antibiotic-cv-1 has been researched along with Brain-Injuries* in 1 studies
1 other study(ies) available for antibiotic-cv-1 and Brain-Injuries
| Article | Year |
|---|---|
Inhibiting the CD38/cADPR pathway protected rats against sepsis associated brain injury.
The CD38/cADPR pathway has been found to play roles in various inflammatory conditions. However, whether CD38 plays a protective or detrimental effect in the central nervous system (CNS) is controversial. The aim of this study was to determine the effect of CD38/cADPR pathway in sepsis associated brain injury.. Male Sprague-Dawley rats were undergone cecal ligation and puncture (CLP) or sham laparotomies. NAD. NAD. In this study, we found that the CD38/cADPR pathway was activated in sepsis associated brain injury. Blocking this pathway protected the hippocampus from apoptosis, oxidative stress and ultrastructural morphology damages in septic rats. Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Apoptosis; Brain Injuries; Cecum; Cyclic ADP-Ribose; Disease Models, Animal; Hippocampus; Male; Membrane Glycoproteins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sepsis; Superoxide Dismutase | 2018 |