Page last updated: 2024-10-22

anthralin and Skin Neoplasms

anthralin has been researched along with Skin Neoplasms in 30 studies

Anthralin: An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.
anthralin : An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.

Skin Neoplasms: Tumors or cancer of the SKIN.

Research Excerpts

ExcerptRelevanceReference
"Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare and chronic skin disorder, which may trouble the patient considerably."2.67Treatment of inflammatory linear verrucous epidermal nevus. ( Rulo, HF; van de Kerkhof, PC, 1991)
"Anthralin was first synthesized in 1916."2.36Anthralin: historical and current perspectives. ( Andre, P; Ashton, RE; Lowe, NJ; Whitefield, M, 1983)
"Stubborn and extensive dermatoses, such as psoriasis vulgaris or atopic dermatitis (eczema), are indications for phototherapeutic methods."1.32[Phototherapy and photochemotherapy of inflammatory dermatoses]. ( Kerscher, M; Peter, RU; Pillekamp, H; Schiener, R, 2003)
" Although dose-response comparisons indicated that chrysarobin was several orders of magnitude less potent than TPA for promoting papilloma formation, this anthrone was 1."1.27Mechanism of mouse skin tumor promotion by chrysarobin. ( Aalfs, KK; Cantor, J; Coombs, MM; Decina, PC; DiGiovanni, J; Prichett, WP, 1985)
" However, dose-response studies with respect to DMBA in the two strains in two-stage carcinogenesis suggested that metabolic activation of DMBA to the active carcinogen was not limiting in the resistant strain."1.26Two-stage skin carcinogenesis in sensitive and resistant mouse strains. ( Ashman, LK; Cook, MG; Kotlarski, I; Murray, AW, 1982)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199019 (63.33)18.7374
1990's8 (26.67)18.2507
2000's3 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Van Duuren, BL1
Segal, A1
Tseng, SS1
Rusch, GM1
Loewengart, G1
Maté, U1
Roth, D1
Smith, A1
Melchionne, S1
Seidman, I1
Schiener, R1
Pillekamp, H1
Kerscher, M1
Peter, RU1
Rundhaug, JE1
Pavone, A1
Kim, E1
Fischer, SM2
Ashton, RE1
Andre, P1
Lowe, NJ1
Whitefield, M1
Gensler, H1
Bowden, GT1
Männistö, PT2
Vaissi, L1
Mustakallio, KK1
Viluksela, M2
Kosma, VM2
Collan, Y2
Ashman, LK1
Murray, AW1
Cook, MG1
Kotlarski, I1
Dimitrova, I1
Kostova, M1
Mitrova, Z1
Boutwell, RK1
Hoel, MJ1
Digiovanni, J3
Briffa, DV1
De Young, LM1
Helmes, CT2
Chao, WR2
Young, JM1
Miller, V1
Yamamoto, S1
Jiang, H1
Kato, R1
Phillips, DH1
Alldrick, AJ1
La, E1
Muga, SJ1
Locniskar, MF1
Messer, G1
Rupec, RA1
Driedger, PE1
Blumberg, PM1
Zackheim, HS1
Baxter, CS1
Andringa, A1
Chalfin, K1
Miller, ML1
Merk, HF1
Jugert, FK1
Rulo, HF1
van de Kerkhof, PC2
Tabara, M1
Watanabe, M1
de Mare, S1
Happle, R1
Marks, F1
Fürstenberger, G1
Naukkarinen, A1
Aalto, ML1
Männistö, P1
Kruszewski, FH1
Coombs, MM2
Bhatt, TS1
Pezeshk, A1
Yuspa, SH1
Dawson, MI1
Puotunen, E1
Newman, AJ1
Goerz, G1
Merk, H1
Hölzle, E1
Decina, PC1
Prichett, WP1
Cantor, J1
Aalfs, KK1

Reviews

3 reviews available for anthralin and Skin Neoplasms

ArticleYear
Anthralin: historical and current perspectives.
    Journal of the American Academy of Dermatology, 1983, Volume: 9, Issue:2

    Topics: Anthracenes; Anthralin; Cell Division; Chemistry; Cyclic AMP; Cyclic GMP; DNA Replication; Drug Admi

