anticodon and Autoimmune-Diseases

anticodon has been researched along with Autoimmune-Diseases* in 2 studies

Other Studies

2 other study(ies) available for anticodon and Autoimmune-Diseases

Article	Year
Autoreactive epitope defined as the anticodon region of alanine transfer RNA. Science (New York, N.Y.), 1987, Nov-20, Volume: 238, Issue:4830 Autoantibodies to aminoacyl-transfer RNA (tRNA) synthetases are common in the human autoimmune diseases polymyositis and dermatomyositis. Sera of the PL-12 specificity contain separate antibodies reacting with alanyl-tRNA synthetase and alanine tRNA (tRNAAla). The antibodies to tRNA recognize at least six distinguishable human tRNAAla species grouped into two sequence families. The antibody-reactive determinants on the tRNA were identified through ribonuclease protection and oligonucleotide binding experiments. The antibody binding site is a seven- to nine-nucleotide sequence containing the anticodon loop and requires an intact anticodon. No requirement for anticodon stem structure or sequence is observed, although the 5' portion of the stem is protected from nuclease attack. Antibodies from several patients appear to share the same specificitym, indicating that the antibodies are induced by a unique sequence feature in the immunogen. Topics: Alanine-tRNA Ligase; Anticodon; Autoantigens; Autoimmune Diseases; Epitopes; Myositis; Nucleic Acid Conformation; RNA, Transfer; RNA, Transfer, Ala; RNA, Transfer, Amino Acid-Specific; Structure-Activity Relationship	1987
Two human tRNA(Ala) families are recognized by autoantibodies in polymyositis sera. Molecular biology & medicine, 1987, Volume: 4, Issue:1 Autoantibodies to aminoacyl-tRNA synthetases are common in myositis. Sera of one particular class, the PL-12 specificity, contain separate antibodies reacting with alanyl-tRNA synthetase and tRNA(Ala). We show here that the anti-RNA antibodies recognize at least six distinguishable human tRNA(Ala) species, grouped in two sequence families. We have elucidated the complete nucleotide sequence of two tRNA(Ala) species from HeLa cells that are closely related to silkworm moth tRNA(Ala), as well as the partial sequence of a third species. All three contain the anticodon IGC. No tRNAs with pyrimidine in the "wobble" position were found in the immunoprecipitate, and such species may fail to interact with the antibody. Topics: Alanine; Anticodon; Autoantibodies; Autoimmune Diseases; Base Sequence; Myositis; Oligoribonucleotides; Repetitive Sequences, Nucleic Acid; RNA, Transfer; Sequence Homology, Nucleic Acid	1987

Article

Year

Autoreactive epitope defined as the anticodon region of alanine transfer RNA.

Science (New York, N.Y.), 1987, Nov-20, Volume: 238, Issue:4830

Autoantibodies to aminoacyl-transfer RNA (tRNA) synthetases are common in the human autoimmune diseases polymyositis and dermatomyositis. Sera of the PL-12 specificity contain separate antibodies reacting with alanyl-tRNA synthetase and alanine tRNA (tRNAAla). The antibodies to tRNA recognize at least six distinguishable human tRNAAla species grouped into two sequence families. The antibody-reactive determinants on the tRNA were identified through ribonuclease protection and oligonucleotide binding experiments. The antibody binding site is a seven- to nine-nucleotide sequence containing the anticodon loop and requires an intact anticodon. No requirement for anticodon stem structure or sequence is observed, although the 5' portion of the stem is protected from nuclease attack. Antibodies from several patients appear to share the same specificitym, indicating that the antibodies are induced by a unique sequence feature in the immunogen.

Topics: Alanine-tRNA Ligase; Anticodon; Autoantigens; Autoimmune Diseases; Epitopes; Myositis; Nucleic Acid Conformation; RNA, Transfer; RNA, Transfer, Ala; RNA, Transfer, Amino Acid-Specific; Structure-Activity Relationship

1987

Two human tRNA(Ala) families are recognized by autoantibodies in polymyositis sera.

Molecular biology & medicine, 1987, Volume: 4, Issue:1

Autoantibodies to aminoacyl-tRNA synthetases are common in myositis. Sera of one particular class, the PL-12 specificity, contain separate antibodies reacting with alanyl-tRNA synthetase and tRNA(Ala). We show here that the anti-RNA antibodies recognize at least six distinguishable human tRNA(Ala) species, grouped in two sequence families. We have elucidated the complete nucleotide sequence of two tRNA(Ala) species from HeLa cells that are closely related to silkworm moth tRNA(Ala), as well as the partial sequence of a third species. All three contain the anticodon IGC. No tRNAs with pyrimidine in the "wobble" position were found in the immunoprecipitate, and such species may fail to interact with the antibody.

Topics: Alanine; Anticodon; Autoantibodies; Autoimmune Diseases; Base Sequence; Myositis; Oligoribonucleotides; Repetitive Sequences, Nucleic Acid; RNA, Transfer; Sequence Homology, Nucleic Acid

1987