ankaflavin and Liver-Cirrhosis

ankaflavin has been researched along with Liver-Cirrhosis* in 1 studies

Other Studies

1 other study(ies) available for ankaflavin and Liver-Cirrhosis

Article	Year
Ankaflavin and Monascin Induce Apoptosis in Activated Hepatic Stellate Cells through Suppression of the Akt/NF-κB/p38 Signaling Pathway. Journal of agricultural and food chemistry, 2016, Dec-14, Volume: 64, Issue:49 The increased proliferation of activated hepatic stellate cells (HSCs) is associated with hepatic fibrosis and excessive extracellular matrix (ECM)-protein production. We examined the inhibitory effects of the Monascus purpureus-fermented metabolites, ankaflavin and monascin (15 and 30 μM), on the Akt/nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK) signaling pathways in HSC-T6 (activated hepatic stellate cell line). Ankaflavin and monascin (30 μM) induced apoptosis and significantly inhibited cell growth (cell viabilities: 80.2 ± 5.43% and 62.8 ± 8.20%, respectively, versus control cells; P < 0.05). Apoptosis and G1 phase arrest (G1 phase percentages: 76.1 ± 2.85% and 79.9 ± 1.80%, respectively, versus control cells 65.9 ± 4.94%; P < 0.05) correlated with increased p53 and p21 levels and caspase 3 activity and decreased cyclin D1 and Bcl-2-family protein levels (P < 0.05, all cases). The apoptotic effects of ankaflavin and monascin were HSC-T6-specific, suggesting their potential in treating liver fibrosis. Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Down-Regulation; Flavins; Hepatic Stellate Cells; Heterocyclic Compounds, 3-Ring; Humans; Liver Cirrhosis; Male; Monascus; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction	2016

Article

Year

Ankaflavin and Monascin Induce Apoptosis in Activated Hepatic Stellate Cells through Suppression of the Akt/NF-κB/p38 Signaling Pathway.

Journal of agricultural and food chemistry, 2016, Dec-14, Volume: 64, Issue:49

The increased proliferation of activated hepatic stellate cells (HSCs) is associated with hepatic fibrosis and excessive extracellular matrix (ECM)-protein production. We examined the inhibitory effects of the Monascus purpureus-fermented metabolites, ankaflavin and monascin (15 and 30 μM), on the Akt/nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK) signaling pathways in HSC-T6 (activated hepatic stellate cell line). Ankaflavin and monascin (30 μM) induced apoptosis and significantly inhibited cell growth (cell viabilities: 80.2 ± 5.43% and 62.8 ± 8.20%, respectively, versus control cells; P < 0.05). Apoptosis and G1 phase arrest (G1 phase percentages: 76.1 ± 2.85% and 79.9 ± 1.80%, respectively, versus control cells 65.9 ± 4.94%; P < 0.05) correlated with increased p53 and p21 levels and caspase 3 activity and decreased cyclin D1 and Bcl-2-family protein levels (P < 0.05, all cases). The apoptotic effects of ankaflavin and monascin were HSC-T6-specific, suggesting their potential in treating liver fibrosis.

Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Down-Regulation; Flavins; Hepatic Stellate Cells; Heterocyclic Compounds, 3-Ring; Humans; Liver Cirrhosis; Male; Monascus; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction

2016