10, Issue:20

Nucleotide sequences of normal mouse liver tRNAPhe and tumor-specific tRNAPhes isolated from Ehrlich ascites tumor and neuroblastoma cells were examined by post-labeling techniques. The results showed that their sequences are identical, except for changes in post-transcriptional modifications that are located in the anticodon region. Normal mouse liver tRNAPhe contained Cm32, Gm34 and YOH37. On the other hand, tumor-specific tRNAPhes were found in one of two possible configurations: 1) Cm32, Gm34 and Y*OH37 (under-modified YOH) or 2) C32, G34 and m1G37. The ratio of the two forms of tRNAPhes differed in different tumor cells; Ehrlich ascites tumor tRNAPhe had mainly Y*OH-containing tRNAPhe whereas neuroblastoma tRNAPhe has predominantly m1G-containing tRNAPhe. It was concluded that tumor-specific tRNAPhes are products of different extents of modification, rather than of new tRNA transcription.

Topics: Animals; Anticodon; Base Sequence; Carcinoma, Ehrlich Tumor; Guanine; Liver; Mice; Neoplasms, Experimental; Neuroblastoma; Nucleic Acid Conformation; RNA Processing, Post-Transcriptional; RNA, Transfer, Amino Acyl

1982

Detection of unique tRNA species in tumor tissues by Escherichia coli guanine insertion enzyme.

Proceedings of the National Academy of Sciences of the United States of America, 1978, Volume: 75, Issue:9

The guanine insertion enzyme from Escherichia coli catalyzes exchange of guanine located at the first position of the anticodon of tRNA with radioactive guanine (N. Okada and S. Nishimura, unpublished data). tRNA isolated from various tumors, including slowly growing Morris hepatoma 7794A, incorporated considerable guanine with E. coli guanine insertion enzyme, whereas tRNA isolated from all normal tissues so far tested, except regenerating rat liver, incorporated scarcely any. In the rat ascites hepatoma AH7974, the guanine was mostly incorporated into minor isoaccepting species of tRNAAsp that contained the guanine residue instead of Q base in the first position of the anticodon. This is a sensitive and easy method for identifying unique tRNA species in tumor tissues.

Topics: Animals; Anticodon; Base Sequence; Carcinoma, Ehrlich Tumor; Cell Line; Escherichia coli; Guanine; Liver Neoplasms, Experimental; Pentosyltransferases; RNA, Neoplasm; RNA, Transfer; Transferases

1978