aniracetam has been researched along with Seizures in 5 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The evaluation is reported of their anticonvulsant effects, both in the audiogenic seizures test with DBA/2 mice and against the maximal electroshock- and pentylenetetrazole-induced seizures in Swiss mice." | 3.70 | 3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists. ( Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Libri, V; Quartarone, S; Zappalà, M, 1998) |
| "We have previously shown that 1-aryl-3,5-dihydro-7, 8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (3) possess marked anticonvulsant properties and antagonize seizures induced by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) in analogy to the structurally related 1-(4-aminophenyl)-4-methyl-7, 8-methylenedioxy-5H-2,3-benzodiazepine (1, GYKI 52466), a well-known noncompetitive AMPA/kainate receptor antagonist." | 3.70 | Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists. ( Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M, 1999) |
| " The new compounds were found to possess anticonvulsant effects against seizures induced both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice." | 3.70 | Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones. ( Bevacqua, F; Chimirri, A; De Sarro, A; De Sarro, G; Gitto, R; Quartarone, S; Rizzo, M; Zappalà, M, 2000) |
| " The seizures were evoked both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice." | 3.69 | 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. ( Chapman, AG; Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Giusti, P; Grasso, S; Libri, V; Quartarone, S; Zappalà, M, 1997) |
| "Pretreatment with aniracetam (50 nmol i." | 1.29 | Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice. ( al-Zubaidy, Z; Chapman, AG; Meldrum, BS, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chapman, AG | 2 |
| al-Zubaidy, Z | 1 |
| Meldrum, BS | 1 |
| Chimirri, A | 3 |
| De Sarro, G | 4 |
| De Sarro, A | 4 |
| Gitto, R | 3 |
| Grasso, S | 2 |
| Quartarone, S | 3 |
| Zappalà, M | 4 |
| Giusti, P | 1 |
| Libri, V | 2 |
| Constanti, A | 2 |
| Micale, N | 1 |
| Puia, G | 1 |
| Baraldi, M | 1 |
| De Micheli, C | 1 |
| Bevacqua, F | 1 |
| Rizzo, M | 1 |
5 other studies available for aniracetam and Seizures
| Article | Year |
|---|---|
Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Dose-Response | 1993 |
1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1998 |
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; | 1999 |
Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones.
Topics: Acoustic Stimulation; Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2000 |