1983
Cutaneous NAD(P)H: quinone reductase: a xenobiotica-metabolizing enzyme with potential cancer and oxidation stress-protecting properties.
    Skin pharmacology : the official journal of the Skin Pharmacology Society, 1991, Volume: 4 Suppl 1

    Topics: Animals; Anthralin; Humans; Oxidation-Reduction; Quinone Reductases; Skin; Skin Neoplasms; Xenobioti

1991
Cutaneous chemical carcinogenesis.
    Journal of the American Academy of Dermatology, 1986, Volume: 15, Issue:5 Pt 1

    Topics: Animals; Anthralin; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; DNA; Enzym

1986

Trials

1 trial available for anthralin and Skin Neoplasms

ArticleYear
Treatment of inflammatory linear verrucous epidermal nevus.
    Dermatologica, 1991, Volume: 182, Issue:2

    Topics: Adolescent; Anthralin; Female; Humans; Inflammation; Isotretinoin; Nevus; Skin Neoplasms

1991

Other Studies

26 other studies available for anthralin and Skin Neoplasms

ArticleYear
Structure and tumor-promoting activity of analogues of anthralin (1,8-dihydroxy-9-anthrone).
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:1

    Topics: Animals; Anthracenes; Anthralin; Anthraquinones; Chemical Phenomena; Chemistry; Female; Metals; Mice

1978
[Phototherapy and photochemotherapy of inflammatory dermatoses].
    MMW Fortschritte der Medizin, 2003, Feb-20, Volume: 145, Issue:8

    Topics: Administration, Topical; Adolescent; Anthralin; Anti-Inflammatory Agents; Child; Combined Modality T

2003
The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent.
    Molecular carcinogenesis, 2007, Volume: 46, Issue:12

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Blotting, Northern; Blotting, Western; Carcino

2007
Influence of 13-cis-retinoic acid on mouse skin tumor initiation and promotion.
    Cancer letters, 1984, Volume: 22, Issue:1

    Topics: Animals; Anthralin; Benzo(a)pyrene; Benzopyrenes; Female; Isotretinoin; Methylnitronitrosoguanidine;

1984
Tumor-producing activity of dithranol (anthralin) and two of its 10-acyl analogs in the dorsal skin of female NMRI mice.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anthracenes; Anthralin; Body Wei

1984
Two-stage skin carcinogenesis in sensitive and resistant mouse strains.
    Carcinogenesis, 1982, Volume: 3, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Dose-Response Relationship, Drug; Female; Mice

1982
[Linear psoriasis?].
    Zeitschrift fur Hautkrankheiten, 1983, Apr-15, Volume: 58, Issue:8

    Topics: Anthralin; Female; Humans; Middle Aged; Nevus, Pigmented; Psoriasis; Skin Neoplasms

1983
The role of anthralin in mouse skin tumour promotion.
    The British journal of dermatology, 1981, Volume: 105 Suppl 20

    Topics: Animals; Anthracenes; Anthralin; DNA; Enzyme Induction; Mice; Neoplasms, Experimental; Ornithine Dec

1981
Antipsoriatic therapy and skin cancer.
    The British journal of dermatology, 1981, Volume: 105 Suppl 20

    Topics: Anthracenes; Anthralin; Humans; Psoriasis; Skin Neoplasms

1981
Paradoxical effect of anthralin on 12-O-tetradecanoylphorbol-13-acetate-induced mouse epidermal ornithine decarboxylase activity, proliferation, and tumor promotion.
    Cancer research, 1981, Volume: 41, Issue:1

    Topics: Animals; Anthracenes; Anthralin; Carboxy-Lyases; Cell Division; Enzyme Induction; Epidermal Cells; E

1981
Inhibition of anthralin-caused skin tumor promotion and interleukin-1 alpha production by potent immunosuppressant FK506.
    Cancer letters, 1994, Aug-15, Volume: 83, Issue:1-2

    Topics: Administration, Topical; Animals; Anthralin; Anticarcinogenic Agents; Carcinogens; Female; Interleuk

1994
Tumorigenicity of a combination of psoriasis therapies.
    British journal of cancer, 1994, Volume: 69, Issue:6

    Topics: Adenosine Triphosphate; Administration, Topical; Animals; Anthralin; Benzo(a)pyrene; Carcinogens; Co

