ansamitocins and Neoplasms

ansamitocins has been researched along with Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for ansamitocins and Neoplasms

Article	Year
Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo. Chemistry (Weinheim an der Bergstrasse, Germany), 2017, Sep-07, Volume: 23, Issue:50 Conjugates based on nanostructured, superparamagnetic particles, a thermolabile linker and a cytotoxic maytansinoid were developed to serve as a model for tumour-selective drug delivery and release. It combines chemo- with thermal therapy. The linker-modified toxin was prepared by a combination of biotechnology and semisynthesis. Drug release was achieved by hyperthermia through an external oscillating electromagnetic field that induces heat inside the particles. Efficacy of this release concept was demonstrated both for cancer cell proliferation in vitro, and for tumour growth in vivo, in a xenograft mouse model. Biocompatibility studies for these magnetic-nanoparticle/ansamitocin conjugates complement this work. Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cycloaddition Reaction; Drug Carriers; Drug Liberation; Humans; Hyperthermia, Induced; Ki-67 Antigen; Magnetic Resonance Spectroscopy; Magnetite Nanoparticles; Maytansine; Mice; Mice, Nude; Neoplasms; Transplantation, Heterologous	2017
The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library. Angewandte Chemie (International ed. in English), 2012, Jan-16, Volume: 51, Issue:3 Topics: Actinomycetales; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Humans; Lactams, Macrocyclic; Maytansine; Mutation; Neoplasms; Streptomyces; Tubulin Modulators	2012

Article

Year

Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo.

Chemistry (Weinheim an der Bergstrasse, Germany), 2017, Sep-07, Volume: 23, Issue:50

Conjugates based on nanostructured, superparamagnetic particles, a thermolabile linker and a cytotoxic maytansinoid were developed to serve as a model for tumour-selective drug delivery and release. It combines chemo- with thermal therapy. The linker-modified toxin was prepared by a combination of biotechnology and semisynthesis. Drug release was achieved by hyperthermia through an external oscillating electromagnetic field that induces heat inside the particles. Efficacy of this release concept was demonstrated both for cancer cell proliferation in vitro, and for tumour growth in vivo, in a xenograft mouse model. Biocompatibility studies for these magnetic-nanoparticle/ansamitocin conjugates complement this work.

Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cycloaddition Reaction; Drug Carriers; Drug Liberation; Humans; Hyperthermia, Induced; Ki-67 Antigen; Magnetic Resonance Spectroscopy; Magnetite Nanoparticles; Maytansine; Mice; Mice, Nude; Neoplasms; Transplantation, Heterologous

2017

The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.

Angewandte Chemie (International ed. in English), 2012, Jan-16, Volume: 51, Issue:3

Topics: Actinomycetales; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Humans; Lactams, Macrocyclic; Maytansine; Mutation; Neoplasms; Streptomyces; Tubulin Modulators

2012