anisomycin and Migraine-Disorders

Migraine attacks are often triggered by normally innocuous stimuli, suggesting that sensitization within the nervous system is present. One mechanism that may contribute to neuronal sensitization in this context is translation regulation of new protein synthesis. The goal of this study was to determine whether protein synthesis contributes to behavioral responses and priming in preclinical models of migraine.. Mice received a dural injection of interleukin-6 in the absence or presence of the protein synthesis inhibitor anisomycin or the translation initiation inhibitor 4EGI-1 and were tested for facial hypersensitivity. Upon returning to baseline, mice were given a second, non-noxious dural injection of pH 7.0 to test for priming. Additionally,. Dural injection of interleukin-6 in the presence of anisomycin or 4EGI-1 or in. These studies show that

Topics: Animals; Anisomycin; Disease Models, Animal; Eukaryotic Initiation Factor-4E; Hyperalgesia; Interleukin-6; Mice; Migraine Disorders