1994
Altered expression of interleukin-1 receptor antagonist in different stages of mouse skin carcinogenesis.
    Molecular carcinogenesis, 1999, Volume: 24, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Blotting, Northern; Blotting, Western; Carcino

1999
[Nuclear factor kappa B (NF-kappa B). II. Pathophysiologic meaning].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2001, Volume: 52, Issue:8

    Topics: Acute-Phase Reaction; Administration, Topical; Animals; Anthralin; Anti-Inflammatory Agents; Autoimm

2001
Non-phorbol mouse skin tumor promoters do not mimic phorbol myristate acetate in its effects on chick embryo fibroblasts.
    International journal of cancer, 1978, Jul-15, Volume: 22, Issue:1

    Topics: Acetates; Animals; Anthralin; Cantharidin; Carcinogens; Cell Membrane; Chick Embryo; Cytochalasin B;

1978
Evaluation of anthralin for mycosis fungoides.
    Journal of the American Academy of Dermatology, 1992, Volume: 27, Issue:1

    Topics: Adult; Aged; Anthralin; Erythema; Female; Humans; Male; Middle Aged; Mycosis Fungoides; Ointments; S

1992
Effect of tumor-promoting agents on density and morphometric parameters of mouse epidermal Langerhans and Thy-1+ cells.
    Carcinogenesis, 1991, Volume: 12, Issue:6

    Topics: Alkanes; Animals; Anthralin; Antigens, Surface; Carcinogens; Cell Count; Dendritic Cells; Epidermis;

1991
Suppression of footpad reaction in mice by anthralin.
    The Japanese journal of experimental medicine, 1990, Volume: 60, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Erythrocytes; Hindlimb; Hypersensitivity, Dela

1990
Dithranol in the treatment of inflammatory linear verrucous epidermal nevus.
    Acta dermato-venereologica, 1989, Volume: 69, Issue:1

    Topics: Adult; Anthralin; Humans; Inflammation; Male; Nevus; Skin Neoplasms

1989
Experimental evidence that skin carcinogenesis is a multistep phenomenon.
    The British journal of dermatology, 1986, Volume: 115 Suppl 31

    Topics: Animals; Anthralin; Benzoyl Peroxide; Iodoacetates; Iodoacetic Acid; Lyngbya Toxins; Mice; Neoplasm

1986
Histopathological and morphometrical analysis applied to skin changes in NMRI mice induced by dithranol (anthranil) and its acyl analogs.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1986, Volume: 9

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Cell Nucleus; DNA; Female; Hyperplasia; Mice;

1986
Structure-activity relationships for epidermal ornithine decarboxylase induction and skin tumor promotion by anthrones.
    Carcinogenesis, 1988, Volume: 9, Issue:8

    Topics: Animals; Anthracenes; Anthralin; Enzyme Induction; Female; Free Radicals; Mice; Ornithine Decarboxyl

1988
Inhibition by retinoids of anthralin-induced mouse epidermal ornithine decarboxylase activity and anthralin-promoted skin tumor formation.
    Cancer research, 1987, Dec-01, Volume: 47, Issue:23

    Topics: Administration, Topical; Animals; Anthralin; Chemical Phenomena; Chemistry; Enzyme Induction; Epider

1987
Tumor-producing and skin-irritating activity of dithranol (anthralin) and its 10-acyl analogues in SENCAR mice.
    Carcinogenesis, 1986, Volume: 7, Issue:10

    Topics: Animals; Anthralin; Blood; Body Weight; Female; Irritants; Male; Mice; Neoplasms, Experimental; Orga

1986
[Tar treatment of psoriasis].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1985, Volume: 36, Issue:1

    Topics: Anthralin; Combined Modality Therapy; Drug Therapy, Combination; Humans; Psoriasis; Radiotherapy Dos

1985
Mechanism of mouse skin tumor promotion by chrysarobin.
    Cancer research, 1985, Volume: 45, Issue:6

    Topics: Animals; Anthracenes; Anthralin; Carcinogens; Dose-Response Relationship, Drug; Edema; Female; Hyper

1985