anomalin has been researched along with Neuralgia* in 1 studies
1 other study(ies) available for anomalin and Neuralgia
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Attenuation of neuropathic pain and neuroinflammatory responses by a pyranocoumarin derivative, anomalin in animal and cellular models.
The present study investigated the neuropathic pain, anti-neuroinflammatory and neuroprotective properties of a pyranocoumarin derivative (anomalin) in in vivo and in vitro models. An in vivo streptozotocin (STZ)-induced diabetic neuropathic pain model demonstrated that anomalin significantly suppressed neuropathic pain in mice. To identify the molecular mechanism of the anti-neuropathic pain activity of anomalin, sodium-nitroprusside (SNP)-induced neuroinflammation in neuro-2a (N2a) cells was further investigated in signaling pathways. The effects of anomalin against SNP-induced toxicity, nitrite production and related mRNA gene expression (iNOS and COX-2) were considerably reduced by anomalin in the SNP-induced N2a cells. In the molecular signaling pathway, anomalin effectively blocked the SNP-induced activation of the IKKα/β, IκBα, ERK1/2 and p38 MAPK pathways. Furthermore, anomalin remarkably reduced the increase in the SNP-induced nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. Additionally, the pro-inflammatory cytokines level was remarkably inhibited by anomalin in high glucose-induced DRG primary neurons and SNP-induced N2a cells. These findings indicate that anomalin has anti-neuropathic pain, anti-neuroinflammatory and neuroprotective effects against STZ-induced diabetic type I neuropathic pain and SNP-induced in neuronal cell models via the inactivation of the NF-κB, Nrf2 and MAPK signaling pathways. Topics: Animals; Antioxidants; Cell Line, Tumor; Cold Temperature; Coumarins; Cyclooxygenase 2; Cytokines; Diabetes Mellitus, Type 1; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation, Enzymologic; Inflammation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Neuralgia; Neurons; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pyranocoumarins; Rats; RNA, Messenger | 2016 |