annonacin and Urinary-Bladder-Neoplasms

annonacin has been researched along with Urinary-Bladder-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for annonacin and Urinary-Bladder-Neoplasms

ArticleYear
Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway.
    Life sciences, 2003, May-09, Volume: 72, Issue:25

    Annonaceous acetogenins are a group of potential anti-neoplastic agents isolated from Annonaceae plants. In this study, we purified annonacin, a cytotoxic mono-tetrahydrofuran acetogenin, from the seeds of Annona reticulata and analyzed its biological effects. Herein, we have shown that annonacin caused significant cell death in various cancer cell lines. T24 bladder cancer cells at the S phase were more vulnerable to the cytotoxicity of annonacin. Furthermore, annonacin activated p21 in a p53-independent manner and arrested T24 cells at the G1 phase. It also induced Bax expression, enhanced caspase-3 activity, and caused apoptotic cell death in T24 cells. In summary, these results suggest that annonacin is potentially a promising anti-cancer compound.

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Blotting, Western; Bromodeoxyuridine; Carcinoma, Transitional Cell; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Flow Cytometry; Fluorescent Antibody Technique; Furans; G1 Phase; Humans; Lactones; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2003